ShelleyMShapiroMDPh.D

Cardiology • Los Angeles, CA

Adult Congenital Heart Disease, Echocardiography, Heart Failure & Transplantation

Professor, Medicine, UCLA School of Medicine

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Office
UCLA Medical Center
200 Medical Plaza, Suite 365
Los Angeles, CA 90095
Phone+1 310-825-8061

Fax+1 310-825-8061
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Education & Training

UCLA David Geffen School of Medicine/UCLA Medical CenterResidency, Internal Medicine, 1978 - 1981
Albert Einstein College of MedicineClass of 1978

Certifications & Licensure

CA State Medical License 1979 - 2025
NY State Medical License 2015 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
Fellow (FACC) American College of Cardiology

Clinical Trials

Effects of the Combination of Bosentan and Sildenafil Versus Sildenafil Monotherapy on Pulmonary Arterial Hypertension (PAH) Start of enrollment: 2006 May 01
Completed
Phase 4
Treprostinil Therapy For Patients With Interstitial Lung Disease And Severe Pulmonary Arterial Hypertension Start of enrollment: 2008 Jul 01
Completed
Phase 2
Exercise Induced Pulmonary Hypertension in Systemic Sclerosis and Treatment With Ambrisentan Start of enrollment: 2009 Mar 01
Completed
Phase 4
Study in Subjects With PAH and PH Secondary to IPF Using Inhaled GeNOsyl. Start of enrollment: 2011 Mar 01
Completed
Phase 2
Bardoxolone Methyl Evaluation in Patients With Pulmonary Hypertension (PH) - LARIAT Start of enrollment: 2014 May 31
Completed
Phase 2
Extended Access Program to Assess Long-term Safety of Bardoxolone Methyl in Patients With Pulmonary Hypertension RANGER Start of enrollment: 2017 Apr 18
Terminated
Phase 3
Phase 2 Study to Assess Safety, Tolerability and Efficacy of Once Weekly SC Pemziviptadil (PB1046) in Subjects With Symptomatic PAH Start of enrollment: 2018 Jul 15
Terminated
Phase 2
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Publications & Presentations

