RogerArgelioAlvarezDOMPH(He/Him)

Pulmonology • Weston, FL

Critical Care Medicine, Interstitial Lung Diseases, Pulmonary Vascular Medicine

Staff Physician

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Office
Cleveland Clinic
2950 Cleveland Clinic Blvd
Weston, FL 33331
Phone+1 954-659-5450

Fax+1 888-663-6137
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Summary

I specialize in the care and study of pulmonary vascular diseases, including pulmonary hypertension, pulmonary embolism, and CTEPH. I am also passionate about caring for patients with interstitial lung disease. I enjoy collaborating with other physicians to provide outstanding, compassionate, evidence-based, and cutting edge care to patients with serious lung diseases.

Education & Training

UPMC Medical EducationFellowship, Pulmonary Disease and Critical Care Medicine, 2013 - 2016
Emory University School of MedicineChief Residency, Internal Medicine, 2012 - 2013
Emory University School of MedicineResidency, Internal Medicine, 2010 - 2012
Emory University School of MedicineInternship, Internal Medicine, 2009 - 2010
Nova Southeastern University College of Osteopathic MedicineClass of 2009, DO, MPH, With Honors
Georgetown UniversityMaster of Science, Physiology and Biophysics, 2003 - 2004
University of MiamiBachelor of Science, Biology, 1999 - 2003

Certifications & Licensure

FL State License 2016 - 2024
PA State License 2013 - 2016
GA State License 2011 - 2014

Awards, Honors, & Recognition

Outstanding Clinician, Department of Medicine University of Miami Miller School of Medicine, 2019
Minority Trainee Developmental Scholarship, ATS Meeting American Thoracic Society, 2015
Abstract Scholarship ATS Assembly on Pulmonary Circulation, 2015
Outstanding Teaching Fellow Award UPMC Department of Internal Medicine, 2014
Best Case Report Award - Infectious Disease Student/Resident Cases CHEST, 2012
Outstanding PGY-3 Resident Award Emory University, 2012
Outstanding PGY-1 Resident Award Emory University, 2010
Public Policy Senior Award Nova Southeastern University, 2009
Psi Sigma Alpha Scholastic Honor Society Nova Southeastern University, 2009
American Osteopathic Association Presidential Memorial Leadership Award 2008
Student of the Year Nova Southeastern University, 2008
Gold Humanism Honor Society A.P. Gold Foundation, 2008
Medical Student of the Year Nova Southeastern University, 2007
Mathew Terry, DO Scholarship Award Nova Southeastern University, 2007
Welch Scholars Grant American Osteopathic Foundation, 2006
Bowman Foster Ashe Scholarship University of Miami, 2003
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Clinical Trials

OPsumit USers Registry Start of enrollment: 2014 Apr 30
Completed
Macitentan in Pulmonary Hypertension of Sickle Cell Disease Start of enrollment: 2015 Jul 01
Terminated
Phase 2
A Study to Assess Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis at Risk for Pulmonary Hypertension Start of enrollment: 2020 Dec 14
Terminated
Phase 3
PRIMEx - A Study of 2 Doses of Oral CXA-10 in Pulmonary Arterial Hypertension (PAH) Start of enrollment: 2018 Aug 01
Terminated
Phase 2
A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients Start of enrollment: 2018 Aug 30
Recruiting
Phase 3
A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension Start of enrollment: 2019 Sep 23
Enrolling by invitation
Phase 3
A Dose Escalation Study to Assess the Safety and Efficacy of Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis or Sarcoidosis Start of enrollment: 2019 Jan 30
Completed
Phase 2
iNOPulse for COVID-19 Start of enrollment: 2020 Dec 01
Withdrawn
Phase 2
Safety, Efficacy, and Dosing of VIX001 in Patients With Neurological Symptoms of Post Acute COVID-19 Syndrome (PACS). Start of enrollment: 2023 Oct 01
Not yet recruiting
Phase 1
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

