RichardStanleyBedlackJr.MDPhD

Neurology • Durham, NC

Neuromuscular Medicine

Professor of Neurology, Duke University School of Medicine

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Office
932 Morreene Rd
Durham, NC 27705
Phone+1 919-668-7600
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Education & Training

Duke University HospitalResidency, Neurology, 1996 - 1999
Duke University HospitalInternship, Internal Medicine, 1995 - 1996
Uconn School Of MedicineClass of 1995

Certifications & Licensure

NC State Medical License 1995 - 2024
VA State Medical License 2000 - 2002
American Board of Psychiatry and Neurology Neurology
American Board of Psychiatry and Neurology Neuromuscular Medicine

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013

Clinical Trials

Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron Disease Start of enrollment: 2006 May 01
Completed
Phase 2
A Clinical Demonstration of EEG Brain-computer Interface for ALS Patients Start of enrollment: 2011 Sep 01
Completed
Humanitarian Device Exemption Post-Approval Study of NeuRx Diaphragm Pacing System for Amyotrophic Lateral Sclerosis Start of enrollment: 2012 Jul 01
Completed
Not Applicable
Therapy in Amyotrophic Lateral Sclerosis (TAME) Start of enrollment: 2018 Nov 07
Completed
Phase 2
Clinical Trial of Ezogabine (Retigabine) in ALS Subjects Start of enrollment: 2015 Jun 01
Completed
Phase 2
ALS Reversals - Lunasin Regimen Start of enrollment: 2016 Apr 01
Completed
Phase 2
Study of ALS Reversals 2: Genetic Analyses Start of enrollment: 2018 Jun 22
Completed
A Pilot Trial of Triheptanoin for People With Amyotrophic Lateral Sclerosis (PALS) Start of enrollment: 2018 Jun 21
Completed
Phase 1, Phase 2
Trial of Theracurmin for Patients With Amyotrophic Lateral Sclerosis (ALS) Start of enrollment: 2020 Aug 28
Completed
Phase 2
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Publications & Presentations

