Robert Friedlander MD

PubMed

• Blockade of the Platelet-Driven CXCL7-CXCR1/2 Inflammatory Axis Prevents Murine Cerebral Aneurysm Formation and Rupture.
  Kamil W Nowicki, Aditya Mittal, Joseph S Hudson, Michael P D'Angelo, Michael M McDowell
  Translational Stroke Research. 2025-08-01
• Clinical comparison of flow diversion and microsurgery for retreatment of intracranial aneurysms.
  Samer S Hoz, Li Ma, Prateek Agarwal, Rachel C Jacobs, Alhamza R Al-Bayati
  Journal of Clinical Neuroscience. 2025-06-01
• 1 citations
  First-in-human study of epidural spinal cord stimulation in individuals with spinal muscular atrophy.
  Genís Prat-Ortega, Scott Ensel, Serena Donadio, Luigi Borda, Amy Boos
  Nature Medicine. 2025-04-01

Journal Articles

• Application of high-definition fiber tractography in the management of supratentorial cavernous malformations: a combined qualitative and quantitative approach  
  Abhinav K, Pathak S, Richardson RM, Engh J, Gardner P, Yeh FC, Friedlander, RM, Fernandez-Miranda, JC, Neurosurgery, 6/1/2014
• Inhibition of mitochondrial protein import by mutant huntingtin  
  Yano H, Baranov SV, Baranova OV, Kim J, Pan Y, Yablonska S, Carlisle DL, Ferrante RJ, Km AH, Friedlander, RM, Nat Neurosci, 5/18/2014
• Results of a national cerebrovascular neurosurgery survey on the management of cerebral vasospasm/delayed cerebral ischemia  
  Bulara KR, Gunel M, Amin-Hanjani S, Chen PR, Connolly ES, Friedlander RM, J Neurointerv Surg, 5/1/2014
• Use of diffusion spectrum imaging in preliminary longitudinal evaluation of amyotrophic lateral sclerosis; development of an imaging biomarker  
  Abhinav K, Yeh FC, El-Dokla A, Ferrando LM, Chang YF, Lacomis D, Friedlander RM, Fernandez-Miranda JC, Front Hum Neurosci, 4/29/2014
• Aneurysmal Subarachnoid Hemorrhage with Concomitan Posterior Communicating Artery Fenestration  
  Weiner GM, Grandhi R, Zwagerman NT, Agarwal N, Friedlander RM, Int J Neurosci, 4/25/2014
• A brief history of early neuroanesthesia  
  Chivukula S, Grandhi R, Friedlander RM, Neurosurg Focus, 4/1/2014
• Therapeutic Neuroprotective agents for amyotrophic lateral sclerosis  
  Pandya RS, Zhu H, Li W, Bowser R, Friedlander RM, Wang X, Cell Mol Life Sci, 12/1/2013
• Bioengeneering solutions for neural repair and recovery in stroke  
  Modo M, Ambrosio F, Friedlander RM, Badylak SF, Wechsler LR, Curr Opin Neurol, 12/1/2013
• Therapeutic neuroprotective agents for amyotrophic lateral sclerosis  
  Friedlander RM, Wang, Xin, Cellular and Molecular Life Sciences, 11/1/2013
• Philanthropy funding for neurosurgery research and program development  
  Zusman EE, Heary RF, Stroink AR, Berger MS, Popp AJ, Friedlander RM, Martin NA, Lonser RR, Asthagiri AR, Neurosurgery, 7/1/2013
• Oxidative stress is associated with cell death, wall degradation, and increased risk of rupture of the intracranial aneurysm wall  
