RichardSLegroMD

Obstetrics & Gynecology • Hershey, PA

Reproductive Endocrinology & Infertility

Chair and University Professor of Obstetrics & Gynecology, Penn State College of Medicine

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Office
670 Cherry Dr
Ste 202/204
Hershey, PA 17033
Phone+1 800-233-4082
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Education & Training

University of Southern California/LAC+USC Medical CenterFellowship, Reproductive Endocrinology and Infertility, 1991 - 1993
UPMC Medical EducationResidency, Obstetrics and Gynecology, 1987 - 1991
Icahn School of Medicine at Mount SinaiClass of 1987

Certifications & Licensure

CA State Medical License 2007 - Present
PA State Medical License 1989 - 2024
American Board of Obstetrics and Gynecology Obstetrics & Gynecology
American Board of Obstetrics and Gynecology Reproductive Endocrinology/Infertility
American Board of Obesity Medicine Obesity Medicine

Awards, Honors, & Recognition

Member National Academy of Medicine, 2019
Fellow, Ad Eundem Royal College of Obstetricians and Gynaecologists, 2017
America's Top Doctors Castle Connolly, 2004-2014
Fellow (FACOG) American Congress of Obstetricians and Gynecologists
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Clinical Trials

Viagra in the Treatment of Primary Dysmenorrhea Start of enrollment: 2007 May 01
Completed
Phase 1, Phase 2
Treatment of Endometrial Hyperplasia With an Intrauterine Device (IUD) Start of enrollment: 2009 Sep 01
Withdrawn
Phase 1, Phase 2
Ultrasound and Endometrial Hyperplasia Start of enrollment: 2005 Apr 01
Terminated
Not Applicable
The Effects of Continuous Administration of a Monophasic Oral Contraceptive on Bleeding Days and Endometrial and Ovarian Function Start of enrollment: 2001 Jun 01
Completed
Obesity and Weight Loss on Reproductive Function Start of enrollment: 2005 Jun 01
Terminated
The Incidence and Treatment of Insulin Resistance Among Men With Erectile Dysfunction Start of enrollment: 2005 Jun 01
Completed
Weight Loss and Cardiovascular Disease (CVD) Prevention Via a Whole Grain Diet in Men and Women With Metabolic Syndrome Start of enrollment: 2005 Aug 01
Completed
Not Applicable
Effect of Meal Composition on Postprandial Testosterone Concentration in Women With Polycystic Ovary Syndrome Start of enrollment: 2005 May 01
Completed
Not Applicable
Continuous Administration of Oral Contraceptive, Primary Dysmenorrhea Start of enrollment: 2007 Aug 01
Completed
Phase 1, Phase 2
Treatment of Hyperandrogenism Versus Insulin Resistance in Infertile Polycystic Ovary Syndrome (PCOS) Women Start of enrollment: 2008 Sep 01
Completed
Phase 2
Pregnancy in Polycystic Ovary Syndrome II Start of enrollment: 2009 Feb 01
Completed
Phase 3
Microsurgical Varicocelectomy Versus No Surgery in Men With a Palpable Varicocele and an Abnormal Semen Analysis Start of enrollment: 2010 May 01
Terminated
Phase 3
Registry of Pregnancies Conceived Following Exposure to Ovulation Stimulation Medications Start of enrollment: 2009 May 01
Completed
Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation Start of enrollment: 2010 Jun 01
Completed
Phase 3
A Trial of Intravenous Fluids During Labor Start of enrollment: 2010 Apr 01
Completed
Not Applicable
Reproductive Medicine Network Biologic Specimen Repository Start of enrollment: 2010 Sep 01
Completed
Metformin for the Treatment of Premature Pubarche in Girls Start of enrollment: 2011 May 01
Terminated
Not Applicable
Stress Reduction for Overweight or Obese Women Either With Polycystic Ovary Syndrome (PCOS) or Without PCOS (Non-PCOS) Start of enrollment: 2011 Nov 01
Completed
Not Applicable
Acupuncture and Clomiphene Citrate on Live Birth in Anovulatory Women With Polycystic Ovary Syndrome Start of enrollment: 2012 Jul 06
Completed
Not Applicable
Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location Start of enrollment: 2014 Jul 25
Completed
Phase 3
Self-Monitoring of Carbon Monoxide to Enhance Reproductive Outcomes in Women Start of enrollment: 2014 Sep 01
Terminated
Not Applicable
Sonographic Hysterosalpingography: Oil vs Water Based Media (SHOW Trial) Start of enrollment: 2019 Jan 11
Completed
Phase 4
Inositol Supplementation to Treat PCOS (INSUPP-PCOS) Start of enrollment: 2020 Jan 24
Recruiting
Phase 2
Novel Subtypes of Polycystic Ovary Syndrome Start of enrollment: 2021 Jan 01
Recruiting
Roles: Contact
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Publications & Presentations

