RichardSLegroMD

Obstetrics & Gynecology • Hershey, PA

Reproductive Endocrinology & Infertility

Chair and University Professor of Obstetrics & Gynecology, Penn State College of Medicine

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Office
670 Cherry Dr
Ste 202/204
Hershey, PA 17033
Phone(800) 233-4082
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Education & Training

University of Southern California - LAC+USC Medical CenterFELLOWSHIP
University of Pittsburgh Medical CenterRESIDENCY
Icahn School of Medicine at Mount SinaiMEDICAL_SCHOOL

Certifications & Licensure

CA State Medical License 2007 - Present
PA State Medical License 1989 - 2020
American Board of Obstetrics and Gynecology Obstetrics & Gynecology
American Board of Obstetrics and Gynecology Reproductive Endocrinology/Infertility
American Board of Obesity Medicine Obesity Medicine

Awards, Honors, & Recognition

Member National Academy of Medicine, 2019
Fellow, Ad Eundem Royal College of Obstetricians and Gynaecologists, 2017
America's Top Doctors Castle Connolly, 2004-2014
Fellow (FACOG) American Congress of Obstetricians and Gynecologists
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Clinical Trials

Self-Monitoring of Carbon Monoxide to Enhance Reproductive Outcomes in Women Start of enrollment: 2014 Sep 01Rawa, P.,Legro, R.S.
Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location Start of enrollment: 2014 May 01Steiner, A.,Edwards, C.,Ober, J.,Marunich, J.,Eun, J.,Hansen, K.,Diamond, M.,Rodriguez, M.,Legro, R.
Effect of Acupuncture and Clomiphene Citrate on Live Birth in Anovulatory Women With Polycystic Ovary Syndrome: A Randomized Controlled Trial (PCOSAct) Start of enrollment: 2012 Apr 01Legro, R.S.
Stress Reduction for PCOS and Non-PCOS Women Start of enrollment: 2011 Dec 01Legro, R.S.,Raja-Khan, N.
Metformin for the Treatment of Premature Pubarche in Girls Start of enrollment: 2011 May 01Legro, R.S.
Reproductive Medicine Network Biologic Specimen Repository Start of enrollment: 2010 Sep 01Brzyski, R.,Casson, P.,Christman, G.,Coutifaris, C.,Diamond, M.,Eisenberg, E.,Legro, R.,Santoro, N.,Schlaff, W.,Zhang, H.
Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation Start of enrollment: 2010 Jun 01Alvero, R.,Baker, V.,Bates, W.,Brzyski, R.,Casson, P.,Christman, G.,Coutifaris, C.,Diamond, M.,Eisenberg, E.,Hansen, K.,Legro, R.,Rosen, M.,Santoro, N.,Schlaff, W.,Seungdamrong, A.,Usadi, R.,Zhang, H.,Zha...