  Laaksamo E, Tulamo R, Liiman A, Baumann M, Friedlander RM, Hernesniemi J, Kangasniemi M, Niemela M, Laakso A, Frosen J, Neurosurgery, 1/1/2013
• High-definition fiber tractography of the human brain: neuroanatomical validation and neurosurgical applications  
  Fernandez-Miranda JC, Pathak S, Engh J, Jarbo K, Verstynen T, Yeh F, Mintz A, Boada F, Schneider W, Friedlander R, Neurosurgery, 8/1/2012
• Intracellular signaling pathways and size, shape and rupture history of human intracranial aneurysms  
  Laaksamo E, Ramachandran M, Frosen J, Tulamo R, Baumann M, Friedlander RM, Harbaugh RE, Hernesniemi J, Niemela M, Raghavan ML, Laasko A, Neurosurgery, 6/1/2012
• Treatment of ruptured and unruptured cerebral aneurysms in the USA: a paradigm shift  
  Lin N, Cahill KS, Frerichs KU, Friedlander RM, Claus EB, J. Neurointerv Surg, 5/1/2012
• Carotid Endarterectomy with primary closure:Analysis of outcomes and review of the literature  
  Zenonos G, Lin N, Kim A, Kim JE, Governale L, Friedlander RM, Neurosurgery, 3/1/2012
• Use of a simple internal fiducial as an adjunct to enhance intraoperative ultrasound-assisted guidance: technical note  
  Wong JM, Governale LS, Friedlander RM, Neurosurgery, 9/1/2011
• Dipyrone inhibits neuronal cell death and diminishes hypoxic/ischemic brain injury  
  Zhang Y, Wang X, Baranov SV, Zhu S, Huang Z, Fellows-Mayle W, Jiang J, Day AL, Kristal BS, Friedlander RM, Neurosurgery, 5/1/2011
• The use of a simple fiducial as an adjunct to enhance intraoperative ultrasound assisted guidance: technical note  
  Wong JM, Governale LS, Friedlander RM, Neurosurgery, 2/22/2011
• Using non-coding small RNAs to develop therapies for Huntington’s disease  
  Zhang Y, Friedlander RM, Gene Therapy, 1/1/2011
• Complement in neuroprotection and neurodegeneration  
  Yanamadala V, Friedlander RM, Trends Mol Med, 2/1/2010
• Composite ganglioneuroma-paraganglioma of the filum terminale  
  Shankar GM, Chen L, Kim AH, Ross GL, Folkerth RD, Friedlander RM, Journal of Neurosurg Spine, 1/1/2010
• Pro-apoptotic functions of PCDC10, the gene mutated in Cerebral Cavernous Malformation 3  
  Chen L, Tanriover G, Yano H, Friendlander RM, Louvi A, Gunel M, Stroke, 1/1/2009
• Allele-specific silencing of mutant Huntington’s disease gene  
  Zhang Y, Engelman J, Friedlander RM, Journal of Neurochemistry, 1/1/2009
• Stenting versus endartectomy for carotid-artery stenosis  
  Friedlander RM, New England Journal of Medicine, 10/1/2008
• Inhibitors of cytochrome c release with therapeutic potential for Huntington’s disease  
  Wang X, Zhu S, Pei Z, Drozda M, Stavrovskaya IG, Del Signore SJ, Cormier K, Shimony EM, Wang H, Ferrante RJ, Kristal BS, Friedlander RM, Journal of Neuroscience, 1/1/2008
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Books/Book Chapters

