RolandGKallenMD

Internal Medicine • Bala Cynwyd, PA

Professor, Biochemistry & Biophysics, Perelman School of Medicine

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Office
101 Colwyn Ln
Bala Cynwyd, PA 19004
Phone+1 610-664-4028
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Education & Training

NYU Grossman School of MedicineInternship, Internal Medicine, 1960 - 1961
Columbia University Vagelos College of Physicians and SurgeonsClass of 1960

Publications & Presentations

PubMed

7 citations
Direct evidence that scorpion α-toxins (site-3) modulate sodium channel inactivation by hindrance of voltage-sensor movements.
Zhongming Ma, Jun Kong, Dalia Gordon, Michael Gurevitz, Roland G. Kallen> ;Plos One. 2013 Nov 26
47 citations
Location analysis for the estrogen receptor-α reveals binding to diverse ERE sequences and widespread binding within repetitive DNA elements
Christopher E. Mason, Feng-jue Shu, Cheng Wang, Ryan M. Session, Roland G. Kallen, Neil Sidell, Tianwei Yu, Mei Hui Liu, Edwin Cheung, Caleb B. Kallen> ;Nucleic Acids Research. 2010 Apr 1
5 citations
Studies of α-Helicity and Intersegmental Interactions in Voltage-Gated Na+ Channels: S2D4
Zhongming Ma, Jun Kong, Roland G. Kallen> ;Plos One. 2009 Nov 2
45 citations
An ‘Old World’ scorpion β‐toxin that recognizes both insect and mammalian sodium channels
Dalia Gordon, Nitza Ilan, Noam Zilberberg, Nicolas Gilles, Daniel Urbach, Lior Cohen, Izhar Karbat, Oren Froy, Ariel Gaathon, Roland G. Kallen, Morris Benveniste, Mich...> ;European Journal of Biochemistry. 2003 Jun 1
13 citations
Lidocaine stabilizes the open state of CNS voltage-dependent sodium channels.
David R. Castaneda-Castellanos, Igor Nikonorov, Roland G. Kallen, Esperanza Recio-Pinto> ;Brain Research. Molecular Brain Research. 2002 Mar 28
11 citations
A carboxy-terminal α-helical segment in the rat skeletal muscle voltage-dependent Na+ channel is responsible for its interaction with the amino-terminus
Hui Zhang, Sylvia Kolibal, Jane M. Vanderkooi, Sidney Cohen, Roland G. Kallen> ;Biochimica Et Biophysica Acta. 2000 Aug 25
126 citations
The Na Channel Voltage Sensor Associated with Inactivation Is Localized to the External Charged Residues of Domain IV, S4
Michael F. Sheets, John W. Kyle, Roland G. Kallen, Dorothy A. Hanck> ;Biophysical Journal. 1999 Aug 1
20 citations
Interaction between the skeletal muscle type 1 Na+ channel promoter E-box and an upstream repressor element. Release of repression by myogenin.
Susan D. Kraner, Mark M. Rich, Martha A. Sholl, Huanying Zhou, Catherine S. Zorc, Roland G. Kallen, Robert L. Barchi> ;The Journal of Biological Chemistry. 1999 Mar 19
37 citations
Comparison of slow inactivation in human heart and rat skeletal muscle Na+ channel chimaeras
John P. O'Reilly, Sho-Ya Wang, Roland G. Kallen, Ging Kuo Wang> ;The Journal of Physiology. 1999 Feb 1
7 citations
Dual tandem promoter elements containing CCAC-like motifs from the tetrodotoxin-resistant voltage-sensitive Na+ channel (rSkM2) gene can independently drive muscle-spe...
Hui Zhang, Michelle Maldonado, Robert L. Barchi, Roland G. Kallen> ;Gene Expression. 1999 Jan 1
8 citations
Electrophysiological Study of Chimeric Sodium Channels from Heart and Skeletal Muscle
Isabelle Deschenes, L.-Q. Chen, Roland G. Kallen, Mohamed Chahine> ;The Journal of Membrane Biology. 1998 Jul 1
49 citations
Extrapore Residues of the S5-S6 Loop of Domain 2 of the Voltage-Gated Skeletal Muscle Sodium Channel (rSkM1) Contribute to the μ-Conotoxin GIIIA Binding Site
M. Chahine, J. Sirois, P. Marcotte, L.-Q. Chen, Roland G. Kallen> ;Biophysical Journal. 1998 Jul 1
22 citations
Two E-Boxes Are the Focal Point of Muscle-specific Skeletal Muscle Type 1 Na+ Channel Gene Expression
