RobertDavidGuzyMDPhD

PubMed

• Implementation of a prospective screening strategy to identify adults with a telomere biology disorder among those undergoing lung transplant evaluation for interstiti...
  Lauren G Banaszak, Kelcy Smith-Simmer, Kyle Shoger, Lauren Lovrien, Amy Malik, Nathan Sandbo, Samir Sultan, Robert Guzy, Erin M Lowery, Jane E Churpek> ;Respiratory Medicine. 2023 Dec 1
• 7 citations
  Telomere length associates with chronological age and mortality across racially diverse pulmonary fibrosis cohorts.
  Ayodeji Adegunsoye, Chad A Newton, Justin M Oldham, Brett Ley, Cathryn T Lee, Angela L Linderholm, Jonathan H Chung, Nicole Garcia, Da Zhang, Rekha Vij, Robert Guzy, R...> ;Nature Communications. 2023 Mar 17
• Central lung gene expression associates with myofibroblast features in idiopathic pulmonary fibrosis.
  Yong Huang, Rob Guzy, Shwu-Fan Ma, Catherine A Bonham, Jonathan Jou, Jefree J Schulte, John S Kim, Andrew J Barros, Milena S Espindola, Aliya N Husain, Cory M Hogaboam...> ;BMJ Open Respiratory Research. 2023 Feb 1
• From the Gut to the Lung: Evidence of Antifibrotic Activity of Endocrine Fibroblast Growth Factor 19.
  Robert D Guzy, Seth Bollenbecker, Stefanie Krick> ;American Journal of Respiratory Cell and Molecular Biology. 2022 Aug 1
• 8 citations
  High-titer rheumatoid factor seropositivity predicts mediastinal lymphadenopathy and mortality in rheumatoid arthritis-related interstitial lung disease.
  Albina Tyker, Iazsmin Bauer Ventura, Cathryn Lee, Rachel Strykowski, Nicole Garcia, Robert D. Guzy, R. Jablonski, Rekha Vij, Mary E. Strek, Jonathan H. Chung, Ayodeji ...> ;Scientific Reports. 2021 Nov 24
• 4 citations
  SARS-CoV-2 Infection is Associated with Reduced Krüppel-Like Factor 2 in Human Lung Autopsy.
  David Wu, Tzu-Han Lee, Ru-Ting Huang, Robert D. Guzy, Nathan Schoettler, Ayodeji Adegunsoye, Jeffrey Mueller, Aliya N. Husain, Anne I. Sperling, Gökhan M. Mutlu, Yun Fang> ;American Journal of Respiratory Cell and Molecular Biology. 2021 May 10
• 7 citations
  A series of COVID-19 autopsies with clinical and pathologic comparisons to both seasonal and pandemic influenza.
  Phillip McMullen, Peter Pytel, Alexis Snyder, Heather L. Smith, Jasmine Vickery, James Brainer, Robert D. Guzy, David Wu, Nathan Schoettler, Ayodeji Adegunsoye, Anne I...> ;The Journal of Pathology. Clinical Research. 2021 May 7
• 1 citations
  Kindlin for the Fire: Targeting Proline Synthesis to Extinguish Matrix Production in Pulmonary Fibrosis
  Robert D. Guzy, Elizabeth F. Redente> ;American Journal of Respiratory Cell and Molecular Biology. 2021 Jul 9
• 1 citations
  SARS-CoV-2 infection reduces Krüppel-Like Factor 2 in human lung autopsy
  David Wu, Robert D. Guzy, Nathan Schoettler, Ayodeji Adegunsoye, Jeffrey Mueller, Aliya Hussein, Anne I. Sperling, Gökhan M. Mutlu, Yun Fang> ;Biorxiv. 2021 Jan 18
• 6 citations
  Fibroblast Growth Factor Inhibitors in Lung Fibrosis: Friends or Foes?
  Robert D. Guzy> ;American Journal of Respiratory Cell and Molecular Biology. 2020 Sep 1
• 58 citations
  Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization.
  Tzu-Han Lee, Chih-Fan Yeh, Y.-H. Lee, Ying-Chun Shih, Yen-Ting Chen, Chen-Ting Hung, Ming-Yi You, Pei-Chen Wu, Tzu-Pin Shentu, Ru-Ting Huang, Yu-Shan Lin, Yueh-Feng Wu...> ;Nature Communications. 2020 Aug 26
• 5 citations
  Fibroblast Growth Factor 2 Augments Transforming Growth Factor Beta 1 Induced Epithelial-mesenchymal Transition in Lung Cell Culture Model.
  Lamis M.F. El-Baz, Nahla M. Shoukry, Hani S. Hafez, Robert D. Guzy, Mohamed L. Salem> ;Iranian Journal of Allergy, Asthma, and Immunology. 2020 Aug 25
• 20 citations
  FGFR2 Is Required for AEC2 Homeostasis and Survival after Bleomycin-induced Lung Injury
  Samuel J. Dorry, Brandon O. Ansbro, David M. Ornitz, Gökhan M. Mutlu, Robert D. Guzy> ;American Journal of Respiratory Cell and Molecular Biology. 2020 May 1
