RomaineCharlesNicholsJr.MD

PubMed

• Implementation of Machine Learning Models to Ensure Radiotherapy Quality for Multicenter Clinical Trials: Report from a Phase III Lung Cancer Study.
  Huaizhi Geng, Zhongxing Liao, Quynh-Nhu Nguyen, Abigail T Berman, Clifford Robinson, Abraham Wu, Romaine Charles Nichols Jr, Henning Willers, Nasiruddin Mohammed, Pran...> ;Cancers. 2023 Feb 5
• 4 citations
  Chemoradiation with Hypofractionated Proton Therapy in Stage II-III Non-Small Cell Lung Cancer: A Proton Collaborative Group Phase 2 Trial.
  Bradford S Hoppe, Romaine C Nichols, Stella Flampouri, Mark Pankuch, Christopher G Morris, Dat C Pham, Pranshu Mohindra, William F Hartsell, Nasiruddin Mohammed, Brian...> ;International Journal of Radiation Oncology, Biology, Physics. 2022 Jul 15
• 2 citations
  Dose-escalated proton therapy with elective nodal irradiation and concomitant chemotherapy for unresectable, borderline resectable, or medically inoperable pancreatic ...
  Cooper T Rapp, Michael S Rutenberg, Christopher G Morris, Romaine C Nichols> ;Journal of Gastrointestinal Oncology. 2022 Jun 1
• A Phase II Trial of Escalated Dose Proton Radiotherapy With Elective Nodal Irradiation and Concomitant Chemotherapy for Patients with Unresectable, Borderline Resectab...
  C. Rapp, Michael S. Rutenberg, Christopher G. Morris, Romaine C. Nichols> ;International Journal of Radiation Oncology Biology Physics. 2021 Nov 1
• 10-Year Outcomes Following Proton Therapy for Localized Prostate Cancer.
  Curtis Bryant, R.H. Henderson, William M. Mendenhall, Romaine C. Nichols, Xiaoying Liang, Zhong Su, Mark Bandyk, K.C. Balaji, Joseph Costa, Nancy P. Mendenhall> ;International Journal of Radiation Oncology Biology Physics. 2021 Nov 1
• 9 citations
  Consensus Statement on Proton Therapy for Prostate Cancer.
  Curtis Bryant, Randal H. Henderson, R. Charles Nichols, William M. Mendenhall, Bradford S. Hoppe, Carlos Vargas, Thomas B. Daniels, C. Richard Choo, Rahul R. Parikh, H...> ;International Journal of Particle Therapy. 2021 Sep 1
• 3 citations
  Insurance Approval for Definitive Proton Therapy for Prostate Cancer
  William M. Mendenhall, Eric Brooks, Stephanie Smith, Christopher G. Morris, Curtis B. Bryant, Randal H. Henderson, Romaine C. Nichols, Kathy McIntyre, Stuart L. Klein,...> ;International Journal of Particle Therapy. 2021 Jul 27
• Postoperative or Salvage Proton Radiotherapy for Prostate Cancer After Radical Prostatectomy.
  Shivam M Kharod, Catherine E. Mercado, Christopher G. Morris, Curtis Bryant, Nancy P. Mendenhall, William M. Mendenhall, R. Charles Nichols, Bradford S. Hoppe, Xiaoyin...> ;International Journal of Particle Therapy. 2021 Mar 1
• 5 citations
  A comparative study of prostate PTV margins for patients using hydrogel spacer or rectal balloon in proton therapy.
  Zhong Su, Randal H. Henderson, Romaine C. Nichols, Curtis Bryant, Bradford S. Hoppe, William M. Mendenhall, Nancy P. Mendenhall> ;Physica Medica. 2021 Jan 1
• 3 citations
  Image-Guided Hypofractionated Proton Therapy in Early-Stage Non-Small Cell Lung Cancer: A Phase 2 Study
  Shivam M Kharod, R. Charles Nichols, Randal H. Henderson, Christopher G. Morris, Dat C. Pham, Vandana Seeram, Lisa Jones, Maria Antonio-Miranda, Daniel Siragusa, Zuofe...> ;International Journal of Particle Therapy. 2020 Sep 1
• 4 citations
  Image-guided hypofractionated double-scattering proton therapy in the management of centrally-located early-stage non-small cell lung cancer.
