SamarIbrahimMD

PubMed

• Severe Acute Hepatitis of Unknown Etiology in Children: New Virus or Immune Dysregulation.
  Luz Helena Gutierrez Sanchez, Samar H Ibrahim> ;Gastroenterology. 2024 Apr 23
• Extracellular Vesicles in Hepatobiliary Health and Disease.
  Gopanandan Parthasarathy, Petra Hirsova, Enis Kostallari, Guneet S Sidhu, Samar H Ibrahim, Harmeet Malhi> ;Comprehensive Physiology. 2023 Jun 26
• Rho-associated protein kinase 1 inhibition in hepatocytes attenuates nonalcoholic steatohepatitis.
  Ester Dohnalkova, Rachel L Bayer, Qianqian Guo, Adebowale O Bamidele, Hyun Se Kim Lee, Lucía Valenzuela-Pérez, Anuradha Krishnan, Kevin D Pavelko, Nicolas E S Guisot, ...> ;Hepatology Communications. 2023 Jun 1
• 3 citations
  Liver transplantation recovers hepatic N-glycosylation with persistent IgG glycosylation abnormalities: Three-year follow-up in a patient with phosphomannomutase-2-con...
  Shawn Tahata, Jody Weckwerth, Anna Ligezka, Miao He, Hee Eun Lee, Julie Heimbach, Samar H Ibrahim, Tamas Kozicz, Katryn Furuya, Eva Morava> ;Molecular Genetics and Metabolism. 2023 Apr 1
• 5 citations
  Endotheliopathy in the metabolic syndrome: Mechanisms and clinical implications.
  Kunimaro Furuta, Xiaofang Tang, Shahidul Islam, Alonso Tapia, Zhen Bouman Chen, Samar H Ibrahim> ;Pharmacology & Therapeutics. 2023 Apr 1
• 16 citations
  The evolving role of liver sinusoidal endothelial cells in liver health and disease.
  Matthew J McConnell, Enis Kostallari, Samar H Ibrahim, Yasuko Iwakiri> ;Hepatology. 2023 Aug 1
• 24 citations
  Mechanotransduction-induced glycolysis epigenetically regulates a CXCL1-dominant angiocrine signaling program in liver sinusoidal endothelial cells in vitro and in vivo.
  Thomas Greuter, Usman Yaqoob, Can Gan, Nidhi Jalan-Sakrikar, Enis Kostallari, Jianwen Lu, Jinhang Gao, Liankang Sun, Mengfei Liu, Tejasav S Sehrawat, Samar H Ibrahim, ...> ;Journal of Hepatology. 2022 Sep 1
• The Global Alagille Alliance study: Redefining the natural history of Alagille syndrome.
  Nawras Habash, Samar H Ibrahim> ;Hepatology. 2023 Feb 1
• Reply.
  Samar H Ibrahim, Binita M Kamath, Kathleen M Loomes, Saul J Karpen> ;Hepatology. 2022 Aug 1
• 3 citations
  Ultra-rapid whole genome sequencing: A paradigm shift in the pre-transplant evaluation of neonatal acute liver failure.
  Whitney S Thompson, Jacob R Greenmyer, Brendan C Lanpher, Jane E Brumbaugh, Ellen M Bendel-Stenzel, David P Dimmock, Charlotte A Hobbs, Samar H Ibrahim, Amber N Hildreth> ;Liver Transplantation. 2023 Jan 1
• 15 citations
  Cholestatic liver diseases of genetic etiology: Advances and controversies.
  Samar H Ibrahim, Binita M Kamath, Kathleen M Loomes, Saul J Karpen> ;Hepatology. 2022 Jun 1
• 15 citations
  Liver sinusoidal endothelial cell expressed vascular cell adhesion molecule 1 promotes liver fibrosis.
  Qianqian Guo, Kunimaro Furuta, Shahidul Islam, Nunzia Caporarello, Enis Kostallari, Kobe Dielis, Daniel J Tschumperlin, Petra Hirsova, Samar H Ibrahim> ;Frontiers in Immunology. 2022 Jan 1
• 2 citations
  Isolation and Characterization of Mouse Primary Liver Sinusoidal Endothelial Cells.
  Qianqian Guo, Kunimaro Furuta, Ahmed Aly, Samar H Ibrahim> ;Journal of Visualized Experiments. 2021 Dec 16
