PurnaCKashyapMDAGAF

Gastroenterology • Rochester, MN

Gastrointestinal Functional & Motility Disorders

Associate Professor, Medicine, Physiology and Biomedical Engineering, Mayo Clinic

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Office
200 1st St Sw
Rochester, MN 55905
Phone+1 507-284-2511
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Education & Training

Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Gastroenterology, 2007 - 2010
University of Texas Medical Branch HospitalsResidency, Internal Medicine, 2004 - 2007
Bangalore Medical CollegeClass of 1999

Certifications & Licensure

MN State Medical License 2007 - 2024
American Board of Internal Medicine Gastroenterology

Clinical Trials

Developing Novel Microbiota-Targeted Therapies for Irritable Bowel Syndrome Start of enrollment: 2014 Sep 19
Completed
Small Bowel Microbiota Characterization in Healthy Individuals Before and After Consumption of a Western Diet Start of enrollment: 2017 Jan 09
Completed
Not Applicable
Effect of Gum Arabic on Gastrointestinal Transit and Permeability Start of enrollment: 2018 Dec 18
Completed
Not Applicable
The Characteristics and Role of Mucosal Microbiome After Treatment of Clostridioides Difficile Infection Start of enrollment: 2019 Sep 01
Completed
The Role of Mucosal Microbiome in Recurrence of Clostridioides Difficile Infection Start of enrollment: 2019 Sep 23
Completed
The Role of Mucosal Microbiome in the Development, Clearance and Recurrence of Clostridioides Difficile Infection Start of enrollment: 2019 Sep 23
Withdrawn
Roles: Principal Investigator
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Publications & Presentations

