StephenLeeLessnickMDPhD

PubMed

• The DBD-4 helix of EWS::FLI is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma.
  Ariunaa Bayanjargal, Cenny Taslim, Iftekhar A Showpnil, Julia Selich-Anderson, Jesse C Crow, Stephen L Lessnick, Emily R Theisen> ;Biorxiv. 2024 Jan 31
• 9 citations
  Randomized Phase III Trial of Ganitumab With Interval-Compressed Chemotherapy for Patients With Newly Diagnosed Metastatic Ewing Sarcoma: A Report From the Children's ...
  DuBois, S., Krailo, M., Glade-Bender, J., Buxton, A., Laack, N., Randall, R., Chen, H., Seibel, N., Boron, M., Terezakis, S., Hill-Kayser, C., Hayes, A., Reid, J., Teo...> ;Journal of Clinical Oncology. 2023 Apr 10
• 13 citations
  The ETS transcription factor ETV6 constrains the transcriptional activity of EWS-FLI to promote Ewing sarcoma.
  Diana Y Lu, Jana M Ellegast, Kenneth N Ross, Clare F Malone, Shan Lin, Nathaniel W Mabe, Neekesh V Dharia, Ashleigh Meyer, Amy Conway, Angela H Su, Julia Selich-Anders...> ;Nature Cell Biology. 2023 Feb 1
• 9 citations
  Adverse prognostic impact of the loss of STAG2 protein expression in patients with newly diagnosed localised Ewing sarcoma: A report from the Children's Oncology Group.
  David S Shulman, Sonja Chen, David Hall, Anwesha Nag, Aaron R Thorner, Stephen L Lessnick, Kimberly Stegmaier, Katherine A Janeway, Steven G DuBois, Mark D Krailo, Don...> ;British Journal of Cancer. 2022 Dec 1
• 13 citations
  EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma.
  Iftekhar A Showpnil, Julia Selich-Anderson, Cenny Taslim, Megann A Boone, Jesse C Crow, Emily R Theisen, Stephen L Lessnick> ;Nucleic Acids Research. 2022 Sep 23
• 17 citations
  An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma.
  Shulman, D., Whittle, S., Surdez, D., Bailey, K., de Álava, E., Yustein, J., Shlien, A., Hayashi, M., Bishop, A., Crompton, B., DuBois, S., Shukla, N., Leavey, P., Les...> ;NPJ Precision Oncology. 2022 Sep 17
• 3 citations
  Mitochondrial Dysfunction Is a Driver of SP-2509 Drug Resistance in Ewing Sarcoma.
  E John Tokarsky, Jesse C Crow, Lillian M Guenther, John Sherman, Cenny Taslim, Gabriela Alexe, Kathleen I Pishas, Galen Rask, Blake S Justis, Ana Kasumova, Kimberly St...> ;Molecular Cancer Research. 2022 Jul 6
• 7 citations
  Network potential identifies therapeutic miRNA cocktails in Ewing sarcoma.
  Davis T. Weaver, Kathleen I. Pishas, Drew F. K. Williamson, Jessica A. Scarborough, Stephen L. Lessnick, Andrew Dhawan, Jacob G. Scott> ;Plos Computational Biology. 2021 Oct 18
• 10 citations
  Identification of a Novel FUS/ETV4 Fusion and Comparative Analysis with Other Ewing Sarcoma Fusion Proteins.
  Megann A. Boone, Cenny Taslim, Jesse C. Crow, Julia Selich-Anderson, Mike Watson, Peter Heppner, James Hamill, Andrew C. Wood, Stephen L. Lessnick, Mark Winstanley> ;Molecular Cancer Research. 2021 Aug 31
• 11 citations
  The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma.
  Megann A. Boone, Cenny Taslim, Jesse C. Crow, Julia Selich-Anderson, Andrea K Byrum, Iftekhar A. Showpnil, Benjamin Sunkel, Meng Wang, Benjamin Z. Stanton, Emily R. Th...> ;Oncogene. 2021 Jun 18
• 3 citations
  Patterns of Translocation Testing in Patients Enrolling to a Cooperative Group Trial for Newly Diagnosed Metastatic Ewing Sarcoma: A Report From the Children's Oncolog...
