SantoNicosiaMD

Cytopathology, Anatomic Pathology, Surgical Pathology

Emeritus Professor of Pathology and Cell Biology, University South Florida Morsani College of Medicine - Distinguished University Professor, University of South Florida

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Office
13813 Shady Shores Dr
Tampa, FL 33613
Phone+1 813-963-3513

Fax+1 813-963-3513
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Education & Training

University of Pennsylvania Health SystemResidency, Obstetrics and Gynecology, 1972 - 1973
Michael Reese Hospital and Medical CenterResidency, Pathology-Anatomic and Clinical, 1969 - 1972
University of Cattolica del Sacro CuoreClass of 1967

Certifications & Licensure

FL State Medical License 1987 - 2021
American Board of Pathology Anatomic Pathology
American Board of Pathology Cytopathology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2009-2014
America's Top Doctors for Cancer Castle Connolly, 2005-2013

Publications & Presentations

PubMed

28 citations
Increased RHAMM expression relates to ovarian cancer progression.
Stephanie T. Buttermore, Mitchel S. Hoffman, Ambuj Kumar, Anne Champeaux, Santo V. Nicosia, Patricia A. Kruk> ;Journal of Ovarian Research. 2017 Sep 27
33 citations
Mutational heterogeneity in non-serous ovarian cancers.
Jamie K. Teer, Sean Yoder, Anxhela Gjyshi, Santo V. Nicosia, Chaomei Zhang, Alvaro N.A. Monteiro> ;Scientific Reports. 2017 Aug 29
6 citations
Erratum: Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP) (Journal of Biological Chemistry (2004) 279 (5405–5412) DOI: 10.1074/j...
Han C. Dan, Mei Sun, Satoshi Kaneko, Richard I. Feldman, Santo V. Nicosia, Hong Gang Wang, Benjamin K. Tsang, Jin Q. Cheng> ;The Journal of Biological Chemistry. 2016 Jan 1
1 citations
Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212.
Lin Yang, Mei Sun, Xia-Meng Sun, George Z Cheng, Santo V Nicosia, Jin Q Cheng> ;The Journal of Biological Chemistry. 2016 Oct 21
5 citations
AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1. IMPLICATION OF AKT2 IN CHEMORESISTANCE.
Zeng-Qiang Yuan, Richard I Feldman, Gene E Sussman, Domenico Coppola, Santo V Nicosia, Jin Q Cheng> ;The Journal of Biological Chemistry. 2016 Oct 21
3 citations
Positive feedback regulation between Akt2 and MyoD during muscle differentiation. CLONING OF Akt2 PROMOTER.
Satoshi Kaneko, Richard I Feldman, Lu Yu, Zhenguo Wu, Tatiana Gritsko, Sue A Shelley, Santo V Nicosia, Tsutomu Nobori, Jin Q Cheng> ;The Journal of Biological Chemistry. 2016 Oct 21
2 citations
Molecular cloning and characterization of the human AKT1 promoter uncovers its up-regulation by the Src/Stat3 pathway.
Sungman Park, Donghwa Kim, Satoshi Kaneko, Kristen M Szewczyk, Santo V Nicosia, Hua Yu, Richard Jove, Jin Q Cheng> ;The Journal of Biological Chemistry. 2016 Oct 21
2 citations
MicroRNA MiR-214 regulates ovarian cancer cell stemness by targeting p53/Nanog.
Cheng-Xiong Xu, Meng Xu, Lei Tan, Hua Yang, Jennifer Permuth-Wey, Patricia A Kruk, Robert M Wenham, Santo V Nicosia, Johnathan M Lancaster, Thomas A Sellers, Jin Q Cheng> ;The Journal of Biological Chemistry. 2016 Oct 21
3 citations
Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin.
Han C Dan, Mei Sun, Lin Yang, Richard I Feldman, Xue-Mei Sui, Chien Chen Ou, Mark Nellist, Raymond S Yeung, Dicky J J Halley, Santo V Nicosia, Warren J Pledger, Jin Q ...> ;The Journal of Biological Chemistry. 2016 Oct 21
2 citations
ArgBP2γ interacts with Akt and p21-activated kinase-1 and promotes cell survival.
Zeng-Qiang Yuan, Donghwa Kim, Satoshi Kaneko, Melissa Sussman, Gary M Bokoch, Gary D Kruh, Santo V Nicosia, Joseph R Testa, Jin Q Cheng> ;The Journal of Biological Chemistry. 2016 Oct 21
8 citations
Erratum: Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through interaction of p85α, androgen receptor, and Src (Journal of Biological Chemistry (...
Mei Sun, Lin Yang, Richard I. Feldman, Xiameng Sun, Kapil N. Bhalla, Richard Jove, Santo V. Nicosia, Jin Q. Cheng> ;The Journal of Biological Chemistry. 2016 Jan 1
29 citations
Suppression of epithelial ovarian cancer invasion into the omentum by 1α,25-dihydroxyvitamin D3 and its receptor
