RenaRuiyaXianMD

Pathology • Baltimore, MD

Hematopathology, Molecular Genetics, Anatomic Pathology, Clinical Pathology

Physician

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Office
600 N Wolfe St
Baltimore, MD 21287
Phone+1 410-502-4340
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Education & Training

UCLA David Geffen School of Medicine/UCLA Medical CenterFellowship, Molecular Genetic Pathology, 2014 - 2015
Johns Hopkins UniversityFellowship, Hematopathology, 2013 - 2014
University of Pennsylvania Health SystemResidency, Pathology-Anatomic and Clinical, 2009 - 2013
Northwestern University The Feinberg School of MedicineClass of 2009

Certifications & Licensure

MD State Medical License 2018 - 2025
CA State Medical License 2014 - 2019
PA State Medical License 2009 - 2014
American Board of Pathology Pathology - Anatomic/Pathology - Clinical
American Board of Pathology Pathology - Hematology
American Board of Pathology Pathology - Molecular Genetic

Publications & Presentations

PubMed

How to classify risk based on clinical and molecular modeling: integrating molecular markers in the risk assessment of myelodysplastic syndrome.
Xian, R.> ;Hematology. American Society of Hematology. Education Program. 2023 Dec 8
Donor cell-derived genetic abnormalities after sex mismatched allogeneic cell transplantation: a unique challenge of donor cell leukemia.
Melanie Klausner, Brian Phan, Laura Morsberger, Rebecca Parish, Alison Shane, Rebecca Park, Christopher D Gocke, Rena R Xian, Rick John Jones, Javier Bolaños-Meade, Lu...> ;Blood Cancer Journal. 2023 Nov 6
7 citations
The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring.
Syeda Maheen Batool, Anudeep Yekula, Prerna Khanna, Tiffaney Hsia, Austin S Gamblin, Emil Ekanayake, Ana K Escobedo, Dong Gil You, Cesar M Castro, Hyungsoon Im, Tugba ...> ;Cell Reports. Medicine. 2023 Oct 17
Current clinical practices and challenges in molecular testing: a GOAL Consortium Hematopathology Working Group report.
Lee, T., Aisner, D., David, M., Eno, C., Gagan, J., Gocke, C., Guseva, N., Haley, L., Jajosky, A., Jones, D., Mansukhani, M., Mroz, P., Murray, S., Newsom, K., Paulson...> ;Blood Advances. 2023 Aug 22
Cell-Free Circulating Tumor DNA and Epstein-Barr Virus DNA for Early Diagnosis of Epstein-Barr Virus-Associated Cancers.
Rena R Xian, Richard F Ambinder> ;Journal of Clinical Oncology. 2023 Sep 10
1 citations
Co-occurring mutations in ASXL1, SRSF2, and SETBP1 define a subset of myelodysplastic/ myeloproliferative neoplasm with neutrophilia.
Tania Jain, Alisha D Ware, William Brian Dalton, Sergiu Pasca, Hua-Ling Tsai, Christopher D Gocke, Lukasz P Gondek, Rena R Xian, Michael J Borowitz, Mark J Levis> ;Leukemia Research. 2023 Aug 1
5 citations
A New Landscape of Testing and Therapeutics in Metastatic Breast Cancer.
Geetha Jagannathan, Marissa J White, Rena R Xian, Leisha A Emens, Ashley Cimino-Mathews> ;Clinics in Laboratory Medicine. 2023 Jun 1
2 citations
Diagnosis and monitoring of virus-associated cancer using cell-free DNA.
Larissa Ls Scholte, Jeffrey M Bethony, Rena R Xian> ;Current Opinion in Virology. 2023 Jun 1
Colorectal cancer in patients of advanced age is associated with increased incidence ofp.V600E mutation and mismatch repair deficiency.
Eric S Christenson, Hua-Ling Tsai, Dung T Le, Elizabeth M Jaffee, Jonathan Dudley, Rena R Xian, Christopher D Gocke, James R Eshleman, Ming-Tseh Lin> ;Frontiers in Oncology. 2023 Jan 1
2 citations
Significance of lymph node fine needle aspiration for the diagnosis of HIV-associated lymphoma in a low-resource setting.
Samantha L Vogt, Lucia Maloma, Rena R Xian, Richard F Ambinder, Vinitha Philip, Moosa Patel, Neil A Martinson, Tanvier Omar> ;AIDS. 2022 Aug 1
Tiered Somatic Variant Classification Adoption Has Increased Worldwide With Some Practice Differences Based on Location and Institutional Setting.
Frido K Bruehl, Annette S Kim, Marilyn M Li, Neal I Lindeman, Joel T Moncur, Rhona J Souers, Patricia Vasalos, Karl V Voelkerding, Rena R Xian, Lea F Surrey> ;Archives of Pathology & Laboratory Medicine. 2022 Jul 1
1 citations
Clinical Testing for Tumor Cell-Free DNA: College of American Pathologists Proficiency Programs Reveal Practice Trends.
Kelly A Devereaux, Rhona J Souers, Jason D Merker, Neal I Lindeman, Rondell P Graham, Meera R Hameed, Patricia Vasalos, Joel T Moncur, Christina M Lockwood, Rena R Xian> ;Archives of Pathology & Laboratory Medicine. 2023 Apr 1
1 citations