Susan D. Kraner, Mark M. Rich, Roland G. Kallen, Robert L. Barchi> ;The Journal of Biological Chemistry. 1998 May 1
20 citations
Glutamine substitution at alanine1649 in the S4-S5 cytoplasmic loop of domain 4 removes the voltage sensitivity of fast inactivation in the human heart sodium channel.
Lihui Tang, Nabil H. Chehab, Steven J. Wieland, Roland G. Kallen> ;The Journal of General Physiology. 1998 May 1
25 citations
Changes in Thyroid State Affect pHiand Nai+Homeostasis in Rat Ventricular Myocytes
Beata M. Wolska, Vera Averyhart-Fullard, Akira Omachi, Miroslav O. Stojanovic, Roland G. Kallen, R. John Solaro> ;Journal of Molecular and Cellular Cardiology. 1997 Oct 1
30 citations
Differences in the binding sites of two site-3 sodium channel toxins.
G. Richard Benzinger, Chester L. Drum, Li Qiong Chen, Roland G. Kallen, Dorothy A. Hanck, D. Hanck> ;Pflugers Archiv. 1997 Nov 1
8 citations
Restoration of fast inactivation in an inactivation-defective human heart sodium channel by the cysteine modifying reagent benzyl-MTS: analysis of IFM-ICM mutation.
Mohamed Chahine, Isabelle Deschenes, Eric Trottier, Li Qiong Chen, Roland G. Kallen> ;Biochemical and Biophysical Research Communications. 1997 Apr 28
66 citations
Effects of Tityus Serrulatus Scorpion Toxin gamma on Voltage-Gated Na sup + Channels
P. Marcotte, L.-Q. Chen, Roland G. Kallen, M. Chahine> ;Circulation Research. 1997 Mar 1
167 citations
A unique role for the S4 segment of domain 4 in the inactivation of sodium channels.
Li Qiong Chen, V Santarelli, Richard Horn, Roland G. Kallen> ;The Journal of General Physiology. 1996 Dec 1
68 citations
Modulation of human muscle sodium channels by intracellular fatty acids is dependent on the channel isoform.
Steven J. Wieland, Qi-Hua Gong, Honesto Poblete, Jeffrey E. Fletcher, Li Qiong Chen, Roland G. Kallen> ;The Journal of Biological Chemistry. 1996 Aug 9
76 citations
Role of an S4-S5 linker in sodium channel inactivation probed by mutagenesis and a peptide blocker.
Lihui Tang, Roland G. Kallen, Richard Horn> ;The Journal of General Physiology. 1996 Aug 1
50 citations
A molecular link between activation and inactivation of sodium channels.
Michael E. O'Leary, Li Qiong Chen, Roland G. Kallen, Richard Horn> ;The Journal of General Physiology. 1995 Oct 1
105 citations
On the molecular nature of the lidocaine receptor of cardiac NA+ channels : modification of block by alterations in the α-subunit III-IV interdomain
Paul B. Bennett, Carmen Valenzuela, Li Qiong Chen, Roland G. Kallen> ;Circulation Research. 1995 Sep 1
142 citations
Functional Consequences of Sulfhydryl Modification in the Pore-Forming Subunits of Cardiovascular Ca2+ and Na+ Channels
Nipavan Chiamvimonvat, Brian O'Rourke, Timothy J. Kamp, Roland G. Kallen, Franz Hofmann, Veit Flockerzi, Eduardo Marbán> ;Circulation Research. 1995 Mar 1
8 citations
Stable Expression and Functional Characterization of a Human Cardiac Na ÷ Channel Gene in Mammalian Cells
Douglas S. Krafte, Walter A. Volberg, Lottie Rapp, Roland G. Kallen, Patricia H. Lalik, Richard B. Ciccarelli> ;Journal of Molecular and Cellular Cardiology. 1995 Feb 1
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Grant Support

Voltage Sensitive NA Channels--Surface ArchitectureNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1998–2002
Voltage-Sensitive Na+ Channels--Structure And FunctionNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1994–1995
Voltage-Sensitive Na+ Channels: Structure &FunctionNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1993
Voltage-Sensitive Na+ Channels--Structure &FunctionNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1992

RolandGKallenMD

Dr. Kallen is on Doximity

Education & Training

Publications & Presentations

Grant Support

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