ScottLindhorstMD

Oncology • Charleston, SC

Hematologic Oncology, Neuro-Oncology

Associate Professor at Medical University of South Carolina

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Office
96 Jonathan Lucas St
Charleston, SC 29425
Phone+1 843-876-7770

Fax+1 843-876-7766
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Education & Training

Duke University HospitalFellowship, Hematology and Medical Oncology, 2012 - 2013
University of Alabama Medical CenterFellowship, Hematology and Medical Oncology, 2009 - 2012
University of Alabama Medical CenterResidency, Internal Medicine, 2006 - 2009
University of South Alabama College of MedicineClass of 2005

Certifications & Licensure

SC State Medical License 2013 - 2025
NC State Medical License 2012 - 2013
AL State Medical License Active through 2012
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology
United Council for Neurologic SubspecialtiesNeuro-Oncology

Clinical Trials

Study of Panobinostat in Combination With Sorafenib in Kidney, Soft Tissue or Lung Cancers Start of enrollment: 2009 Nov 01
Completed
Phase 1
Docetaxel and Lycopene in Metastatic Prostate Cancer Start of enrollment: 2013 Nov 01
Completed
Phase 1
Safety and Efficacy Study of SL-701, a Glioma-Associated Antigen Vaccine To Treat Recurrent Glioblastoma Multiforme Start of enrollment: 2014 May 01
Completed
Phase 1, Phase 2
Pivotal, Open-label, Randomized Study of Radiosurgery With or Without Tumor Treating Fields (TTFields) for 1-10 Brain Metastases From Non-small Cell Lung Cancer (NSCLC). Start of enrollment: 2016 Jul 01
Active, not recruiting
Phase 3
Roles: Contact, Principal Investigator
Pivotal, Randomized, Open-label Study of Optune® (Tumor Treating Fields) Concomitant With RT & TMZ for the Treatment of Newly Diagnosed GBM Start of enrollment: 2020 Dec 08
Active, not recruiting
Not Applicable
Roles: Contact
Immune Checkpoint Inhibitor Nivolumab in People With Recurrent Select Rare CNS Cancers Start of enrollment: 2017 Jul 13
Recruiting
Phase 2
Roles: Contact
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Publications & Presentations