PubMed

Best Methods in Reproductive Medicine Clinical Trials.
Richard S Legro> ;Fertility and Sterility. 2024 Mar 29
1 citations
Antimüllerian hormone level predicts ovulation in women with polycystic ovary syndrome treated with clomiphene and metformin.
Allison S Komorowski, Lydia Hughes, Prottusha Sarkar, David A Aaby, Ajay Kumar, Bhanu Kalra, Richard S Legro, Christina E Boots> ;Fertility and Sterility. 2024 Apr 1
Moderate and increased physical activity is not detrimental to live birth rates among women with unexplained infertility and obesity.
Wendy S Vitek, Fangbai Sun, Eden Cardozo, Kathleen M Hoeger, Karl R Hansen, Nanette Santoro, Heping Zhang, Richard S Legro> ;F&S Reports. 2023 Sep 1
Use and misuse of statistics in reproductive medicine.
Richard S Legro> ;Fertility and Sterility. 2023 Jun 1
1 citations
Quantitation of 5α-androstanedione in normal women and women with PCOS.
Frank Z Stanczyk, Rachel Mandelbaum, Marsha Baker, Lihong Ma, Intira Sriprasert, Christina E Dancz, Richard S Legro> ;The Journal of Steroid Biochemistry and Molecular Biology. 2023 Jul 1
2 citations
Oil-based or saline contrast for sono-hysterosalpingography in infertile women: a pilot randomized controlled double blind trial.
Richard S Legro, Christy M Stetter, Allen R Kunselman, William M Geisler, William C Dodson, Stephanie J Estes> ;F&S Reports. 2023 Mar 1
1 citations
The new International Federation of Gynecology and Obstetrics (FIGO) classification of ovulatory disorders: getting from here to there.
Richard S Legro> ;Fertility and Sterility. 2023 Apr 1
1 citations
11-Oxygenated Androgen Metabolite Concentrations Are Affected by Pubertal Progression and Obesity.
Emily Breslow, Anya Taylor, Christine L Chan, Cameron Severn, Laura Pyle, Laura Torchen, Ryan Sisk, Richard Legro, Adina F Turcu, Richard J Auchus, Andrea Dunaif, Mega...> ;Hormone Research in Paediatrics. 2023 Jan 1
1 citations
Establishing Normative Values to Determine the Prevalence of Biochemical Hyperandrogenism in Premenopausal Women of Different Ethnicities from Eastern Siberia.
Larisa Suturina, Daria Lizneva, Alina Atalyan, Ludmila Lazareva, Aleksey Belskikh, Tatyana Bairova, Leonid Sholokhov, Maria Rashidova, Irina Danusevich, Iana Nadeliaev...> ;Diagnostics. 2022 Dec 22
3 citations
Women's beliefs of pain after childbirth: Critical insight for promoting behavioral strategies to regulate pain and reduce risks for maternal mortality.
Abigail M Pauley, Krista S Leonard, Nicole Cumbo, Isabella F Teti, Jaimey M Pauli, Mohamed Satti, Mark Stephens, Tammy Corr, Robert W Roeser, Richard S Legro, A Dhanya...> ;Patient Education and Counseling. 2023 Feb 1
Is the "E" being removed from Reproductive Endocrinology to be replaced by a "G" for Genetics?
Alan H DeCherney, Marja Brolinson, Grace Whiteley, Richard S Legro, Nanette Santoro> ;Fertility and Sterility. 2022 Dec 1
Dietary and/or physical activity interventions in women with overweight or obesity prior to fertility treatment: protocol for a systematic review and individual partic...
Emily Evans-Hoeker, Zheng Wang, Henk Groen, Astrid E P Cantineau, Ann Thurin-Kjellberg, Christina Bergh, Joop S E Laven, Alexandra Dietz de Loos, Geranne Jiskoot, Jean...> ;BMJ Open. 2022 Nov 7
Periconception care of the infertile patient: Are we doing enough?
Richard S Legro> ;Fertility and Sterility. 2022 Oct 1
3 citations
Preconception weight loss in the obese patient: overhyped or underutilized?
