RichardAplencMD

PubMed

• Structural variants involving MLLT10 fusion are associated with adverse outcomes in pediatric acute myeloid leukemia.
  Oussama Abla, Rhonda E Ries, Tim Triche Jr, Robert B Gerbing, Betsy Hirsch, Susana Raimondi, Todd Cooper, Jason E Farrar, Nathaniel Buteyn, Lauren M Harmon, Hong Wen, ...> ;Blood Advances. 2024 Apr 23
• INSPIRED Symposium Part 5: Expanding the Use of CAR T cells in Children and Young Adults.
  Crystal Mackall, Rosa Nguyen, Aimee C Talleur, Vanessa A Fabrizio, Richard Aplenc, Stephan A Grupp, Robbie Majzner, Rayne Rouce, Amy Moskop, Kevin O McNerney> ;Transplantation and Cellular Therapy. 2024 Apr 6
• Household income and health-related quality of life in children receiving treatment for acute myeloid leukemia: Potential impact of selection bias in health equity res...
  Haley Newman, Yimei Li, Yuan-Shung V Huang, Caitlin W Elgarten, Regina M Myers, Jenny Ruiz, Daniel J Zheng, Alison Barz Leahy, Catherine Aftandilian, Staci D Arnold, K...> ;Cancer Medicine. 2024 Apr 1
• Absolute neutrophil count clinical trial eligibility criteria for pediatric oncology phase I and phase I/II trials by sponsorship.
  Jenny Ruiz, Rebecca K Kelly, Richard Aplenc, Theodore W Laetsch, Alix E Seif> ;Pediatric Blood & Cancer. 2024 May 1
• Reinfusion of CD19 CAR T Cells for Relapse Prevention and Treatment in Children with Acute Lymphoblastic Leukemia.
  Myers, R., Devine, K., Li, Y., Lawrence, S., Barz Leahy, A., Liu, H., Vernau, L., Callahan, C., Baniewicz, D., Kadauke, S., McGuire, R., Wertheim, G., Kulikovskaya, I....> ;Blood Advances. 2024 Feb 22
• CD74 is expressed in a subset of pediatric acute myeloid leukemia patients and is a promising target for therapy: a report from the Children's Oncology Group.
  Andrew J Menssen, Chad A Hudson, Todd Alonzo, Robert Gerbing, Laura Pardo, Amanda Leonti, Jacqueline A Cook, Fan-Chi Hsu, Loren L Lott, Fangyan Dai, Collette Fearing, ...> ;Haematologica. 2024 Feb 1
• Prognostic Impact of Co-occurring Mutations in FLT3-ITD Pediatric Acute Myeloid Leukemia.
  Gerbing, R., Ries, R., Smith, J., Leonti, A., Huang, B., Kirkey, D., Robinson, L., Peplinski, J., Lange, B., Cooper, T., Kolb, E., Pollard, J., Tarlock, K., Gamis, A.,...> ;Blood Advances. 2024 Jan 31
• Bayesian semiparametric model for sequential treatment decisions with informative timing.
  Oganisian, A., Getz, K., Alonzo, T., Roy, J., Aplenc, R.> ;Biostatistics. 2024 Jan 16
• Genetic variation in DNA damage response pathway and response to Gemtuzumab Ozogamicin in pediatric AML: a report from the Children's Oncology Group.
  Shastri, V., Chauhan, L., Gbadamosi, M., Alonzo, T., Wang, Y., Hirsch, B., Kolb, E., Lamba, J., Aplenc, R., Gamis, A., Meshinchi, S.> ;Clinical Cancer Research. 2024 Jan 10
• Association of the social disorganization index with time to first septic shock event in children with acute myeloid leukemia.
  Jenny Ruiz, Yimei Li, Lusha Cao, Yuan-Shung V Huang, Vicky Tam, Heather M Griffis, Lena E Winestone, Brian T Fisher, Todd A Alonzo, Yi-Cheng J Wang, Alice T Dang, E An...> ;Cancer. 2024 Mar 15
• Racial and ethnic disparities in acuity of presentation among children with newly diagnosed acute leukemia.
  Lena E Winestone, Kelly D Getz, Yimei Li, Evanette Burrows, Michael E Scheurer, Vicky Tam, Jennifer J Wilkes, Tamara P Miller, Alix E Seif, Karen R Rabin, Brian T Fish...> ;Pediatric Blood & Cancer. 2024 Jan 1
• Acute and chronic kidney injury during therapy for pediatric acute leukemia: A report from the Leukemia Electronic Abstraction of Records Network (LEARN).
  Wendy Hsiao, Yimei Li, Kelly Getz, Lusha Cao, Edward Krause, Mark Ramos, Judy Lee, Maria Monica Gramatges, Karen R Rabin, Michael E Scheurer, Richard Aplenc, Michelle ...> ;Pediatric Blood & Cancer. 2023 Dec 1
• 1 citations
  Children's Oncology Group's 2023 blueprint for research: Myeloid neoplasms.
