RichardJBarohnMD

Neuromuscular Medicine, Neurophysiology

Gertrude and Dewey Ziegler Professor of Neurology; University Distinguished Professor; Vice Chancellor for Research; President, Research Institute; Director, Frontiers: University of Kansas Clinical and Translational Science Institute

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Office
1020 Hitt Street
Columbia, MO 65212
Phone+1 573-882-4577
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Education & Training

Ohio State University HospitalResidency, Neurology, 1986 - 1987
San Antonio Uniformed Services Health Education ConsortiumResidency, Neurology, 1983 - 1986
San Antonio Uniformed Services Health Education ConsortiumInternship, Internal Medicine, 1980 - 1981
University of Missouri Kansas City School of MedicineClass of 1980
Ohio State University HospitalFellowship, Neuromuscular Medicine (Neurology)

Certifications & Licensure

MO State Medical License 1981 - 2025
TX State Medical License 1989 - 2024
KS State Medical License 2001 - 2024
American Board of Psychiatry and Neurology Neurology
American Board of Psychiatry and Neurology Clinical Neurophysiology
American Board of Psychiatry and Neurology Neuromuscular Medicine

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2004-2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013
Super Doctor SuperDoctors.com

Clinical Trials

Characteristics of Nondystrophic Myotonias Start of enrollment: 2006 Feb 01
Completed
Efficacy of Methotrexate in Myasthenia Gravis Start of enrollment: 2009 Apr 01
Completed
Phase 2
Efficacy of Prednisone In the Treatment of Ocular Myasthenia Start of enrollment: 2011 Dec 01
Terminated
Phase 3
Extension Study for Patients Who Have Participated in a BMN 701 Study Start of enrollment: 2011 Aug 15
Terminated
Phase 2
Finding the Optimum Regimen for Duchenne Muscular Dystrophy Start of enrollment: 2013 Jan 01
Completed
Phase 3
Rasagiline in Subjects With Amyotrophic Lateral Sclerosis (ALS) Start of enrollment: 2013 Nov 21
Completed
Phase 2
A Study of Tadalafil for Duchenne Muscular Dystrophy Start of enrollment: 2013 Sep 01
Terminated
Phase 3
BMN 701 Phase 3 in rhGAA Exposed Subjects With Late Onset Pompe Disease (INSPIRE Study) Start of enrollment: 2014 Apr 01
Terminated
Phase 3
Tocilizumab in the Treatment of Refractory Polymyositis and Dermatomyositis Start of enrollment: 2014 Oct 01
Completed
Phase 2
Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations Start of enrollment: 2014 Oct 01
Completed
Phase 4
A Trial of Tocilizumab in ALS Subjects Start of enrollment: 2015 Nov 01
Completed
Phase 2
A Systematic Investigation of Phonetic Complexity Effects on Articulatory Motor Performance in Progressive Dysarthria Start of enrollment: 2017 Jul 15
Completed
Not Applicable
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Publications & Presentations