Richard S Legro> ;Fertility and Sterility. 2022 Sep 1
77 citations
Polycystic ovary syndrome.
Anju E Joham, Robert J Norman, Elisabet Stener-Victorin, Richard S Legro, Stephen Franks, Lisa J Moran, Jacqueline Boyle, Helena J Teede> ;The Lancet. Diabetes & Endocrinology. 2022 Sep 1
6 citations
Effect of Incorporating 1 Avocado Per Day Versus Habitual Diet on Visceral Adiposity: A Randomized Trial.
Alice H Lichtenstein, Penny M Kris-Etherton, Kristina S Petersen, Nirupa R Matthan, Samuel Barnes, Mara Z Vitolins, Zhaoping Li, Joan Sabaté, Sujatha Rajaram, Shilpy C...> ;Journal of the American Heart Association. 2022 Jul 19
2 citations
dividual participant data meta-analysis of trials comparingrzen versus fesh ebryo transfer strategy (INFORM): a protocol.
Rui Wang, David J McLernon, Shimona Lai, Marian G Showell, Zi-Jiang Chen, Daimin Wei, Richard S Legro, Ze Wang, Yun Sun, Keliang Wu, Lan N Vuong, Pollyanna Hardy, Anja...> ;BMJ Open. 2022 Jul 18
1 citations
Obstetricians' prescribing practices for pain management after delivery.
A Dhanya Mackeen, Richard S Vigh, Lisa Bailey Davis, Mohamed Satti, Nicole Cumbo, Abigail M Pauley, Krista S Leonard, Mark Stephens, Tammy E Corr, R W Roeser, Timothy ...> ;Pain Management. 2022 Jul 1
The application of artificial intelligence in reproductive medicine: baby steps.
Daimin Wei, Richard S Legro, Zi-Jiang Chen> ;Fertility and Sterility. 2022 Jul 1
13 citations
Exclusion of Reproductive-aged Women in COVID-19 Vaccination and Clinical Trials.
Kelly M Kons, Megan L Wood, Lindsey C Peck, Sarah M Hershberger, Allen R Kunselman, Christina Stetter, Richard S Legro, Timothy A Deimling> ;Women's Health Issues. 2022 Jun 15
2 citations
Poor reproducibility of percentage of normally shaped sperm using the World Health Organization Fifth Edition strict grading criteria.
Karen C Baker, Anne Z Steiner, Karl R Hansen, Kurt T Barnhart, Marcelle I Cedars, Richard S Legro, Michael P Diamond, Stephen A Krawetz, Rebecca Usadi, Valerie L Baker...> ;F&S Reports. 2022 Jun 1
2 citations
Ovarian stimulation strategies for intrauterine insemination in couples with unexplained infertility: a systematic review and individual participant data meta-analysis.
J A Wessel, N A Danhof, R van Eekelen, M P Diamond, R S Legro, K Peeraer, T M D'Hooghe, M Erdem, T Dankert, B J Cohlen, C Thyagaraju, B W J Mol, M Showell, M van Wely,...> ;Human Reproduction Update. 2022 Aug 25
2 citations
A personalized medicine approach to ovulation induction/ovarian stimulation: development of a predictive model and online calculator from level-I evidence.
Irene Souter, Fangbai Sun, Heping Zhang, Michael P Diamond, Richard S Legro, Robert A Wild, Karl R Hansen, Nanette Santoro> ;Fertility and Sterility. 2022 Feb 1
24 citations
Effects of preconception lifestyle intervention in infertile women with obesity: The FIT-PLESE randomized controlled trial.
Richard S Legro, Karl R Hansen, Michael P Diamond, Anne Z Steiner, Christos Coutifaris, Marcelle I Cedars, Kathleen M Hoeger, Rebecca Usadi, Erica B Johnstone, Daniel ...> ;Plos Medicine. 2022 Jan 1
84 citations
Live Birth with or without Preimplantation Genetic Testing for Aneuploidy.
Junhao Yan, Yingying Qin, Han Zhao, Yun Sun, Fei Gong, Rong Li, Xiaoxi Sun, Xiufeng Ling, Hong Li, Cuifang Hao, Jichun Tan, Jing Yang, Yi-Min Zhu, Fenghua Liu, Dawei C...> ;The New England Journal of Medicine. 2021 Nov 25
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Journal Articles