  Shivam M Kharod, R. Charles Nichols, Randal H. Henderson, Christopher G. Morris, Dat C. Pham, Vandana Seeram, Lisa Jones, Maria Antonio-Miranda, Soon Huh, Zuofeng Li, ...> ;Acta Oncologica. 2020 May 12
• 14 citations
  Hypofractionated Proton Therapy with Concurrent Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer: A Phase 1 Trial from the University of Florida and Proton...
  Bradford S. Hoppe, Romaine C. Nichols, S. Flampouri, Zuofeng Li, Christopher G. Morris, Dat C. Pham, Pranshu Mohindra, William F. Hartsell, Nasiruddin Mohammed, B.H. C...> ;International Journal of Radiation Oncology, Biology, Physics. 2020 Apr 3
• 14 citations
  Proton beam radiotherapy for pancreas cancer
  Michael S. Rutenberg, Romaine C. Nichols> ;Journal of Gastrointestinal Oncology. 2020 Feb 1
• 4 citations
  Optimizing neoadjuvant radiotherapy for resectable and borderline resectable pancreatic cancer using protons.
  Romaine C. Nichols, Michael S. Rutenberg> ;World Journal of Gastrointestinal Surgery. 2019 Jul 27
• 7 citations
  Radiation-induced tumor immunity in patients with non-small cell lung cancer.
  Natalie A. Lockney, Mei Zhang, Christopher G. Morris, Romaine C. Nichols, Paul Okunieff, Steven Swarts, Zhenhuan Zhang, Bingrong Zhang, Amy Zhang, Bradford S. Hoppe> ;Thoracic Cancer. 2019 Jul 1
• 2 citations
  Patient-Reported Sexual Survivorship Following High-Dose Image-Guided Proton Therapy for Prostate Cancer.
  Adam L. Holtzman, Curtis Bryant, Nancy P. Mendenhall, William M. Mendenhall, R. Charles Nichols, Randal H. Henderson, Nicholas B. Figura, Christopher G. Morris, Christ...> ;Radiotherapy and Oncology. 2019 May 1
• 5 citations
  Serum Testosterone 60 Months after Passive-Scatter Proton Therapy for Localized Prostate Cancer
  R. Charles Nichols, Christopher G. Morris, Curtis Bryant, Bradford S. Hoppe, Randal H. Henderson, William M. Mendenhall, Zuofeng Li, Joseph Costa, Christopher R. Willi...> ;Cancer Investigation. 2019 Mar 5
• 1 citations
  Impact of unfavorable factors on outcomes among inoperable stage II-IV Nonsmall cell lung cancer patients treated with proton therapy.
  He J Zhu, Romaine C. Nichols, Randal H. Henderson, Christopher G. Morris, Stella Flampouri, Dat C. Pham, Christopher Klassen, Vandana Seeram, James Cury, Lisa Jones, L...> ;Acta Oncologica. 2019 Jan 18
• 2 citations
  PTV margin analysis for prostate patients treated with initial pelvic nodal IMRT and prostate proton boost.
  Zhong Su, Zuofeng Li, Randal H. Henderson, Bradford S. Hoppe, R. Charles Nichols, Curtis Bryant, William M. Mendenhall, Nancy P. Mendenhall> ;Physics in Medicine and Biology. 2019 Feb 8
• 1 citations
  Rectal Culture and Sensitivity Analysis for Reducing Sepsis Risk After Fiducial Marker Placement.
  William M. Mendenhall, Gail Sarto, Curtis Bryant, Christopher G. Morris, Christopher R. Williams, Joseph Costa, Mark Bandyk, Bradford S. Hoppe, Randal H. Henderson, Ro...> ;American Journal of Clinical Oncology. 2018 Dec 1
• 21 citations
  Pencil beam scanning versus passively scattered proton therapy for unresectable pancreatic cancer
  Michael D. Chuong, Shahed N. Badiyan, Man Yam, Zuofeng Li, K Langen, William F. Regine, Christopher G. Morris, James W. Snider, Minesh P. Mehta, Soon Huh, Michael S. R...> ;Journal of Gastrointestinal Oncology. 2018 Apr 24
• 15 citations
  Rationale and early outcomes for the management of thymoma with proton therapy.