PubMed

Clinical and biological landscape of constitutional mismatch-repair deficiency syndrome: an International Replication Repair Deficiency Consortium cohort study.
Ayse Bahar Ercan, Melyssa Aronson, Nicholas R Fernandez, Yuan Chang, Adrian Levine, Zhihui Amy Liu, Logine Negm, Melissa Edwards, Vanessa Bianchi, Lucie Stengs, Jiil C...> ;The Lancet. Oncology. 2024 Mar 26
117 citations
Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma: A P...
Linda M Liau, Keyoumars Ashkan, Steven Brem, Jian L Campian, John E Trusheim, Fabio M Iwamoto, David D Tran, George Ansstas, Charles S Cobbs, Jason A Heth, Michael E S...> ;JAMA Oncology. 2023 Jan 1
37 citations
NRG Oncology/RTOG1205: A Randomized Phase II Trial of Concurrent Bevacizumab and Reirradiation Versus Bevacizumab Alone as Treatment for Recurrent Glioblastoma.
Christina I Tsien, Stephanie L Pugh, Adam P Dicker, Jeffrey J Raizer, Martha M Matuszak, Enrico C Lallana, Jiayi Huang, Ozer Algan, Nimisha Deb, Lorraine Portelance, J...> ;Journal of Clinical Oncology. 2023 Feb 20
6 citations
Low-risk meningioma: Initial outcomes from NRG Oncology/RTOG 0539.
C Leland Rogers, Stephanie L Pugh, Michael A Vogelbaum, Arie Perry, Lynn S Ashby, Jignesh M Modi, Anthony M Alleman, Igor J Barani, Steve Braunstein, Joseph A Bovi, Jo...> ;Neuro-Oncology. 2023 Jan 5
1 citations
Establishing a Standardized Method for the Effective Intraoperative Collection and Biological Preservation of Brain Tumor Tissue Samples Using a Novel Tissue Preservat...
Arabinda Das, Arunprasad Gunasekaran, Heather R Stephens, Joseph Mark, Scott M Lindhorst, David Cachia, Sunil J Patel, Bruce M Frankel> ;World Neurosurgery. 2022 May 1
3 citations
Case report: Awake craniotomy during pregnancy for resection of glioblastoma.
Arun Gunasekaran, Kyle D Kulbarsh, Arabinda Das, Christina Voelkel-Johnson, Sunil J Patel, Scott Lindhorst, Milad Yazdani, Jessica Barley, Nathan C Rowland> ;Clinical Neurology and Neurosurgery. 2022 May 1
49 citations
Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency.
Anirban Das, Sumedha Sudhaman, Daniel Morgenstern, Ailish Coblentz, Jiil Chung, Simone C Stone, Noor Alsafwani, Zhihui Amy Liu, Ola Abu Al Karsaneh, Shirin Soleimani, ...> ;Nature Medicine. 2022 Jan 1
Current Use and Limitations of Cultured High-Grade Meningioma Cells in Neuro-Oncological Research - In Response to: "Caution Using Meningioma Cell Lines as Tumor Models".
Jaime L Martinez Santos, Paola Suarez-Meade, David Cachia, Scott Lindhorst, Arabinda Das> ;Cancer Investigation. 2021 Oct 19
25 citations
Survival Benefit for Individuals With Constitutional Mismatch Repair Deficiency Undergoing Surveillance.
Carol Durno, Ayse Bahar Ercan, Vanessa Bianchi, Melissa Edwards, Melyssa Aronson, Melissa Galati, Eshetu G. Atenafu, Gadi Abebe-Campino, Abeer Al-Battashi, Musa Alharb...> ;Journal of Clinical Oncology. 2021 May 4
35 citations
DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells.
Jiil Chung, Yosef E. Maruvka, Sumedha Sudhaman, Jacalyn Kelly, Nicholas J. Haradhvala, Vanessa Bianchi, Melissa Edwards, Victoria J. Forster, Nuno Miguel Nunes, Meliss...> ;Cancer Discovery. 2021 May 1
9 citations
MGMT-inhibitor in combination with TGF-βRI inhibitor or CDK 4/6 inhibitor increases temozolomide sensitivity in temozolomide-resistant glioblastoma cells
Arabinda Das, Fraser Henderson, Mohammed Alshareef, Guilherme B. F. Porto, Indira Kanginakudru, Libby Kosnik Infinger, William Alexander Vandergrift, Scott Lindhorst, ...> ;Clinical & Translational Oncology. 2021 Mar 1
7 citations
Near haploidization is a genomic hallmark which defines a molecular subgroup of giant cell glioblastoma.
Tiffany G. Baker, Jay Alden, Adrian M. Dubuc, Cynthia T. Welsh, Iya Znoyko, Linda D. Cooley, Midhat S. Farooqi, Stuart Schwartz, Yvonne Y. Li, Andrew D. Cherniack, Sco...> ;Neuro-Oncology Advances. 2020 Nov 12
16 citations
Adult immuno-oncology: using past failures to inform the future.
Maryam Rahman, W. Gregory Sawyer, Scott Lindhorst, Loic P. Deleyrolle, Jeffrey K. Harrison, Aida Karachi, Farhad Dastmalchi, Joseph Flores-Toro, Duane Mitchell, Michae...> ;Neuro-Oncology. 2020 Sep 29