PubMed

ALSUntangled #72: Insulin.
Andrew Brown, Carmel Armon, Paul Barkhaus, Morgan Beauchamp, Tulio Bertorini, Mark Bromberg, Javier Mascias Cadavid, Gregory T Carter, Jesse Crayle, Eva L Feldman, Ter...> ;Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 2024 May 1
ALSUntangled #75: Portable neuromodulation stimulator therapy.
Laurel Officer, Carmel Armon, Paul Barkhaus, Morgan Beauchamp, Michael Benatar, Tulio Bertorini, Robert Bowser, Mark Bromberg, Andrew Brown, Olimpia Mihaela Carbunar, ...> ;Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 2024 Apr 26
Evaluating emerging drugs in phase II & III for the treatment of amyotrophic lateral sclerosis.
Xiaoyan Li, Richard Bedlack> ;Expert Opinion on Emerging Drugs. 2024 Mar 22
ALSUntangled #74: Withania Somnifera (Ashwagandha).
Jhooty, S., Barkhaus, P., Brown, A., Mascias Cadavid, J., Carter, G., Crayle, J., Heiman-Patterson, T., Li, X., Mallon, E., Mcdermott, C., Mushannen, T., Pattee, G., R...> ;Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 2024 Feb 6
ALSUntangled #73: Lion's Mane.
Maya Muhanna, Issac Lund, Mark Bromberg, Paul Wicks, Michael Benatar, Benjamin Barnes, Kaitlyn Pierce, Dylan Ratner, Andrew Brown, Tulio Bertorini, Paul Barkhaus, Greg...> ;Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 2024 May 1
1 citations
ALSUntangled #71: Nuedexta.
Yuyao Sun, Michael Benatar, Javier Mascías Cadavid, Dave Ennist, Paul Wicks, Kim Staats, Morgan Beauchamp, Sartaj Jhooty, Gary Pattee, Andrew Brown, Tulio Bertorini, P...> ;Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 2024 Feb 1
ALSUntangled #70: caffeine.
Hatch, J., Barkhaus, P., Barnes, B., Beauchamp, M., Benatar, M., Bertorini, T., Bowser, R., Bromberg, M., Brown, A., Mascias Cadavid, J., Carter, G., Cole, N., Crayle,...> ;Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 2023 Jun 8
2 citations
Clenbuterol Treatment Is Safe and Associated With Slowed Disease Progression in a Small Open-Label Trial in Patients With Amyotrophic Lateral Sclerosis.
Xiaoyan Li, Dwight D Koeberl, Michael W Lutz, Richard Bedlack> ;Journal of Clinical Neuromuscular Disease. 2023 Jun 1
The amyotrophic lateral sclerosis-health index (ALS-HI): development and evaluation of a novel outcome measure.
Anika Varma, Jennifer Weinstein, Jamison Seabury, Spencer Rosero, Christine Zizzi, Danae Alexandrou, Ellen Wagner, Nuran Dilek, John Heatwole, Joanne Wuu, James Caress...> ;Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 2023 Aug 1
ALSUntangled # 69: astaxanthin.
Timothy Fullam, Carmel Armon, Paul Barkhaus, Benjamin Barnes, Morgan Beauchamp, Michael Benatar, Tulio Bertorini, Robert Bowser, Mark Bromberg, Javier Mascias Cadavid,...> ;Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 2023 Aug 1
5 citations
Patient reported impact of symptoms in amyotrophic lateral sclerosis (PRISM-ALS): A national, cross-sectional study.
Christine Zizzi, Jamison Seabury, Spencer Rosero, Danae Alexandrou, Ellen Wagner, Jennifer S Weinstein, Anika Varma, Nuran Dilek, John Heatwole, Joanne Wuu, James Care...> ;Eclinicalmedicine. 2023 Jan 1
8 citations
An evaluation of the combination of sodium phenylbutyrate and taurursodiol for the treatment of amyotrophic lateral sclerosis.
Yuyao Sun, Xiaoyan Li, Richard Bedlack> ;Expert Review of Neurotherapeutics. 2023 Jan 1
1 citations
Filtered Cerebrospinal Fluid From Patients With Amyotrophic Lateral Sclerosis Displays an Altered Proteome and Affects Motor Phenotype in a Mouse Model.
Anthony J Filiano, Li Xu, Leonard Collins, Emily Luo, Katelyn M Ripple, George C de Castro, Jane-Valeriane K Boua, Choiselle Marius, Charles Giamberardino, Shivanand P...> ;Cureus. 2022 Dec 1
13 citations
Amyotrophic Lateral Sclerosis Clinical Trials and Interpretation of Functional End Points and Fluid Biomarkers: A Review.
Jeremy M Shefner, Richard Bedlack, Jinsy A Andrews, James D Berry, Robert Bowser, Robert Brown, Jonathan D Glass, Nicholas J Maragakis, Timothy M Miller, Jeffrey D Rot...> ;JAMA Neurology. 2022 Dec 1
ALSUntangled #68: ozone therapy.
Yuyao Sun, Paul Barkhaus, Benjamin Barnes, Morgan Beauchamp, Michael Benatar, Tulio Bertorini, Mark Bromberg, Gregory T Carter, Jesse Crayle, Merit Cudkowicz, Mazen Di...> ;Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 2023 Aug 1
6 citations
ALSUntangled #64: butyrates.
Yuyao Sun, Richard Bedlack, Carmel Armon, Morgan Beauchamp, Tulio Bertorini, Robert Bowser, Mark Bromberg, James Caress, Gregory Carter, Jesse Crayle, Merit E Cudkowic...> ;Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 2022 Nov 1
2 citations
ALSUntangled #67: rituximab.
Xiaoyan Li, Carmel Armon, Paul Barkhaus, Benjamin Barnes, Michael Benatar, Tulio Bertorini, Mark Bromberg, Gregory T Carter, Merit Cudkowicz, Mazen Dimachkie, Eva L Fe...> ;Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 2023 Aug 1
2 citations
Intronic NEFH variant is associated with reduced risk for sporadic ALS and later age of disease onset.
Frances Theunissen, Ryan S Anderton, Frank L Mastaglia, Ian James, Richard Bedlack, P Anthony Akkari> ;Scientific Reports. 2022 Aug 30
ALSUntangled #65: glucocorticoid corticosteroids.
Jill Ann Goslinga, Mark Terrelonge Jr, Richard Bedlack, Paul Barkhaus, Benjamin Barnes, Tulio Bertorini, Mark Bromberg, Gregory Carter, Amy Chen, Jesse Crayle, Mazen D...> ;Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 2023 May 1
ALSUntangled #66: antimycobacterial antibiotics.
Ellen S Pierce, Paul Barkhaus, Morgan Beauchamp, Mark Bromberg, Gregory T Carter, Jill Goslinga, David Greeley, Sky Kihuwa-Mani, Gleb Levitsky, Isaac Lund, Christopher...> ;Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 2023 Aug 1
15 citations
Phase 2B randomized controlled trial of NP001 in amyotrophic lateral sclerosis: Pre-specified and post hoc analyses.
Robert G Miller, Rongzhen Zhang, Paige M Bracci, Ari Azhir, Richard Barohn, Richard Bedlack, Michael Benatar, James D Berry, Merit Cudkowicz, Edward J Kasarskis, Hiros...> ;Muscle & Nerve. 2022 Jul 1
17 citations
MN-166 (ibudilast) in amyotrophic lateral sclerosis in a Phase IIb/III study: COMBAT-ALS study design.
Bjorn Oskarsson, Nicholas J. Maragakis, Richard Bedlack, Namita Goyal, Jenny A Meyer, Angela Genge, Cynthia Bodkin, Samuel Maiser, Nathan P. Staff, Lorne Zinman, Nicho...> ;Neurodegenerative Disease Management. 2021 Nov 24
2 citations
ALSUntangled #63: ketogenic diets
Richard Bedlack, Paul E. Barkhaus, Benjamin Barnes, Morgan Beauchamp, Tulio E. Bertorini, Mark B. Bromberg, Gregory T. Carter, Vinay Chaudry, Merit Cudkowicz, Ce Jacks...> ;Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 2021 Oct 14
8 citations
Safety and efficacy of oral levosimendan in people with amyotrophic lateral sclerosis (the REFALS study): a randomised, double-blind, placebo-controlled phase 3 trial.
Merit Cudkowicz, Angela Genge, Nicholas J. Maragakis, Susanne Petri, Leonard H. van den Berg, Valtteri V Aho, Toni Sarapohja, Mikko Kuoppamäki, Chris Garratt, Ammar Al...> ;The Lancet. Neurology. 2021 Oct 1
7 citations
Infection rate, mortality and characteristics of veterans with amyotrophic lateral sclerosis with COVID-19.
Marinella D Galea, Vincent P Galea, Adam C Eberhart, Huned S. Patwa, Ileana M. Howard, Christina Fournier, Richard Bedlack> ;Muscle & Nerve. 2021 Jul 13
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Journal Articles

Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis
Brian J Wainger, Nicholas J Maragakis, Richard Bedlack, Namita A Goyal, Seward B Rutkove, Michael H Rivner, Stephen A Goutman, Shafeeq S Ladha, Elizabeth A Mauricio, R..., JAMA Neurology