• 1 citations
  Clinical Implications for Children Developing Direct Hyperbilirubinemia on Extracorporeal Membrane Oxygenation.
  Erin Alexander, Donnchadh O'Sullivan, Devon Aganga, Sara Hassan, Samar H. Ibrahim, Imad Absah> ;Journal of Pediatric Gastroenterology and Nutrition. 2021 Dec 1
• An Adolescent with Chanarin-Dorfman Syndrome Presenting with Ichthyosis and Hepatic Steatosis.
  Nawras Habash, Yaohong Wang, Eva Morava, Samar H Ibrahim> ;JPGN Reports. 2021 Nov 1
• 41 citations
  North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position Paper on the Diagnosis and Management of Pediatric Acute Liver Failure.
  James E. Squires, Estella M. Alonso, Samar H. Ibrahim, Vania Kasper, Mohit Kehar, Mercedes Martinez, Robert H. Squires> ;Journal of Pediatric Gastroenterology and Nutrition. 2021 Aug 3
• 10 citations
  Sinusoidal endotheliopathy in nonalcoholic steatohepatitis: therapeutic implications
  Samar H. Ibrahim> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2021 Jul 1
• 51 citations
  Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis.
  Kunimaro Furuta, Qianqian Guo, Kevin D. Pavelko, Jeong Heon Lee, Keith D. Robertson, Yasuhiko Nakao, Jan Melek, Vijay H. Shah, Petra Hirsova, Samar H. Ibrahim> ;The Journal of Clinical Investigation. 2021 Mar 15
• 4 citations
  Renal Function Parameters and Serum Sodium Enhance Prediction of Wait-List Outcomes in Pediatric Liver Transplantation.
  Leanne Thalji, Nassir M. Thalji, Julie K. Heimbach, Samar H. Ibrahim, Patrick S. Kamath, Andrew C. Hanson, Phillip J. Schulte, Dawit T. Haile, Daryl J. Kor> ;Hepatology. 2021 Mar 1
• 24 citations
  Emerging roles of liver sinusoidal endothelial cells in nonalcoholic steatohepatitis
  Kunimaro Furuta, Qianqian Guo, Petra Hirsova, Samar H. Ibrahim> ;Biology. 2020 Nov 12
• 8 citations
  Serum ROCK2, miR-300 and miR-450b-5p levels in two different clinical phenotypes of multiple sclerosis: Relation to patient disability and disease progression
  Samar H. Ibrahim, Karim M. El-Mehdawy, Mae Seleem, Maha M. El-Sawalhi, Amira A. Shaheen> ;Journal of Neuroimmunology. 2020 Oct 15
• Impact of Acuity Circles on Outcomes for Pediatric Liver Transplant Candidates.
  Douglas B Mogul, Emily R Perito, Nicholas Wood, George V Mazariegos, Douglas VanDerwerken, Samar H Ibrahim, Saeed Mohammad, Pamela L Valentino, Sommer Gentry, Evelyn Hsu> ;Transplantation. 2020 Aug 1
• 98 citations
  IRE1A Stimulates Hepatocyte-Derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis
  Debanjali Dasgupta, Yasuhiko Nakao, Amy S. Mauer, Jill Thompson, Tejasav S. Sehrawat, Chieh Yu Liao, Anuradha Krishnan, Fabrice Lucien, Qianqian Guo, Mengfei Liu, Fei ...> ;Gastroenterology. 2020 Jun 20
• 7 citations
  Nonalcoholic Steatohepatitis Promoting Kinases
  Samar H. Ibrahim, Petra Hirsova, Harmeet Malhi, Gregory J. Gores> ;Seminars in Liver Disease. 2020 Jun 11
• 144 citations
  Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis
  Jinhang Gao, Bo Wei, Thiago M. De Assuncao, Zhikui Liu, Xiao Hu, Samar H. Ibrahim, Shawna A. Cooper, Sheng Cao, Vijay H. Shah, Enis Kostallari> ;Journal of Hepatology. 2020 May 8
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Journal Articles