• The Causes of Epilepsy: Common and Uncommon Causes in Adults and Children 
  Chapter: Arteriovenous malformations: indications for stereotactic radiosurgery 
  Tharin SA, Klein AM, Friedlander RMEditors: Shorvon SD, Andermann F, Guerrini R.2011
• RNA Technologies and Their Applications 
  Chapter: Silencing Huntington’s Disease Gene with RNAi 
  Zhang Y and Friedlander RMEditors: Erdmann VA, Barciszewski J.2010
• Intracranial Arteriovenous Malformations 
  Chapter: Classification and Grading of Cerebral Arteriovenous Malformation 
  Frerichs K, Stieg PE, Friedlander RMEditors: Stieg PE, Batjer HH, Samson DS.2007
• Clinical Neurosurgery 
  Chapter: Promethazine as a mitochondrial mediated neuroprotectant 
  Narayanan M, Stavroskaya I, Zhang W-H, Kristal BS, Friedlander RM2003
• Clinical Neurosurgery 
  Chapter: Role of Interleukin-1beta Converting Enzyme in Experimental Traumatic Brain Injury 
  Friedlander, R.M, Fink KB, Andrews LJ, Butler WE, Ona VO, Bogdanov M, Endres M, Li M, Khan SQ, Subu N, Beal MF, Moskowitz MA, Yuan J2000
• Neurosurgical Operative Atlas 
  Chapter: Surgical management of middle cerebral artery aneurysms 
  Stieg PE, Friedlander RM1999
• Clinical Neurosurgery 
  Chapter: Management of Meningiomas of the cavernous sinus: Conservative Surgery and Adjuvant Therapy 
  Friedlander RM, Ojemann RG, Thorton AF1999
• Clinical Neurosurgery 
  Chapter: Arteriovenous malformations: indications for stereotactic radiosurgery 
  Stieg PE, Friedlander RM. Loeffler JS, Alexander EA III
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Lectures

• Neurosurgical Issues in the Elderly 
  Shadyside, PA - 6/12/2014
• Mitochondrial Function and Dysfunction in Huntington’s Disease 
  Sheraton Station Square, Pittsburgh, PA - 6/5/2014
• Strategic Research Update 
  Rochester, MN - 5/15/2014
• Plenary Session: Controversies in Neurology 
  Philadelphia, PA - 5/1/2014
• Management of Carotid Disease 
  Pittsburgh, PA - 4/23/2014
• Course: Skating to where the puck will be: Strategies for Neurosurgery Practices and Programs to compete in Health Care’s Future 
  San Francisco, CA - 4/4/2014
• McGowan Retreat, CNS Regeneration Session, Mitochondrial Dysfunction in Huntington’s Disease 
  Nemacolin Woodlands, PA - 3/11/2014
• Southeast European Neurosurgical Society 
  Belgrade, Serbia - 11/1/2013
• RiMed Symposium 
  Rome, Italy - 10/29/2013
• University of Pittsburgh Department of Neurology Lecture, CEA and Management of Aneurysms 
  Pittsburgh, PA - 9/9/2013
• Tri-State Neurovascular Summit 
  New York, NY - 5/3/2013
• Clinic for Neurosurgery 
  Belgrade, Serbia - 3/26/2013
• University of Pittsburgh, Winter Academy 
  Naples, FL - 2/15/2013
• AANS/CNS CV Section Annual Meeting 
  Honolulu, HI - 2/5/2013
• Provost’s Inaugural Lecture 
  Pittsburgh, PA - 1/14/2013
• Visiting Professor, University of Calgary Grand Rounds, University of Calgary 
  Alberta, Canada - 11/7/2012
• UPMC Stroke Update 
  Pittsburgh, PA - 10/12/2012
• Death, Danger, Inflammation & Immunity Conference 
  Paris, France - 5/31/2012
• Organization of the 14th National Congress of Neurosurgery 
  Valencia, Venezuela - 5/22/2012
• ERMI Risk Management Lecture Series 
  Pittsburgh, PA - 5/15/2012
• University of Pittsburgh Drug Discovery Institute 
  Pittsburgh, PA - 4/2/2012
• 2nd Krabbe Translational Research Workgroup Meeting 
  Pittsburgh, PA - 3/13/2012
• Brandeis Colloquium Series 
  Waltham, MA - 2/29/2012
• Grand Rounds, Department of Neurology, University of Pittsburgh School of Medicine 
  Pittsburgh, PA - 1/4/2012
• Pennsylvania Neurological Society Update Clinical Neurology V 
  Pittsburgh, PA - 10/15/2011
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