PubMed

Impact of PAP on the gut microbiome in OSA: A pilot study.
Joshua M Bock, Stephen Johnson, Purna C Kashyap, Virend K Somers, Joseph Cheung> ;Sleep Medicine. 2024 Apr 4
Chronic Visceral Pain: New Peripheral Mechanistic Insights and Resulting Treatments.
Ford, A., Vanner, S., Nasser, Y., Kashyap, P.> ;Gastroenterology. 2024 Feb 5
Industrialized human gut microbiota increases CD8+ T cells and mucus thickness in humanized mouse gut.
Pajau Vangay, Tonya Ward, Sarah Lucas, Lalit K Beura, Dominique Sabas, Max Abramson, Lisa Till, Susan L Hoops, Purna Kashyap, Ryan C Hunter, David Masopust, Dan Knights> ;Gut Microbes. 2023 Dec 1
Altered Bile Acid and Pouch Microbiota Composition in Patients With Chronic Pouchitis.
Priscila Santiago, Kevin P Quinn, Jun Chen, Jessica J Friton, Chad R Rypstra, Purna C Kashyap, Laura E Raffals> ;Inflammatory Bowel Diseases. 2023 Nov 30
4 citations
Role of Diet-Microbiome Interaction in Gastrointestinal Disorders and Strategies to Modulate Them with Microbiome-Targeted Therapies.
Ajita Jadhav, Aditya Bajaj, Yang Xiao, Manasvini Markandey, Vineet Ahuja, Purna C Kashyap> ;Annual Review of Nutrition. 2023 Aug 21
1 citations
Small Intestinal Bacterial Overgrowth Complicating Gastrointestinal Manifestations of Systemic Sclerosis: A Systematic Review and Meta-analysis.
Ayesha Shah, Veenaa Pakeerathan, Michael P Jones, Purna C Kashyap, Kate Virgo, Thomas Fairlie, Mark Morrison, Uday C Ghoshal, Gerald J Holtmann> ;Journal of Neurogastroenterology and Motility. 2023 Apr 30
2 citations
Multi-omics for biomarker approaches in the diagnostic evaluation and management of abdominal pain and irritable bowel syndrome: what lies ahead.
Andrea Shin, Purna C Kashyap> ;Gut Microbes. 2023 Apr 3
1 citations
Promote or Prevent? Gut Microbial Function and Immune Status May Determine the Effect of Fiber in Inflammatory Bowel Disease.
Andrea Shin, Purna C Kashyap> ;Gastroenterology. 2023 Feb 1
1 citations
Genesis of fecal floatation is causally linked to gut microbial colonization in mice.
Syed Mohammed Musheer Aalam, Daphne Norma Crasta, Pooja Roy, A Lee Miller 2nd, Scott I Gamb, Stephen Johnson, Lisa M Till, Jun Chen, Purna Kashyap, Nagarajan Kannan> ;Scientific Reports. 2022 Oct 27
Adjustable Intragastric Balloon Leads to Significant Improvement in Obesity-Related Lipidome and Fecal Microbiome Profiles: A Proof-of-Concept Study.
Hisham Hussan, Barham K Abu Dayyeh, Jun Chen, Stephen Johnson, Ken M Riedl, Elizabeth M Grainger, Jeffrey Brooks, Alice Hinton, Christina Simpson, Purna C Kashyap> ;Clinical and Translational Gastroenterology. 2022 Jul 1
39 citations
Identification of shared and disease-specific host gene-microbiome associations across human diseases using multi-omic integration.
Sambhawa Priya, Michael B Burns, Tonya Ward, Ruben A T Mars, Beth Adamowicz, Eric F Lock, Purna C Kashyap, Dan Knights, Ran Blekhman> ;Nature Microbiology. 2022 Jun 1
22 citations
Gut microbial β-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome.
Adam L Edwinson, Lu Yang, Stephanie Peters, Nikita Hanning, Patricio Jeraldo, Pratik Jagtap, Joshua B Simpson, Tzu-Yi Yang, Praveen Kumar, Subina Mehta, Asha Nair, Mar...> ;Nature Microbiology. 2022 May 1
9 citations
Potential Role of Inflammation-Promoting Biliary Microbiome in Primary Sclerosing Cholangitis and Cholangiocarcinoma.
Katsuyuki Miyabe, Vinay Chandrasekhara, Nicha Wongjarupong, Jun Chen, Lu Yang, Stephen Johnson, Nicholas Chia, Marina Walther-Antonio, Janet Z Yao, Sean C Harrington, ...> ;Cancers. 2022 Apr 24
2 citations
Dynamics of plasmid-mediated niche invasion, immunity to invasion, and pheromone-inducible conjugation in the murine gastrointestinal tract.
Helmut Hirt, Kerryl E Greenwood-Quaintance, Aaron M T Barnes, Melissa J Karau, Lisa M Till, Elise Palzer, Weihua Guan, Michael S VanNieuwenhze, Purna C Kashyap, Robin ...> ;Nature Communications. 2022 Mar 16
27 citations
Oxidative ornithine metabolism supports non-inflammatory C. difficile colonization.
Kali M Pruss, Fatima Enam, Eric Battaglioli, Mary DeFeo, Oscar R Diaz, Steven K Higginbottom, Curt R Fischer, Andrew J Hryckowian, William Van Treuren, Dylan Dodd, Pur...> ;Nature Metabolism. 2022 Jan 1
23 citations
The role of microbiome in pancreatic cancer.
Jenny Jing Li, Mojun Zhu, Purna C. Kashyap, Nicholas Chia, Nguyen H Tran, Robert R. McWilliams, Tanios Bekaii-Saab, Wen Wee Ma> ;Cancer Metastasis Reviews. 2021 Aug 28
46 citations
The promise of the gut microbiome as part of individualized treatment strategies
Daniel A. Schupack, Ruben A. T. Mars, Dayne Voelker, Jithma P. Abeykoon, Purna C. Kashyap> ;Nature Reviews. Gastroenterology & Hepatology. 2021 Aug 27
24 citations
Multi-Omics Analyses Show Disease, Diet, and Transcriptome Interactions With the Virome
Kathie A. Mihindukulasuriya, Ruben A. T. Mars, Abigail J. Johnson, Tonya Ward, Sambhawa Priya, Heather Lekatz, Krishna R. Kalari, Lindsay Droit, Tenghao Zheng, Ran Ble...> ;Gastroenterology. 2021 Jul 7
35 citations
Mucin-derived O-glycans supplemented to diet mitigate diverse microbiota perturbations.
Kali M. Pruss, Angela Marcobal, Audrey Southwick, Dylan Dahan, Samuel A. Smits, Jessica A. Ferreyra, Steven K. Higginbottom, Erica D. Sonnenburg, Purna C. Kashyap, Bis...> ;The ISME Journal. 2021 Feb 1
50 citations
Role of gut microbiota in regulating gastrointestinal dysfunction and motor symptoms in a mouse model of Parkinson's disease.
Yogesh Bhattarai, Jie Si, Meng Pu, Owen A. Ross, Pamela J. McLean, Lisa Till, William Moor, Madhusudan Grover, Karunya K. Kandimalla, Gianrico Farrugia, Purna C. Kashy...> ;Gut Microbes. 2021 Jan 18
12 citations
Berberine alters gut microbial function through modulation of bile acids
Patricia G. Wolf, Saravanan Devendran, Heidi L. Doden, Lindsey Ly, Tyler Moore, Hajime Takei, Hiroshi Nittono, Tsuyoshi Murai, Takao Kurosawa, George E. Chlipala, Stef...> ;BMC Microbiology. 2021 Jan 11
25 citations
Functional Gastrointestinal Disorders and the Microbiome-What Is the Best Strategy for Moving Microbiome-based Therapies for Functional Gastrointestinal Disorders into...
Ruben A. T. Mars, Mary Frith, Purna C. Kashyap> ;Gastroenterology. 2021 Jan 1
25 citations
Bacterially Derived Tryptamine Increases Mucus Release by Activating a Host Receptor in a Mouse Model of Inflammatory Bowel Disease.
Yogesh Bhattarai, Si Jie, David R. Linden, Sayak Ghatak, Ruben A. T. Mars, Brianna B. Williams, Meng Pu, Justin L. Sonnenburg, Michael A. Fischbach, Gianrico Farrugia,...> ;Iscience. 2020 Dec 18
13 citations
Plasmid acquisition alters vancomycin susceptibility in Clostridioides difficile.
Meng Pu, Janice M. Cho, Scott A. Cunningham, Gaurav K. Behera, Sarah Becker, Talal Amjad, Kerryl E. Greenwood-Quaintance, Helena Mendes-Soares, Yava Jones-Hall, Patric...> ;Gastroenterology. 2021 Feb 1
40 citations
Erratum: Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome (Cell (2020) 182(6) (1460–1473.e17), (S0092867420309983), (10....
Ruben A. T. Mars, Yi Yang, Tonya Ward, Mo Houtti, Sambhawa Priya, Heather Lekatz, Xiaojia Tang, Zhifu Sun, Krishna R. Kalari, Tal Korem, Yogesh Bhattarai, Tenghao Zhen...> ;Cell. 2020 Nov 12
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Press Mentions

The Future Will Be Personalized: Accelerating Microbiome ResearchNovember 24th, 2022
How the Ecosystems in Our Guts Could Be Linked to Brain DisordersAugust 28th, 2021
Mayo Clinic Analysis Shows How Disease, Diet, and Genomics Interact with Gut ViromeAugust 25th, 2021
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Hospital Affiliations

Mayo Clinic Hospital - RochesterRochester, Minnesota