  He J Zhu, Bradford S. Hoppe, Stella Flampouri, Debbie Louis, John Pirris, R. Charles Nichols, Randal H. Henderson, Catherine E. Mercado> ;Translational Lung Cancer Research. 2018 Apr 1
• 13 citations
  Long-term outcomes following proton therapy for prostate cancer in young men with a focus on sexual health.
  Clement K. Ho, Curtis Bryant, Nancy P. Mendenhall, Randal H. Henderson, William M. Mendenhall, Romaine C. Nichols, Christopher G. Morris, Dvaraju Kanmaniraja, Derek J....> ;Acta Oncologica. 2018 Jan 23
• 11 citations
  Serum testosterone changes in patients treated with radiation therapy alone for prostate cancer on NRG oncology RTOG 9408
  R. Charles Nichols, Chen Hu, Jean Paul Bahary, Kenneth L. Zeitzer, Luis Souhami, Mark H. Leibenhaut, Marvin Rotman, Elizabeth Gore, Alexander Balogh, David G. McGowan,...> ;Advances in Radiation Oncology. 2017 Aug 3
• 5 citations
  Proton therapy in stage II-IV non-small cell lung cancer: pattern of care and impact on trial accrual.
  He J Zhu, Romaine C. Nichols, Randal H. Henderson, Christopher G. Morris, Dat C. Pham, Lisa Jones, Bradford S. Hoppe> ;Acta Oncologica. 2017 Nov 6
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Journal Articles

• Proton-Based Chemoradiation for Synchronous Bilateral Non-Small-Cell Lung Cancers: A Case Report.  
  Wenyin Shi, MD, PhD; †Romaine C. Nichols,Jr., MD. †Stella Flampouri, PhD; †Zuofeng Li, D.Sc.; †Wen Hsi, PhD; †Bradford Hoppe MD, †Randall H. Henderson MD, MBA, Nancy P..., Thoracic Cancer
• Tumor Shrinkage during proton-based chemo-radiation for non-small-cell lung cancer may necessitate a adaptive replanning during treatment.  
  Shi W, Nichols RC Jr, Flampouri S, Hsi W, Li, Z, Henderson RH, Mendenhall NP, Hoppe BS, Hong Kong Journal of Radiology
• Proton therapy with concurrent chemotherapy for Non-Small Cell Lung cancer: Technique and early outcomes.  
  Hoppe BS, Flampouri S, Henderson RH, Pham D, Bajwa A, D'Agostino H, Huh SN, Li Z, Mendenhall NP, Nichols RC Jr, CLC
• Selective Nodal Irradiation of Regionally Advanced Non-small-cell Lung Cancer with Proton Therapy and IMRT: A Dosimetric Comparison.  
  Nichols RC Jr, Huh SH, Henderson RH, Li, Z, Flampouri S, D'Agostino HJ, Cury JD, Pham DC, Mendenhall NP, Hoppe BS, Thoracic Cancer
• When Is Elective Pelvic Lymph Node Irradiation Indicated in Definitive Radiotherapy for Localized Prostate Cancer?  
  Mendenhall WM, Hoppe BS, Nichols RC Jr, Henderson RH, Mendenhall NP, Am J Clin Oncol. 2012 Jan 10. [Epub ahead of print] PMID: 22237149
• T2-T3 Carcinoma of the Supraglottic Larynx: A Comparison of Surgery and Radiotherapy.  
  Fein DA, Nichols RC Jr, Lee WR, Mendenhall WM, Parsons JT, Stringer SP, Cassisi NJ, Million RR, Radiation Oncology Investigations 2:237-244 (1995)
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Abstracts/Posters

• Proton radiotherapy for prostate cancer is not associated with post treatment testosterone suppression.
  Nichols RC Jr, Morris CG, Hoppe BS, Henderson RH, Marcus RB, Mendenhall WM, Li Z, Williams CR, Costa JA, Mendenhall NP, 51st annual meeting of the American Society for Therapeutic Radiology and Oncology, Chicago, Illinois
• Dosimetric comparison of photon-based and proton-based stereotactic body radiotherapy for stage I non-small cell lung cancer.
  Hoppe BS, Huh SN, Nichols RC Jr, Mendenhall NP, Flampouri S, Li Z, 51st annual meeting of the American Society for Therapeutic Radiology and Oncology, Chicago, Illinois
• Dosimetric comparison study between IMRT and 3D conformal proton therapy for treatment of cervical cancer.
