SallyWenzelMD

Pulmonology • Pittsburgh, PA

Critical Care Medicine, Pleural Disease

Professor of Medicine, University Pittsburgh Chair Department of Environmental and Occupational Health

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Office
3601 Fifth Avenue
GSPH
Pittsburgh, PA 15213
Phone+1 412-648-6161
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Education & Training

Virginia Commonwealth University Health SystemFellowship, Pulmonary Disease and Critical Care Medicine, 1984 - 1987
Wake Forest University School of MedicineInternship, Internal Medicine, 1981 - 1982
University of Florida College of MedicineClass of 1981

Certifications & Licensure

PA State Medical License 2006 - 2024
CO State Medical License 1987 - 2007
NC State Medical License 1982 - 1988
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Pulmonary Disease

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2002-2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011
Pittsburgh Magazine Castle Connolly, 2008, 2011
CORE Magazine Castle Connolly, 2006
Fellow (FAAAAI) American Academy of Allergy Asthma and Immunology
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Clinical Trials

Microarray Analysis of Gene Expression in Idiopathic Pulmonary Fibrosis (IPF) Start of enrollment: 2001 Oct 01
Active, not recruiting
A Study of the Treatment-Sparing Effects of AEROVANT™ AER 001 Inhalation Powder in Asthma Patients, AEROTRIAL Start of enrollment: 2009 Mar 01
Completed
Phase 2
Study of the Effect of Vitamin D as an Add-on Therapy to Corticosteroids in Asthma Start of enrollment: 2011 Apr 01
Completed
Phase 3
Airway Microbiome in Asthma: Relationships to Asthma Phenotype and Inhaled Corticosteroid Treatment Start of enrollment: 2012 Oct 01
Completed
Not Applicable
Severe Asthma Research Program Start of enrollment: 2012 Oct 01
Active, not recruiting
Implications and Stability of Clinical and Molecular Phenotypes of Severe Asthma Start of enrollment: 2013 Jan 01
Completed
Immune Interactions in Severe Asthma Start of enrollment: 2015 Sep 01
Active, not recruiting
Anti-Inflammatory Lipid Mediators in Asthma
Withdrawn
Phase 2
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Publications & Presentations