Artificial Intelligence-Assisted Serial Analysis of Clinical Cancer Genomics Data Identifies Changing Treatment Recommendations and Therapeutic Targets.
Catherine G Fischer, Aparna Pallavajjala, LiQun Jiang, Valsamo Anagnostou, Jessica Tao, Emily Adams, James R Eshleman, Christopher D Gocke, Ming-Tseh Lin, Elizabeth A ...> ;Clinical Cancer Research. 2022 Jun 1
4 citations
A New Landscape of Testing and Therapeutics in Metastatic Breast Cancer.
Geetha Jagannathan, Marissa J White, Rena R Xian, Leisha A Emens, Ashley Cimino-Mathews> ;Surgical Pathology Clinics. 2022 Mar 1
Case Report: Hematologic Recovery Following Stereotactic Ablative Radiotherapy in a Patient With Early-Stage Non-Small Cell Lung Cancer and Paraneoplastic Myelofibrosis.
Lindsey Sloan, Rakhi P Naik, Kavita Umrau, Rena Ruiyu Xian, Kristen A Marrone, Khinh Ranh Voong> ;Frontiers in Oncology. 2022 Jan 1
CloneRetriever: An Automated Algorithm to Identify Clonal B and T Cell Gene Rearrangements by Next-Generation Sequencing for the Diagnosis of Lymphoid Malignancies.
Eitan Halper-Stromberg, Chad M. McCall, Lisa Haley, Ming-Tseh Lin, Samantha L. Vogt, Christopher D. Gocke, James R. Eshleman, Wendy Stevens, Neil A. Martinson, Marta E...> ;Clinical Chemistry. 2021 Nov 1
1 citations
Double PIK3CA Alterations and Parallel Evolution in Colorectal Cancers.
Ming-Tseh Lin, Gang Zheng, Erika F. Rodriguez, Li Hui Tseng, Vamsi Parini, Rena Xian, Ying Zou, Christopher D. Gocke, James R. Eshleman> ;American Journal of Clinical Pathology. 2021 Sep 14
Molecular Pathology of Mature Lymphoid Malignancies.
Alisha D. Ware, Katelynn Davis, Rena R. Xian> ;Surgical Pathology Clinics. 2021 Jul 8
11 citations
IDH1 and IDH2 Mutations in Colorectal Cancers.
Jialing Huang, Li Hui Tseng, Vamsi Parini, Parvez M. Lokhandwala, Aparna Pallavajjala, Erika F. Rodriguez, Rena Xian, Liam Chen, Christopher D. Gocke, James R. Eshlema...> ;American Journal of Clinical Pathology. 2021 Oct 13
7 citations
Feasibility of cell-free DNA collection and clonal immunoglobulin sequencing in South African patients with HIV-associated lymphoma
Samantha L. Vogt, Moosa Patel, Atul Lakha, Vinitha Philip, Tanvier Omar, Philippa Ashmore, Sugeshnee Pather, Lisa Haley, Gang Zheng, Jennifer Stone, Elizabeth S Mayne,...> ;JCO Global Oncology. 2021 Apr 1
8 citations
Plasma EBV DNA: A Promising Diagnostic Marker for Endemic Burkitt Lymphoma.
Rena R Xian, Tobias Kinyera, Isaac Otim, Joshua N Sampson, Hadijah Nabalende, Ismail D Legason, Jennifer Stone, Martin D Ogwang, Steven J Reynolds, Patrick Kerchan, Ki...> ;Frontiers in Oncology. 2021 Jan 1
28 citations
CREBBP and STAT6 co-mutation and 16p13 and 1p36 loss define the t(14;18)-negative diffuse variant of follicular lymphoma
Rena R. Xian, Yi Xie, Lisa Haley, Raluca Yonescu, Aparna Pallavajjala, Stefania Pittaluga, Elaine S. Jaffe, Amy S. Duffield, Chad M. McCall, Shereen M F Gheith Md, Chr...> ;Blood Cancer Journal. 2020 Jun 17
3 citations
Clonal Origin Evaluated by Trunk and Branching Drivers and Prevalence of Mutations in Multiple Lung Tumor Nodules
Erika F. Rodriguez, Li Hui Tseng, Federico De Marchi, Jialing Haung, Deborah A. Belchis, Rena Xian, Christopher D. Gocke, James R. Eshleman, Peter B. Illei, Ming Tseh Lin> ;Molecular Diagnosis & Therapy. 2020 Aug 1
14 citations
IDH1 and IDH2 mutations in lung adenocarcinomas: Evidences of subclonal evolution.
Erika F. Rodriguez, Federico De Marchi, Parvez M. Lokhandwala, Deborah A. Belchis, Rena Xian, Christopher D. Gocke, James R. Eshleman, Peter B. Illei, Ming Tseh Li> ;Cancer Medicine. 2020 Apr 25
7 citations
CpG methylation in cell-free Epstein-Barr virus DNA in patients with EBV-Hodgkin lymphoma.
Meir Shamay, Jennifer A. Kanakry, John Soon Wah Low, Netanel A. Horowitz, Guy Journo, Anuj Ahuja, Yonatan Eran, Elinor Barzilai, Eldad J. Dann, Jennifer Stone, Wan Lu ...> ;Blood Advances. 2020 Apr 28
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Journal Articles

Clinical Validation of Coexisting Driver Mutations in Colorectal Cancers
Junaid Ibrahim, James R Eshleman, Gang Zheng, Christopher D Gocke, Rena Xian, ScienceDirect

Authored Content

Proficiency Testing of Standardized Samples Shows High Interlaboratory Agreement for Clinical Next Generation Sequencing–Based Hematologic Malignancy Assays with Survey Material–Specific Differences in Variant FrequenciesJanuary 2020
Proficiency Testing of Standardized Samples Shows High Interlaboratory Agreement for Clinical Next Generation Sequencing–Based Hematologic Malignancy Assays with Survey Material–Specific Differences in Variant FrequenciesJanuary 2020