• A Molecular Signature of Mouse NASH: A Step Closer to a Human Predictive Biomarker?  
  Ibrahim SH, Malhi H, Cellular and Molecular Gastroenterology and Hepatology, 1/1/2017
• Who pulls the trigger in JNK activation in lipotoxicity?  
  Samar H. Ibrahim and Gregory J Gores, Journal of Hepatology, 1/1/2012

Books/Book Chapters

• Hepatocyte Lethal and Nonlethal Lipotoxic Injury 
  Chapter: Book #1 �Cell Death in Liver Diseases 
  Ibrahim SHEditors: Petra Hirsova, Samar H. Ibrahim, Harmeet Malhi, Gregory J. Gores.2016
• Nelson�s text book of pediatrics 
  Chapter: Mitochondrial Hepatopathies 
  Samar H. Ibrahim and William F. BalistreriEditors: Robert M. Kliegman, Bonita F. Stanton, Joseph St. Geme, and Nina Schor.Edition 20th,2013
• Walker�s Pediatric Gastrointestinal Disease: Physiology, Diagnosis, Management 
  Chapter: Systemic Conditions Affecting the Liver 
  Samar H. Ibrahim, Deborah Freese, Mounif El-YoussefEditors: Ronald E. Kleinman, Olivier Goulet, Giorgina Mieli-Vergani, Ian R. Sanderson, Philip M. Sherman, and Benjamin L. Shneider.Edition 6th,2013
• Transplantation of the Liver 
  Chapter: Transplantation for Cholestatic Liver Disease in the Pediatric Patient 
  Samar H. Ibrahim, Jorge A. Bezerra, and William F. BalistreriEditors: Ronald W. Busuttil and G�ran B. Klintmalm.Edition 3rd,2012
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Abstracts/Posters

• Perinatal Nutritional Reprogramming of the Epigenome Promotes Subsequent Development of Nonalcoholic Steatohepatitis
  Ibrahim SH, Liver meeting, San Francisco, CA, 1/10/2018
• Ibrahim SH, Liver meeting, San Francisco, CA, 1/10/2018
• Obesity-Inducing Diet during Conception and Lactation Enhances the Progression of Murine Nonalcoholic Steatohepatitis in Offspring
  Ibrahim SH, Liver meeting, Washington DC, 1/23/2017
• MLK3 Pharmacological Inhibition Is Protective against NASH
  Ibrahim SH, Liver Meeting, Boston, MA, 1/1/2016
• MLK3 Mediates the Induction of CXCL10 by a STAT1-Dependent Mechanism during Hepatocyte Lipotoxicity
  Ibrahim SH, Liver Meeting, Boston, MA, 1/1/2016
• CXCR3-/- mice are protected against nutrient excess diet-induced non-alcoholic steatohepatitis
  Ibrahim SH, Liver Meeting, Boston, MA, 1/1/2016
• MLK3 Pharmacological Inhibition Is Protective against NASH
  Ibrahim SH, Digestive Disease Research Consortium Workshop, Rochester, MN, 1/1/2016
• MLK3 Mediates the Induction of CXCL10 by a STAT1-Dependent Mechanism during Hepatocyte Lipotoxicity
  Ibrahim SH, Digestive Disease Research Consortium Workshop, Rochester, MN, 1/1/2016
• Mixed lineage kinase 3 mediates the release of chemotactic extracellular vesicles in nonalcoholic steatohepatitis (NASH)
  Ibrahim SH, Translational Science, Washington D.C., 1/1/2016
• Mixed lineage kinase 3 mediates the release of chemotactic extracellular vesicles in nonalcoholic steatohepatitis (NASH)
  Ibrahim SH, The annual meeting of the American Society for Exosomes and Microvesicles, Marco Island, FL, 1/1/2016
• Mixed Lineage Kinase 3 Mediates Release of C-X-C Motif Ligand 10-Enriched Chemotactic Extracellular Vesicles from lipotoxic hepatocytes in NASH
  Ibrahim SH, Liver meeting, San Francisco, CA, 1/15/2015
• Mixed Lineage Kinase 3 Mediates the release of extracellular vesicles and Contributes to the Pathogenesis of Nonalcoholic Steatohepatitis
  Ibrahim SH, The annual meeting of the American Society for Exosomes and Microvesicles, Pacific groove CA, 1/12/2014
• Mixed Lineage Kinase 3 Mediates the release of extracellular vesicles and Contributes to the Pathogenesis of Nonalcoholic Steatohepatitis
  Ibrahim SH, Hirsova P, Bronk SF, Gores GJ, Annual meeting of the American Society for Exosomes and Microvesicles, 1/12/2014
• Rapidly progressive fibrosing nonalcoholic steatohepatitis in a 6-year-old with panhypopituitarism. Clinical vignette
  Ibrahim SH, Annual meeting, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Atlanta, GA, 1/1/2014
• Rapidly progressive fibrosing nonalcoholic steatohepatitis in a 6-year-old with panhypopituitarism
  Ibrahim S, Freese D, Annual meeting of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, 1/1/2014
• MLK3-/- mice are protected against high fat high carbohydrate diet-induced steatohepatitis
  Ibrahim SH, Annual meeting, Mayo Center for Cell Signaling in Gastroenterology, Rochester, MN, 1/1/2013
• IGG4+plasm cell infiltration correlates with pediatric autoimmune sclerosing cholangitis
  Yang DY, Mounajjed T, Ibrahim S, Freese D, Zhang LZ, J Gastroenterol Hepatol, 1/1/2013
• Hedgehog Signaling Antagonist GDC-0449 Reverses Inflammation and Fibrosis in a Diet-Induced Mouse Model of Nonalcoholic Steatohepatitis (NASH)
  Hirsova P, Ibrahim SH, Bronk SE, Gores GJ, Gastroenterology, 1/1/2013
• MLK3-/- mice are protected against high fat high carbohydrate diet-induced steatohepatitis
  Ibrahim SH, The Liver Meeting, Boston, MA, 1/1/2012
• MLK3-/- mice are protected against the development of high-fat-high-carbohydrate (HCHC) diet induced steatohepatitis
  Ibrahim S, Kirby M, Miles L, Ramirez AL, Jaeschke A, Kohli R, Hepatology, 1/1/2012
• Hepatic Venous Outflow Obstruction after Liver Transplantation
  Ibrahim SH, Annual Meeting, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Orlando, FL, 1/1/2011
• Glycogen Synthase Kinase-3 (GSK-3) Inhibition Attenuates Palmitate Induced JNK & PUMA Upregulation and Hepatocyte Lipoapoptosis
  Ibrahim SH, Annual Meeting, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, New Orleans, LA, 1/1/2010
• Autoimmune Cholangitis in a 3-year-old patient
  Ibrahim SH, Clinical Vignette, Annual Meeting, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, New Orleans, LA, 1/1/2010
• Glycogen Synthase Kinase-3 (GSK-3) Inhibition Attenuates Hepatocyte Lipoapoptosis
  Ibrahim SH, Annual Meeting, Mayo Center for Cell Signaling in Gastroenterology, Rochester, MN, 1/1/2010
• Autoimmune cholangitis in a 3 year old patient
  Ibrahim SH, Freese DK, Zhang L, J Pediatr Gastroenterol Nutr, 1/1/2010
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Lectures