  Song, W, Huh SN, Liang Y, White G, Nichols RC Jr, Mundt A, Mell L, the 51st annual meeting of the American Society for Therapeutic Radiology and Oncology, Chicago, Illinois
• Proton radiotherapy for prostate cancer is not associated with post treatment testosterone suppression.
  Nichols RC Jr, Morris G, Hoppe BG, Henderson RH, Marcus RM, Mendenhall WM, Li Z, Williams CR, Costa JA, Mendenhall NP, 51st annual meeting of the American Society for Therapeutic Radiology and Oncology, Chicago, Illinois
• Dosimetric comparison of photon-based and proton-based stereotactic body radiotherapy for stage I non-small cell lung cancer.
  Hoppe, BS, Huh SN, Nichols RC Jr, Mendenhall NP, Flampouri S, Li Z, 51st annual meeting of the American Society for Therapeutic Radiology and Oncology, Chicago, Illinois
• Dosimetric comparison study between IMRT and 3D conformal proton therapy for treatment of cervical cancer.
  Song W, Huh SN, Liang Y, White G, Nichols RC Jr, Mundt A, Mell L, 51st annual meeting of the American Society for Therapeutic Radiology and Oncology, Chicago, Illinois
• radiotherapy for non-small cell lung cancer.
  Nichols RC Jr, Hoppe BS, Henderson RH, Huh SN, Flampouri S, Li Z, Mendenhall NP, 13th world conference on lung cancer, San Francisco, California
• Absence of late gastrointestinal toxicity for image guided prostate IMRT to 81Gy when the rectal V70 is limited to 10cc or less.
  Nichols RC Jr, Neuenfeldt L, Morris C, Gainer CD, Genitourinary cancers symposium, Orlando, Florida
• Proton radiotherapy offers reduced bone marrow and normal lung exposure for patients receiving dose escalated radiotherapy and concomitant chemotherapy for regionally ...
  Nichols RC Jr, Henderson RH, Huh SN, Flampouri S, Cury JD, Pham DC, D’Agostino HJ, Louis D, Li Z, Mendenhall NP, 3rd Latin American conference on lung cancer, Vina del Mar, Chile
• Absence of gastrointestinal or urinary toxicity with prostate IMRT to 81Gy.
  Nichols RC Jr, Neuenfeldt LM, Gainer CD, Kyker JS, Varner JC, Proceedings at the genitourinary cancers symposium, San Francisco, California
• Does obesity increase positioning uncertainty for men undergoing prostate IMRT?
  Nichols RC Jr, Gainer C, Neuenfeldt LM, Varner JC, Hitt WT, Kyker JS, Adams JP, Dunn NP, Healy DC, Ramos CE, 3rd annual ASCO/ASTRO/SUO multidisciplinary prostate cancer symposium, Orlando, Florida
• Radiation dose escalation in patients with regionally advanced non-small cell lung cancer facilitated by the use of the cytoprotectant amifostine.
  Nichols RC Jr, Neuenfeldt LM, England GJ, Mahmood SK, Nanfro JJ, Malamud FC, Sweetser MG, Varner JC, Gainer C, 4th international Chicago symposium on malignancies of the chest and head and neck, Chicago, Illinois
• 3-year results of RTOG-0012 randomized phase II study of neoadjuvant combined modality chemoradiation for distal rectal cancer.
  Mohiuddin M, Garcia M, Mitchell E, Hanna N, Yuen A, Nichols RC Jr, Share RE, Hayostek C, Willett C, 48th annual meeting of the American Society for Therapeutic Radiology and Oncology, Philadelphia, Pennsylvania
• Changes in gene expression induced by chemoradiation in advanced cervical carcinoma: A microarray study of RTOG C-0128.
  Zempolich K, Milash B, Fuhrman C, Robert F, Greven K, Ryu J, Forbes A, Kerlin K, Nichols RC Jr, Gaffney DK, 47th annual meeting of the American Society for Therapeutic Radiology and Oncology, Denver, Colorado
• Radiation dose escalation in patients with non-small cell lung cancer facilitated by the use of the cytoprotectant amifostine.