PubMed

The ALPHA phase 1 study: pulmonary ArteriaL hypertension treated with CardiosPHere-Derived allogeneic stem cells.
Azizad, P., Mirocha, J., Karpov, O., Van Eyk, J., Marbán, E., Lewis, M., Shapiro, S., Oudiz, R., Nakamura, M., Geft, D., Matusov, Y., Hage, A., Tapson, V., Henry, T., ...> ;Ebiomedicine. 2024 Feb 1
Tyvaso DPI: Drug-device characteristics and patient clinical considerations.
Colleen McEvoy, Rahul Argula, Sandeep Sahay, Shelley Shapiro, Christina Eagan, Anthony J Hickey, Chad Smutney, Chris Dillon, Thomas Winkler, Brittany N Davis, Meredith...> ;Pulmonary Pharmacology & Therapeutics. 2023 Dec 1
9 citations
BREEZE: Open-label clinical study to evaluate the safety and tolerability of treprostinil inhalation powder as Tyvaso DPI™ in patients with pulmonary arterial hyperten...
Leslie A Spikes, Abubakr A Bajwa, Charles D Burger, Sapna V Desai, Michael S Eggert, Karim A El-Kersh, Micah R Fisher, Shilpa Johri, Joanna M Joly, Jinesh Mehta, Harol...> ;Pulmonary Circulation. 2022 Apr 1
2 citations
Tadalafil for veterans with chronic obstructive pulmonary disease-pulmonary hypertension: A multicenter, placebo-controlled randomized trial.
Bradley A Maron, Gaurav Choudhary, Rebekah L Goldstein, Eric Garshick, Matthew Jankowich, Troo J S Tucker, Kathleen A LaCerda, Brack Hattler, Edward C Dempsey, Ruxana ...> ;Pulmonary Circulation. 2022 Jan 1
26 citations
Efficacy of Inhaled Treprostinil on Multiple Disease Progression Events in Patients with Pulmonary Hypertension Due to Parenchymal Lung Disease in the INCREASE Trial.
Steven D. Nathan, Victor F. Tapson, Jean M. Elwing, Franz Rischard, Jinesh Mehta, Shelley M. Shapiro, Eric Shen, Chunqin Deng, Peter Smith, Aaron B. Waxman> ;American Journal of Respiratory and Critical Care Medicine. 2021 Nov 12
3 citations
Significance of autoimmune disease in severe pulmonary hypertension complicating extensive pulmonary fibrosis: a prospective cohort study.
Rajeev Saggar, Paresh C. Giri, Chunqin Deng, Dana Johnson, Mary K McCloy, Lloyd L. Liang, Faisal Shaikh, Jason S. Hong, Richard N. Channick, Shelley Shapiro, Joseph P....> ;Pulmonary Circulation. 2021 May 2
1 citations
Implantable system for treprostinil and lung transplantation: case series from delivery for pulmonary arterial hypertension study.
Jeremy Feldman, Mardi Gomberg-Maitland, Shelley M. Shapiro, Amy A Lautenbach, Marty Morris, Jeffrey A. Murphy, Aaron B. Waxman, Robert C. Bourge> ;Pulmonary Circulation. 2021 Jan 1
5 citations
Survival and drug persistence in patients receiving inhaled treprostinil at doses greater than 54 µg (nine breaths) four times daily.
Shelley Shapiro, Stacy Mandras, Ricardo Restrepo-Jaramillo, Eric Shen, Meredith Broderick, Youlan Rao, Dasom Lee, Andrew Nelsen> ;Pulmonary Circulation. 2021 Jan 1
1 citations
Long-term study of oral treprostinil to treat pulmonary arterial hypertension: dosing, tolerability, and pharmacokinetics:
R. James White, Keyur Parikh, Roblee P Allen, Jeremy Feldman, Carlos Jerjez-Sanchez, Lei Pan, Anne Keogh, C. Dario Vizza, Shelley Shapiro, Kathryn Gordon, Meredith Bro...> ;Pulmonary Circulation. 2020 Dec 8
7 citations
Implantable system for treprostinil: a real-world patient experience study.
Shelley Shapiro, Robert C. Bourge, Patti Pozella, David F Harris, Erick Borg, Andrew Nelsen> ;Pulmonary Circulation. 2020 Apr 22
13 citations
Long-term results of the DelIVery for Pulmonary Arterial Hypertension trial
Mardi Gomberg-Maitland, Robert C. Bourge, Shelley M. Shapiro, James H. Tarver, Dianne L Zwicke, Jeremy Feldman, Murali M. Chakinala, Robert P. Frantz, Fernando Torres,...> ;Pulmonary Circulation. 2019 Nov 5
4 citations
Capillary Proliferation in Systemic-Sclerosis-Related Pulmonary Fibrosis: Association with Pulmonary Hypertension.
Atsuko Seki, Zafia Anklesaria, Rajeev Saggar, Mark W. Dodson, Kristin Schwab, Ming-Chang Liu, Deepshikha Charan Ashana, William D. Miller, Sitaram Vangala, Ariss Derho...> ;ACR Open Rheumatology. 2019 Mar 1
13 citations
Clinical and hemodynamic improvements after adding ambrisentan to background PDE5i therapy in patients with pulmonary arterial hypertension exhibiting a suboptimal the...
