RussellAMillerMD

PubMed

• 8 citations
  Direct small molecule ADaM-site AMPK activators reveal an AMPKγ3-independent mechanism for blood glucose lowering.
  Nicolas O. Jørgensen, Rasmus Kjøbsted, Magnus R. Larsen, Jesper B. Birk, Nicoline R. Andersen, Bina Albuquerque, Peter Schjerling, Russell A. Miller, David Carling, Ch...> ;Molecular Metabolism. 2021 May 23
• 1 citations
  Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia.
  Russell A. Miller, Yuji Shi, Wenyun Lu, David Pirman, Aditi Jatkar, Matthew Blatnik, Hong Wu, César Cárdenas, Min Wan, J. Kevin Foskett, Junyoung O. Park, Yiyi Zhang, ...> ;Nature Medicine. 2018 Sep 1
• 13 citations
  Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives ...
  Tim F. Ryder, Matthew F. Calabrese, Gregory S. Walker, Kimberly O. Cameron, Allan R. Reyes, Kris A. Borzilleri, Jake Delmore, Russell A. Miller, Ravi G. Kurumbail, Jes...> ;Journal of Medicinal Chemistry. 2018 Jul 23
• 87 citations
  Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models.
  Ryan M. Esquejo, Christopher T. Salatto, Jake Delmore, Bina Albuquerque, Allan R. Reyes, Yuji Shi, Rob Moccia, Emily Cokorinos, Matthew Peloquin, Mara Monetti, Jason B...> ;Ebiomedicine. 2018 May 1
• 46 citations
  Targeting hepatic glutaminase activity to ameliorate hyperglycemia
  Russell A. Miller, Yuji Shi, Wenyun Lu, David Pirman, Aditi Jatkar, Matthew Blatnik, Hong Wu, César Cárdenas, Min Wan, J. Kevin Foskett, Junyoung O. Park, Yiyi Zhang, ...> ;Nature Medicine. 2018 Mar 26
• 8 citations
  Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).
  David J. Edmonds, Daniel W. Kung, Amit S. Kalgutkar, Kevin J. Filipski, David Christopher Ebner, Shawn Cabral, Aaron C. Smith, Gary Erik Aspnes, Samit Kumar Bhattachar...> ;Journal of Medicinal Chemistry. 2018 Feb 21
• 179 citations
  Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.
  Emily Cokorinos, Jake Delmore, Allan R. Reyes, Bina Albuquerque, Rasmus Kjøbsted, Nicolas O. Jørgensen, Jean-Luc Tran, Aditi Jatkar, Katherine Cialdea, Ryan M. Esquejo...> ;Cell Metabolism. 2017 May 2
• 54 citations
  Selective Activation of AMPK β1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy.
  Christopher T. Salatto, Russell A. Miller, Kimberly O. Cameron, Emily Cokorinos, Allan R. Reyes, Jessica Ward, Matthew F. Calabrese, Ravi G. Kurumbail, Francis Rajamoh...> ;The Journal of Pharmacology and Experimental Therapeutics. 2017 May 1
• 7 citations
  Phenotyping hepatocellular metabolism using uniformly labeled carbon-13 molecular probes and LC-HRMS stable isotope tracing.
  John K. Meissen, David Pirman, Min Wan, Emily Miller, Aditi Jatkar, Russell A. Miller, Rick C. Steenwyk, Matthew Blatnik> ;Analytical Biochemistry. 2016 Sep 1
• 84 citations
  Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Mon...
  Kimberly O. Cameron, Daniel W. Kung, Amit S. Kalgutkar, Ravi G. Kurumbail, Russell A. Miller, Christopher T. Salatto, Jessica Ward, Jane M. Withka, Samit Kumar Bhattac...> ;Journal of Medicinal Chemistry. 2016 Aug 20
• 40 citations
  Glucagon: acute actions on hepatic metabolism
  Russell A. Miller, Morris J. Birnbaum> ;Diabetologia. 2016 Apr 26
• 138 citations
  Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms
  Matthew F. Calabrese, Francis Rajamohan, Melissa S. Harris, Nicole Caspers, Rachelle Magyar, Jane M. Withka, Hong Wang, Kris A. Borzilleri, Parag Sahasrabudhe, Lise R....> ;Structure. 2014 Aug 5
• 590 citations
  Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP
  Russell A. Miller, Qingwei Chu, Jianxin Xie, Marc Foretz, Benoit Viollet, Morris J. Birnbaum> ;Nature. 2013 Feb 14
• 494 citations
  MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.
  Karthik Mallilankaraman, Patrick J. Doonan, César Cárdenas, Harish C. Chandramoorthy, Marioly Müller, Russell A. Miller, Nicholas E. Hoffman, Rajesh Kumar Gandhirajan,...> ;Cell. 2012 Oct 26
• 270 citations
  Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration
  Zheng Sun, Russell A. Miller, Rajesh T. Patel, Jie Chen, Ravindra Dhir, Hong Wang, Dongyan Zhang, Mark J. Graham, Terry G. Unterman, Gerald I. Shulman, Carole Sztalryd...> ;Nature Medicine. 2012 Jun 1
• 129 citations
  Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling
  Russell A. Miller, Qingwei Chu, John Le Lay, Philipp E. Scherer, Rexford S. Ahima, Klaus H. Kaestner, Marc Foretz, Benoit Viollet, Morris J. Birnbaum> ;The Journal of Clinical Investigation. 2011 Jun 1
• 626 citations
  Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
  William L. Holland, Russell A. Miller, Zhao V. Wang, Kai Sun, Brian M. Barth, Hai H. Bui, Kathryn Davis, Benjamin T. Bikman, Nils Halberg, Joseph M. Rutkowski, Mark R....> ;Nature Medicine. 2011 Jan 1
• 798 citations
  Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria
  César Cárdenas, Russell A. Miller, Ian F. Smith, Thi Bui, Jordi Molgó, Marioly Müller, Horia Vais, King-Ho Cheung, Jun Yang, Ian Parker, Craig B. Thompson, Morris J. B...> ;Cell. 2010 Jul 23
• 117 citations
  An energetic tale of AMPK-independent effects of metformin
  Russell A. Miller, Morris J. Birnbaum> ;The Journal of Clinical Investigation. 2010 Jul 1
• 1 citations
  Ligand-regulated peptide aptamers.
  Russell A. Miller> ;Methods in Molecular Biology. 2009 Jan 1
• 7 citations
  Ligand-regulated peptide aptamers that inhibit the 5'-AMP-activated protein kinase
  Russell A. Miller, Brock F. Binkowski, Peter J. Belshaw> ;Journal of Molecular Biology. 2007 Jan 26
• 6 citations
  Ligand-Regulated Peptides: A General Approach for Modulating Protein-Peptide Interactions with Small Molecules
  Brock F. Binkowski, Russell A. Miller, Peter J. Belshaw> ;Chemistry & Biology. 2005 Jul 1
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