Bidirectional Mendelian Randomization to Explore the Causal Relationships Between Body Mass Index and Polycystic Ovary Syndrome
R Azziz, R S Legro, Human Reproduction
Vitamin D Deficiency Is Associated with Poor Ovarian Stimulation Outcome in PCOS but Not Unexplained Infertility
Suneeta Senapati, Nanette Santoro, Richard S Legro, Samantha F Butts, Andrew N Hoofnagle, The Journal of Clinical Endocrinology and Metabolism
Allostatic Load, a Measure of Chronic Physiological Stress, Is Associated with Pregnancy Outcomes, but Not Fertility, Among Women with Unexplained Infertility
Valerie Baker, Peter Casson, Nanette Santoro, Wendy Vitek, Richard S Legro, Randal Robinson, G Wright Bates, Christos Coutifaris, Karl Hansen, Ruben Alvero, Esther Eis..., Human Reproduction

Lectures

Reproductive Endocrinology
ENDO 2019 - New Orleans, LA - 3/25/2019
Guided Posters: Reproductive Endocrinology
ENDO 2019 - New Orleans, LA - 3/25/2019
An International Initiative to Improve Outcomes in PCOS: Evidence-Based Guidelines and Multifaceted Translation
ENDO 2018: 100th Endocrine Society Annual Meeting - Chicago, Illinios - 03/20/2018

Authored Content

Fertility-Related Quality of Life, Gonadal Function, and Erectile Dysfunction in Male Partners of Couples with Unexplained InfertilityMarch 2019
Transfer of Fresh Versus Frozen Embryos in Ovulatory WomenJanuary 2018
Transfer of Fresh Versus Frozen Embryos in Ovulatory WomenJanuary 2018

Press Mentions

Weight Loss May Not Aid Fertility Treatment in Obese WomenJanuary 27th, 2022
Weight Loss May Not Affect Fertility Treatment SuccessJanuary 24th, 2022
Weight Loss May Not Bring Fertility Benefits for Obese WomenJanuary 24th, 2022
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Grant Support

