RichardPiekarzMD

PubMed

• Entinostat, nivolumab and ipilimumab for women with advanced HER2-negative breast cancer: a phase Ib trial.
  Roussos Torres, E., Ho, W., Danilova, L., Tandurella, J., Leatherman, J., Rafie, C., Wang, C., Brufsky, A., LoRusso, P., Chung, V., Yuan, Y., Downs, M., O'Connor, A., ...> ;Nature Cancer. 2024 Feb 14
• A multicenter phase Ib trial of the histone deacetylase inhibitor entinostat in combination with pembrolizumab in patients with myelodysplastic syndromes/neoplasms or ...
  Jan Philipp Bewersdorf, Rory M Shallis, Elad Sharon, Silvia Park, Rahul Ramaswamy, Caroline E Roe, Jonathan M Irish, Anne Caldwell, Wei Wei, Abdulraheem Yacoub, Yazan ...> ;Annals of Hematology. 2024 Jan 1
• 1 citations
  Phase I Study of Entinostat, Atezolizumab, Carboplatin, and Etoposide in Previously Untreated Extensive-Stage Small Cell Lung Cancer, ETCTN 10399.
  Ryan D Gentzler, Liza C Villaruz, John C Rhee, Bethany Horton, Joseph Mock, Michael Hanley, Kyeongmin Kim, Michelle A Rudek, Mitch A Phelps, Michael A Carducci, Richar...> ;The Oncologist. 2023 Nov 2
• A case report of typhlitis during novel use of ropidoxuridine-capecitabine-radiotherapy for treatment-naïve rectal cancer.
  Charles A Kunos, Richard Piekarz, Jerry M Collins, Timothy J Kinsella> ;Cancer Chemotherapy and Pharmacology. 2023 Aug 1
• 1 citations
  A Phase II Trial of Guadecitabine in Children and Adults with SDH-Deficient GIST, Pheochromocytoma, Paraganglioma, and HLRCC-Associated Renal Cell Carcinoma.
  John A Ligon, R Taylor Sundby, Mary F Wedekind, Fernanda I Arnaldez, Jaydira Del Rivero, Lori Wiener, Ramaprasad Srinivasan, Melissa Spencer, Amanda Carbonell, Haiyan ...> ;Clinical Cancer Research. 2023 Jan 17
• Quantitation of navtemadlin in human plasma and brain tissue by liquid chromatography-tandem mass spectrometry.
  Amanda B Kagan, Nicole M Anders, Avelina Hemingway, Eudocia Q Lee, Kevin R Kelly, Hans C Lee, Meng Xu-Welliver, Richard Piekarz, Michelle A Rudek> ;Biomedical Chromatography. 2022 Nov 1
• 16 citations
  Report of the First International Symposium on NUT Carcinoma.
  Christopher A French, Michael L Cheng, Glenn J Hanna, Steven G DuBois, Nicole G Chau, Christine L Hann, Simone Storck, Ravi Salgia, Matteo Trucco, Jennifer Tseng, Anas...> ;Clinical Cancer Research. 2022 Jun 13
• 5 citations
  Clinical activity of single-agent cabozantinib (XL184), a multi-receptor tyrosine kinase inhibitor, in patients with refractory soft tissue sarcomas.
  Geraldine O'Sullivan Coyne, S. Kummar, James C. Hu, Kristen N. Ganjoo, Warren A. Chow, Khanh T. Do, Jennifer Zlott, Ashley Bruns, Larry Rubinstein, Jared C. Foster, La...> ;Clinical Cancer Research. 2021 Oct 29
• 5 citations
  Phase 1 study of the histone deacetylase inhibitor entinostat plus clofarabine for poor-risk Philadelphia chromosome-negative (newly diagnosed older adults or adults w...
  Hetty E. Carraway, Yazeed Sawalha, Ivana Gojo, Min-Jung Lee, Sunmin Lee, Yusuke Tomita, Akira Yuno, Jackie Greer, B. Douglas Smith, Keith W. Pratz, Mark J. Levis, Stev...> ;Leukemia Research. 2021 Sep 10
• 41 citations
  E2112: Randomized Phase III Trial of Endocrine Therapy Plus Entinostat or Placebo in Hormone Receptor-Positive Advanced Breast Cancer. A Trial of the ECOG-ACRIN Cancer...