PubMed

Conducting a bayesian multi-armed trial with response adaptive randomization for comparative effectiveness of medications for CSPN.
Alexandra R Brown, Byron J Gajewski, Dinesh Pal Mudaranthakam, Mamatha Pasnoor, Mazen M Dimachkie, Omar Jawdat, Laura Herbelin, Matthew S Mayo, Richard J Barohn> ;Contemporary Clinical Trials Communications. 2023 Dec 1
Longitudinal course of neurofilament light chain levels in amyotrophic lateral sclerosis-insights from a completed randomized controlled trial with rasagiline.
Simon Witzel, Jeffrey M Statland, Petra Steinacker, Markus Otto, Johannes Dorst, Joachim Schuster, Richard J Barohn, Albert C Ludolph> ;European Journal of Neurology. 2024 Mar 1
3 citations
Safety and efficacy of arimoclomol for inclusion body myositis: a multicentre, randomised, double-blind, placebo-controlled trial.
Pedro M Machado, Michael P McDermott, Thomas Blaettler, Claus Sundgreen, Anthony A Amato, Emma Ciafaloni, Miriam Freimer, Summer B Gibson, Sarah M Jones, Todd D Levine...> ;The Lancet. Neurology. 2023 Oct 1
Team Science and Advancing Research at the University of Missouri.
Richard J Barohn> ;Missouri Medicine. 2023 Mar 2
1 citations
Phase 2 trial in acetylcholine receptor antibody-positive myasthenia gravis of transition from intravenous to subcutaneous immunoglobulin: The MGSCIg study.
Mamatha Pasnoor, Vera Bril, Todd Levine, Jaya Trivedi, Nicholas J Silvestri, Milind Phadnis, Hans D Katzberg, David S Saperstein, Gil I Wolfe, Laura Herbelin, Kiley Hi...> ;European Journal of Neurology. 2023 May 1
Using a Bayesian model of the joint distribution of pain and time on medication to decide on pain medication for neuropathy.
Guangyi Gao, Jo A Wick, Alexandra R Brown, Richard J Barohn, Byron J Gajewski> ;Communications in Statistics. Case Studies, Data Analysis and Applications. 2023 Jan 1
Rituximab in Newly Diagnosed Generalized Myasthenia Gravis: A New Treatment Paradigm?
Miguel Chuquilin, Richard Barohn> ;JAMA Neurology. 2022 Nov 1
1 citations
LRP4 antibody testing in myasthenia gravis.
Michael K Racke, Sat Dev Batish, Robert P Lisak, Richard J Barohn> ;Journal of Neuroimmunology. 2022 Oct 15
1 citations
Open-label pilot study of ranolazine for cramps in amyotrophic lateral sclerosis.
Swathy Chandrashekhar, Anai C Hamasaki, Rebecca Clay, Ayla McCalley, Laura Herbelin, Mamatha Pasnoor, Omar Jawdat, Mazen M Dimachkie, Richard J Barohn, Jeffrey Statland> ;Muscle & Nerve. 2022 Jul 1
15 citations
Phase 2B randomized controlled trial of NP001 in amyotrophic lateral sclerosis: Pre-specified and post hoc analyses.
Robert G Miller, Rongzhen Zhang, Paige M Bracci, Ari Azhir, Richard Barohn, Richard Bedlack, Michael Benatar, James D Berry, Merit Cudkowicz, Edward J Kasarskis, Hiros...> ;Muscle & Nerve. 2022 Jul 1
9 citations
Long-term Safety and Efficacy of Avalglucosidase Alfa in Patients With Late-Onset Pompe Disease.
Mazen M Dimachkie, Richard J Barohn, Barry Byrne, Ozlem Goker-Alpan, Priya S Kishnani, Shafeeq Ladha, Pascal Laforêt, Karl Eugen Mengel, Loren D M Peña, Sabrina Saccon...> ;Neurology. 2022 Aug 1
2 citations
A secondary analysis of PAIN-CONTRoLS: Pain's impact on sleep, fatigue, and activities of daily living.
Salman F Bhai, Alexandra Brown, Byron Gajewski, Kim S Kimminau, Lemuel R Waitman, Mamatha Pasnoor, Richard J Barohn> ;Muscle & Nerve. 2022 Oct 1
39 citations
Effect of Different Corticosteroid Dosing Regimens on Clinical Outcomes in Boys With Duchenne Muscular Dystrophy: A Randomized Clinical Trial.
Michela Guglieri, Kate Bushby, Michael P McDermott, Kimberly A Hart, Rabi Tawil, William B Martens, Barbara E Herr, Elaine McColl, Chris Speed, Jennifer Wilkinson, Jan...> ;JAMA. 2022 Apr 19
4 citations
Pilot Study of Real-World Monitoring of the Heart Rate Variability in Amyotrophic Lateral Sclerosis.
Alexander A Brown, Bradley J Ferguson, Vovanti Jones, Bruce E Green, Justin D Pearre, Ifeoma A Anunoby, David Q Beversdorf, Richard J Barohn, Carmen M Cirstea> ;Frontiers in Artificial Intelligence. 2022 Jan 1
36 citations
Phase 2 Trial of Rituximab in Acetylcholine Receptor Antibody-Positive Generalized Myasthenia Gravis: The BeatMG Study.
, , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Neurology. 2021 Dec 2
5 citations
Meta-analyses of deflazacort versus prednisone/prednisolone in patients with nonsense mutation Duchenne muscular dystrophy.
Perry B. Shieh, Gary Elfring, Panayiota Trifillis, Claudio Santos, Stuart W. Peltz, Julie A. Parsons, Susan D. Apkon, Basil T. Darras, Craig Campbell, Craig M. McDonal...> ;Journal of Comparative Effectiveness Research. 2021 Oct 25
125 citations
Safety, efficacy, and tolerability of efgartigimod in patients with generalised myasthenia gravis (ADAPT): a multicentre, randomised, placebo-controlled, phase 3 trial.
, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,...> ;The Lancet. Neurology. 2021 Jul 1
4 citations
Health related quality of life in young, steroid-naïve boys with Duchenne muscular dystrophy.
Craig Campbell, Elaine McColl, Michael P. McDermott, William B. Martens, Michela Guglieri, Robert C. Griggs, Volker Straub, Anne-Marie Childs, Emma Ciafaloni, Perry B....> ;Neuromuscular Disorders. 2021 Jun 10
26 citations
Tocilizumab is safe and tolerable and reduces C-reactive protein concentrations in the plasma and cerebrospinal fluid of ALS patients
Carol Milligan, Nazem Atassi, Suma Babu, Richard J. Barohn, James Caress, Merit Cudkowicz, Armineuza Evora, Gregory A. Hawkins, Marlena Wosiski-Kuhn, Eric A. Macklin, ...> ;Muscle & Nerve. 2021 Jun 1
4 citations
Oxaloacetate treatment preserves motor function in SOD1G93A mice and normalizes select neuroinflammation-related parameters in the spinal cord
Sudheer Tungtur, Heather M. Wilkins, Robert S. Rogers, Badawi Yomna, Jessica M. Sage, Abdulbaki Agbas, Omar Jawdat, Richard J. Barohn, Russell H. Swerdlow, Hiroshi Nis...> ;Scientific Reports. 2021 May 26
18 citations
Efficacy and Safety of Bimagrumab in Sporadic Inclusion Body Myositis: Long-term Extension of RESILIENT
Anthony A. Amato, Michael G. Hanna, Pedro Machado, Umesh A. Badrising, Hector Chinoy, Olivier Benveniste, Ananda Krishna Karanam, Min Wu, Laszlo Tanko, Agnes Annette S...> ;Neurology. 2021 Mar 23
17 citations
Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations (PAIN-CONTRoLS): Bayesian Adaptive Comparative Effectiveness Randomized T...
Richard J. Barohn, Byron J. Gajewski, Mamatha Pasnoor, Alexandra R. Brown, Laura Herbelin, Kim S. Kimminau, Dinesh Pal Mudaranthakam, Omar Jawdat, Mazen M. Dimachkie, ...> ;JAMA Neurology. 2021 Jan 1
10 citations
The history of acetylcholinesterase inhibitors in the treatment of myasthenia gravis.
Natalie K. Katz, Richard J. Barohn> ;Neuropharmacology. 2021 Jan 1
9 citations
Exacerbation Rate in Generalized Myasthenia Gravis and Its Predictors
Ahmad R. Abuzinadah, Mohammed H. Alanazy, Nadeem Shafique Butt, Richard J. Barohn, Mazen M. Dimachkie> ;European Neurology. 2020 Dec 15
9 citations
Epidemiological evidence for a hereditary contribution to myasthenia gravis: a retrospective cohort study of patients from North America.
Joshua D. Green, Richard J. Barohn, Emanuela Bartoccion, Michael Benatar, Derrick Blackmore, Vinay Chaudhry, Manisha Chopra, Andrea M. Corse, Mazen M. Dimachkie, Ameli...> ;BMJ Open. 2020 Sep 18
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Journal Articles

Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations (PAIN-CONTRoLS)
Richard J Barohn, Mamatha Pasnoor, Omar Jawdat, Mazen M Dimachkie, JAMA Neurology

Authored Content

Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations (PAIN-CONTRoLS)August 2020
Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations (PAIN-CONTRoLS)August 2020

Press Mentions

Class of 2023 Urged to ‘Change the World’ in School of Medicine Hooding CeremonyMay 16th, 2023
Siteman to Collaborate with University of Missouri on Cancer Research, with Aim to Improve CareSeptember 20th, 2022
Siteman, University of Missouri to Collaborate on Cancer Research, with Aim to Improve CareSeptember 20th, 2022
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Grant Support

Heartland Unit For Neuroscience TrialsNational Institute Of Neurological Disorders And Stroke2011
Heartland Institute For Clinical And Translational ResearchNational Center For Research Resources2011
CTSA Infrastructure For Pediatric ResearchNational Center For Research Resources2011
CTSA Infrastructure For Clinical TrialsNational Center For Research Resources2011
CTSA Infrastructure For AIDS ResearchNational Center For Research Resources2011
Phase II Trial Of Methotrexate In Myasthenia Gravis FDA Ind#:101,306 01/06/2008Food And Drug Administration2009–2011
Phase II Therapeutic Trial Of MexiletineFood And Drug Administration2008–2010
Clinical Trial: Rituximab In DM And PMNational Center For Research Resources2009
Clinical Trial: Mexiletine In NdmNational Center For Research Resources2009
Clinical Trial: Gentamicin In Duchenne MDNational Center For Research Resources2009
Clinical Trial: Etanercept In DermatomyositisNational Center For Research Resources2009
Anderson-Tawil SyndromeNational Center For Research Resources2009
Episodic Ataxia StudyNational Center For Research Resources2008–2009
CinchNational Center For Research Resources2008–2009
Clinical Trial: Rituximab In DM And PMNational Center For Research Resources2008
Clinical Trial: Gentamicin In Duchenne MDNational Center For Research Resources2008
Clinical Trial: COQ10 In ALSNational Center For Research Resources2008
International Conference On The Non-Dystrophic MyotoniasNational Institute Of Neurological Disorders And Stroke2007
11th International Myasthenia Gravis MeetingNational Institute Of Neurological Disorders And Stroke2007
Rituximab Treatment Of Refract Adult &Juvenile Dermatomyositis(Dm) &Adult (PM)National Center For Research Resources2007
Clinical Trial Of High Dose COQ10 In ALSNational Center For Research Resources2007
Clinical Investigation Of Neurological Channelopathies(Cinch)National Center For Research Resources2007
A Double-Blind, Placebo-Control Trial Of Etanercept In DermatomyositisNational Center For Research Resources2007
IVIG In Generalized Myasthenia GravisNational Center For Research Resources1998–2002
IVIG Versus Placebo In Chronic Inflammatory Demyelinating PolyneuropathyNational Center For Research Resources1996–1999