  Todd M Cooper, Todd A Alonzo, Sarah K Tasian, Matthew A Kutny, Johann Hitzler, Jessica A Pollard, Richard Aplenc, Soheil Meshinchi, E Anders Kolb> ;Pediatric Blood & Cancer. 2023 Sep 1
• Valosin-containing protein (VCP/p97) is prognostically unfavorable in pediatric AML, and negatively correlates with unfolded protein response proteins IRE1 and GRP78: ...
  Fieke W Hoff, Yihua Qiu, Brandon D Brown, Robert B Gerbing, Amanda R Leonti, Rhonda E Ries, Alan S Gamis, Richard Aplenc, Edward Anders Kolb, Todd A Alonzo, Soheil Mes...> ;Proteomics. Clinical Applications. 2023 Nov 1
• 3 citations
  Characteristics and prognostic impact of IDH mutations in AML: a COG, SWOG, and ECOG analysis.
  Sara Zarnegar-Lumley, Todd A Alonzo, Robert B Gerbing, Megan Othus, Zhuoxin Sun, Rhonda E Ries, Jim Wang, Amanda Leonti, Matthew A Kutny, Fabiana Ostronoff, Jerald P R...> ;Blood Advances. 2023 Oct 10
• 5 citations
  CD38 as a pan-hematologic target for chimeric antigen receptor T cells.
  Tina Glisovic-Aplenc, Caroline Diorio, John A Chukinas, Kimberly Veliz, Olga Shestova, Feng Shen, Selene Nunez-Cruz, Tiffaney L Vincent, Fei Miao, Michael C Milone, Ca...> ;Blood Advances. 2023 Aug 22
• 9 citations
  Dexrazoxane and Long-Term Heart Function in Survivors of Childhood Cancer.
  Chow, E., Aggarwal, S., Doody, D., Aplenc, R., Armenian, S., Baker, K., Bhatia, S., Blythe, N., Colan, S., Constine, L., Freyer, D., Kopp, L., Laverdière, C., Leisenri...> ;Journal of Clinical Oncology. 2023 Apr 20
• 1 citations
  Leveraging machine learning to identify acute myeloid leukemia patients and their chemotherapy regimens in an administrative database.
  Lusha Cao, Yuan-Shung Huang, Chao Wu, Kelly Getz, Tamara P Miller, Jenny Ruiz, Brian T Fisher, Alix E Seif, Richard Aplenc, Yimei Li> ;Pediatric Blood & Cancer. 2023 May 1
• 8 citations
  Comprehensive molecular and clinical characterization offusions in pediatric acute myeloid leukemia.
  Eline J M Bertrums, Jenny L Smith, Lauren Harmon, Rhonda E Ries, Yi-Cheng J Wang, Todd A Alonzo, Andrew J Menssen, Karen M Chisholm, Amanda R Leonti, Katherine Tarlock...> ;Haematologica. 2023 Aug 1
• 4 citations
  Long Noncoding RNA Expression Independently Predicts Outcome in Pediatric Acute Myeloid Leukemia.
  Jason E Farrar, Jenny L Smith, Megan Othus, Benjamin J Huang, Yi-Cheng Wang, Rhonda Ries, Tiffany Hylkema, Era L Pogosova-Agadjanyan, Sneha Challa, Amanda Leonti, Timo...> ;Journal of Clinical Oncology. 2023 Jun 1
• 5 citations
  Pathologic, cytogenetic, and molecular features of acute myeloid leukemia with megakaryocytic differentiation: A report from the Children's Oncology Group.
  Karen M Chisholm, Jenny Smith, Amy E Heerema-McKenney, John K Choi, Rhonda E Ries, Betsy A Hirsch, Susana C Raimondi, Yi-Cheng Wang, Alice Dang, Todd A Alonzo, Lillian...> ;Pediatric Blood & Cancer. 2023 May 1
• 1 citations
  Risk of bacterial bloodstream infection does not vary by central-line type during neutropenic periods in pediatric acute myeloid leukemia.
  Elgarten, C., Otto, W., Shenton, L., Stein, M., Horowitz, J., Aftandilian, C., Arnold, S., Bona, K., Caywood, E., Collier, A., Gramatges, M., Henry, M., Lotterman, C.,...> ;Infection Control and Hospital Epidemiology. 2023 Feb 1
• 18 citations
  Racial and ethnic disparities in childhood and young adult acute lymphocytic leukaemia: secondary analyses of eight Children's Oncology Group cohort trials.
  Sumit Gupta, Yunfeng Dai, Zhiguo Chen, Lena E Winestone, David T Teachey, Kira Bona, Richard Aplenc, Karen R Rabin, Patrick Zweidler-McKay, Andrew J Carroll, Nyla A He...> ;The Lancet. Haematology. 2023 Feb 1
• 3 citations
  SAMHD1 single nucleotide polymorphisms impact outcome in children with newly diagnosed acute myeloid leukemia.