226 citations
Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trial.
Giacomo Lanzoni, E. Linetsky, Diego Correa, Shari Messinger Cayetano, Roger A. Alvarez, Dimitrios Kouroupis, Ana M. Alvarez Gil, Raffaella Poggioli, Phillip Ruiz, Anto...> ;Stem Cells Translational Medicine. 2021 May 1
41 citations
A Randomized, Double-Blind, Placebo-Controlled Study of Pulsed, Inhaled Nitric Oxide in Subjects at Risk of Pulmonary Hypertension Associated With Pulmonary Fibrosis.
Steven D. Nathan, Kevin R. Flaherty, Marilyn K. Glassberg, Ganesh Raghu, Jeffrey J. Swigris, Roger A. Alvarez, Neil A. Ettinger, J.E. Loyd, Peter Fernandes, Hunter Gil...> ;Chest. 2020 Aug 1
Management of crash and burn patients with SARS-CoV-2 associated ARDS.
Ali Ghodsizad, April A. Grant, Mehdi Mirsaeidi, Waleed Sneij, Laiqua Khalid, David Delazerda, Jonathan S. Auerbach, Roger A. Alvarez, Eduardo de Marchena, Joshua M. Ha...> ;Journal of Cardiac Surgery. 2020 Jul 14
52 citations
Home Nitric Oxide Therapy for COVID-19.
Roger A. Alvarez, Lorenzo Berra, Mark T. Gladwin> ;American Journal of Respiratory and Critical Care Medicine. 2020 Jul 1
7 citations
Umbilical Cord-derived Mesenchymal Stem Cells for COVID-19 Patients with Acute Respiratory Distress Syndrome (ARDS)
Giacomo Lanzoni, E. Linetsky, Diego Correa, Roger A. Alvarez, Antonio Marttos, Khemraj Hirani, Shari Messinger Cayetano, J. G. Castro, Michael J. Paidas, J. Efantis Po...> ;Cellr4-- Repair, Replacement, Regeneration, & Reprogramming. 2020 Apr 28
19 citations
Targeting Pulmonary Endothelial Hemoglobin α Improves Nitric Oxide Signaling and Reverses Pulmonary Artery Endothelial Dysfunction.
Roger A. Alvarez, Megan P. Miller, Scott A. Hahn, Joseph C Galley, Eileen Bauer, Timothy N. Bachman, Jian Hu, John Sembrat, Dmitry A. Goncharov, Ana L. Mora, Mauricio ...> ;American Journal of Respiratory Cell and Molecular Biology. 2017 Dec 1
Reply: We Did This, and the Patient Improved: True, True, and Unrelated?
Kyan Askari, Waleed Sneij, Stefanie Krick, Roger A. Alvarez> ;Annals of the American Thoracic Society. 2017 Nov 30
3 citations
Going with the Flow: Saddle Pulmonary Embolism Complicated by Severe Hypoxemia without Shock.
Kyan Askari, Waleed Sneij, Stefanie Krick, Roger A. Alvarez> ;Annals of the American Thoracic Society. 2017 Sep 1
22 citations
Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3 That Increase Nitric Oxide Bioavailability
Md. Mizanur Rahaman, Fabio G. Reinders, David Ryan Koes, Anh T. Nguyen, Stephanie M. Mutchler, Courtney Sparacino-Watkins, Roger A. Alvarez, Megan P. Miller, Dongmei C...> ;The Journal of Biological Chemistry. 2015 Jul 3
3 citations
Bosentan for Sarcoidosis-associated Pulmonary Hypertension, Age-adjusted D-Dimer Levels in Pulmonary Embolism, and Mean Arterial Blood Pressure Targets in Septic Shock
Roger A. Alvarez, Ian J. Barbash, Jason J. Rose> ;American Journal of Respiratory and Critical Care Medicine. 2014 Oct 15
75 citations
Increasing minority research participation through community organization outreach.
Roger A. Alvarez, Elias P. Vasquez, Carla C. Mayorga, Daniel J. Feaster, Victoria B. Mitrani> ;Western Journal of Nursing Research. 2006 Aug 1
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Abstracts/Posters

