SarahE.LearyMD

Pediatric Hematology & Oncology • Seattle, WA

Professor of Pediatrics, University of Washington School of Medicine

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Office
4800 Sand Point Way Ne
Mailstop B-6553
Seattle, WA 98105
Phone+1 206-987-2106

Fax+1 206-987-3946
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Education & Training

University of TennesseeFellowship, Pediatric Hematology/Oncology, 2004 - 2007
Johns Hopkins UniversityResidency, Pediatrics, 2001 - 2004
University of Tennessee Health Science Center College of MedicineClass of 2001

Certifications & Licensure

WA State Medical License 2009 - 2026
AK State Medical License 2021 - 2022
MD State Medical License 2007 - 2010
DC State Medical License 2007 - 2010
VA State Medical License 2007 - 2010
TN State Medical License 2004 - 2008
American Board of Pediatrics Pediatric Hematology-Oncology

Clinical Trials

Vorinostat Combined With Isotretinoin and Chemotherapy in Treating Younger Patients With Embryonal Tumors of the Central Nervous System Start of enrollment: 2009 Feb 25
Completed
Phase 1
Molecularly Determined Treatment of Diffuse Intrinsic Pontine Gliomas (DIPG) Start of enrollment: 2011 Sep 01
Terminated
Phase 2
Trebananib in Treating Younger Patients With Relapsed or Refractory Solid Tumors, Including Central Nervous System Tumors Start of enrollment: 2012 Feb 01
Completed
Phase 1
Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors Start of enrollment: 2012 Jun 27
Active, not recruiting
Phase 2
A Phase II Study of Oral LDE225 in Patients With Hedge-Hog (Hh)-Pathway Activated Relapsed Medulloblastoma (MB) Start of enrollment: 2013 May 06
Completed
Phase 2
PNOC 001: Phase II Study of Everolimus for Recurrent or Progressive Low-grade Gliomas in Children Start of enrollment: 2012 Dec 13
Active, not recruiting
Phase 2
Vemurafenib in Children With Recurrent/Refractory BRAF Gene V600E (BRAFV600E)-Mutant Gliomas Start of enrollment: 2014 Apr 29
Active, not recruiting
Early Phase 1
Selecting Patient-Specific Biologically Targeted Therapy for Pediatric Patients With Refractory Or Recurrent Brain Tumors Start of enrollment: 2013 Dec 01
Unknown status
Not Applicable
Study Assessing the Feasibility of a Surgery and Chemotherapy-Only in Children With Wnt Positive Medulloblastoma Start of enrollment: 2017 Apr 04
Terminated
Early Phase 1
Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors Start of enrollment: 2014 Dec 08
Terminated
Phase 1
Web-Based Physical Activity Intervention in Improving Long Term Health in Children and Adolescents With Cancer Start of enrollment: 2017 Nov 29
Recruiting
Phase 3
REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent Glioma Start of enrollment: 2018 Sep 24
Terminated
Phase 1, Phase 2
Irinotecan Hydrochloride, Temozolomide, and Dinutuximab With or Without Eflornithine in Treating Patients With Relapsed or Refractory Neuroblastoma Start of enrollment: 2019 Jul 08
Active, not recruiting
Phase 2
A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia Start of enrollment: 2019 Jul 03
Recruiting
Phase 3
A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion Start of enrollment: 2021 Apr 08
Recruiting
Early Phase 1
Roles: Contact
ACTEMRA® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma Start of enrollment: 2022 Dec 16
Recruiting
Phase 2
Roles: Contact
Modified Measles Virus (MV-NIS) for Children and Young Adults With Recurrent Medulloblastoma or Recurrent ATRT Start of enrollment: 2017 Feb 22
Completed
Phase 1
Roles: Contact
Bosutinib in Pediatric Patients With Newly Diagnosed Chronic Phase or Resistant/Intolerant Ph + Chronic Myeloid Leukemia Start of enrollment: 2020 Apr 06
Active, not recruiting
Phase 1, Phase 2
Roles: Principal Investigator, Contact
A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma Start of enrollment: 2018 Aug 01
Active, not recruiting
Phase 1
Roles: Principal Investigator, Contact
Fimepinostat in Treating Brain Tumors in Children and Young Adults Start of enrollment: 2019 Aug 07
Active, not recruiting
Early Phase 1
Roles: Contact
PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma Start of enrollment: 2024 Apr 15
Not yet recruiting
Phase 2
Roles: Contact, Principal Investigator
MEKTOVI® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma Start of enrollment: 2023 Apr 10
Recruiting
Phase 2
Roles: Contact
Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors Start of enrollment: 2022 Nov 21
Recruiting
Phase 1, Phase 2
Roles: Contact
Targeted Pediatric High-Grade Glioma Therapy Start of enrollment: 2024 Jan 15
Not yet recruiting
Roles: Contact
Study of Ribociclib and Everolimus in HGG and DIPG Start of enrollment: 2024 Jan 15
Not yet recruiting
Phase 2
Roles: Contact
Study of Olutasidenib and Temozolomide in HGG Start of enrollment: 2024 Jun 01
Not yet recruiting
Phase 2
Roles: Contact
Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion Start of enrollment: 2024 Sep 01
Not yet recruiting
Early Phase 1
Roles: Contact
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Publications & Presentations

