Seth Leo Alper MD

Professor of Medicine, Beth Israel Deaconess Medical Center

99 Brookline AveRN380F Beth Israel Deaconess Medical CenterBoston, MA 02215
Phone+1 617-667-2930
Fax+1 617-667-0445

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Education & Training

Beth Israel Deaconess Medical CenterFellowship, Nephrology, 1983 - 1987
Beth Israel Deaconess Medical CenterResidency, Internal Medicine, 1980 - 1983
Yale School of MedicineClass of 1980

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Certifications & Licensure

MA State Medical License 1984 - 2027
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Nephrology

Awards, Honors, & Recognition

Fellow (ASNF) American Society of Nephrology

Publications & Presentations

PubMed

GLUT9b- and ABCG2-mediated collecting duct urate transport uncovers a vasopressin-independent mechanism of renal water reabsorption.
Mohamad Hadla, Jean Marc Mardirossian, Daniel G Bichet, Abdul Hamid Borghol, Georges Abboud
The Journal of Clinical Investigation. 2026-07-15
Developmental genetic determinants of the human cerebrospinal fluid-ventricular system.
Garrett Allington, Evan Dennis, Qiang Li, Stephen McGee, Neel H Mehta
Science Translational Medicine. 2026-07-08
Towards precision medicine for brain arteriovenous malformations.
Andrew T Hale, Adam J Kundishora, Pazhanichamy Kalailingam, Tanyeri Barak, Phan Q Duy
The Journal of Clinical Investigation. 2026-05-15

Journal Articles

Study of Cathepsin B Inhibition in VEGFR TKI Treated Human Renal Cell Carcinoma Xenografts
David A Frank, Rupal S Bhatt, Seth L Alper, Prateek Khanna, Nature
Noninvasive Immunohistochemical Diagnosis and Novel MUC1 Mutations Causing Autosomal Dominant Tubulointerstitial Kidney Disease
Anna Greka, Seth L Alper, Journal of the American Society of Nephrology

Grant Support

RBC Ion Transporters As Hemoglobinopathy Risk ModifiersNational Heart, Lung, And Blood Institute2006–2009
Molecular Physiology Of Band 3 LIKE Proteins Of KidneyNational Institute Of Diabetes And Digestive And Kidney Diseases1998–2007
Ion Channel Regulation By The Cytoplasmic Tail Of PDK1National Institute Of Diabetes And Digestive And Kidney Diseases2002–2005
Sickle Red Cell K+ Transporter Genetics In S. CerevisiaeNational Institute Of Diabetes And Digestive And Kidney Diseases2001–2002
Endostatin Receptor CDNA Cloning And Ionic SignalingNational Cancer Institute2000–2001