  Steven G. DuBois, Mark Krailo, Allen Buxton, Stephen L. Lessnick, Lisa A. Teot, Dinesh Rakheja, Brian D. Crompton, Katherine A. Janeway, Richard Gorlick, Julia Glade-B...> ;Archives of Pathology & Laboratory Medicine. 2021 Dec 1
• 12 citations
  Survey of Paediatric Oncologists and Pathologists regarding Their Views and Experiences with Variant Translocations in Ewing and Ewing-Like Sarcoma: A Report of the Ch...
  Michael D. Kinnaman, Chong Zhu, Daniel A. Weiser, Pooja Hingorani, Michael Roth, Jonathan Gill, Katherine A. Janeway, Richard Gorlick, Stephen L. Lessnick, Patrick J. ...> ;Sarcoma. 2020 Dec 5
• 14 citations
  Chromatin profiling reveals relocalization of lysine-specific demethylase 1 by an oncogenic fusion protein.
  Emily R. Theisen, Julia Selich-Anderson, Kyle R. Miller, Jason M. Tanner, Cenny Taslim, Kathleen I. Pishas, Sunil Sharma, Stephen L. Lessnick> ;Epigenetics. 2021 Apr 3
• 15 citations
  Identifying States of Collateral Sensitivity during the Evolution of Therapeutic Resistance in Ewing's Sarcoma
  Jessica A. Scarborough, Erin McClure, Peter M. Anderson, Andrew Dhawan, Arda Durmaz, Stephen L. Lessnick, Masahiro Hitomi, Jacob G. Scott> ;Iscience. 2020 Jul 24
• 4 citations
  Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis.
  Iftekhar A. Showpnil, Kyle R. Miller, Cenny Taslim, Kathleen I. Pishas, Stephen L. Lessnick, Emily R Theisen> ;Journal of Visualized Experiments. 2020 Jun 27
• 5 citations
  Protein phosphatase 1 regulatory subunit 1A regulates cell cycle progression in Ewing sarcoma.
  Wen Luo, Changxin Xu, Sarah Phillips, Aliza Gardenswartz, Jeremy Rosenblum, Janet Ayello, Stephen L. Lessnick, Huai-Xiang Hao, Mitchell S. Cairo> ;Oncotarget. 2020 May 12
• 2 citations
  Increased risk for other cancers in individuals with Ewing sarcoma and their relatives.
  Diana Abbott, Schuyler O'Brien, James M. Farnham, Erin L. Young, Jeffrey T. Yap, Kevin B. Jones, Stephen L. Lessnick, R. Lor Randall, Joshua D. Schiffman, Lisa A. Cann...> ;Cancer Medicine. 2019 Oct 31
• 59 citations
  High-Dose Chemotherapy Compared With Standard Chemotherapy and Lung Radiation in Ewing Sarcoma With Pulmonary Metastases: Results of the European Ewing Tumour Working ...
  Uta Dirksen, Bernadette Brennan, Marie-Cécile Le Deley, Nathalie Cozic, Henk van den Berg, Vivek A Bhadri, Bénédicte Brichard, Line Claude, Alan W. Craft, Susanne Amle...> ;Journal of Clinical Oncology. 2019 Sep 25
• 2 citations
  Investigating the role of LSD2 as an epigenetic regulator in Ewing sarcoma.
  Priyal O. Patel, Kathleen I. Pishas, Cenny Taslim, Julia Selich-Anderson, Emily R. Theisen, Stephen L. Lessnick> ;Oncotarget. 2019 Jun 11
• 2 citations
  Correction: Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children’s Oncology Group (Br...
  , , , , , , , , , , , , , , , , , , , > ;British Journal of Cancer. 2019 Apr 16
• 49 citations
  Emerging novel agents for patients with advanced Ewing sarcoma: a report from the Children's Oncology Group (COG) New Agents for Ewing Sarcoma Task Force.
