ShehzadZafarSheikhMD

PubMed

• Aberrant miR-29 is a predictive feature of severe phenotypes in pediatric Crohn's disease.
  Alexandria J Shumway, Michael T Shanahan, Emilie Hollville, Kevin Chen, Caroline Beasley, Jonathan W Villanueva, Sara Albert, Grace Lian, Moises R Cure, Matthew Schane...> ;JCI Insight. 2024 Feb 22
• Cutting Edge: Hypoxia Sensing by the Histone Demethylase UTX (KDM6A) Limits Colitogenic CD4+ T Cells in Mucosal Inflammation.
  Mandy I Cheng, Lee Hong, Christian Bustillos, Bryan Chen, Scott Chin, Christopher R Luthers, Au Vo, Shehzad Z Sheikh, Maureen A Su> ;Journal of Immunology. 2024 Apr 1
• promoter hypomethylation is associated with mucosal inflammation in IBD and anti-TNF response.
  Levic, D., Niedzwiecki, D., Kandakatla, A., Karlovich, N., Juneja, A., Park, J., Stolarchuk, C., Adams, S., Willer, J., Schaner, M., Lian, G., Beasley, C., Marjoram, L...> ;Medrxiv. 2024 Feb 6
• Linking gene expression to clinical outcomes in pediatric Crohn's disease using machine learning.
  Chen, K., Nishiyama, N., Kennedy Ng, M., Shumway, A., Joisa, C., Schaner, M., Lian, G., Beasley, C., Bantumilli, S., Kapadia, M., Gomez, S., Furey, T., Zhu, L., Sheikh...> ;Scientific Reports. 2024 Feb 1
• Intestinal epithelial cell barrier dysfunction and elevated Angiopoietin-like 4 identified in orally susceptible peanut allergy model.
  Erin C Steinbach, Johanna M Smeekens, Satyaki Roy, Takahiko Toyonaga, Caleb Cornaby, Layna B Perini, Ana E Berglind, Michael D Kulis, Edwin H Kim, Martin T Ferris, Ter...> ;Clinical and Experimental Allergy. 2023 Feb 1
• 45 citations
  Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility.
  Aleksejs Sazonovs, Christine R Stevens, Guhan R Venkataraman, Kai Yuan, Brandon Avila, Maria T Abreu, Tariq Ahmad, Matthieu Allez, Ashwin N Ananthakrishnan, Gil Atzmon...> ;Nature Genetics. 2022 Sep 1
• 4 citations
  BET Protein Inhibition Regulates Macrophage Chromatin Accessibility and Microbiota-Dependent Colitis.
  Michelle Hoffner O'Connor, Ana Berglind, Meaghan M Kennedy Ng, Benjamin P Keith, Zachary J Lynch, Matthew R Schaner, Erin C Steinbach, Jeremy Herzog, Omar K Trad, Will...> ;Frontiers in Immunology. 2022 Jan 1
• 7 citations
  Single-Cell Analysis Reveals Unexpected Cellular Changes and Transposon Expression Signatures in the Colonic Epithelium of Treatment-Naïve Adult Crohn's Disease Patients.
  Matt Kanke, Meaghan M Kennedy Ng, Sean Connelly, Manvendra Singh, Matthew Schaner, Michael T Shanahan, Elizabeth A Wolber, Caroline Beasley, Grace Lian, Animesh Jain, ...> ;Cellular and Molecular Gastroenterology and Hepatology. 2022 Jan 1
• 7 citations
  Biochemical and rheological analysis of human colonic culture mucus reveals similarity to gut mucus.
  R. Logan Howard, Matthew R. Markovetz, Yuli Wang, Camille Ehre, Shehzad Z. Sheikh, Nancy L. Allbritton, David B. Hill> ;Biophysical Journal. 2021 Oct 22
• 5 citations
  A machine learning approach identifies 5-ASA and ulcerative colitis as being linked with higher COVID-19 mortality in patients with IBD.
  Satyaki Roy, Shehzad Z. Sheikh, Terrence S. Furey> ;Scientific Reports. 2021 Aug 13
• 4 citations
  Increased colonic expression of ACE2 associates with poor prognosis in Crohn's disease.
  Takahiko Toyonaga, Kenza C Araba, Meaghan M. Kennedy, Benjamin P Keith, Elisabeth A. Wolber, Caroline Beasley, Erin C. Steinbach, Matthew R. Schaner, Animesh Jain, Mil...> ;Scientific Reports. 2021 Jun 29
• 9 citations
  RNF20 and RNF40 regulate vitamin D receptor-dependent signaling in inflammatory bowel disease
  Robyn Laura Kosinsky, Maria Zerche, Ana P. Kutschat, Asha Nair, Zhenqing Ye, Dominik Saul, Maximilian von Heesen, Jessica Friton, Ana C. de A. P. Schwarzer, Nadia Pagl...> ;Cell Death and Differentiation. 2021 Jun 4
• 7 citations
  Increased Colonic Expression of ACE2 Associates with Poor Prognosis in Crohn's disease.
