RonaldJBuckanovichMD

Oncology • Pittsburgh, PA

Physician

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Office
5115 Centre Avenue
B1 Floor Cancer Recp C
Pittsburgh, PA 15232
Phone+1 734-647-8906
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Education & Training

University of Pennsylvania Health SystemFellowship, Hematology and Medical Oncology, 2001 - 2004
University of Pennsylvania Health SystemResidency, Internal Medicine, 1998 - 2001
Weill Cornell MedicineClass of 1998

Certifications & Licensure

PA State Medical License 1999 - 2024
MI State Medical License 2006 - 2019
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014
Elected Member The American Society for Clinical Investigation, 2012
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013

Clinical Trials

Cediranib Maleate and Olaparib in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Peritoneal Cancer or Recurrent Triple-Negative Breast Cancer Start of enrollment: 2010 Apr 14
Active, not recruiting
Phase 1, Phase 2
Evaluation of Metformin, Targeting Cancer Stem Cells for Prevention of Relapse in Gynecologic Patients Start of enrollment: 2011 Oct 01
Completed
Phase 2
Cabozantinib S-Malate in Treating Patients With Recurrent or Metastatic Endometrial Cancer Start of enrollment: 2013 Apr 29
Active, not recruiting
Phase 2
Ribociclib (Ribociclib (LEE-011)) With Platinum-based Chemotherapy in Recurrent Platinum Sensitive Ovarian Cancer Start of enrollment: 2017 Jun 10
Completed
Phase 1
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Publications & Presentations

