Samuel Jacob Klempner MD

PubMed

• The pan-tumor landscape of gene amplifications and copy number amplification ratio for established and emerging clinical targets.
  Jessica K Lee, Julia C F Quintanilha, Kuei-Ting Chen, Bernard Fendler, Candice Francheska B Tambaoan
  Clinical Cancer Research. 2026-03-23
• First-line zolbetuximab plus mFOLFOX6 and nivolumab in unresectable CLDN18.2-positive gastric or gastroesophageal junction adenocarcinoma: a phase 2 trial.
  Kohei Shitara, Hirokazu Shoji, Nicola Fazio, Sara Lonardi, Keun-Wook Lee
  Nature Medicine. 2026-03-16
• Advances in the management of metastatic gastric cancer: current strategies and emerging therapeutics.
  Joan Choo, Amalya Sargsyan, Vahe Khachatryan, Sara Lonardi, Filippo Pietrantonio
  Nature Reviews. Clinical Oncology. 2026-03-10

Journal Articles

• PD-1 as an emerging target in gastric cancer: current evidence  
  Tran PN, Sarkissian S, Chao J, Klempner SJ, Gastrointestinal Cancer: Targets and Therapy, 1/1/2017
• Moving Molecular Subtypes to the Clinic in Gastric Cancer  
  Chao J, Lee J, Klempner SJ, Transl Cancer Res, 1/1/2016
• ROS1 (c-ros oncogene 1)  
  Klempner SJ, Ou, SH, Atlas Genet Cytogenet Oncol Haematol, 1/1/2014

Books/Book Chapters

• Targeted Therapy in Cancer 
  Chapter: The Phosphatidylinositol 3-kinase Pathway in Human Malignancy. 
  Klempner SJ, Vo T, Myers AP, Cantley LCEditors: Kurzrock R, Anderson KC and Tsimberidou AM.Wiley, New York, NY2015
• The PI3K Pathway in Colorectal Cancer. 
  Chapter: Molecular Pathogenesis of Colorectal Cancer. 
  Yun J, Poulogiannis G, Brown E, Klempner S, Cantley LCEditors: K.M. Haigis.Springer, New York, NY2013

Abstracts/Posters

• Neoadjuvant Chemotherapy Improves Survival In Patients With Clinical T4b Colon Cancer.
  Dehal A, Graff-Baker AN, Voung B, Fischer T, Klempner SJ, et al, Digestive Disease Week, Chicago, IL, 1/6/2017
• Genomic profiling of circulating tumor DNA (ctDNA) from patients with advanced cancers of the GI tract and anus.
  Schrock AB, Young L, Klempner SJ, Bordoni R, Ross JS, et al, GI ASCO, 1/1/2017
• Comprehensive genomic profiling (CGP) of esophageal and tubular GI tumors identifies differing frequencies of ErbB family member amplifications with therapeutic implic...
  Bailey M, Ali SM, Schrock AB, Klempner SJ, George B, Lipson D, et al, GI ASCO, 1/1/2017

Lectures

• Early Is Better: The Roles of Prevention, Screening, and Early Detection 
  ASCO Gastrointestinal Cancers Symposium - San Francisco, CA - 1/23/2020
• DKN-01 in combination with pembrolizumab in patients with advanced gastroesophageal adenocarcinoma (GEA): Tumoral DKK1 expression as a predictor of response and survival. 
  ASCO Gastrointestinal Cancers Symposium - San Francisco, CA - 1/23/2020
• Help From Within: DNA to Personalized Therapy for Gastric Cancer 
  1/18/2017

Other

• Navigating the complexity of cancer with tumor mutational burden (TMB). 
  Klempner SJ, Oncology Times
  1/1/2017
• Advancing precision medicine in colorectal cancer. 
  Klempner SJ, Pharma Letter
  1/1/2017