  Roisin M. Connolly, Fengmin Zhao, Kathy D. Miller, Min-Jung Lee, Richard Piekarz, Karen L. Smith, Ursa Brown-Glaberman, Jennifer S. Winn, Bryan A. Faller, Adedayo A. O...> ;Journal of Clinical Oncology. 2021 Aug 6
• 12 citations
  Phase I Study of Entinostat and Nivolumab with or without Ipilimumab in Advanced Solid Tumors (ETCTN-9844)
  Evanthia T. Roussos Torres, Christine Rafie, Chenguang Wang, David Lim, Adam Brufsky, Patricia LoRusso, Joseph Paul Eder, Vincent Chung, Melinda Downs, Molly Geare, Ri...> ;Clinical Cancer Research. 2021 Jun 16
• 30 citations
  Safety, Antitumor Activity, and Biomarker Analysis in a Phase I Trial of the Once-daily Wee1 Inhibitor Adavosertib (AZD1775) in Patients with Advanced Solid Tumors.
  Naoko Takebe, Abdul Rafeh Naqash, Geraldine O'Sullivan Coyne, Shivaani Kummar, Khanh T. Do, Ashley Bruns, Lamin Juwara, Jennifer Zlott, Larry Rubinstein, Richard Pieka...> ;Clinical Cancer Research. 2021 Apr 16
• 7 citations
  A Surgical Window Trial Evaluating Medroxyprogesterone Acetate with or without Entinostat in Patients with Endometrial Cancer and Validation of Biomarkers of Cellular ...
  Linda R. Duska, Virginia L. Filiaci, Joan L. Walker, Laura L. Holman, Emily K. Hill, Richard G. Moore, Kari L. Ring, Michael L. Pearl, Carolyn Y. Muller, Christina L. ...> ;Clinical Cancer Research. 2021 May 15
• 6 citations
  Phase 1 study of Z-endoxifen in patients with advanced gynecologic, desmoid, and hormone receptor-positive solid tumors.
  Naoko Takebe, Geraldine O'Sullivan Coyne, S. Kummar, Jerry M. Collins, Joel M. Reid, Richard Piekarz, Nancy Moore, Lamin Juwara, Barry C. Johnson, Rachel Bishop, Frank...> ;Oncotarget. 2021 Feb 16
• 20 citations
  Molecular Profiling-Based Assignment of Cancer Therapy (NCI-MPACT): A Randomized Multicenter Phase II Trial.
  Alice P. Chen, S. Kummar, Nancy Moore, Larry Rubinstein, Yingdong Zhao, P. Mickey Williams, Alida Palmisano, David J. Sims, Geraldine O'Sullivan Coyne, Christina L. Ro...> ;JCO Precision Oncology. 2021 Jan 12
• 5 citations
  Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas
  Geraldine O.Sullivan Coyne, Shivaani Kummar, Robert S. Meehan, Khanh T. Do, Jerry M. Collins, Larry D. Anderson, Kazusa Ishii, Naoko Takebe, Jennifer Zlott, Lamin Juwa...> ;Oncotarget. 2020 Nov 3
• 11 citations
  Intravenous 5-fluoro-2′-deoxycytidine administered with tetrahydrouridine increases the proportion of p16-expressing circulating tumor cells in patients with advanced ...
  Geraldine O.Sullivan Coyne, Lihua Wang, Jennifer Zlott, Lamin Juwara, Joseph M. Covey, Jan H. Beumer, Mihaela C. Cristea, Edward M. Newman, S. Koehler, Jorge Nieva, Ag...> ;Cancer Chemotherapy and Pharmacology. 2020 Apr 20
• 18 citations
  Phase 1 study of the Aurora kinase A inhibitor alisertib (MLN8237) combined with the histone deacetylase inhibitor vorinostat in lymphoid malignancies.