Shelley Shapiro, Fernando Torres, Jeremy Feldman, Anne Keogh, Martine Allard, Christiana Blair, Hunter Gillies, James Tislow, Ronald J. Oudiz> ;Respiratory Medicine. 2017 May 1
29 citations
Recommendations for the use of oral treprostinil in clinical practice: a Delphi consensus project pulmonary circulation.
Franck Rahaghi, Jeremy Feldman, Roblee P Allen, Victor F. Tapson, Zeenat Safdar, Vijay Balasubramanian, Shelley Shapiro, Michael A. Mathier, Jean M. Elwing, Murali M. ...> ;Pulmonary Circulation. 2017 Mar 21
43 citations
Treprostinil Administered to Treat Pulmonary Arterial Hypertension Using a Fully Implantable Programmable Intravascular Delivery System: Results of the DelIVery for PA...
Robert C. Bourge, Aaron B. Waxman, Mardi Gomberg-Maitland, Shelley M. Shapiro, James H. Tarver, Dianne L Zwicke, Jeremy Feldman, Murali M. Chakinala, Robert P. Frantz,...> ;Chest. 2016 Jul 1
50 citations
Changes in right heart haemodynamics and echocardiographic function in an advanced phenotype of pulmonary hypertension and right heart dysfunction associated with pulm...
Rajeev Saggar, Dinesh Khanna, Anjali Vaidya, Ariss Derhovanessian, Paul Maranian, Erin Lindsey Duffy, John A. Belperio, S. Sam Weigt, Shiv Dua, Shelley Shapiro, Jonath...> ;Thorax. 2014 Feb 1
7 citations
Study design and rationale for investigating phosphodiesterase type 5 inhibition for the treatment of pulmonary hypertension due to chronic obstructive lung disease: t...
Bradley A. Maron, Ronald H. Goldstein, Sharon Rounds, Shelley Shapiro, Matthew D. Jankowich, Eric Garshick, Marilyn L. Moy, David R. Gagnon, Gaurav Choudhary> ;Pulmonary Circulation. 2013 Dec 1
12 citations
Safety, tolerability, and efficacy of overnight switching from sildenafil to tadalafil in patients with pulmonary arterial hypertension.
Shelley Shapiro, Glenna Traiger, Wendy Hill, Lixia Zhang, Aimee Doran> ;Cardiovascular Therapeutics. 2013 Oct 1
196 citations
Oral treprostinil for the treatment of pulmonary arterial hypertension in patients receiving background endothelin receptor antagonist and phosphodiesterase type 5 inh...
Victor F Tapson, Zhi-Cheng Jing, Kai-Feng Xu, Lei Pan, Jeremy Feldman, David G Kiely, Eugene Kotlyar, C Shane McSwain, Kevin Laliberte, Carl Arneson, Lewis J Rubin> ;Chest. 2013 Sep 1
7 citations
Systemic BP and Heart Rate as Prognostic Indicators in Pulmonary Arterial Hypertension
Malcolm M. Bersohn, Michelle Turner, Glenna Traiger, Adaani E. Frost, Shelley Shapiro> ;Chest. 2013 Sep 1
20 citations
Catheter ablation of typical atrial flutter in severe pulmonary hypertension.
Jason Bradfield, Shelley Shapiro, B S William Finch, Roderick Tung, Noel G. Boyle, Eric Buch, Nilesh Mathuria, Ravi Mandapati, Kalyanam Shivkumar, Malcolm M. Bersohn> ;Journal of Cardiovascular Electrophysiology. 2012 Nov 1
27 citations
Frequency of edema in patients with pulmonary arterial hypertension receiving ambrisentan
Shelley Shapiro, David M. Pollock, Hunter Gillies, Noreen Henig, Martine Allard, Christiana Blair, Crystal Anglen, Donald E. Kohan> ;The American Journal of Cardiology. 2012 Nov 1
27 citations
Rapid Transition from Inhaled Iloprost to Inhaled Treprostinil in Patients with Pulmonary Arterial Hypertension
Robert C. Bourge, Victor F. Tapson, Zeenat Safdar, Raymond L. Benza, Richard N. Channick, Erika B. Rosenzweig, Shelley Shapiro, R. James White, Christopher Shane McSwa...> ;Cardiovascular Therapeutics. 2013 Feb 1
175 citations
Oral treprostinil for the treatment of pulmonary arterial hypertension in patients on background endothelin receptor antagonist and/or phosphodiesterase type 5 inhibit...
Victor F Tapson, Fernando Torres, Fiona Kermeen, Anne M Keogh, Roblee P Allen, Robert P Frantz, David B Badesch, Adaani E Frost, Shelley M Shapiro, Kevin Laliberte, Je...> ;Chest. 2012 Dec 1
50 citations
Brief report: effect of ambrisentan treatment on exercise-induced pulmonary hypertension in systemic sclerosis: a prospective single-center, open-label pilot study.
Rajeev Saggar, Dinesh Khanna, Shelley M. Shapiro, Daniel E. Furst, Paul Maranian, P. J. Clements, Fereidoun Abtin, Shiv Dua, John A. Belperio, Rajan Saggar> ;Arthritis and Rheumatism. 2012 Dec 1
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