Panida Lungchukiet, Yuefeng Sun, Ravi Kasiappan, Waise Quarni, Santo V. Nicosia, Xiaohong Zhang, Wenlong Bai> ;The Journal of Steroid Biochemistry and Molecular Biology. 2015 Apr 1
7 citations
Urinary interleukin-1β levels among gynecological patients.
Kamisha T. Woolery, Mitchel S. Hoffman, Joshua Kraft, Santo V. Nicosia, Ambuj Kumar, Patricia A. Kruk> ;Journal of Ovarian Research. 2014 Nov 18
Procurement and cytological features of human fallopian tube fimbrial cells by ex vivo imprinting and washing
Kimberly P. Dobrinski, Nicole N. Esposito, Patricia A. Kruk, Robert M. Wenham, Mitchell Hoffman, Domenico Coppola, Wenlong Bai, Xiaohong Zhang, Nikhut Siddique, Santo ...> ;Journal of the American Society of Cytopathology. 2014 Nov 1
96 citations
HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα.
Mu Zhang, Shengyan Xiang, Heui Yun Joo, Lei Wang, Kendra A. Williams, Wei Liu, Chen Hu, Dan Tong, Joshua Haakenson, Chuangui Wang, Shengping Zhang, Ryan E. Pavlovicz, ...> ;Molecular Cell. 2014 Jul 3
32 citations
Association between IHC and MSI testing to identify mismatch repair-deficient patients with ovarian cancer.
Ji-Hyun Lee, Deborah Cragun, Zachary J. Thompson, Domenico Coppola, Santo V. Nicosia, Mohammad R. Akbari, Shiyu Zhang, John R. McLaughlin, Steven A. Narod, Joellen M. ...> ;Genetic Testing and Molecular Biomarkers. 2014 Apr 1
202 citations
One mouse, one patient paradigm: New avatars of personalized cancer therapy
Prerna Malaney, Santo V. Nicosia, Vrushank Davé> ;Cancer Letters. 2014 Mar 1
78 citations
Extracellular Signal-Regulated Kinase (ERK) Phosphorylates Histone Deacetylase 6 (HDAC6) at Serine 1035 to Stimulate Cell Migration
Kendra A. Williams, Mu Zhang, Shengyan Xiang, Chen Hu, Jheng-Yu Wu, Shengping Zhang, Meagan B. Ryan, Adrienne D. Cox, Channing J. Der, Bin Fang, John M. Koomen, Eric B...> ;The Journal of Biological Chemistry. 2013 Nov 15
95 citations
1,25-Dihydroxyvitamin D3 Suppresses Telomerase Expression and Human Cancer Growth through MicroRNA-498
Ravi Kasiappan, Zheng Shen, Anfernee K-W Tse, Umesh K. Jinwal, Jinfu Tang, Panida Lungchukiet, Yuefeng Sun, Patricia A. Kruk, Santo V. Nicosia, Xiaohong Zhang, Wenlong...> ;The Journal of Biological Chemistry. 2012 Nov 30
60 citations
Frequency of mutations in mismatch repair genes in a population-based study of women with ovarian cancer
Tuya Pal, Mohammad R. Akbari, Ping Sun, Ji-Hyun Lee, Jimmy Fulp, Zachary J. Thompson, Domenico Coppola, Santo V. Nicosia, Thomas A. Sellers, John R. McLaughlin, Harvey...> ;British Journal of Cancer. 2012 Nov 6
8 citations
Uncertainty in the Utility of Immunohistochemistry in Mismatch Repair Protein Expression in Epithelial Ovarian Cancer
Domenico Coppola, Santo V. Nicosia, Andrea Doty, Thomas A. Sellers, Ji-Hyun Lee, Jimmy Fulp, Zachary J. Thompson, Sanja Galeb, John R. McLaughlin, Steven A. Narod, Joe...> ;Anticancer Research. 2012 Nov 1
17 citations
Measurement of Phospholipids May Improve Diagnostic Accuracy in Ovarian Cancer
Lian Shan, Y. Ann Chen, Lorelei Davis, Gang Han, Weiwei Zhu, Ashley D. Molina, Hector Arango, James P. LaPolla, Hoffman Ms, Thomas A. Sellers, Tyler Kirby, Santo V. Ni...> ;Plos One. 2012 Oct 17
58 citations
Depletion of HDAC6 Enhances Cisplatin-Induced DNA Damage and Apoptosis in Non-Small Cell Lung Cancer Cells
Lei Wang, Shengyan Xiang, Kendra A. Williams, Huiqin Dong, Wenlong Bai, Santo V. Nicosia, Saadi Khochbin, Gerold Bepler, Xiaohong Zhang> ;Plos One. 2012 Sep 5
87 citations
MicroRNA miR-214 regulates ovarian cancer cell stemness by targeting p53/Nanog.
Cheng-Xiong Xu, Meng Xu, Lei Tan, Hua Yang, Jennifer Permuth-Wey, Patricia A Kruk, Robert M Wenham, Santo V Nicosia, Johnathan M Lancaster, Thomas A Sellers, Jin Q Cheng> ;The Journal of Biological Chemistry. 2012 Oct 12
9 citations
Expression of thyroid transcription factor-1 in malignant pleural effusions
Andras Khoor, Angela L. Byrd-Gloster, Santo V. Nicosia> ;Pathology Oncology Research. 2011 Jun 1
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Grant Support

Core--Pathology FacilityNational Cancer Institute2000–2002
Core--PathologyNational Cancer Institute1998–2002

Hospital Affiliations

Tampa General HospitalTampa, Florida