PubMed

1 citations
Somatic Versus Germline: A Case Series of Three Children With-Mutated Medulloblastoma.
Tam, L., Stasi, S., Hoeppner, C., Holtzclaw, S., Ellenbogen, R., Lee, A., Lockwood, C., Cole, B., Wright, J., Crotty, E., Ermoian, R., Leary, S., Ronsley, R., Paulson, V.> ;JCO Precision Oncology. 2024 Jan 1
A multi-institutional pediatric dataset of clinical radiology MRIs by the Children's Brain Tumor Network.
Familiar, A., Kazerooni, A., Anderson, H., Lubneuski, A., Viswanathan, K., Breslow, R., Khalili, N., Bagheri, S., Haldar, D., Kim, M., Arif, S., Madhogarhia, R., Nguye...> ;Arxiv. 2023 Oct 2
51 citations
Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic Pontine Glioma: Preliminary First-in-Human Bioactivity and Safety.
Nicholas A Vitanza, Ashley L Wilson, Wenjun Huang, Kristy Seidel, Christopher Brown, Joshua A Gustafson, Jason K Yokoyama, Adam J Johnson, Blake A Baxter, Ryan W Konin...> ;Cancer Discovery. 2023 Jan 9
3 citations
Volumetric endpoints in diffuse intrinsic pontine glioma: comparison to cross-sectional measures and outcome correlations in the International DIPG/DMG Registry.
Margot A Lazow, Martijn T Nievelstein, Adam Lane, Pratiti Bandopadhayhay, Mariko DeWire-Schottmiller, Maryam Fouladi, John W Glod, Robert J Greiner, Lindsey M Hoffman,...> ;Neuro-Oncology. 2022 Sep 1
12 citations
Vorinostat and isotretinoin with chemotherapy in young children with embryonal brain tumors: A report from the Pediatric Brain Tumor Consortium (PBTC-026).
Sarah E S Leary, Lindsay Kilburn, J Russell Geyer, Mehmet Kocak, Jie Huang, Kyle S Smith, Jennifer Hadley, Ralph Ermoian, Tobey J MacDonald, Stewart Goldman, Peter Phi...> ;Neuro-Oncology. 2022 Jul 1
4 citations
Phase I study of ribociclib and everolimus in children with newly diagnosed DIPG and high-grade glioma: A CONNECT pediatric neuro-oncology consortium report.
Mariko DeWire, Margot Lazow, Olivia Campagne, James Leach, Christine Fuller, Shiva Senthil Kumar, Joseph Stanek, Peter de Blank, Trent R Hummel, Natasha Pillay-Smiley,...> ;Neuro-Oncology Advances. 2022 Apr 16
2 citations
Two cases of pineal anlage tumor with molecular analysis.
Kathryn P Scherpelz, Erin E Crotty, Christina M Lockwood, Sarah E S Leary, Richard G Ellenbogen, Amy Lee, Ralph P Ermoian, Nicholas A Vitanza, Bonnie L Cole, Paulson, V.> ;Pediatric Blood & Cancer. 2022 Apr 1
4 citations
Mutations of the DNA repair gene PNKP in a patient with microcephaly, seizures, and developmental delay (MCSZ) presenting with a high-grade brain tumor.
Bingcheng Jiang, Cameron Murray, Bonnie L Cole, J N Mark Glover, Gordon K Chan, Jean Deschenes, Rajam S Mani, Sudip Subedi, John D Nerva, Anthony C Wang, Christina M L...> ;Scientific Reports. 2022 Mar 30
Carboplatin During Craniospinal Radiotherapy for Children With Group 3 Medulloblastoma-A New Standard of Care?-Reply.
Sarah E S Leary, Yimei Li, James M Olson> ;JAMA Oncology. 2022 Feb 1
4 citations