  Richard J Marrero, Xueyuan Cao, Huiyun Wu, Abdelrahman H Elsayed, Jeffery M Klco, Raul C Ribeiro, Jeffrey E Rubnitz, Xiaotu Ma, Soheil Meshinchi, Richard Aplenc, E And...> ;Blood Advances. 2023 Jun 13
• Absolute lymphocyte count recovery following initial acute myelogenous leukemia therapy: Implications for adoptive cell therapy.
  John C Molina, Yimei Li, William R Otto, Tamara P Miller, Kelly D Getz, Carly Mccoubrey, Mark Ramos, Edward Krause, Lusha Cao, M Monica Gramatges, Karen Rabin, Michael...> ;Pediatric Blood & Cancer. 2023 Jan 1
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Abstracts/Posters

• Structural Variants Involving MLLT10/AF10 Are Associated with Adverse Outcome in AML Regardless of the Partner Gene _ a COG/Tpaml Study
  Richard Aplenc, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Area-Based Socioeconomic Disparities in Survival of Children with Newly Diagnosed Acute Myeloid Leukemia: A Report from the ChildrenÍs Oncology Group
  Richard Aplenc, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Prognostic Significance of FOXO3 in Pediatric Acute Myeloid Leukemia (AML) Patients Treated with Bortezomib Addition to Standard Therapy: Results from a ChildrenÍs Onc...
  Richard Aplenc, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Long Non-Coding RNAs (lncRNAs) Are Highly Associated with Disease Characteristics and Outcome in Pediatric Acute Myeloid Leukemia _ a COG and Tpaml Study
  Richard Aplenc, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Sorafenib in Combination with Standard Chemotherapy for Children with High Allelic Ratio FLT3/ITD+ AML Improves Event-Free Survival and Reduces Relapse Risk: A Report ...
  Richard Aplenc, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Transient Elevations in Markers of Hepatic Function during Pediatric Acute Lymphoblastic Leukemia Treatment Are Common but Do Not Influence Outcomes: A Study of 805 Pa...
  Richard Aplenc, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Somatic Bzip Mutations of CEBPA Are Associated with Favorable Outcome Regardless of Presence As Single Vs. Double Mutation
  Richard Aplenc, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Disparities in Barriers and Facilitators of Acute Leukemia Diagnosis in Young Patients
  Richard Aplenc, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Reduced Relapse Risk in Children with Acute Myeloid Leukemia (AML) Who Experience Septic Shock (SS)
  Richard Aplenc, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Delays in Therapy Do Not Impact Survival in Childhood Acute Lymphoblastic Leukemia: A Report from the Learn Consortium
  Richard Aplenc, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Rates of Laboratory Adverse Events By Chemotherapy Course for Pediatric Acute Leukemia Patients within the Leukemia Electronic Abstraction of Records Network (LEARN)
  Richard Aplenc, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• CD117 Expression Is Associated with Cytogenetic and Molecular Profiles and Outcome in Pediatric Acute Myeloid Leukemia
  Richard Aplenc, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Early Broad-Spectrum Antibiotics and Risk of Acute Graft-Versus-Host Disease in Children: An Analysis from the Center for International Blood and Marrow Transplantatio...
  Richard Aplenc, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Response to Sorafenib in FLT3/ITD AML Is Depedent on Co-Occurring Mutational Profile
  Richard Aplenc, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Home or Away from Home: A Multi-Institution Study Comparing Medical Outcomes, Patient Perspectives, and Health-Related Quality of Life for Outpatient Versus Inpatient ...
  Richard Aplenc, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Transcriptome Profiling of Glycosylation Genes Defines Correlation with E-Selectin Ligand Expression and Clinical Outcome in AML
  Richard Aplenc, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Occurrence and Resolution of Anthracycline Cardiotoxicity and Impact on Treatment Outcomes Among Children Treated on the AAML1031 Clinical Trial: A Report from the Chi...
  Richard Aplenc, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Trends in Inpatient and Intensive Care Resource Utilization after Chimeric Antigen Receptor T Cell Therapy for Pediatric Acute Lymphoblastic Leukemia from 2012-2019
  Richard Aplenc, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
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Lectures

• Effect of intensification of induction II chemotherapy and liberalization of stem cell donor source on outcome for children with high risk acute myeloid leukemia: A re... 
  2019 ASCO Annual Meeting - 6/1/2019
• Phase I Study of the Selinexor in Relapsed/Refractory Childhood Acute Leukemia 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Comparing the Liver Function of Children with Acute Lymphoblastic Leukemia (ALL) Receiving Standard or High Intensity Treatment during the Interim Maintenance I Phase ... 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Pediatric Patient-Reported Symptom Tracking in Oncology (Pedi-PReSTO): A Feasibility Study 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Enhancement of Eligibility Guidelines for Gemtuzumab Ozogamicin Therapy for Childhood Acute Myeloid Leukemia: A Report from Children's Oncology Group Protocol AAML0531 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
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