SaulJosephKarpenMDPh.D.

PubMed

• Diagnostic accuracy of serum matrix metalloproteinase-7 as a biomarker of biliary atresia in a large North American cohort.
  Sindhu Pandurangi, Reena Mourya, Shreya Nalluri, Lin Fei, Shun Dong, Sanjiv Harpavat, Stephen L Guthery, Jean P Molleston, Philip Rosenthal, Ronald J Sokol, Kasper S W...> ;Hepatology. 2024 Mar 6
• A novel model to study mechanisms of cholestasis in human cholangiocytes reveals a role for the SIPR2 pathway.
  Islam, D., Israr, I., Taleb, M., Rao, A., Yosief, R., Sultana, R., Sampaziotis, F., Tysoe, O., Trauner, M., Ghanekar, A., Kamath, B., Karpen, S.> ;Hepatology Communications. 2024 Mar 1
• Pediatric Cholestatic Diseases: Common and Unique Pathogenic Mechanisms.
  Sutton, H., Kamath, B., Karpen, S.> ;Annual Review of Pathology. 2024 Jan 24
• Event-free survival of maralixibat-treated patients with Alagille syndrome compared to a real-world cohort from GALA.
  Hansen, B., Vandriel, S., Vig, P., Garner, W., Mogul, D., Loomes, K., Piccoli, D., Rand, E., Jankowska, I., Czubkowski, P., Gliwicz-Miedzińska, D., Gonzales, E., Jacqu...> ;Hepatology. 2023 Dec 25
• Neonatal cholestasis in children with Alpha-1-AT deficiency is a risk for earlier severe liver disease with male predominance.
  Jeffrey Teckman, Philip Rosenthal, Rosalinda V Ignacio, Cathie Spino, Lee M Bass, Simon Horslen, Kasper Wang, John C Magee, Saul Karpen, Akihiro Asai, Jean P Molleston...> ;Hepatology Communications. 2023 Dec 1
• 1 citations
  Trends in sedation-analgesia practices in pediatric liver transplant patients admitted postoperatively to the pediatric intensive care unit: An analysis of data from t...
  Matthew Goldstein, Andrew Jergel, Saul Karpen, Zhulin He, Thomas M Austin, Matt Hall, Akash Deep, Laura Gilbertson, Pradip Kamat> ;Pediatric Transplantation. 2024 Feb 1
• 3 citations
  Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis.
  Ahmed Ghallab, Daniela González, Ellen Strängberg, Ute Hofmann, Maiju Myllys, Reham Hassan, Zaynab Hobloss, Lisa Brackhagen, Brigitte Begher-Tibbe, Julia C Duda, Carol...> ;Journal of Hepatology. 2024 Feb 1
• Sarcopenia is associated with osteopenia and impaired quality of life in children with genetic intrahepatic cholestatic liver disease.
  Julia M Boster, Nathan P Goodrich, Cathie Spino, Kathleen M Loomes, Estella M Alonso, Binita M Kamath, Ronald J Sokol, Saul Karpen, Alexander Miethke, Benjamin L Shnei...> ;Hepatology Communications. 2023 Nov 1
• Erratum to: Genetic Contributions to Biliary Atresia: A Developmental Cholangiopathy.
  Dominick J Hellen, Saul J Karpen> ;Seminars in Liver Disease. 2023 Aug 1
• Loss of zebrafish pkd1l1 causes biliary defects that have implications for biliary atresia splenic malformation.
  Rouknuddin Q Ali, Anne Meyer-Miner, Marie David-Rachel, Fiona J H Lee, Benjamin J Wilkins, Saul J Karpen, Brian Ciruna, Anand Ghanekar, Binita M Kamath> ;Disease Models & Mechanisms. 2023 Oct 1
• 2 citations
  Genetic Contributions to Biliary Atresia: A Developmental Cholangiopathy.
  Dominick J Hellen, Saul J Karpen> ;Seminars in Liver Disease. 2023 Aug 1
• 3 citations
  Interim results from an ongoing, open-label, single-arm trial of odevixibat in progressive familial intrahepatic cholestasis.
  Thompson, R., Artan, R., Baumann, U., Calvo, P., Czubkowski, P., Dalgic, B., D'Antiga, L., Di Giorgio, A., Durmaz, Ö., Gonzalès, E., Grammatikopoulos, T., Gupte, G., H...> ;JHEP Reports. 2023 Aug 1
• : An Improved Method for Quantitative Analysis of Liver Pathology.
  Dominick J Hellen, Saul J Karpen> ;Bio-Protocol. 2023 Jul 20
• Opportunities and considerations for studying liver disease with microphysiological systems on a chip.
