Robert Charles Sergott MD

Neuro-Ophthalmology, Retinal Disease

Professor of Ophthalmology, Thomas Jefferson University

840 Walnut StSuite 930Philadelphia, PA 19107
Phone+1 215-928-3130
Fax+1 215-592-1923

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Summary

Dr. Robert Sergott is an ophthalmologist based in Philadelphia, PA, with subspecialties in neuro-ophthalmology and retinal disease. He completed his medical education at Johns Hopkins University School of Medicine and his ophthalmology residencies at the University of Miami and Wills Eye Hospital. He is the Margaret and Richard Hayne Distinguished Professor of Ophthalmology and Neuroscience, Sidney Kimmel Medical School, Thomas Jefferson University, and an attending surgeon at Wills Eye Hospital, among other roles. He is also the founding and current director of the William H. Annesley EyeBrain Center at Jefferson partnered with Wills Eye. This center concentrates upon mitochondrial involvement in neurodegenerative diseases. His research is focused on neuro-ophthalmology and related fields, with recent publications in notable journals. Dr. Sergott has led clinical trials exploring interventions for optic neuritis and visual impairment due to trauma. He has received multiple awards, including recognition as one of America's Top Doctors and Best Ophthalmologist in America.

Education & Training

University of Miami/Jackson Health System/Bascom Palmer Eye InstituteResidency, Ophthalmology, 1979 - 1980
Sidney Kimmel Medical College at Thomas Jefferson University/Wills Eye HospitalResidency, Ophthalmology, 1976 - 1979
Bassett Medical CenterInternship, Internal Medicine, 1975 - 1976
Johns Hopkins University School of MedicineClass of 1975
Johns Hopkins UniversityB.A., 1967 - 1971

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Certifications & Licensure

PA State Medical License 1977 - 2026
NJ State Medical License 1978 - 2019
DE State Medical License 2000 - 2017
MD State Medical License 1975 - 1991
American Board of Ophthalmology Ophthalmology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory - Core EMR, Epic Systems Corporation, 2012, 2014
America's Top Doctors Castle Connolly, 2002-2014
Philadelphia Magazine Castle Connolly, 2004-2005, 2007-2014

Clinical Trials

Single Oral Doses Study of Nerispirdine on Visual Function in Patients With Multiple Sclerosis
COMPLETED
PHASE2
Defining the Functional and Neuro-Protective Potential of ACTHAR in Acute Optic Neuritis
COMPLETED
EARLY_PHASE1
Electric Stimulation of the Eye to Improve Vision After Trauma
COMPLETED
NA

Publications & Presentations

PubMed

Green vessel signal on multicolor imaging as an early sign of ischemic vasculitis in IRVAN Syndrome: A case report.
Daniel M Markowitz, Jirat Nimworaphan, Carl D Regillo, James P Dunn, Robert C Sergott
American Journal of Ophthalmology Case Reports. 2026-06-01
1 citations
Predictors of Final Visual Outcome in Patients With Leber Hereditary Optic Neuropathy Treated With Lenadogene Nolparvovec Gene Therapy.
Robert C Sergott, Valerio Carelli, Nancy J Newman, Valérie Biousse, Patrick Yu-Wai-Man
Investigative Ophthalmology & Visual Science. 2025-07-01
20 citations
Five-Year Outcomes of Lenadogene Nolparvovec Gene Therapy in Leber Hereditary Optic Neuropathy.
Patrick Yu-Wai-Man, Nancy J Newman, Valérie Biousse, Valerio Carelli, Mark L Moster
JAMA Ophthalmology. 2025-02-01

Journal Articles

ATON: Results from a Phase II randomized trial of the B-cell-targeting agent atacicept in patients with optic neuritis
Jeffrey L. Bennett, Peter Rieckmann, Xavier Montalbane, Daniel Mikol, Ulrich Freudensprung, Thomas Plitz, Johan van Beek, for the ATON Trial Group, Journal of Neurologic Science, 1/1/2015
Segmental Analysis of Macular Layers in Patients with Unilateral Primary Open-Angle Glaucoma
Zangalli C, Ahmed O, Waisbourd M, et al, Journal of Glaucoma, 1/1/2015
Simultaneous, bilateral ophthalmoplegia as the presenting sign of paediatric multiple sclerosis: Case report and discussion of the differential diagnosis
Adam MK, Krespan K, Moster ML, Neuro-Ophthalmology, 1/1/2014

Books/Book Chapters

Medical Imaging in Clinical Trials
Chapter: Chapter 13: Optical Coherence Tomography in Clinical Trials for Ophthalmology and Neurology
Page 277 - 291Sergott RCEditors: Miller CG, Krasnow J and Schwartz LH.Springer2014
Craniopharyngiomas
Chapter: Chapter 6: Neuro-ophthalmic Manifestations of Craniopharyngiomas
Sergott RCEditors: Kenning and Evana.Springer2014
International Ophthalmology Clinics
Chapter: Historical perspective and future prospective for retinal nerve fiber layer loss in optic neuritis and multiple sclerosis
Page 15 - 24Sergott RCEditors: Foroozan R.Lippincott Williams & Wilkins, Philadelphia, PA2007

Abstracts/Posters

Segmental Analysis of Macular Layers in Patients with Unilateral Primary Open-Angle Glaucoma
Sergott RC, Association for Research in Vision and Ophthalmology Meeting, Denver, 1/3/2015
Lebers hereditary optic neuropathy & untreated remitting relapsing MS share multicolor OCT findings: potential biomarker for mitochondrial flavoprotein biosynthesis an...
with M.L. Moster, ECTRIMS, Barcelona Spain, 1/1/2015
The Sabril Registry After 5 Years: Patient Characteristics and Vision Loss
R Foroozan, E Faught, et al, American Association of Neurology, Philadelphia, 1/1/2015

Lectures

Green Retinas and Mitochondria: MultiColor OCT Illuminates Leber’s Hereditary Optic Neuropathy, MS, Alzheimer’s Parkinson’s, Glaucoma and Vitreo-Macular Traction
1/13/2015
Found in Translation: What the Retina and OCT Are Telling Us About MS, Parkinson’s, and Alzheimer’s
Temple University, Philadelphia PA - 1/1/2015
Retina Examination with Examination with Curcumin for the Diagnosis of Alzheimer’s Disease
Istanbul, Turkey - 1/12/2014

Authored Content

Defining Ocular Ischemic Processes: An AtlasDecember 2022

Press Mentions

GenSight Biologics Announces Publication on Predictors of Final Visual Outcome in Patients Treated with LUMEVOQ® Gene TherapyJuly 17th, 2025
GenSight Biologics Reports Clinically Meaningful Vision Improvement Is Maintained 4 Years After One-Time Treatment with LUMEVOQ® Gene TherapyJanuary 24th, 2022
GenSight Biologics to Host Key Opinion Leader Webcasts on the Topline Results from REFLECT Phase III Clinical Trial of LUMEVOQ®July 5th, 2021