Every Other Day Dosing of Rosuvastatin for Patients Intolerant to Statins.
Achtchi, A. N., Alvarez, R. A., Nell-Dybdahl, C., Smiley, W. H., Sperling, L. S., Resident Research Day, Emory University School of Medicine., Atlanta, GA.
Metastatic Pulmonary Calcifications In A Bilateral Lung Transplant Recipient
Bhadriraju, S., Alvarez, R. A., Pilewski, J. M., American Thoracic Society, San Diego, CA, 5/18/2014
Miliary Tuberculosis Presenting With GI Bleed From Hepatic Artery Pseudoaneurysm Rupture in an HIV Infected Patient
Alvarez RA, Venado A, CHEST, Atlanta, GA, 10/21/2012
Alternate Day Rosuvastatin Dosing for Statin Intolerant Patients.
Achtchi, A. N., Alvarez, R. A., Nell-Dybdahl, C., Smiley, W. H., Sperling, L. S., American College of Cardiology 60th Annual Scientific Session., New Orleans, LA.
Commercial Board Review Courses and COMLEX-USA Level 1 Performance.
Alvarez, R. A., DeMastes, C. S., Hunt, A., Kester, R., Kostelnik, B., Maughan, C., McGinnis, S., Opoku, J., Tropea, T., Mason, C., American Osteopathic Association Meeting., New Orleans, LA.
Prevalence of metabolic syndrome and other CVD risk factors in rural versus urban regions of Ecuador.
LaCorte, L., Alvarez, R. A., Caban-Martinez, A. J., Davila, E. P., American Public Health Association Meeting & Exposition., San Diego, CA.
Three shortcomings of current osteopathic medical education curricula, a student perspective.
Alvarez, R. A., Feitell, S., Jones, A., Landry, B., Mapley, A., Mason, C, Sarmiento, P, Schrick-Senasac, S., AOA Convention & Scientific Seminar., San Diego, CA
Ethnic Differences in the Treatment Outcome of Lung Cancer in Florida by Histology and Stage.
Alvarez, R. A., Alvarez, M. S., Markle, S., Aguiluz, C., Suciu, G., 2007 AMSA Annual Convention., Washington, DC.
A Model and Time-Line to Support Community-Based Research in Minority Communities.
Alvarez, R. A., Vasquez, E., Mayorga, C. C., National Association of Hispanic Nurses Conference. Orlando, Orlando, FL.
Ethnic Differences in the Treatment Outcome of Lung Cancer in Florida by Histology and Stage.
Alvarez, R. A., Alvarez, M. S., Markle, S., Aguiluz, C., Lalani, E, Suciu, G., American Public Health Association Meeting & Exposition., Washington, DC
Recruiting HIV+ Latina Women in HIV/Aids Research: Lessons Learned.
Alvarez, R. A., Vasquez, E., Mitrani, V. B., Mayorga, C. C., National Association of Hispanic Nurses Conference., Orlando, FL.
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Press Mentions

Miami Valves 2022 Brings International Perspective to Advances in Treatment Devices and ProceduresMarch 7th, 2022
11 Things to Do When You Test Positive for COVID-19December 11th, 2020
What to Do if You Test Positive for the Coronavirus This WinterDecember 4th, 2020
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Grant Support

Warfield Garson Lung Disease Research Developmental GrantBreathe Pennsylvania2015–2016

Committees

Director, Pulmonary Embolism Response Team 2019 - Present
Member, Residency Clinical Competence Committee 2012 - 2013
Member, Residency Leadership Committee 2012 - 2013

Research History

Research FellowResearch fellow at the Vascular Medicine Institute in Pittsburgh, PA in the Straub laboratory, studying the role of hemoglobin alpha and cytochrome b5 reductase 3 (CYB5R3) in the nitric oxide signaling pathway in the pulmonary circulation.2014 - 2016

Professional Memberships

American College of Physicians - ACP
Associate
American College of Chest Physicians - ACCP
Associate Member
American Thoracic Society - ATS
Associate Member

Other Languages

Spanish

Hospital Affiliations

Cleveland Clinic FloridaFort Lauderdale, Florida
UMHC - Bascom Palmer Eye InstituteMiami, Florida

External Links

University of Miami Profilehttp://uhealthsystem.com/doctors/profile/148198
UPMC PACCMhttp://www.paccm.pitt.edu

Reviews

Very likely to recommend October 2023

Dr. Alvarez is the most thorough and knowledgeable physician I have ever met. His bedside manner is unmatched. He is compassionate and fights for what is best for his patients. I HIGHLY recommend him.