  Adiya E Otumala, Dominick J Hellen, C Alessandra Luna, Priscilla Delgado, Anjana Dissanayaka, Chidozie Ugwumadu, Oluwamayokun Oshinowo, Md Mydul Islam, Luyao Shen, Sau...> ;Lab on a Chip. 2023 Jun 28
• 2 citations
  Clinical spectrum and genetic causes of mitochondrial hepatopathy phenotype in children.
  James E Squires, Alexander G Miethke, C Alexander Valencia, Kieran Hawthorne, Lisa Henn, Johan L K Van Hove, Robert H Squires, Kevin Bove, Simon Horslen, Rohit Kohli, ...> ;Hepatology Communications. 2023 Jun 1
• 2 citations
  Elevated bile acids are associated with left ventricular structural changes in biliary atresia.
  Manpreet K Virk, Muhammad Umair M Mian, Dalia A Bashir, John K Wilkes, Saul Flores, Curtis Kennedy, Fong Lam, Ayse A Arikan, Trung Nguyen, Krupa Mysore, Nhu Thao Nguye...> ;Hepatology Communications. 2023 May 1
• 8 citations
  Defining the serum proteomic signature of hepatic steatosis, inflammation, ballooning and fibrosis in non-alcoholic fatty liver disease.
  Arun J Sanyal, Stephen A Williams, Joel E Lavine, Brent A Neuschwander-Tetri, Leigh Alexander, Rachel Ostroff, Hannah Biegel, Kris V Kowdley, Naga Chalasani, Srinivasa...> ;Journal of Hepatology. 2023 Apr 1
• 2 citations
  Active enterohepatic cycling is not required for the choleretic actions of 24-norUrsodeoxycholic acid in mice.
  Jennifer K Truong, Jianing Li, Qin Li, Kimberly Pachura, Anuradha Rao, Sanjeev Gumber, Claudia Daniela Fuchs, Andrew P Feranchak, Saul J Karpen, Michael Trauner, Paul ...> ;JCI Insight. 2023 Mar 22
• 16 citations
  Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study.
  Vandriel, S., Li, L., She, H., Wang, J., Gilbert, M., Jankowska, I., Czubkowski, P., Gliwicz-Miedzińska, D., Gonzales, E., Jacquemin, E., Bouligand, J., Spinner, N., L...> ;Hepatology. 2023 Feb 1
• Treating Itch in Primary Biliary Cholangitis: A GLIMMER of Hope That Needs a Nugget of Validation.
  Raj Vuppalanchi, Saul J Karpen> ;Clinical Gastroenterology and Hepatology. 2023 Jul 1
• 2 citations
  Surgical and Medical Aspects of the Initial Treatment of Biliary Atresia: Position Paper.
  Mark Davenport, Omid Madadi-Sanjani, Christophe Chardot, Henkjan J Verkade, Saul J Karpen, Claus Petersen> ;Journal of Clinical Medicine. 2022 Nov 7
• 6 citations
  Serum bile acids as a prognostic biomarker in biliary atresia following Kasai portoenterostomy.
  Sanjiv Harpavat, Kieran Hawthorne, Kenneth D R Setchell, Monica Narvaez Rivas, Lisa Henn, Charlotte A Beil, Saul J Karpen, Vicky L Ng, Estella M Alonso, Jorge A Bezerr...> ;Hepatology. 2023 Mar 1
• 2 citations
  Serum biomarkers correlated with liver stiffness assessed in a multicenter study of pediatric cholestatic liver disease.
  Daniel H Leung, Sridevi Devaraj, Nathan P Goodrich, Xinpu Chen, Deepthi Rajapakshe, Wen Ye, Victor Andreev, Charles G Minard, Danielle Guffey, Jean P Molleston, Lee M ...> ;Hepatology. 2023 Feb 1
• 38 citations
  Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial.
  Thompson, R., Arnell, H., Artan, R., Baumann, U., Calvo, P., Czubkowski, P., Dalgic, B., D'Antiga, L., Durmaz, Ö., Fischler, B., Gonzalès, E., Grammatikopoulos, T., Gu...> ;The Lancet. Gastroenterology & Hepatology. 2022 Sep 1
• 10 citations
  Ileal bile acid transporter inhibition in Cyp2c70 KO mice ameliorates cholestatic liver injury.
  Jennifer K Truong, Ashley L Bennett, Caroline Klindt, Ajay C Donepudi, Sudarshan R Malla, Kimberly J Pachura, Alex Zaufel, Tarek Moustafa, Paul A Dawson, Saul J Karpen> ;Journal of Lipid Research. 2022 Sep 1
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Journal Articles

• A Randomized, Controlled, Crossover Pilot Study of Losartan for Pediatric Nonalcoholic Fatty Liver Disease  
  Saul Karpen, Jennifer K Frediani, Miriam B Vos, BioMed Central