PubMed

Clinical outcomes following identification of an incidental p53 signature in the fallopian tube.
T Rinda Soong, Emily C MacARTHUR, Mackenzy Radolec, Esther Elishaev, Ronald Buckanovich, Sarah E Taylor, Jamie Lesnock> ;Gynecologic Oncology Reports. 2024 Apr 1
EGFL6 promotes endometrial cancer cell migration and proliferation.
Bai, S., Cascio, S., Gupta, N., Yang, D., Garrett, A., Buckanovich, R.> ;Gynecologic Oncology. 2024 Feb 17
Development of substituted benzimidazoles as inhibitors of human aldehyde dehydrogenase 1A isoenzymes.
Cyrus Takahashi, Mikhail Chtcherbinine, Brandt C Huddle, Michael W Wilson, Timothy Emmel, Robert M Hohlman, Stacy McGonigal, Ronald J Buckanovich, Scott D Larsen, Thom...> ;Chemico-Biological Interactions. 2024 Mar 1
Single-cell analysis reveals the stromal dynamics and tumor-specific characteristics in the microenvironment of ovarian cancer.
Zhang, L., Cascio, S., Osmanbeyoglu, H., Mellors, J., Buckanovich, R.> ;Communications Biology. 2024 Jan 5
Evaluating the trophic transfer of PCBs from fish to humans: Insights from a synergism of environmental monitoring and physiologically-based pharmacokinetic modeling.
Adam M Simpson, Samuel A Nutile, Olivia C Hodgson, Ashley E Russell, Jeremiah D Keyes, Cody C Wood, Ronald J Buckanovich> ;Environmental Pollution. 2023 Nov 1
1 citations
A putative role for ALDH inhibitors and chemoprevention of BRCA-mutation-driven tumors.
Stacy McGonigal, Rong Wu, Ed Grimley, Ekrem G Turk, Yali Zhai, Kathleen R Cho, Ronald J Buckanovich> ;Gynecologic Oncology. 2023 Sep 1
3 citations
Generation and characterization of humanized affinity-matured EGFL6 antibodies for ovarian cancer therapy.
Huijuan Tang, Adetunji P Fayomi, Shoumei Bai, Navneet Gupta, Sandra Cascio, Dongli Yang, Ronald J Buckanovich> ;Gynecologic Oncology. 2023 Apr 1
2 citations
Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy.
Alexander J Cole, Santiago Panesso-Gómez, Jaynish S Shah, Tonge Ebai, Qi Jiang, Ece Gumusoglu-Acar, Maya G Bello, Anda Vlad, Francesmary Modugno, Robert P Edwards, Ron...> ;Clinical Cancer Research. 2023 May 15
2 citations
The role of adjuvant treatment for early-stage uterine clear cell carcinomas.
T J Orellana, A A Garrett, T R Soong, T Rives, M Courtney-Brooks, S E Taylor, J Lesnock, J Berger, M Boisen, L Coffman, R Buckanovich, H Mahdi, J C Comerci, S Beriwal,...> ;Gynecologic Oncology. 2023 Mar 1
1 citations
Clinical factors associated with failed sentinel lymph node mapping in endometrial cancer.
Alison A Garrett, Alyssa Wield, Brigid Mumford, Isabel Janmey, Li Wang, Philip Grosse, Emily MacArthur, Ronald Buckanovich, Madeleine Courtney-Brooks, Paniti Sukumvani...> ;Gynecologic Oncology Reports. 2022 Dec 1
6 citations
Phase I trial of ribociclib with platinum chemotherapy in ovarian cancer.
Lan G Coffman, Taylor J Orellana, Tianshi Liu, Leonard G Frisbie, Daniel Normolle, Kent Griffith, Shitanshu Uppal, Karen McLean, Jessica Berger, Michelle Boisen, Madel...> ;JCI Insight. 2022 Sep 22
Targeting Therapeutic Resistance and Multinucleate Giant Cells in CCNE1-Amplified HR-Proficient Ovarian Cancer.
Shoumei Bai, Sarah E Taylor, Mohd Azrin Jamalruddin, Stacy McGonigal, Edward Grimley, Dongli Yang, Kara A Bernstein, Ronald J Buckanovich> ;Molecular Cancer Therapeutics. 2022 Sep 6
27 citations
Carcinoma-Associated Mesenchymal Stem/Stromal Cells: Architects of the Pro-tumorigenic Tumor Microenvironment.
Len Frisbie, Ronald J Buckanovich, Lan Coffman> ;Stem Cells. 2022 Aug 25
12 citations
Intestinal Radiation Protection and Mitigation by Second-Generation ProbioticEngineered to Deliver Interleukin-22.
Alexis Espinal, Michael W Epperly, Amitava Mukherjee, Renee Fisher, Donna Shields, Hong Wang, M Saiful Huq, Diala Fatima Hamade, Anda M Vlad, Lan Coffman, Ronald Bucka...> ;International Journal of Molecular Sciences. 2022 May 17
4 citations
Shifting the Soil: Metformin Treatment Decreases the Protumorigenic Tumor Microenvironment in Epithelial Ovarian Cancer.
Sarah E Taylor, Daniel K Chan, Dongli Yang, Tulia Bruno, Richard Lieberman, Javed Siddiqui, Thing Rinda Soong, Lan Coffman, Ronald J Buckanovich> ;Cancers. 2022 May 5
6 citations
Metformin and survival: Is there benefit in a cohort limited to diabetic women with endometrial, breast, or ovarian cancer?
Lara S Lemon, Brian Orr, Francesmary Modugno, Ronald J Buckanovich, Lan Coffman, Robert P Edwards, Sarah Taylor> ;Gynecologic Oncology. 2022 Apr 1
16 citations
Prevalence of intratumoral regulatory T cells expressing neuropilin-1 is associated with poorer outcomes in patients with cancer.
Christopher A Chuckran, Anthony R Cillo, Jessica Moskovitz, Abigail Overacre-Delgoffe, Ashwin S Somasundaram, Feng Shan, Grant C Magnon, Sheryl R Kunning, Irina Abecas...> ;Science Translational Medicine. 2021 Dec 8
31 citations
Cancer-associated MSC drive tumor immune exclusion and resistance to immunotherapy, which can be overcome by Hedgehog inhibition
Sandra Cascio, Chelsea Chandler, Linan Zhang, Sarah Sinno, Bingsi Gao, Sayali Onkar, Tullia C. Bruno, Dario A. A. Vignali, Haider Mahdi, Hatice U. Osmanbeyoglu, Anda M...> ;Science Advances. 2021 Nov 12
7 citations
Cost-effectiveness analysis of tumor molecular classification in high-risk early-stage endometrial cancer.
Taylor Orellana, Hyun Soo Kim, Sushil Beriwal, Rohit Bhargava, Jessica Berger, Ronald J. Buckanovich, Lan G. Coffman, Madeleine Courtney-Brooks, H. Mahdi, Alexander B....> ;Gynecologic Oncology. 2021 Nov 2
13 citations
The MEK1/2 Pathway as a Therapeutic Target in High-Grade Serous Ovarian Carcinoma.
Mikhail Chesnokov, Imran Khan, Yeonjung Park, Jessica Ezell, Geeta Mehta, Abdelrahman Yousif, Linda J. Hong, Ronald J. Buckanovich, Akimasa Takahashi, Ilana Chefetz> ;Cancers. 2021 Mar 18
8 citations
Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy.
Brandt C. Huddle, Edward Grimley, Mikhail Chtcherbinine, Cameron D. Buchman, Cyrus Takahashi, Bikash Debnath, Stacy McGonigal, Shuai Mao, Siwei Li, Jeremy Felton, Shu ...> ;European Journal of Medicinal Chemistry. 2021 Feb 5
16 citations
Aldehyde dehydrogenase inhibitors promote DNA damage in ovarian cancer and synergize with ATM/ATR inhibitors
Edward Grimley, Alexander J. Cole, Thong T Luong, Stacy McGonigal, Sarah Sinno, Dongli Yang, Kara A. Bernstein, Ronald J. Buckanovich> ;Theranostics. 2021 Jan 20
20 citations
Immunotherapy Advances for Epithelial Ovarian Cancer.
Erin G. Hartnett, Julia Knight, Mackenzy Radolec, Ronald J. Buckanovich, Robert P. Edwards, Anda M. Vlad> ;Cancers. 2020 Dec 11
28 citations
Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis
Huihui Fan, Huda Atiya, Yeh Wang, Thomas R. Pisanic, Tza-Huei Wang, Ie Ming Shih, Kelly K. Foy, Leonard Frisbie, Ronald J. Buckanovich, Alison A. Chomiak, Rochelle L. ...> ;Cell Reports. 2020 Dec 8
40 citations
Regulation and pharmacological targeting of RAD51 in cancer.
McKenzie K Grundy, Ronald J. Buckanovich, Kara A. Bernstein> ;NAR Cancer. 2020 Sep 1
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Journal Articles

Leukemia Inhibitory Factor Functions in Parallel with Interleukin-6 to Promote Ovarian Cancer Growth
Karen McLean, Ronald J Buckanovich, Moshe Talpaz, Nature

Lectures

Changing the Perspective for ""Successful"" Maintenance Therapy
ASCO Annual Meeting 2019 - Chicago, IL - 6/2/2019

Press Mentions

Oncologists Debate Using Maintenance Bevacizumab in Stage IIIc Ovarian CancerOctober 28th, 2019
Targeting Stem-like Cells Could Prevent Ovarian Cancer RecurrenceMarch 12th, 2019
Findings Support Cancer Stem Cell Model, with ExceptionsNovember 30th, 2015
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Grant Support

Targeting Ovarian Tumor Associated Myeloid Cells With Nanoparticles TherapeuticsNational Cancer Institute2012
Using Embryonic Stem Cells To Re-Create A Human Tumor Microenvironment To DevelopOffice Of The Director, National Institutes Of Health2008