  Kelly M. Bailey, Carrye R. Cost, Ian J. Davis, Julia Glade-Bender, Patrick J. Grohar, Peter J. Houghton, Michael S. Isakoff, Elizabeth Stewart, Nadia N. Laack, Jason T...> ;F1000research. 2019 Apr 15
• 11 citations
  Transcriptomic analysis functionally maps the intrinsically disordered domain of EWS/FLI and reveals novel transcriptional dependencies for oncogenesis.
  Emily R. Theisen, Kyle R. Miller, Iftekhar A. Showpnil, Cenny Taslim, Kathleen I. Pishas, Stephen L. Lessnick> ;Genes & Cancer. 2019 Feb 1
• 303 citations
  Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort
  Sigbjørn Smeland, Stefan S. Bielack, Jeremy Whelan, Mark L. Bernstein, Pancras C.W. Hogendoorn, Mark Krailo, Richard Gorlick, Katherine A. Janeway, Fiona C. Ingleby, J...> ;European Journal of Cancer. 2019 Mar 1
• 27 citations
  Trabectedin Inhibits EWS-FLI1 and Evicts SWI/SNF from Chromatin in a Schedule-dependent Manner.
  Matt Harlow, Maggie H. Chasse, Elissa Boguslawski, Katie M. Sorensen, Jenna M. Gedminas, Susan M. Kitchen-Goosen, Scott B. Rothbart, Cenny Taslim, Stephen L. Lessnick,...> ;Clinical Cancer Research. 2019 Jun 1
• 11 citations
  Ewing sarcoma resistance to SP-2509 is not mediated through KDM1A/LSD1 mutation.
  Kathleen I. Pishas, Stephen L. Lessnick> ;Oncotarget. 2018 Nov 23
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Journal Articles

• Author Correction: EWS–FLI1 Increases Transcription to Cause R-loops and Block BRCA1 Repair in Ewing Sarcoma  
  Kimberly Stegmaier, Stephen L Lessnick, Jeffrey A Toretsky, Nature
• Impact of Two Different Measures of Micrometastatic Disease on Clinical Outcomes in Patients with Newly Diagnosed Ewing Sarcoma: A Report from the Children's Oncology ...  
  Vo, KT, Edwards, JV, Epling, CL, Sinclair, E, Hawkins, DS, Grier, HE, Janeway, KA, Barnette, P, McIlvaine, E, Krailo, MD, Barkauskas, DA, Matthay, KK, Womer, RB, Gorli..., Clin Cancer Res, 1/1/2016
• Identification of mithramycin analogs with improved targeting of the EWS-FLI1 transcription factor  
  Osgood, CL, Maloney, N, Kidd, CG, Segars, L, Gebregiorgis, M, Woldemichael, G, He, M, Sankar, S, Lessnick, SL, Kang, M, Smith, M, Goosen, S, Turner, L, Nuñez, LE, Gonz..., Clin Cancer Res, 1/1/2016
• Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop  
  Hingorani P, Janeway K, Crompton BD, Kadoch C, Mackall CL, Khan J, Shern JF, Schiffman J, Mirabello L, Savage SA, Ladanyi M, Meltzer P, Bult CJ, Adamson PC, Lupo PJ, M..., Cancer Genet, 1/1/2016
• Recent advances in targeted therapy for Ewing sarcoma  
  Pishas, KI and Lessnick, SL, F1000Research, 1/1/2016
• Comparison of Clinical Features and Outcomes in Patients with Extraskeletal Versus Skeletal Localized Ewing Sarcoma: A Report from the Children’s Oncology Group  
  Cash, T, McIlvaine, E, Krailo, MD, Lessnick, SL, Lawlor, ER, Laack, N, Sorger, J, Marina, N, Grier, HE, Granowetter, L, Womer, RB, and Dubois SG, Pediatr Blood Cancer, 1/1/2016
• EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma  
  Fadul, J, Bell, R, Hoffman, LM, Beckerle, MC, Engel, ME, and Lessnick, SL, Genes & Cancer, 1/1/2015
• Tumoral TP53 and/or CDKN2A Alterations are Not Reliable Prognostic Biomarkers in Patients with Localized Ewing Sarcoma: A Report from the Children’s Oncology Group  
  Lerman, DM, Monument, MJ, McIlvaine, E, Liu, X-q, Huang, D, Monovich, L, Beeler, N, Gorlick, RG, Marina, NM, Womer, RB, Bridge, JA, Krailo, MD, Randall, RL, Lessnick, ..., Pediatr Blood Cancer, 1/1/2015