A Prospective, Randomized, Study of Microsurgical Varicocelectomy Versus Observation in the Treatment of Male Partners With a Palpable Varicocele and an Abnormal Semen Analysis Start of enrollment: 2010 May 01Brzyski, R.,Casson, P.,Christman, G.M.,Coutifaris, C.,Diamond, M.,Eisenberg, E.,Legro, R.,Ohl, D.A.,Santoro, N.,Schlaff, W.D.,Zhang, H.
A Trial of Intravenous Fluids During Labor Start of enrollment: 2010 Apr 01Smulian, J.,Legro, R.S.
Treatment of Endometrial Hyperplasia With an Intrauterine Device (IUD) Start of enrollment: 2009 Sep 01Legro, R.
Registry of Pregnancies Conceived Following Exposure to Ovulation Stimulation Medications Start of enrollment: 2009 May 01Brzyski, R.,Casson, P.,Christman, G.,Coutifaris, C.,Diamond, M.,Eisenberg, E.,Legro, R.,Santoro, N.,Schlaff, W.,Zhang, H.
A 20 Week Double-Blind Randomized Trial of Clomiphene Citrate and Letrozole for the Treatment of Infertility in Women With Polycystic Ovary Syndrome Start of enrollment: 2009 Feb 01Brzyski, R.,Casson, P.,Christman, G.M.,Coutifaris, C.,Diamond, M.,Eisenberg, E.,Legro, R.,Santoro, N.,Schlaff, W.D.,Zhang, H.
Treatment of Hyperandrogenism vs. Insulin Resistance in Infertile PCOS Women Start of enrollment: 2008 Sep 01Coutifaris, C.,Lecks, K.,Legro, R.S.,Rawa, P.D.
Continuous Administration of Oral Contraceptive, Primary Dysmenorrhea Start of enrollment: 2007 Aug 01Legro, R.S.
Viagra in the Treatment of Primary Dysmenorrhea Start of enrollment: 2007 May 01Legro, R.
Weight Loss and Cardiovascular Disease (CVD) Prevention Via a Whole Grain Diet in Men and Women With Metabolic Syndrome Start of enrollment: 2005 Aug 01Kris-Etherton, P.M.,Legro, R.S.
The Incidence and Treatment of Insulin Resistance Among Men With Erectile Start of enrollment: 2005 Jul 01Trussell, J.C.,Worley, S.
Obesity and Weight Loss on Reproductive Function Start of enrollment: 2005 Jun 01Legro, R.
Effect of Meal Composition on Postprandial Testosterone Concentration in Women With Polycystic Ovary Syndrome Start of enrollment: 2005 May 01Legro, R.S.
Ultrasound and Endometrial Hyperplasia Start of enrollment: 2005 Apr 01Legro, R.
The Effects of Continuous Administration of a Monophasic Oral Contraceptive on Bleeding Days and Endometrial and Ovarian Function Start of enrollment: 2001 Jun 01Legro, R.S.
Inositol Supplementation to Treat PCOS (INSUPP-PCOS) Richard S. Legro, M.D.
Sonographic Hysterosalpingography: Oil vs Water Based Media (SHOW Trial) Richard Legro, M.D.
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Publications & Presentations