•  
  San Diego, CA - 1/20/2019
• Lipotoxicity and Liver Inflammation 
  Hollywood FL - 1/27/2018
• Antenatal Exposure to Obesity-Inducing Diet Accentuates Fibrosing Murine Nonalcoholic Steatohepatitis in Offspring 
  NASPGHAN, Hollywood FL - 1/27/2018
• Perinatal Exposure to an Obesity-Inducing Diet Accentuated Fibrosing Murine NASH in offspring 
  1/23/2018
• Developmental Origin of NAFLD 
  1/30/2017
• The Role of Mixed Lineage Kinase 3 in Nonalcoholic Steatohepatitis Pathogenesis and Its Therapeutic Implications 
  1/24/2017
• Update on Hepatitis B in children 
  1/9/2017
• MLK3 Pharmacological Inhibition Attenuates Diet-induced Murine Non-alcoholic Steatohepatitis 
  Chicago,IL - 1/8/2017
• Mixed Lineage Kinase 3 inhibition attenuates murine nonalcoholic steatohepatitis 
  NASPGHAN, Las Vegas NV - 1/1/2017
• Update on Neonatal Cholestasis 
  1/16/2016
• Acute Liver Failure & Immune Dysregulation 
  1/8/2016
• CXCL10-/- Mice Are Protected Against Diet-induced Non-alcoholic Steatohepatitis 
  Rochester, MN - 1/4/2016
• Neonatal Cholestasis 
  1/10/2015
• Mixed Lineage Kinase 3 Mediates Release of C-X-C Motif Ligand 10-Bearing Extracellular Vesicles from lipotoxic hepatocytes 
  Washington D.C. - 1/10/2015
• Case Discussion: Addressing Parental Decision Making in Pediatric Transplantation 
  Minneapolis, MN - 1/8/2015
• Pediatric Liver Mass 
  1/6/2015
• Rapidly Progressive Fibrosing Nonalcoholic Steatohepatitis in a 6 Year-Old with Panhypopituitarism 
  1/5/2015
• Hepatocyte Lipotoxicity and Liver Inflammation 
  1/2/2015
• Mixed Lineage Kinase 3 Mediates the Release of Proinflammatory Extracellular Vesicles in Nonalcoholic Steatohepatitis 
  University of Washington, St. Louis MO - 1/1/2015
• Multiple Liver Lesions in an Immunosuppressed Patient: Is Infection Always the Answer 
  1/3/2013
• Non Alcoholic Fatty Liver Disease: The Growing Health Problem 
  1/30/2012
• Glycogen Synthase Kinase-3 (GSK-3) Inhibition Attenuates Hepatocyte Lipoapoptosis 
  Scottsdale, AZ - 1/2/2011
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