• Targeting Glutathione S-transferase M4 in Ewing sarcoma  
  Zhuo, R, Kosak, KM, Sankar, S, Wiles, ET, Sun, Y, Zhang, J, Ayello, J, Prestwich, GD, Shami, PJ, Cairo, MS, Lessnick, SL, Luo, W, Front Pediatr, 1/1/2014
• Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth  
  Sankar, S, Theisen, ER, Bearss, J, Mulvihill, T, Hoffman, LM, Sorna, V, Beckerle, MC, Sharma, S, and Lessnick, SL, Clin Cancer Res, 1/1/2014
• Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex  
  Kumar, PP, Emechebe U, Smith, R, Moore, B, Yandell, M, Lessnick, SL, and Moon AM, eLife, 1/1/2014
• Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma  
  Chaturvedi, A, Hoffman, LM, Jensen, CC, Lin, Y-C, Grossman, AH, Randall, RL, Lessnick, SL, Welm, AL, and Beckerle, MB, Mol Biol Cell, 1/1/2014
• Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: a report from the Children's Oncology Group  
  Monument, MJ, Johnson, KM, McIlvaine, E, Abegglen, L, Watkins, WS, Jorde, LB, Womer, RB, Beeler, N, Monovich, L, Bridge, JA, Schiffman, JD, Krailo, MD, Randall, RL, an..., PLoS ONE, 1/1/2014
• Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma  
  Sankar, S, Bell, R, Stephens, B, Zhuo, R, Sharma, S, Bearss, DJ, and Lessnick, SL, Oncogene, 1/1/2013
• A decade in banking Ewing sarcoma: a report from the Children's Oncology Group  
  Borinstein, SC, Beeler, N, Block, J, Gorlick, R, Grohar, P, Jedlicka, P, Krailo, M, Morris, S, Siegal, GP, Lawlor, E, Lessnick, SL, Front Oncol, 1/1/2013
• Biomarkers in Ewing sarcoma: The promise and challenge of personalized medicine A report from the Children’s Oncology Group  
  Shukla, N, Schiffman, J, Reed, D, Davis IJ, Womer, RB, Lessnick, SL, Lawlor, ER, COG Ewing Sarcoma Biology Committee, Front Oncol, 1/1/2013
• EWS and RE1-Silencing Transcription Factor inhibit neural phenotype development and oncogenic transformation in Ewing sarcoma  
  Sankar, S, Gomez, NC, Bell, R, Patel, M, Davis, IJ, Lessnick, SL, and Luo, W, Genes & Cancer, 1/1/2013
• ZEB2 represses the epithelial phenotype and facilitates metastasis in Ewing sarcoma  
  Wiles, ET, Bell, R, Thomas, D, Beckerle, M, and Lessnick, SL, Genes & Cancer, 1/1/2013
• The second European interdisciplinary Ewing sarcoma research summit - A joint effort to deconstructing the multiple layers of a complex disease  
  Kovar, H, Amatruda, J, Brunet, E, Burdach, S, Cidre-Aranaz, F, de Alava, E, Dirksen, U, van der Ent, W, Grohar, P, Gruenewald, T, Helman, L, Houghton, P, Iljin, K, Kor..., Oncotarget, 1/1/2013
• Children’s Oncology Group’s 2013 Blueprint for Research: Bone Tumors  
  Gorlick, R, Janeway, K, Lessnick S., Randall, RL, and Marina, N., on behalf of the COG Bone Tumor Committee, Pediatr Blood Cancer, 1/1/2013
• The First European Interdisciplinary Ewing´s Sarcoma Research Summit  
  Kovar, H, Alonso, J, Aman, P, Aryee, DNT, Ban, J, Burchill, SA, Burdach, S, De Alava, E, Delattre, O, Dirksen, U, Fourtouna, A, Fulda, S, Helman, LJ, Herrero-Martin, D..., Front Oncol, 1/1/2012
• The clone wars – revenge of the metastatic rogue state: the sarcoma paradigm  
  Spraker, HL, Price, SL, Chaturvedi, A, Schiffman, JD, Jones, KB, Lessnick, SL, Beckerle, M, Randall, RL, Front Oncol, 1/1/2012
• Microsatellites with macro-influence in Ewing sarcoma  
  Monument, MJ, Johnson, KM, Grossman, AH, Schiffman, JD, Randall, RL, Lessnick, SL, Genes, 1/1/2012
• Microsatellite instability in sarcoma: fact or fiction?  
