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Sharon Savage, MD, Pediatric Hematology & Oncology, Rockville, MD, NIH Clinical Center

SharonAnnSavageMD

Pediatric Hematology & Oncology • Rockville, MD

Chief of the Clinical Genetics Branch, and Clinical Director of the Division of Cancer Epidemiology and Genetics, National Cancer Institute

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Summary

  • Dr. Savage joined the Clinical Genetics Branch, DCEG, NCI in 2006 as a tenure-track investigator. She was awarded scientific tenure by the NIH and appointed senior investigator in 2012. In 2013, she was promoted to Branch Chief, and in 2018, she became the Clinical Director for DCEG. Dr. Savage earned her M.D. from the University of Vermont College of Medicine, completed residency training in Pediatrics at Children’s National Medical Center, in Washington DC, and a fellowship in Pediatric Hematology/Oncology at the NCI Pediatric Oncology Branch and Johns Hopkins University. She is board-certified in both Pediatrics and Pediatric Hematology-Oncology. Dr. Savage is an elected member of the American Society for Clinical Investigation.
    Dr. Savage leads clinical, genetic, and epidemiologic studies of individuals and families at high risk of cancer. Her comprehensive approach combines genomics with clinical genetics and molecular biology to improve understanding of cancer etiology and the lives of patients with complex cancer-prone disorders.
    Dr. Savage investigates the connection between telomere biology and cancer through studies of the association between telomere length and cancer risk, the telomere biology disorder dyskeratosis congenita, and the genetic contribution to telomere biology.
    Li-Fraumeni syndrome (LFS) is a highly-penetrant autosomal dominant cancer predisposition syndrome associated with a wide range of cancer types which occur at younger-than-expected ages. It was first described in 1969 and germline mutations in TP53 were recognized as the primary cause in 1990. Dr. Savage and her colleagues have initiated a new clinical, genetic, and epidemiologic study of LFS in order to further characterize the clinical and molecular consequences of this disorder, and to develop a cancer screening program for TP53 mutation carriers (www.lfs.cancer.gov). They also assisted in the creation of an international LFS research consortium.

Education & Training

  • National Cancer Institute
    National Cancer InstitutePost-Doctoral Fellowship, Cancer Reearch, 2000 - 2006
  • Johns Hopkins University
    Johns Hopkins UniversityFellowship, Pediatric Hematology/Oncology, 2000 - 2003
  • Children's National Medical Center
    Children's National Medical CenterResidency, Pediatrics, 1997 - 2000
  • University of Vermont College of Medicine
    University of Vermont College of MedicineClass of 1997
  • Worcester Polytechnic Institute
    Worcester Polytechnic InstituteBS, Biochemistry, 1987 - 1991

Certifications & Licensure

  • MD State Medical License
    MD State Medical License 2000 - 2025
  • American Board of Pediatrics Pediatrics
  • American Board of Pediatrics Pediatric Hematology-Oncology

Clinical Trials

Publications & Presentations

PubMed

Press Mentions

  • This Rare Genetic Condition Leads to Cancer After Cancer
    This Rare Genetic Condition Leads to Cancer After CancerMay 17th, 2021
  • Establishing Links Between Germline Mutations and Oncogenesis
    Establishing Links Between Germline Mutations and OncogenesisSeptember 27th, 2017

Grant Support

  • Genetic Epidemiology Of Telomere Maintenance And Cancer EtiologyNational Cancer Institute2010–2011
  • Genetic Epidemiology Of Telomere Maintenance And Cancer EtiologyDivision Of Cancer Epidemiology And Genetics2009
  • Genetic Epidemiology Of Telomere Maintenance And Cancer EtiologyNational Cancer Institute2008
  • Genetic Epidemiology Of Telomere MaintenanceDivision Of Cancer Epidemiology And Genetics2006

Hospital Affiliations

External Links

  • Bibliographyhttps://www.ncbi.nlm.nih.gov/myncbi/sharon.savage.1/bibliography/public/

Dr. Sharon Savage, Dr. Sharon Savage, MD, Dr. S Savage, Dr. Sharon Ann Savage