  Tanya Siddiqi, Paul Frankel, Jan H. Beumer, Brian F. Kiesel, Susan M. Christner, Chris Ruel, Joo Y. Song, Robert T. Chen, Kevin R. Kelly, Sikander Ailawadhi, Paul Kaes...> ;Leukemia & Lymphoma. 2020 Jan 28
• 17 citations
  A phase 1 trial of alisertib and romidepsin for relapsed/refractory aggressive B-cell and T-cell lymphomas
  Paolo Strati, Loretta J. Nastoupil, Richard E. Davis, Luis Fayad, Nathan Fowler, Fredrick B. Hagemeister, Larry W. Kwak, Yasuhiro Oki, Michael Wang, Jason R. Westin, C...> ;Haematologica. 2020 Jan 1
• 8 citations
  Phase I trial of belinostat in combination with 13-cis-retinoic acid in advanced solid tumor malignancies: a California Cancer Consortium NCI/CTEP sponsored trial.
  Thehang Luu, Paul Frankel, Jan H. Beumer, Dean Lim, Mihaela C. Cristea, Leonard Joseph Appleman, Heinz Joseph Lenz, David R. Gandara, Brian F. Kiesel, Richard Piekarz,...> ;Cancer Chemotherapy and Pharmacology. 2019 Sep 14
• 10 citations
  A phase I pharmacokinetic study of belinostat in patients with advanced cancers and varying degrees of liver dysfunction
  Naoko Takebe, Jan H. Beumer, Shivaani Kummar, Brian F. Kiesel, Afshin Dowlati, Geraldine O'Sullivan Coyne, Richard Piekarz, Larry Rubinstein, Laura K. Fogli, Ulka N. V...> ;British Journal of Clinical Pharmacology. 2019 Nov 1
• 17 citations
  A phase Ib study of entinostat plus lapatinib with or without trastuzumab in patients with HER2-positive metastatic breast cancer that progressed during trastuzumab tr...
  Bora Lim, Rashmi Krishna Murthy, Jangsoon Lee, S. Jackson, Toshiaki Iwase, Darren W. Davis, Jie Willey, Jimin Wu, Yu Shen, Debu Tripathy, Ricardo H. Alvarez, Nuhad K. ...> ;British Journal of Cancer. 2019 May 17
• 7 citations
  Population pharmacokinetics and exposure-response assessment of veliparib co-administered with temozolomide in patients with myeloid leukemias.
  Renu Singh, Shailly Mehrotra, Mathangi Gopalakrishnan, Ivana Gojo, Judith E. Karp, Jacqueline Greer, Alice P. Chen, Richard Piekarz, Brian F. Kiesel, Jogarao V. S. Gob...> ;Cancer Chemotherapy and Pharmacology. 2019 Feb 1
• 16 citations
  Inhibition of Parp1 by BMN673 Effectively Sensitizes Cells to Radiotherapy by Upsetting the Balance of Repair Pathways Processing DNA Double-Strand Breaks
  Aashish Soni, Fanghua Li, You Wang, Martha Grabos, Lisa Marie Krieger, Shipra Chaudhary, Mohammad Sharif Mortoga Hasan, Mansoor M. Ahmed, C. Norman Coleman, Beverly A....> ;Molecular Cancer Therapeutics. 2018 Jul 3
• 2 citations
  A population pharmacokinetic/toxicity model for the reduction of platelets during a 48-h continuous intravenous infusion of the histone deacetylase inhibitor belinostat.
  Cody J. Peer, Oliver Morgan Hall, Tristan M. Sissung, Richard Piekarz, Sanjeeve Balasubramaniam, Susan E. Bates, William D. Figg> ;Cancer Chemotherapy and Pharmacology. 2018 Jun 27
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Abstracts/Posters

• A Phase Ib/II Study of the Histone Methyltransferase Inhibitor Pinometostat in Combination with Azacitidine in Patients with 11q23-Rearranged Acute Myeloid Leukemia
  Richard Piekarz, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019