  Monument, MJ, Lessnick, SL, Schiffman, JD, Randall RL, ISRN Oncology, 1/1/2012
• At-risk populations for osteosarcoma: The syndromes and beyond  
  Calvert, GT, Randall, RL, Jones, KB, Cannon-Albright, L, Lessnick, S, Schiffman, JB, Sarcoma, 1/1/2012
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Books/Book Chapters

• Principles and Practice of Pediatric Oncology 
  Chapter: Chapter 33: Ewing Sarcoma. 
  Hawkins, D, Bolling, T, DuBois, S, Hogendoorn, PCW., Jurgens, H, Paulussen, M, Randall, RL, and Lessnick, SLEditors: Pizzo, PA and Poplack DG.Lippincott Williams & Wilkins, Philadelphia, PAEdition 7th,2014
• Oncology of Infancy and Childhood. 
  Chapter: Chapter 61: Ewing's Sarcoma. 
  Dubois, S, Grier, HE, and Lessnick, SLEditors: Orkin, S.H., Fisher, D.E., Look, A.T., Lux, S.E., Ginsburg, D., and Nathan, D.G..Saunders-Elsevier, Philadelphia, PA2013
• WHO Classification of Tumors of Soft Tissue and Bone 
  Chapter: Chapter 19-1: Ewing sarcoma. 
  de Alava, E, Lessnick, SL, and Sorensen, PEditors: Fletcher, C, Hogendorn, P, Mertens, F, and Bridge, J.International Agency for Research on Cancer (IARC), Lyon, FranceEdition 4th,2012
• Principles and Practice of Pediatric Oncology 
  Chapter: Chapter 33: Ewing Sarcoma 
  Hawkins, D, Bolling, T, DuBois, S, Hogendoorn, PCW., Jurgens, H, Paulussen, M, Randall, RL, and Lessnick, SLEditors: Pizzo, PA and Poplack DG.Lippincott Williams & Wilkins, Philadelphia, PAEdition 6th,2011
• Oncology of Infancy and Childhood. 
  Chapter: Chapter 21: Ewing's Sarcoma. 
  Dubois, S, Grier, HE, and Lessnick, SLEditors: Orkin, S.H., Fisher, D.E., Look, A.T., Lux, S.E., Ginsburg, D., and Nathan, D.G..Saunders-Elsevier, Philadelphia, PA2009
• American Society of Clinical Oncology 2007 Educational Book. 
  Chapter: EWS/FLI Biology. 
  Lessnick, SLEditors: Ramaswamy Govindan.2007
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Abstracts/Posters

• Epigenomic profiling reveals global reorganization of the chromatin regulatory network in Ewing sarcoma.
  Saund, R, Lessnick SL, Cell Symposia- Biology and Data Science, Berkeley, CA, 1/1/2016
• Targeting the Chromatin Regulatory Machiner Hijacked by EWS/FLI in Ewing Sarcoma.
  Theisen ER, Pishas KI, Lessnick SL, Special Conference ON Pediatric Clinical Oncology. CAC2- From Bench to Bedside and Beyond, Cold Spring Harbor, NY, 1/1/2016
• Bad Influence: EWS/FLI Coopts Chromatin Regulatory Machinery to Enforce Malignancy in Ewing Sarcoma.