• 42 citations
  Effect of FGF/FGFR pathway blocking on lung adenocarcinoma and its cancer-associated fibroblasts
  Ahmed E. Hegab, Mari Ozaki, Naofumi Kameyama, Jingtao Gao, Shizuko Kagawa, Hiroyuki Yasuda, Kenzo Soejima, Yongjun Yin, Robert D. Guzy, Yoshikazu Nakamura, David M. Or...> ;The Journal of Pathology. 2019 Oct 1
• 10 citations
  Anti-fibrotic effects of tannic acid through regulation of a sustained TGF-beta receptor signaling
  Eleanor B. Reed, Shawn Ard, Jennifer La, Chan Young Park, Laura Culligan, Jeffrey J. Fredberg, Larisa V. Smolyaninova, Sergei N. Orlov, Bohao Chen, Robert D. Guzy, Gök...> ;Respiratory Research. 2019 Jul 29
• 634 citations
  Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.
  Paul A. Reyfman, James M. Walter, Nikita Joshi, Kishore R. Anekalla, Alexandra C. McQuattie-Pimentel, Stephen Chiu, Ramiro Fernandez, Mahzad Akbarpour, Ching I. Chen, ...> ;American Journal of Respiratory and Critical Care Medicine. 2019 Jun 15
• 8 citations
  Sustained Smad2 Phosphorylation Is Required for Myofibroblast Transformation in Response to TGF-β.
  Shawn Ard, Eleanor B. Reed, Larisa V. Smolyaninova, Sergei N. Orlov, Gökhan M. Mutlu, Robert D. Guzy, Nickolai O. Dulin> ;American Journal of Respiratory Cell and Molecular Biology. 2019 Mar 1
• 56 citations
  Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation.
  Hyun Young Koo, Lamis M.F. El-Baz, Stacey L. House, Sarah N. Cilvik, Samuel J. Dorry, Nahla M. Shoukry, Mohamed L. Salem, Hani S. Hafez, Nickolai O. Dulin, David M. Or...> ;The Journal of Pathology. 2018 Sep 1
• 44 citations
  Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.
  Robert B. Hamanaka, Recep Nigdelioglu, Angelo Y. Meliton, Yufeng Tian, Leah J. Witt, E.M. O'Leary, Kaitlyn A. Sun, Parker S. Woods, David Wu, Brandon O. Ansbro, Shawn ...> ;American Journal of Respiratory Cell and Molecular Biology. 2017 Oct 11
• 20 citations
  Transient Notch Activation Induces Long-Term Gene Expression Changes Leading to Sick Sinus Syndrome in Mice.
  Yun Qiao, Catherine E. Lipovsky, Stephanie C. Hicks, Somya Bhatnagar, Gang Li, Aditi Khandekar, Robert D. Guzy, Kel Vin Woo, Colin G. Nichols, Igor R. Efimov, Stacey R...> ;Circulation Research. 2017 Aug 18
• 53 citations
  Comprehensive Care of the Lung Transplant Patient.
  Ayodeji Adegunsoye, Mary E. Strek, Edward R. Garrity, Robert D. Guzy, Remzi Bag> ;Chest. 2017 Jul 1
• 43 citations
  Pulmonary fibrosis requires cell-autonomous mesenchymal fibroblast growth factor (FGF) signaling
  Robert D. Guzy, Ling Li, Craig Smith, Samuel J. Dorry, Hyun Young Koo, Lin Chen, David M. Ornitz> ;The Journal of Biological Chemistry. 2017 Jun 23
• 65 citations
  Fibroblast growth factor 2 is required for epithelial recovery, but not for pulmonary fibrosis, in response to bleomycin.
  Robert D. Guzy, Ivan Stoilov, Timothy J. Elton, Robert P. Mecham, David M. Ornitz> ;American Journal of Respiratory Cell and Molecular Biology. 2015 Jan 1
• 2 citations
  YKL-40 in pediatric asthma, MUC5B promoter polymorphism in idiopathic pulmonary fibrosis, and esmolol in septic shock
  Hrishikesh S. Kulkarni, Robert D. Guzy, Colleen McEvoy> ;American Journal of Respiratory and Critical Care Medicine. 2014 May 1
• 114 citations
  Superoxide generated at mitochondrial complex III triggers acute responses to hypoxia in the pulmonary circulation.
  Gregory B. Waypa, Jeremy D. Marks, Robert D. Guzy, Paul T. Mungai, Jacqueline M. Schriewer, Danijela Dokic, Molly K. Ball, Paul T. Schumacker> ;American Journal of Respiratory and Critical Care Medicine. 2013 Mar 22
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Journal Articles

• Fibroblast Growth Factor 2 Decreases Bleomycin‐Induced Pulmonary Fibrosis and Inhibits Fibroblast Collagen Production and Myofibroblast Differentiation  
  David M Ornitz, Stacey L House, Robert D Guzy, The Journal of Pathology