PubMed

Lifestyle modifications alone or combined with hormonal contraceptives improve sexual dysfunction in women with polycystic ovary syndrome.
Weiss, M. S., Roe, A. H., Allison, K. C., Dodson, W. C., Kris-Etherton, P. M., Kunselman, A. R., Stetter, C. M., Williams, N. I., Gnatuk, C. L., Estes, S. J., Sarwer, ...> ;Fertility and sterility. 2020 Oct 17
Short-term weight change and live birth among women with unexplained infertility and polycystic ovary syndrome undergoing ovulation induction.
Vitek, W., Sun, F., Hoeger, K. M., Santoro, N., Diamond, M. P., Zhang, H., Legro, R. S.> ;Fertility and sterility. 2020 Oct 11
Endometrial thickness after ovarian stimulation with gonadotropin, clomiphene, or letrozole for unexplained infertility, and association with treatment outcomes.
Quaas, A. M., Gavrizi, S. Z., Peck, J. D., Diamond, M. P., Legro, R. S., Robinson, R. D., Casson, P., Christman, G. M., Zhang, H., Hansen, K. R.> ;Fertility and sterility. 2020 Sep 26
Effects of Oral Contraception and Lifestyle Modification on Incretins and TGF-ß Superfamily Hormones in PCOS.
Shah, A., Dodson, W. C., Kris-Etherton, P. M., Kunselman, A. R., Stetter, C. M., Gnatuk, C. L., Estes, S. J., Allison, K. C., Sarwer, D. B., Sluss, P. M., Coutifaris, ...> ;The Journal of clinical endocrinology and metabolism. 2020 Sep 25
Highly elevated level of antimüllerian hormone associated with preterm delivery in polycystic ovary syndrome patients who underwent ovulation induction.
Kaing, A., Jaswa, E. A., Diamond, M. P., Legro, R. S., Cedars, M. I., Huddleston, H. G.> ;Fertility and sterility. 2020 Sep 5
11-Oxygenated C19 Steroids Do Not Distinguish the Hyperandrogenic Phenotype of PCOS Daughters from Girls with Obesity.
Torchen, L. C., Sisk, R., Legro, R. S., Turcu, A. F., Auchus, R. J., Dunaif, A.> ;The Journal of clinical endocrinology and metabolism. 2020 Aug 17
Increased Body Mass Index Is Associated With A Nondilutional Reduction in Antimüllerian Hormone.
Jaswa, E. G., Rios, J. S., Cedars, M. I., Santoro, N. F., Pavone, M. E., Legro, R. S., Huddleston, H. G.> ;The Journal of clinical endocrinology and metabolism. 2020 Aug 7
Live birth after a freeze-only strategy versus fresh embryo transfer in three randomized trials considering progesterone concentration.
Yu, Y., Zhao, S., Li, Y., Niu, Y., Wei, D., Zhang, S., Chen, Z., Zhang, H., Legro, R. S.> ;Reproductive biomedicine online. 2020 Jul 1
Distinct subtypes of polycystic ovary syndrome with novel genetic associations: An unsupervised, phenotypic clustering analysis.
Dapas, M., Lin, F. T., Nadkarni, G. N., Sisk, R., Legro, R. S., Urbanek, M., Hayes, M. G., Dunaif, A.> ;PLoS medicine. 2020 Jun 24
Management of newborns exposed to mothers with confirmed or suspected COVID-19.
Amatya, S., Corr, T. E., Gandhi, C. K., Glass, K. M., Kresch, M. J., Mujsce, D. J., Oji-Mmuo, C. N., Mola, S. J., Murray, Y. L., Palmer, T. W., Singh, M., Fricchione, ...> ;Journal of perinatology : official journal of the California Perinatal Association. 2020 May 23
Intrauterine insemination performance characteristics and post-processing total motile sperm count in relation to live birth for couples with unexplained infertility i...
Hansen, K. R., Peck, J. D., Coward, R. M., Wild, R. A., Trussell, J. C., Krawetz, S. A., Diamond, M. P., Legro, R. S., Coutifaris, C., Alvero, R., Robinson, R. D., Cas...> ;Human reproduction (Oxford, England). 2020 May 21
