RobertPhilipFisherMD

PubMed

• 32 citations
  Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase II.
  Pabitra K. Parua, Sampada Kalan, Bradley Benjamin, Miriam Sansó, Robert P. Fisher> ;Nature Communications. 2020 Aug 28
• 48 citations
  Dissecting the Pol II transcription cycle and derailing cancer with CDK inhibitors
  Pabitra K. Parua, Robert P. Fisher> ;Nature Chemical Biology. 2020 Jun 22
• 1 citations
  Splice or Die: When MYC Is Driving, Transcription Needs NUAK1 to Avoid Fatal Pileups.
  Robert P. Fisher> ;Molecular Cell. 2020 Mar 19
• Cdk7: a kinase at the core of transcription and in the crosshairs of cancer drug discovery.
  Fisher, R. P.> ;Transcription. 2018 Nov 30
• 93 citations
  A Cdk9–PP1 switch regulates the elongation–termination transition of RNA polymerase II
  Pabitra K. Parua, Gregory T. Booth, Miriam Sansó, Bradley Benjamin, Jason C. Tanny, John T. Lis, Robert P. Fisher> ;Nature. 2018 Jun 13
• 4 citations
  Taking Aim at Glycolysis with CDK8 Inhibitors.
  Robert P. Fisher> ;Trends in Endocrinology and Metabolism. 2018 May 1
• Cdk9 Regulates a Promoter-Proximal Checkpoint to Modulate RNA Polymerase II Elongation Rate in Fission Yeast
  Robert Fisher, MD> ;Nature. 2018 Feb 09
• Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages.
  Rollins, D. A.,Kharlyngdoh, J. B.,Coppo, M.,Tharmalingam, B.,Mimouna, S.,Guo, Z.,Sacta, M. A.,Pufall, M. A.,Fisher, R. P.,Hu, X.,Chinenov, Y.,Rogatsky, I.> ;Nat Commun. 2017 Nov 25
• 57 citations
  Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors
  Sampada Kalan, Ramon Amat, Miriam Merzel Schachter, Nicholas Kwiatkowski, Brian J. Abraham, Yanke Liang, Tinghu Zhang, Calla M. Olson, Stéphane Larochelle, Richard A. ...> ;Cell Reports. 2017 Oct 10
• P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates.
  Sansó M, Levin RS, Lipp JJ, Wang VY, Greifenberg AK, Quezada EM, Ali A, Ghosh A, Larochelle S, Rana TM, Geyer M, Tong L, Shokat KM, Fisher RP> ;Genes Dev.. 2016-01-01
• Functional interaction of Rpb1 and Spt5 C-terminal domains in co-transcriptional histone modification.
  Mbogning, J.,Pagé, V.,Burston, J.,Schwenger, E.,Fisher, R. P.,Schwer, B.,Shuman, S.,Tanny, J. C.> ;Nucleic Acids Res.. 2015 Aug 16
• Modelling the CDK-dependent transcription cycle in fission yeast.
  Sansó, M.,Fisher, R. P.> ;Biochem. Soc. Trans.. 2013 Nov 22
• The CDK-activating kinase Cdk7: Taking yes for an answer.
  Schachter, M. M.,Fisher, R. P.> ;Cell Cycle. 2013 Sep 13
• A cdk7-cdk4 T-loop phosphorylation cascade promotes g1 progression.
  Schachter, M. M.,Merrick, K. A.,Larochelle, S.,Hirschi, A.,Zhang, C.,Shokat, K. M.,Rubin, S. M.,Fisher, R. P.> ;Mol. Cell. 2013 Apr 25
• The CDK Network: Linking Cycles of Cell Division and Gene Expression.
  Fisher, R. P.> ;Genes Cancer. 2012 Nov
• Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate re...
  St Amour CV, Sansó M, Bösken CA, Lee KM, Larochelle S, Zhang C, Shokat KM, Geyer M, Fisher RP> ;Mol. Cell. Biol.. 2012-07-01
• Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways.
  Horiuchi, D., Huskey, N. E., Kusdra, L., Wohlbold, L., Merrick, K. A., Zhang, C., Creasman, K. J., Shokat, K. M., Fisher, R. P., Goga, A.> ;Proc Natl Acad Sci USA. 2012 Apr 24
• 70 citations
  Switching Cdk2 On or Off with Small Molecules to Reveal Requirements in Human Cell Proliferation
  Karl A. Merrick, Lara Wohlbold, Chao Zhang, Jasmina J. Allen, Dai Horiuchi, Noelle E. Huskey, Andrei Goga, Kevan M. Shokat, Robert P. Fisher> ;Molecular Cell. 2011 Jun 10
• Putting one step before the other: distinct activation pathways for Cdk1 and Cdk2 bring order to the mammalian cell cycle.
  Merrick, K.A., Fisher, R.P.> ;Cell Cycle. 2010 Feb 15
• 6 citations
  Coming Full Circle: Cyclin-Dependent Kinases as Anti-cancer Drug Targets
  Robert P. Fisher> ;Sub-Cellular Biochemistry. 2010 Jan 1
• TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II.
  Glover-Cutter, K., Larochelle, S., Erickson, B., Zhang, C., Shokat, K., Fisher, R.P., Bentley, D.L.> ;Mol Cell Biol. 2009-10-01
• A long-term, multitrophic level study to assess pulp and paper mill effluent effects on aquatic communities in four US receiving waters: background and status.
  Hall, T. J., Fisher, R. P., Rodgers, J. H., Minshall, G. W., Landis, W. G., Kovacs, T. G., Firth, B. K., Dubé, M. G., Deardorff, T. L., Borton, D. L.> ;Integr Environ Assess Manag. 2009-04-01
• A long-term, multitrophic level study to assess pulp and paper mill effluent effects on aquatic communities in four US receiving waters: lessons learned.
  Hall, T. J., Fisher, R. P., Rodgers, J. H., Minshall, G. W., Landis, W. G., Kovacs, T., Firth, B. K., Dubé, M. G., Flinders, C. A., Deardorff, T. L., Borton, D. L.> ;Integr Environ Assess Manag. 2009-04-01
• TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast.
  Viladevall, L., St Amour, C.V., Rosebrock, A., Schneider, S., Zhang, C., Allen, J.J., Shokat, K.M., Schwer, B., Leatherwood, J.K., Fisher, R.P.> ;Mol Cell. 2009 Mar 27
• p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes.
  Ray, A., James, M.K., Larochelle, S., Fisher, R.P., Blain, S.W.> ;Mol Cell Biol. 2009-02-01
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