Treatment Of Hyperandrogenism Vs. Insulin Resistance In Infertile PCOS WomenEunice Kennedy Shriver National Institute Of Child Health &Human Development2008–2012
Hyperandrogenism And Insulin Resistance In The Ontogeny Of PCOSEunice Kennedy Shriver National Institute Of Child Health &Human Development2008–2012
A Randomized Trial Of Letrozole VS Clomiphene In Infertile Women With PCOSEunice Kennedy Shriver National Institute Of Child Health &Human Development2007–2011
Treatment Of Hyperandrogenism VS Insulin Resistance In Infertile PCOS WomenNational Center For Research Resources2009
Pregnancy In Polycystic Ovary Syndrome IINational Center For Research Resources2009
Hyperandrogenism And Insulin Resistance In The Ontogeny Of PCOSNational Center For Research Resources2009
24hr Blood Pressure Monitoring In Patients At Risk For Hypertension In PregnancyNational Center For Research Resources2008–2009
Development Of A Screening Test For Endometrial Hyperplasia In An At Risk CohortNational Center For Research Resources2007–2009
Atorvastatin For Treatment Of PCOS Women With Elevated LDL CholesterolNational Center For Research Resources2007–2009
Continuous Glucose Monitoring In Pregnant Women With Polycystic Ovary SyndromeNational Center For Research Resources2005–2009
Genotyping Families Of Women With PCOSNational Center For Research Resources2004–2009
Phenotyping Kindreds Of Familial PCOSNational Center For Research Resources1997–2009
The Treatment Of Dysmenorrhea: Effects Of Sildenafil And Oral ContraceptivesFogarty International Center2006–2008
Racial Differences In Circulating Sex Steroids: Mechanisms And Effect On BoneNational Center For Research Resources2005–2008
Effect Of Lifestyle Intervention &Metformin In Polycystic Ovary SyndromeNational Center For Research Resources2005–2008
Meals Of Varying Fat &Fiber Content Effect On Postprandial Testosterone ConcNational Center For Research Resources2007
Effect Of Meals Of Varying Fat &Fiber Content On Postprandial TestosteroneNational Center For Research Resources2006–2007
Insulin Resistance Markers In ChildrenNational Center For Research Resources2004–2007
Effects Of Meals Of Varying Fat&Fiber Content On Postprandial Testosterone ConcNational Center For Research Resources2006
Trial Of Clomiphene Citrate, Metformin &Combined Clom/Metf In Infertility PCOSNational Center For Research Resources2005–2006
Effects Of Continuous Admin Of A Monophasic Oral Contraceptive On Bleeding DaysNational Center For Research Resources2005–2006
Insulin Resistance In Pcos--Sequelae And TreatmentEunice Kennedy Shriver National Institute Of Child Health &Human Development2001–2005
Trial Of Clomiphene Citrate/Metformin In PCOS InfertilitNational Center For Research Resources2004
Continuous Dose Of Oral Contracetive On Bleeding DaysNational Center For Research Resources2004
Atorvastatin Treatment Of PCOS Women With Ldl/CholesteroNational Center For Research Resources2004
Effect Of Continuous Vs. Sequential Oral ContraceptionEunice Kennedy Shriver National Institute Of Child Health &Human Development2002–2004
Cooperative Multicenter Reproductive Medicine NetworkEunice Kennedy Shriver National Institute Of Child Health &Human Development2000–2004
Exercise On Insulin Tolerance In Women With PCOSNational Center For Research Resources2000–2002
Phenotyping Kindrids Of Familial Polycystic Ovary SyndromeNational Center For Research Resources1998–2002
Phenotype And Genotype In Familial Polycystic Ovary SyndromeNational Center For Research Resources1998–2002
Genotyping Families Of Women With Pcos--Polycystic Ovary SyndromeNational Center For Research Resources1998–2002
Assessing Safety/Efficacy Of Troglitazone In Pcos--Polycystic Ovary SyndromeNational Center For Research Resources1998–2002
Genetics Of Familial Polycystic Ovary SyndromeEunice Kennedy Shriver National Institute Of Child Health &Human Development1996–2000
Effects Of 3 Oral Contraceptives On Various Metabolic ParametersNational Center For Research Resources1998–1999
Bone Density In Women With Polycystic Ovary SyndromeNational Center For Research Resources1998–1999
Insulin Action In The Polycystic Ovary SyndromeNational Center For Research Resources1997–1999