Pregnancy registry: three-year follow-up of children conceived from letrozole, clomiphene, or gonadotropins.
Legro, R. S., Diamond, M. P., Coutifaris, C., Schlaff, W. D., Alvero, R., Casson, P., Christman, G. M., Rosen, R. M., Cedars, M. I., Hansen, K. R., Robinson, R., Baker...> ;Fertility and sterility. 2020 May 11
Publisher Correction: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.
Hayes, M. G., Urbanek, M., Ehrmann, D. A., Armstrong, L. L., Lee, J. Y., Sisk, R., Karaderi, T., Barber, T. M., McCarthy, M. I., Franks, S., Lindgren, C. M., Welt, C. ...> ;Nature communications. 2020 Apr 30
Families with children resulting from ART: psychosocial and financial implications.
Miller, V., Diamond, M. P., Hansen, K. R., Steiner, A. Z., Cedars, M., Legro, R. S., Krawetz, S. A., Coutifaris, C., Huang, H., Santoro, N., Zhang, H.> ;Human reproduction open. 2020 Apr 21
Association Between Mode of First Delivery and Subsequent Fecundity and Fertility.
Kjerulff, K. H., Paul, I. M., Weisman, C. S., Hillemeier, M. M., Wang, M., Legro, R. S., Repke, J. T.> ;JAMA network open. 2020 Apr 21
Androgenicity and fertility treatment in women with unexplained infertility.
Wang, E. T., Diamond, M. P., Alvero, R., Casson, P., Christman, G. M., Coutifaris, C., Hansen, K. R., Sun, F., Legro, R. S., Robinson, R. D., Usadi, R. S., Pisarska, M...> ;Fertility and sterility. 2020 Mar 21
The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial.
Steiner, A. Z., Hansen, K. R., Barnhart, K. T., Cedars, M. I., Legro, R. S., Diamond, M. P., Krawetz, S. A., Usadi, R., Baker, V. L., Coward, R. M., Huang, H., Wild, R...> ;Fertility and sterility. 2020 Mar 1
The cumulative live birth rate after a freeze-only strategy versus a conventional fresh embryo transfer strategy: a call for more level 1 evidence.
Wei, D., Legro, R. S., Chen, Z.> ;BMC medicine. 2020 Jan 24
Waljit S. Dhillo, MD.
Legro, R. S.> ;Seminars in reproductive medicine. 2020 Jan 24
Waljit S. Dhillo, MD.
Legro, R. S.> ;Seminars in reproductive medicine. 2019 Dec 24
Cardiometabolic health in offspring of women with PCOS compared to healthy controls: a systematic review and individual participant data meta-analysis.
Gunning, M. N., Petermann, T. S., Crisosto, N., van Rijn, B. B., de Wilde, M. A., Christ, J. P., Uiterwaal, C. S., de Jager, W., Eijkemans, M. J., Kunselman, A. R., Le...> ;Human reproduction update. 2019 Dec 24
Waljit S. Dhillo, MD.
Legro, R. S.> ;Seminars in reproductive medicine. 2019 Dec 18
Reproductive Life Planning and Contraceptive Action Planning for Privately Insured Women: The MyNewOptions Study.
Chuang, C. H., Weisman, C. S., Velott, D. L., Lehman, E., Chinchilli, V. M., Francis, E. B., Moos, M., Sciamanna, C. N., Armitage, C. J., Legro, R. S.> ;Perspectives on sexual and reproductive health. 2019 Dec 11
Correction:Â Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria.
Day, F., Karaderi, T., Jones, M. R., Meun, C., He, C., Drong, A., Kraft, P., Lin, N., Huang, H., Broer, L., Magi, R., Saxena, R., Laisk, T., Urbanek, M., Hayes, M. G.,...> ;PLoS genetics. 2019 Dec 6
First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis.
Wang, R., Li, W., Bordewijk, E. M., Legro, R. S., Zhang, H., Wu, X., Gao, J., Morin-Papunen, L., Homburg, R., König, T. E., Moll, E., Kar, S., Huang, W., Johnson, N. P...> ;Human reproduction update. 2019 Oct 28
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Lectures