Phase II Trial of Response-Based Radiation Therapy for Patients with Localized Germinoma: A Children's Oncology Group Study.
Ute Bartels, Arzu Onar-Thomas, Sunita K. Patel, Dennis Shaw, Jason Fangusaro, Girish Dhall, Mark M. Souweidane, Aashim Bhatia, Leanne Embry, Christine L. Trask, Erin S...> ;Neuro-Oncology. 2021 Nov 29
7 citations
Accuracy of Central Neuro-Imaging Review of DIPG Compared with Histopathology in the International DIPG Registry.
Margot A Lazow, Christine E. Fuller, Mariko DeWire, Adam Lane, Pratiti Bandopadhayay, Ute Bartels, Eric Bouffet, Sylvia Cheng, Kenneth J. Cohen, Tabitha Cooney, Scott ...> ;Neuro-Oncology. 2021 Oct 20
1 citations
Predictors of mortality and tumor recurrence in desmoplastic infantile ganglioglioma and astrocytoma-and individual participant data meta-analysis (IPDMA).
Shelly Wang, Matthew Z. Sun, I Joshua Abecassis, Alexander G. Weil, George M. Ibrahim, Aria Fallah, Chibawanye I. Ene, Sarah Leary, Bonnie Cole, Christina M. Lockwood,...> ;Journal of Neuro-Oncology. 2021 Oct 6
10 citations
Clinical phenotypes and prognostic features of embryonal tumours with multi-layered rosettes: a Rare Brain Tumor Registry study
Sara Khan, Palma Solano-Paez, Tannu Suwal, Mei Lu, Salma Al-Karmi, Ben Ho, Iqra Mumal, Mary Shago, Lindsey Hoffman, Andrew Dodgshun, Sumihito Nobusawa, Uri Tabori, Ute...> ;The Lancet. Child & Adolescent Health. 2021 Sep 29
30 citations
Subgroup and subtype-specific outcomes in adult medulloblastoma.
Hallie Coltin, Lakshmikirupa Sundaresan, Kyle S. Smith, Patryk Skowron, Luca Massimi, Charles G. Eberhart, Karisa C. Schreck, Nalin Gupta, William A. Weiss, Daniela Pr...> ;Acta Neuropathologica. 2021 Aug 18
50 citations
Efficacy of Carboplatin and Isotretinoin in Children With High-risk Medulloblastoma: A Randomized Clinical Trial From the Children's Oncology Group.
Sarah Leary, Roger J. Packer, Yimei Li, Catherine A. Billups, Kyle S. Smith, Alok Jaju, Linda Heier, Peter C. Burger, Karin S. Walsh, Yuanyuan Han, Leanne Embry, Jenni...> ;JAMA Oncology. 2021 Jul 22
38 citations
Optimal therapeutic targeting by HDAC inhibition in biopsy-derived treatment-naïve diffuse midline glioma models.
Nicholas A Vitanza, Matt Biery, Carrie Myers, Eric Ferguson, Ye Zheng, Emily J. Girard, Justyna M Przystal, Giulia Park, Alyssa Noll, Fiona Pakiam, Conrad A Winter, Sh...> ;Neuro-Oncology. 2021 Mar 25
2 citations
Molecularly Targeted Treatments for NF1-Mutant Diffuse Intrinsic Pontine Glioma.
Nicholas A Vitanza, Hedieh Khalatbari, Ralph P. Ermoian, Jay F. Sarthy, Christina M. Lockwood, Bonnie Cole, Sarah Leary> ;The Journal of Applied Laboratory Medicine. 2021 Mar 1
27 citations
Clinical outcomes and patient-matched molecular composition of relapsed medulloblastoma
Rahul Kumar, Kyle S. Smith, Maximilian Deng, Colt Terhune, Giles W. Robinson, Brent A. Orr, Anthony P. Y. Liu, Tong Lin, Catherine A. Billups, Murali Chintagumpala, Da...> ;Journal of Clinical Oncology. 2021 Jan 27
22 citations