  Theisen ER, Lessnick SL, Gordon Research Conference: Chromatin Structure and Function, Les Diablerets, Switzerland, 1/1/2016
• EWS/FLI regulates transcriptional activation in Ewing sarcoma via length dependent GGAA microsatellites.
  Johnson, KM, Lessnick SL, Connective Tissue Oncology Society annual meeting, Lisbon, Portugal, 1/1/2016
• Defining the mechanisms of sensitivity to HCI-2509: A novel LSD1 inhibitor for the treatment of Ewing sarcoma.
  Pishas, KI, Sharma, S, Lessnick, SL, Connective Tissue Oncology Society annual meeting, Lisbon, Portugal, 1/1/2016
• EWS/FLI Hijacks Chromatin Regulatory Complexes to Maintain Malignancy in Ewing Sarcoma Cells.
  Theisen ER, Lessnick SL, Connective Tissue Oncology Society annual meeting, Lisbon, Portugal, 1/1/2016
• Epigenomic analysis of inhibition of histone demethylase LSD1 reveals novel enhancer elements in Ewing sarcoma cells.
  Saund, R, Smiley, B, Tanner, J., and Lessnick, SL, Chromatin and Epigenetics in Cancer Conference of American Association of Cancer Research, Atlanta, GA, 1/1/2015
• Defining the mechanisms of resistance to LSD1 inhibition.
  Pishas, KI, Sharma, S, Lessnick, SL, Connective Tissue Oncology Society annual meeting, Salt Lake City, UT, 1/1/2015
• Clinical impact of bone marrow micrometastatic disease burden detected by flow cytometry in patients with Ewing sarcoma.
  Vo, K, Epling, L, Sinclair, E, Hawkins, D, Grier, HE, Janeway, K, Barnette, P, Barkauskas, DA, Matthay, K, Lessnick, SL, Dubois, S, Connective Tissue Oncology Society annual meeting, Salt Lake City, UT, 1/1/2015
• Tumoral TP53 and/or CDKN2A Alterations are Not Reliable Prognostic Biomarkers in Patients with Localized Ewing Sarcoma: A Report from the Children's Oncology Group.
  Lerman, DM, Monument, MJ, McIlvaine, E, Liu, X-q, Huang, D, Monovich, L, Beeler, N, Gorlick, RG, Marina, NM, Womer, RB, Bridge, JA, Krailo, MD, Randall, RL, Lessnick, ..., Connective Tissue Oncology Society annual meeting, Berlin, Germany, 1/1/2014
• Inhibition of LSD1 disrupts global EWS/ETS transcriptional function in Ewing sarcoma.
  Theisen E, Sankar S, Bearss J, Mulvihill T, Sorna, V, Sharma S, and Lessnick SL, American Association of Cancer Research Annual Meeting, San Diego, CA, 1/1/2014
• Modulating glutathione s-transferase M4 activity for the treatment of Ewing sarcoma.
  Zhuo R, Kosak KM, Sankar S, Wiles ET, Sun Y, Zhang J, Prestwich GD, Shami PJ, Lessnick SL, Cairo MS, and Luo W, American Association of Cancer Research Annual Meeting, San Diego, CA, 1/1/2014
• Biochemical and clinical assessment of GGAA microsatellite polymorphisms in Ewing sarcoma.
  Monument MJ, Randall RL, Mcilvaine E, Krailo M, and Lessnick SL, Connective Tissue Oncology Society annual meeting, New York, NY, 1/1/2013
• Ethnic polymorphisms in the GGAA microsatellite response element of key Ewing's sarcoma EWS/FLI-target genes.
  Monument MJ, Beck R, Watkins WS, Jorde LB, Randall RL, Lessnick SL, American Association of Cancer Research Annual Meeting, Chicago, IL, 1/1/2012
• Mechanism of transcriptional repression by EWS/FLI in Ewing's sarcoma.