  Takahiko Toyonaga, Kenza C Araba, Meaghan M. Kennedy, Benjamin P Keith, Elisabeth A. Wolber, Caroline Beasley, Erin C. Steinbach, Matthew R. Schaner, Animesh Jain, Mil...> ;Biorxiv. 2020 Nov 24
• 8 citations
  Crohn's Disease Differentially Affects Region-Specific Composition and Aerotolerance Profiles of Mucosally Adherent Bacteria.
  Nur M Shahir, Jeremy Wang, E Ashley Wolber, Matthew S Schaner, Daniel N. Frank, Diana Ir, Charles E. Robertson, Nicole Chaumont, Timothy S. Sadiq, Mark J. Koruda, Reza...> ;Inflammatory Bowel Diseases. 2020 Nov 19
• 7 citations
  Decreased Colonic Activin Receptor-Like Kinase 1 Disrupts Epithelial Barrier Integrity in Patients With Crohn's Disease.
  Takahiko Toyonaga, Erin C. Steinbach, Benjamin P Keith, Jasmine B. Barrow, Matthew R. Schaner, Elisabeth A. Wolber, Caroline Beasley, Jennifer Huling, Yuli Wang, Nancy...> ;Cellular and Molecular Gastroenterology and Hepatology. 2020 Jun 16
• 5 citations
  Chronic Antibiotic Dependent Pouchitis Is Associated With Older Age at the Time of Ileal Pouch Anal Anastomosis (J-pouch) Surgery
  Kimberly N. Weaver, Bharati Kochar, Jonathan J. Hansen, Kim L. Isaacs, Animesh Jain, Shehzad Z. Sheikh, Alessandro Fichera, Nicole Chaumont, Tim Sadiq, Mark J. Koruda,...> ;Crohn's & Colitis 360. 2019 Oct 1
• 46 citations
  Redefining the IBDs using genome-scale molecular phenotyping
  Terrence S. Furey, Praveen Sethupathy, Shehzad Z. Sheikh> ;Nature Reviews. Gastroenterology & Hepatology. 2019 May 1
• 9 citations
  Perigastric abscess as a delayed adverse event in endoscopic sleeve gastroplasty
  Theodore W. James, Shehzad Z. Sheikh, Christopher E. McGowan> ;Gastrointestinal Endoscopy. 2019 Apr 1
• 14 citations
  Colonic epithelial miR-31 associates with the development of Crohn’s phenotypes
  Benjamin P. Keith, Jasmine B. Barrow, Takahiko Toyonaga, Nevzat Kazgan, Michelle Hoffner O’Connor, Neil D. Shah, Matthew S Schaner, Elisabeth A. Wolber, Omar K. Trad, ...> ;JCI Insight. 2018 Oct 4
• 76 citations
  Molecular classification of Crohn's disease reveals two clinically relevant subtypes
  Matthew Weiser, Jeremy M. Simon, Bharati Kochar, Adelaide Tovar, Jennifer W Israel, Adam Robinson, Gregory R. Gipson, Matthew S Schaner, Hans H Herfarth, R. Balfour Sa...> ;Gut. 2018 Jan 1
• 58 citations
  Genomic dissection of conserved transcriptional regulation in intestinal epithelial cells.
  Colin R. Lickwar, J. Gray Camp, Matthew Weiser, Jordan L. Cocchiaro, David M. Kingsley, Terrence S. Furey, Shehzad Z. Sheikh, John F. Rawls> ;Plos Biology. 2017 Aug 29
• 26 citations
  Alterations to chromatin in intestinal macrophages link IL-10 deficiency to inappropriate inflammatory responses
  Jeremy M. Simon, James P. Davis, Saangyoung E. Lee, Matthew R. Schaner, Gregory R. Gipson, Matthew Weiser, R. Balfour Sartor, Hans H Herfarth, Reza Rahbar, Timothy S. ...> ;European Journal of Immunology. 2016 May 1
• Harnessing the Power of Posttranscriptional Gene Silencing in Crohn’s Disease
  Maisa Abdalla, Shehzad Z. Sheikh> ;Clinical and Translational Gastroenterology. 2016 Mar 31
• O-004 Analysis of Chromatin and Transcriptional Profiles in Crohn's Disease Reveals Molecular Subclasses and Highlights Functional Regulatory Regions Implicated in Dis...
  Weiser, M.,Sheikh, S.,Kochar, B.,Gipson, G.,Herfarth, H.,Sartor, R.,McGovern, D.,Rahbar, R.,Sadiq, T.,Furey, T.,Koruda, M.,Robinson, A.> ;Inflamm. Bowel Dis.. 2016 Feb 06
• 57 citations
  MicroRNAs Classify Different Disease Behavior Phenotypes of Crohn's Disease and May Have Prognostic Utility.
  Bailey C.E. Peck, Matthew Weiser, Saangyoung E. Lee, Gregory R. Gipson, Vishal B. Iyer, Ryan Balfour Sartor, Hans H Herfarth, Millie D. Long, Jonathan J. Hansen, Kim L...> ;Inflammatory Bowel Diseases. 2015 Sep 1
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