  Nichols RC Jr, Neuenfeldt LM, England GJ, Mahmood SK, Nanfro JJ, Malamud FC, Sweetser MG, Varner JC, Gainer C, world conference on lung cancer, Barcelona, Spain
• Ongoing, prospective multicenter safety study of subcutaneous amifostine for non-small cell lung cancer (NSCLC).
  Nichols RC Jr, Fullmer KR, Published abstract in the proceedings of the American Society for Clinical Oncology, Vol. 23:2005
• Rectal tolerance for patients receiving dose escalated external beam radiotherapy or IMRT for localized prostate cancer.
  Nichols RC Jr, Moss DC, Varner JC, Neuenfeldt LM, Varner JC, 1st annual ASCO/ASTRO multidisciplinary prostate cancer symposium, Orlando, Florida
• Effect of subcutaneous amifostine on systolic blood pressure in patients receiving daily fractionated radiotherapy.
  Nichols RC Jr, Henderson HR, Mahmood SK, Malamud FC, American Society for Clinical Oncology, Vol. 22:2004 (ASCO abstr. 8176)
• Randomized phase II trial of preoperative combined modality chemoradiation for distal rectal cancer.
  Mitchell EP, Winter K, Mohiuddin M, Hanna A, Yuen C, Nichols RC Jr, Share C, Hayostek C, Willet C, American Society for Clinical Oncology, Vol. 22:2004 (ASCO abstr. 3535)
• Tangential breast conserving radiotherapy with multileaf collimation (MLC) may reduce scatter radiation dose to the contralateral breast compared to treatment with con...
  Nichols RC Jr, Moss DC, Varner JC, Rivard AA, Kinsey SW, Bruce WG, Ahmad A, Pappas JC, Neuenfeldt LM, 6th annual Lynn Sage breast cancer symposium, Chicago, Illinois
• Results of RTOG-0012 randomized phase II study of neoadjuvant combined modality chemoradiation for distal rectal cancer.
  Mohiuddin, M, Winter K, Mitchell E, Hanna N, Yuen A, Nichols RC Jr, Shane RE, Hayostek C, Willett C, 46th annual meeting of the American Society for Therapeutic Radiology and Oncology, Philadelphia, Pennsylvania
• Feasibility of daily subcutaneous amifostine administration with fractionated radiotherapy for head and neck and non-small cell lung cancers.
  Nichols RC Jr, Henderson HR, Moss D, American Society for Clinical Oncology, Vol. 22:2003 (ASCO abstr. 3187)
• Internal mammary chain radiotherapy using partially deep tangents: How many intercostals spaces can we safely cover?
  Nichols RC Jr, Moss DC, Rivard AA, Wilson TR, Reiss GE, Terracina DL, Osborn RB, Wilson RB, Bruce WG, Morris RC, Richards JJ, Kinsey SW, Mockler RA, Lydick K, 3rd annual Lynn Sage breast cancer symposium, Chicago, Illinois
• Tissue inhomogeneity correction in high dose conformal radiotherapy for lung cancer demonstrates increased tumor dose without substantial increase in the percentage of...
  Nichols RC Jr, Moss DC, Ortega VM, Dent WW, Cvitkovich DG, Ramirez JM, Moriarty TG, Lydick K, 2nd international Chicago symposium on malignancies of the chest and head and neck, Chicago, Illinois
• Post-implant instructions to patients after prostate brachytherapy.
  Moss DC, Nichols RC Jr, Lydick K, annual meeting of the American Society for Therapeutic Radiology and Oncology, Boston, Massachusetts
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Lectures

• Proton Therapy for Pancreatic Cancer 
  http://mediasite.med.upenn.edu/Mediasite/Play/e72e8491ef1346c8aa6b5633e6174f301d?catalog=5078bba3-1f
• Evidence for the Role of proton therapy for pancreatic cancer. 
  IBA ASTRO symposium – San Diego, California
• Proton Therapy for Pancreatic Cancers. 
  Mayo Clinic GI Tumor Board, 2011, UF Gainesville GI Research Meeting, 2011
• Proton Therapy, an Overview. 
  Georgetown University Department of Radiation Oncology – Guest Professor
• Proton therapy in the treatment of non-small cell lung cancer. 
  Central European Lung Cancer Conference, Prague, Czech Republic
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