  Sankar S and Lessnick SL, American Association of Cancer Research Annual Meeting, Chicago, IL, 1/1/2012
• BCL11B is a critical EWS/FLI up-regulated target in Ewing's sarcoma.
  Toomey E, Lui B, Lessnick S, American Association of Cancer Research Annual Meeting, Chicago, IL, 1/1/2012
• Impact of EWS-FLI induced changes in gene expression and cell behavior on metastatic potential.
  Chaturvedi AP, Welm A, Lessnick S, Beckerle M, American Association of Cancer Research Annual Meeting, Orlando, FL, 1/1/2011
• Antibody detection of translocations (ADOT) in Ewing’s sarcoma.
  Luo W, Milash B, Dalley B, Smith R, Dutrow N, Cairns, B, Lessnick SL, American Association of Cancer Research Annual Meeting, Orlando, FL, 1/1/2011
• Novel use of molecular inversion probes to interrogate formalin-fixed paraffin-embedded (FFPE) samples of Ewing's sarcoma.
  Druzgal CH, Downie J, Putnam A, Lessnick S, and Schiffman JD, American Society of Pediatric Hematology/Oncology Annual Meeting, Montreal, Quebec, Canada, 1/1/2010
• Identification of a heritable contribution to sarcoma predisposition.
  Jones KB, Schiffman JD, Kohlmann W, Randall R, Lessnick SL, Cannon-Albright L, Connective Tissue Oncology Society annual meeting, Paris, France, 1/1/2010
• Antibody detection of translocations (ADOT) in Ewing's sarcoma.
  Luo W, Milash B, Dalley B, Smith R, Dutrow N, Cairns S, and Lessnick SL, Connective Tissue Oncology Society annual meeting, Paris, France, 1/1/2010
• Ewing sarcoma (EWS): How does percent necrosis of the primary tumor, in post chemotherapy surgical specimens, aid in distinguishing treatment failures?
  Million L, Putnam A, Randall L, Coffin C, Lessnick S, Zhou H, Connective Tissue Oncology Society annual meeting, Paris, France, 1/1/2010
• Mechanistic dissection of EWS-FLI impact on Ewing’s sarcoma cell behavior.
  Chaturvedi A, Lessnick SL, and Beckerle MC, American Association of Cancer Research Annual Meeting, Washington, DC, 1/1/2010
• Emergent properties of EWS/FLI regulation via GGAA-microsatellites in Ewing's sarcoma.
  Gangwal K, Enriquez CA, Close D, Hill CP, and Lessnick SL, American Association of Cancer Research Annual Meeting, Washington, DC, 1/1/2010
• Emergent properties of EWS/FLI regulation via GGAA microsatellites in Ewing's sarcoma.
  Gangwal K and Lessnick SL, Cold Spring Harbor meeting on Mechanisms of Eukaryotic Transcription, Cold Spring Harbor, NY, 1/1/2009
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Lectures

• Targeting Translocations in Pediatric Leukemias and Sarcomas 
  Rockville, MD - 1/1/2015
• Topical Advances and Applications in Bone Pathology 
  San Diego, CA - 1/1/2014
• Molecular Biology and Innovative Therapies in Sarcomas of Childhood and Adolescence 
  Pultusk, Poland - 1/1/2012
• RNA Interference - Target Validation & Potential Therapeutic Applications for Childhood Cancer 
  Bethesda, MD - 1/1/2004
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Other

• Epidemiology, pathology, and molecular genetics of the Ewing sarcoma family of tumors. 
  Delaney, T, Hornicek, F, Lessnick, SL, and Mankin H; Basow, DS (Ed), UpToDate
  Waltham, MA - 1/1/2010
• Epidemiology, pathology, and molecular genetics of the Ewing sarcoma family of tumors 
  Lessnick SL, Hornicek FJ, Mankin HJ, DeLaney TF
  http://www.uptodate.com/contents/epidemiology-pathology-and-molecular-genetics-of-the-ewing-sarcoma-
  UpToDate, Wolters Kluwer Health - 2012-04-23