Reproductive Endocrinology
ENDO 2019 - New Orleans, LA - 3/25/2019
Guided Posters: Reproductive Endocrinology
ENDO 2019 - New Orleans, LA - 3/25/2019
An International Initiative to Improve Outcomes in PCOS: Evidence-Based Guidelines and Multifaceted Translation
ENDO 2018: 100th Endocrine Society Annual Meeting - Chicago, Illinios - 03/20/2018

Authored Content

Transfer of Fresh Versus Frozen Embryos in Ovulatory WomenJanuary 2018
Transfer of Fresh Versus Frozen Embryos in Ovulatory WomenJanuary 2018

Press Mentions

Bearding, Balding and Infertile: Polycystic Ovary Syndrome (PCOS) and Nationalist Discourse in IndiaJuly 11, 2020
C-section May Affect Future Fertility After First BabyJuly 10, 2020
What Is PCOS? Symptoms and Treatments for Polycystic Ovary SyndromeFebruary 22, 2020
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Grant Support

Treatment Of Hyperandrogenism Vs. Insulin Resistance In Infertile PCOS WomenEunice Kennedy Shriver National Institute Of Child Health &Human Development2008–2012
Hyperandrogenism And Insulin Resistance In The Ontogeny Of PCOSEunice Kennedy Shriver National Institute Of Child Health &Human Development2008–2012
A Randomized Trial Of Letrozole VS Clomiphene In Infertile Women With PCOSEunice Kennedy Shriver National Institute Of Child Health &Human Development2007–2011
Treatment Of Hyperandrogenism VS Insulin Resistance In Infertile PCOS WomenNational Center For Research Resources2009
Pregnancy In Polycystic Ovary Syndrome IINational Center For Research Resources2009
Hyperandrogenism And Insulin Resistance In The Ontogeny Of PCOSNational Center For Research Resources2009
24hr Blood Pressure Monitoring In Patients At Risk For Hypertension In PregnancyNational Center For Research Resources2008–2009
Development Of A Screening Test For Endometrial Hyperplasia In An At Risk CohortNational Center For Research Resources2007–2009
Atorvastatin For Treatment Of PCOS Women With Elevated LDL CholesterolNational Center For Research Resources2007–2009
Continuous Glucose Monitoring In Pregnant Women With Polycystic Ovary SyndromeNational Center For Research Resources2005–2009
Genotyping Families Of Women With PCOSNational Center For Research Resources2004–2009
Phenotyping Kindreds Of Familial PCOSNational Center For Research Resources1997–2009
The Treatment Of Dysmenorrhea: Effects Of Sildenafil And Oral ContraceptivesFogarty International Center2006–2008
Racial Differences In Circulating Sex Steroids: Mechanisms And Effect On BoneNational Center For Research Resources2005–2008
Effect Of Lifestyle Intervention &Metformin In Polycystic Ovary SyndromeNational Center For Research Resources2005–2008
Meals Of Varying Fat &Fiber Content Effect On Postprandial Testosterone ConcNational Center For Research Resources2007
Effect Of Meals Of Varying Fat &Fiber Content On Postprandial TestosteroneNational Center For Research Resources2006–2007
Insulin Resistance Markers In ChildrenNational Center For Research Resources2004–2007
Effects Of Meals Of Varying Fat&Fiber Content On Postprandial Testosterone ConcNational Center For Research Resources2006
Trial Of Clomiphene Citrate, Metformin &Combined Clom/Metf In Infertility PCOSNational Center For Research Resources2005–2006
Effects Of Continuous Admin Of A Monophasic Oral Contraceptive On Bleeding DaysNational Center For Research Resources2005–2006
Insulin Resistance In Pcos--Sequelae And TreatmentEunice Kennedy Shriver National Institute Of Child Health &Human Development2001–2005
Trial Of Clomiphene Citrate/Metformin In PCOS InfertilitNational Center For Research Resources2004
Continuous Dose Of Oral Contracetive On Bleeding DaysNational Center For Research Resources2004
Atorvastatin Treatment Of PCOS Women With Ldl/CholesteroNational Center For Research Resources2004
Effect Of Continuous Vs. Sequential Oral ContraceptionEunice Kennedy Shriver National Institute Of Child Health &Human Development2002–2004
Cooperative Multicenter Reproductive Medicine NetworkEunice Kennedy Shriver National Institute Of Child Health &Human Development2000–2004
Exercise On Insulin Tolerance In Women With PCOSNational Center For Research Resources2000–2002
Phenotyping Kindrids Of Familial Polycystic Ovary SyndromeNational Center For Research Resources1998–2002
Phenotype And Genotype In Familial Polycystic Ovary SyndromeNational Center For Research Resources1998–2002
Genotyping Families Of Women With Pcos--Polycystic Ovary SyndromeNational Center For Research Resources1998–2002
Assessing Safety/Efficacy Of Troglitazone In Pcos--Polycystic Ovary SyndromeNational Center For Research Resources1998–2002
Genetics Of Familial Polycystic Ovary SyndromeEunice Kennedy Shriver National Institute Of Child Health &Human Development1996–2000
Effects Of 3 Oral Contraceptives On Various Metabolic ParametersNational Center For Research Resources1998–1999
Bone Density In Women With Polycystic Ovary SyndromeNational Center For Research Resources1998–1999
Insulin Action In The Polycystic Ovary SyndromeNational Center For Research Resources1997–1999