PubMed

A Novel Air Trapping Segment Score Identifies Opposing Effects of Obesity and Eosinophilia on Air Trapping in Asthma.
Leung, C., Tang, M., Huang, B., Fain, S., Hoffman, E., Choi, J., Dunican, E., Mauger, D., Denlinger, L., Jarjour, N., Israel, E., Levy, B., Wenzel, S., Sumino, K., Has...> ;American Journal of Respiratory and Critical Care Medicine. 2023 Dec 19
1 citations
Increased epithelial mTORC1 activity in chronic rhinosinusitis with nasal polyps.
George X Huang, Nils R Hallen, Minkyu Lee, Kelly Zheng, Xin Wang, Michael V Mandanas, Sarah Djeddi, Daniela Fernandez, Jonathan Hacker, Tessa Ryan, Regan W Bergmark, N...> ;Biorxiv. 2023 Oct 17
7 citations
CCL5 is a potential bridge between type 1 and type 2 inflammation in asthma.
Marc Gauthier, Sagar Laxman Kale, Timothy B Oriss, Michael Gorry, Richard P Ramonell, Kathryn Dalton, Prabir Ray, John V Fahy, Max A Seibold, Mario Castro, Nizar Jarjo...> ;The Journal of Allergy and Clinical Immunology. 2023 Jul 1
Bronchial epithelial cell transcriptional responses to inhaled corticosteroids dictate severe asthmatic outcomes.
Scott P Ginebaugh, Matthias Hagner, Anuradha Ray, Serpil C Erzurum, Suzy A A Comhair, Loren C Denlinger, Nizar N Jarjour, Mario Castro, Prescott G Woodruff, Stephanie ...> ;The Journal of Allergy and Clinical Immunology. 2023 Jun 1
1 citations
SARS-CoV-2 control on a large urban college campus without mass testing.
Christopher O'Donnell, Katherine Brownlee, Elise Martin, Joe Suyama, Steve Albert, Steven Anderson, Sai Bhatte, Kenyon Bonner, Chad Burton, Micaela Corn, Heather Eng, ...> ;Journal of American College Health. 2023 Jan 3
12 citations
Determining asthma endotypes and outcomes: Complementing existing clinical practice with modern machine learning.
Anuradha Ray, Jishnu Das, Sally E Wenzel> ;Cell Reports. Medicine. 2022 Dec 20
3 citations
IL-33 receptor inhibition in subjects with uncontrolled asthma: A randomized, placebo-controlled trial.
Courtney Crim, Sally Stone, Valerie Millar, Sally Lettis, Elisabeth H Bel, Andrew Menzies-Gow, Pascal Chanez, Sally Wenzel, Njira Lugogo, Eugene R Bleecker> ;The Journal of Allergy and Clinical Immunology. Global. 2022 Nov 1
12 citations
Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity.
Xingnan Li, Stefano Guerra, Julie G Ledford, Monica Kraft, Huashi Li, Annette T Hastie, Mario Castro, Loren C Denlinger, Serpil C Erzurum, John V Fahy, Benjamin Gaston...> ;American Journal of Respiratory and Critical Care Medicine. 2023 Feb 15
4 citations
Quantitative CT Characteristics of Cluster Phenotypes in the Severe Asthma Research Program Cohorts.
Abhaya P Trivedi, Chase Hall, Charles W Goss, Daphne Lew, James G Krings, Mary Clare McGregor, Maanasi Samant, Jered P Sieren, Huashi Li, Ken B Schechtman, Joshua Schi...> ;Radiology. 2022 Aug 1
1 citations
DNA sequencing analysis of cystic fibrosis transmembrane conductance regulator gene identifies cystic fibrosis-associated variants in the Severe Asthma Research Program.
Manuel E Izquierdo, Chad R Marion, Wendy C Moore, Karen S Raraigh, Jennifer L Taylor-Cousar, Gary R Cutting, E Ampleford, Gregory A Hawkins, Joe Zein, M Castro, Loren ...> ;Pediatric Pulmonology. 2022 Jul 1
19 citations
The Impact of Insulin Resistance on Loss of Lung Function and Response to Treatment in Asthma.
Michael C Peters, Mark L Schiebler, Juan Carlos Cardet, Mats W Johansson, Ronald Sorkness, Mark D DeBoer, Eugene R Bleecker, Deborah A Meyers, Mario Castro, Kaharu Sum...> ;American Journal of Respiratory and Critical Care Medicine. 2022 Nov 1
14 citations
Historical Redlining Impacts Contemporary Environmental and Asthma-related Outcomes in Black Adults.
Alexander J Schuyler, Sally E Wenzel> ;American Journal of Respiratory and Critical Care Medicine. 2022 Oct 1
26 citations
Mucus Plugs Persist in Asthma, and Changes in Mucus Plugs Associate with Changes in Airflow over Time.
Monica Tang, Brett M Elicker, Travis Henry, David S Gierada, Mark L Schiebler, Brendan K Huang, Michael C Peters, Mario Castro, Eric A Hoffman, Sean B Fain, Samuel Y A...> ;American Journal of Respiratory and Critical Care Medicine. 2022 May 1
14 citations
The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: an overview of Network organization, procedures and interventions.
Pepper, A. N., Pepper, A. N., LaBere, B., Steve N. Georas, Rosalind J. Wright, Anastasia Ivanova, Elliot Israel, Lisa M. LaVange, Praveen Akuthota, Tara F. Carr, Loren...> ;The Journal of Allergy and Clinical Immunology. 2021 Nov 27
3 citations
Biomarkers to Predict Response to ICS and LAMA in Adolescents and Adults with Mild Persistent Asthma.
Jerry A. Krishnan, Stephen C. Lazarus, Kathryn V. Blake, Christine A. Sorkness, Ronina A. Covar, Anne-Marie Dyer, Jason E. Lang, Njira L Lugogo, David T. Mauger, Micha...> ;Annals of the American Thoracic Society. 2021 Nov 18
38 citations
15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type-2 inflammation
Tadao Nagasaki, Alexander J. Schuyler, Jinming Zhao, S. N. Samovich, Kazuhiro Yamada, Yanhan Deng, Scott P. Ginebaugh, Stephanie A. Christenson, Prescott G. Woodruff, ...> ;The Journal of Clinical Investigation. 2021 Nov 11
8 citations
Pharmacogenetic studies of long-acting beta agonist and inhaled corticosteroid responsiveness in randomised controlled trials of individuals of African descent with as...
Victor E. Ortega, Michelle Daya, Stanley J. Szefler, Eugene R. Bleecker, Vernon M. Chinchilli, Wanda Phipatanakul, Dave Mauger, Fernando D. Martinez, Esther Herrera-Lu...> ;The Lancet. Child & Adolescent Health. 2021 Nov 9
9 citations
Machine learning implicates the IL-18 signaling axis in severe asthma
Matthew J. Camiolo, Xiuxia Zhou, Qi Wei, Humberto E. Trejo Bittar, Naftali Kaminski, Anuradha Ray, Sally E. Wenzel, Kaminski, N.> ;JCI Insight. 2021 Nov 8
1 citations
Using ICLite for deconvolution of bulk transcriptional data from mixed cell populations.
Matthew J. Camiolo, Sally E. Wenzel, Anuradha Ray> ;STAR Protocols. 2021 Sep 27
3 citations
Real-time imaging of asthmatic epithelial cells identifies migratory deficiencies under type-2 conditions
Mingzhu Jin, Simon C. Watkins, Yolanda Larriba, Callen T. Wallace, Claudette M. St. Croix, Xiuxia Zhou, Jinming Zhao, Shyamal D. Peddada, Sally E. Wenzel> ;The Journal of Allergy and Clinical Immunology. 2021 Sep 18
4 citations
β-Agonist exposure preferentially impacts lung macrophage cyclic AMP-related gene expression in asthma and asthma COPD overlap syndrome
Kaveh Moghbeli, Eleanor Valenzi, Rachel Naramore, John Sembrat, Kong Chen, Mauricio Rojas, Sally E. Wenzel, Robert Lafyatis, Brian D. Modena, Nathaniel M. Weathington> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2021 Sep 8
16 citations
Nitroalkene fatty acids modulate bile acid metabolism and lung function in obese asthma.
Michelle L. Manni, Victoria A. Heinrich, Gregory J. Buchan, James P. O’Brien, Crystal E. Uvalle, Veronika Cechova, Adolf Koudelka, Dharti Ukani, Mohamad Rawas-Qalaji, ...> ;Scientific Reports. 2021 Sep 7
53 citations
Defining a Severe Asthma Super-Responder: Findings from a Delphi Process.
John W. Upham, Chantal E. Le Lievre, David A. Jackson, Matthew Masoli, Michael E. Wechsler, David Price, Adel H. Mansur, Aikaterini Detoraki, Alan Altraja, Alan James,...> ;The Journal of Allergy and Clinical Immunology. in Practice. 2021 Jul 13
98 citations
Effect of tezepelumab on airway inflammatory cells, remodelling, and hyperresponsiveness in patients with moderate-to-severe uncontrolled asthma (CASCADE): a double-bl...
Sarah Diver, Latifa Khalfaoui, Claire Emson, Sally E. Wenzel, Andrew Menzies-Gow, Michael E. Wechsler, James Johnston, Nestor Molfino, Jane R. Parnes, Ayman Megally, G...> ;The Lancet. Respiratory Medicine. 2021 Nov 1
50 citations
Baseline FeNO as a prognostic biomarker for subsequent severe asthma exacerbations in patients with uncontrolled, moderate-to-severe asthma receiving placebo in the LI...
William W. Busse, Sally E. Wenzel, Thomas B. Casale, J. Mark FitzGerald, Megan S. Rice, Nadia Daizadeh, Yamo Deniz, Naimish Patel, Sivan Harel, Paul Rowe, Neil M.H. Gr...> ;The Lancet. Respiratory Medicine. 2021 Oct 1
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Journal Articles