20 citations
Germline-driven replication repair-deficient high-grade gliomas exhibit unique hypomethylation patterns.
Andrew Dodgshun, Kohei Fukuoka, Melissa Edwards, Vanessa Bianchi, Anirban Das, Alexandra Sexton-Oates, Valerie Larouche, Magimairajan Issai Vanan, Scott Lindhorst, Mic...> ;Acta Neuropathologica. 2020 Sep 8
5 citations
Preconditioning with INC280 and LDK378 drugs sensitizes MGMT-unmethylated glioblastoma to temozolomide: Pre-clinical assessment
Arabinda Das, Mohammed Alshareef, Guilherme B. F. Porto, Libby Kosnik Infinger, William A. Vandergrift, Scott Lindhorst, Abhay K. Varma, Sunil J. Patel, David Cachia> ;Journal of the Neurological Sciences. 2020 Aug 21
16 citations
Ganoderic acid A/DM-induced NDRG2 over-expression suppresses high-grade meningioma growth
Arabinda Das, Mohammed Alshareef, Fraser Henderson, J. L. Martinez Santos, William Alexander Vandergrift, Scott Lindhorst, Abhay K. Varma, Libby Kosnik Infinger, Sunil...> ;Clinical & Translational Oncology. 2020 Jul 1
11 citations
In Vitro Effect of Dovitinib (TKI258), a Multi-Target Angiokinase Inhibitor on Aggressive Meningioma Cells
Arabinda Das, Jaime L Martinez Santos, Mohammed Alshareef, Guilherme B. F. Porto, Libby Kosnik Infinger, William A. Vandergrift, Scott Lindhorst, Abhay K. Varma, Sunil...> ;Cancer Investigation. 2020 Jun 8
15 citations
Evaluating anti-tumor activity of palbociclib plus radiation in anaplastic and radiation-induced meningiomas: pre-clinical investigations
Arabinda Das, Mohammed Alshareef, J. L. Martinez Santos, Guilherme B. F. Porto, Daniel G. McDonald, Libby Kosnik Infinger, William Alexander Vandergrift, Scott Lindhor...> ;Clinical & Translational Oncology. 2020 Apr 6
11 citations
Seizures in Patients With Metastatic Brain Tumors: Prevalence, Clinical Characteristics, and Features on EEG.
Shaun Ajinkya, Jonah Fox, Peter Houston, Adam Greenblatt, Alain Lekoubou, Scott Lindhorst, David Cachia, Adriana Olar, Ekrem Kutluay> ;Journal of Clinical Neurophysiology. 2019 Dec 17
1 citations
Clinical characteristics, EEG findings and implications of status epilepticus in patients with brain metastases.
Jonah Fox, Shaun Ajinkya, Adam Greenblatt, Peter Houston, Alain Lekoubou, Scott Lindhorst, David Cachia, Adriana Olar, Ekrem Kutluay> ;Journal of the Neurological Sciences. 2019 Dec 15
8 citations
Seizures in patents with primary central nervous system lymphoma: Prevalence and associated features
Jonah Fox, Shaun Ajinkya, Peter Houston, Scott Lindhorst, David Cachia, Adriana Olar, Ekrem Kutluay> ;Journal of the Neurological Sciences. 2019 May 15
24 citations
Functional Repair Assay for the Diagnosis of Constitutional Mismatch Repair Deficiency From Non-Neoplastic Tissue
Andrew Y. Shuen, Stella Lanni, Gagan B. Panigrahi, Melissa Edwards, Lisa Yu, Brittany Campbell, Ariane Mandel, Cindy Zhang, Nataliya Zhukova, Musa Alharbi, Mark L. Ber...> ;Journal of Clinical Oncology. 2019 Jan 4
13 citations
Single agent efficacy of the HDAC inhibitor DATS in preclinical models of glioblastoma.
Arabinda Das, Fraser Henderson, Stephen Lowe, Gerald C. Wallace, William A. Vandergrift, Scott Lindhorst, Abhay K. Varma, Libby Kosnik Infinger, Pierre Giglio, Narendr...> ;Cancer Chemotherapy and Pharmacology. 2018 Sep 12
9 citations
Correction: First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma [J Transl Med., 16, (...
Linda M. Liau, Keyoumars Ashkan, David Tran, Jian Campian, John E. Trusheim, Charles S. Cobbs, Jason Heth, Michael Salacz, Sarah A. Taylor, Stacy D. D’Andre, Fabio M. ...> ;Journal of Translational Medicine. 2018 Jun 29
167 citations
First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma.
Linda M Liau, Keyoumars Ashkan, David D Tran, Jian L Campian, John E Trusheim, Charles S Cobbs, Jason A Heth, Michael Salacz, Sarah Taylor, Stacy D D'Andre, Fabio M Iw...> ;Journal of Translational Medicine. 2018 May 29
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Hospital Affiliations

MUSC Health University Medical CenterCharleston, South Carolina