A phase I trial of the CDK 4/6 inhibitor palbociclib in pediatric patients with progressive brain tumors: A Pediatric Brain Tumor Consortium study (PBTC-042).
David Van Mater, Sridharan Gururangan, Oren J. Becher, Olivia Campagne, Sarah Leary, Joanna J. Phillips, Jie Huang, Tong Lin, Tina Young Poussaint, Stewart Goldman, Pa...> ;Pediatric Blood & Cancer. 2021 Jan 6
6 citations
Cutaneous reactions to pediatric cancer treatment part II: Targeted therapy.
Valerie M. Carlberg, Olivia M. T. Davies, Heather A. Brandling-Bennett, Sarah Leary, Jennifer T. Huang, Carrie C. Coughlin, Deepti Gupta> ;Pediatric Dermatology. 2021 Jan 1
136 citations
Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer
Francesca Petralia, Nicole Tignor, Boris Reva, Mateusz Koptyra, Shrabanti Chowdhury, Dmitry Rykunov, Azra Krek, Weiping Ma, Yuankun Zhu, Jiayi Ji, Anna Calinawan, Jeff...> ;Cell. 2020 Dec 23
35 citations
MR imaging features of diffuse intrinsic pontine glioma and relationship to overall survival: report from the International DIPG Registry.
James L. Leach, James Roebker, Austin Schafer, Joshua J Baugh, Brooklyn Chaney, Christine Fuller, Maryam Fouladi, Adam Lane, Renee Doughman, Rachid Drissi, Mariko DeWi...> ;Neuro-Oncology. 2020 Nov 26
35 citations
Everolimus improves the efficacy of dasatinib in PDGFRα-driven glioma.
Zachary Miklja, Viveka Nand Yadav, Rodrigo Cartaxo, Ruby Siada, Chase Thomas, Jessica R. Cummings, Brendan Mullan, Stefanie Stallard, Alyssa Paul, Amy K. Bruzek, Kyle ...> ;The Journal of Clinical Investigation. 2020 Oct 1
14 citations
Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma
Liana Nobre, Michal Zapotocky, Sara Khan, Kohei Fukuoka, Adriana Fonseca, Tara McKeown, David Sumerauer, Ales Vicha, Wiesława Grajkowska, Joanna Trubicka, Kay Ka Wai L...> ;Cell Reports. Medicine. 2020 Jun 23
21 citations
Children with DIPG and high-grade glioma treated with temozolomide, irinotecan, and bevacizumab: the Seattle Children's Hospital experience.
Erin E. Crotty, Sarah Leary, J. Russell Geyer, James M. Olson, Nathan Millard, Aimee A Sato, Ralph P. Ermoian, Bonnie Cole, Christina M. Lockwood, Vera A. Paulson, Sam...> ;Journal of Neuro-Oncology. 2020 Jun 16
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Journal Articles

Heterogeneity Within the PF-EPN-B Ependymoma Subgroup
Andrew Grossbach, Vijay Ramaswamy, Benjamin Lu, Mariarita Santi, Caterina Giannini, Linda M Liau, Terri S Armstrong, Sarah Leary, Matthias A Karajannis, Kenneth Aldape..., Acta Neuropathologica

Press Mentions

Blaze Bioscience Announces Enrollment Is Complete on Its Pivotal Phase 2/3 Trial of Tozuleristide and the CanvasTM Imaging System in Pediatric Central Nervous System TumorsNovember 2nd, 2022
New Grant Enables Further Testing of Reliable, Non-Invasive Pediatric Brain Cancer PlatformOctober 31st, 2022
Seattle Children’s Research Division: Celebrating 15 Years of InnovationNovember 12th, 2021
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Hospital Affiliations

Seattle Children's HospitalSeattle, Washington