Dupilumab Reduces Severe Exacerbation Rate and Improves Lung Function in Adolescent Patients with Uncontrolled, Moderate-to-Severe Asthma: From the Liberty Asthma Ques...
Sally Wenzel, Neil Graham, Jaman Maroni, Nikhil Amin, Maspero J, Fitzgerald M, Pavord I, et al.

Lectures

Pathogenic Processes in Asthma and COPD
Keystone Symposia, Santa Fe, New Mexico - 1/10/2013

Other

Severe asthma: Evidence for heterogeneity of the disease
Wenzel S
http://www.uptodate.com/contents/severe-asthma-evidence-for-heterogeneity-of-the-disease
UpToDate, Wolters Kluwer Health - 2012-05-11
Evaluation of severe asthma in adolescents and adults
Wenzel S
http://www.uptodate.com/contents/evaluation-of-severe-asthma-in-adolescents-and-adults
UpToDate, Wolters Kluwer Health - 2012-04-23
Treatment of severe asthma in adolescents and adults
Wenzel S
http://www.uptodate.com/contents/treatment-of-severe-asthma-in-adolescents-and-adults
UpToDate, Wolters Kluwer Health - 2013-03-12

Press Mentions

When Periods Make It Tough to BreatheJuly 8th, 2022
More Evidence Links Asthma Severity to Age of OnsetApril 27th, 2022
Medical Hero Story: Rev. Donna J. Matlach & Eosinophilic AsthmaSeptember 17th, 2021
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