StevenHuntGrahamMD

PubMed

• Systemic treatment with ubiquitin carboxy terminal hydrolase L1 TAT protein ameliorates axonal injury and reduces functional deficits after traumatic brain injury in m...
  Mi, Z., Ma, J., Rose, M., Henchir, J., Liu, H., Cao, G., Dixon, C., Graham, S., Zeh, D., Ma, X.> ;Experimental Neurology. 2024 Mar 1
• 11 citations
  Role of UCHL1 in the pathogenesis of neurodegenerative diseases and brain injury.
  Zhiping Mi, Steven H Graham> ;Ageing Research Reviews. 2023 Apr 1
• 1 citations
  Mutation of a Ubiquitin Carboxy Terminal Hydrolase L1 Lipid Binding Site Alleviates Cell Death, Axonal Injury, and Behavioral Deficits After Traumatic Brain Injury in ...
  Zhiping Mi, Hao Liu, Marie E. Rose, Jie Ma, Daniel P. Reay, Xiecheng Ma, Jeremy Henchir, C. Edward Dixon, Steven H. Graham> ;Neuroscience. 2021 Nov 1
• 10 citations
  Abolishing UCHL1's hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice.
  Zhiping Mi, Hao Liu, Marie E. Rose, Xiecheng Ma, Daniel P. Reay, Jie Ma, Jeremy Henchir, C. Edward Dixon, Steven H. Graham> ;Experimental Neurology. 2021 Feb 1
• 44 citations
  Role of UCHL1 in axonal injury and functional recovery after cerebral ischemia
  Hao Liu, N. V. Povysheva, Marie E. Rose, Zhiping Mi, Joseph S. Banton, Wenjin Li, Fenghua Chen, Daniel P. Reay, German Barrionuevo, Feng Zhang, Steven H. Graham> ;Proceedings of the National Academy of Sciences of the United States of America. 2019 Mar 5
• 19 citations
  Intracerebroventricular Delivery of Recombinant NAMPT Deters Inflammation and Protects Against Cerebral Ischemia
  Fenghua Chen, Zhongfang Weng, Qinghai Xia, Catherine Cao, Rehana K. Leak, Lihong Han, Jian Xiao, Steven H. Graham, Guodong Cao> ;Translational Stroke Research. 2019 Feb 28
• 13 citations
  Novel therapies for combating chronic neuropathological sequelae of TBI.
  Milos D. Ikonomovic, Eric E. Abrahamson, Shaun W. Carlson, Steven H. Graham, C. Edward Dixon> ;Neuropharmacology. 2019 Feb 1
• 12 citations
  In vivo transduction of neurons with TAT-UCH-L1 protects brain against controlled cortical impact injury
  Hao Liu, Marie E. Rose, Xiecheng Ma, Sherman Culver, C. Edward Dixon, Steven H. Graham> ;Plos One. 2017 May 24
• Introduction to special issue: Neurovascular aging-A driving force for neurological dysfunction in stroke and neurodegenerative diseases.
  Steven H. Graham> ;Ageing Research Reviews. 2017 Mar 1
• 65 citations
  Life and death in the trash heap: The ubiquitin proteasome pathway and UCHL1 in brain aging, neurodegenerative disease and cerebral Ischemia.
  Steven H. Graham, Hao Liu> ;Ageing Research Reviews. 2017 Mar 1
• 6 citations
  Modification of ubiquitin C-terminal hydrolase L1 by reactive lipid species: role in neural regeneration and diseases of aging
  Steven H. Graham> ;Neural Regeneration Research. 2016 Jun 1
• 30 citations
  Rosiglitazone attenuates inflammation and CA3 neuronal loss following traumatic brain injury in rats
  Hao Liu, Marie E. Rose, Sherman Culver, Xiecheng Ma, C. Edward Dixon, Steven H. Graham> ;Biochemical and Biophysical Research Communications. 2016 Apr 15
• 97 citations
  Newborn Screening for Cystic Fibrosis in California
  Martin Kharrazi, Juan Yang, Tracey Bishop, Shellye Lessing, Suzanne Young, Steven Graham, Michelle Pearl, Helen Chow, Thomson Ho, Robert Currier, Leslie Gaffney, Lisa ...> ;Pediatrics. 2015 Dec 1
• 23 citations
  The point mutation UCH-L1 C152A protects primary neurons against cyclopentenone prostaglandin-induced cytotoxicity: implications for post-ischemic neuronal injury
  Hao Liu, Wenjin Li, Marie E. Rose, Robert W. Hickey, Jun Chen, Guy Uechi, Manimalha Balasubramani, Billy W. Day, K V Patel, Steven H. Graham> ;Cell Death & Disease. 2015 Nov 5
• 13 citations
  Protein disulfide isomerase as a novel target for cyclopentenone prostaglandins: implications for hypoxic ischemic injury.
  Hao Liu, Jie Chen, Wenjin Li, Marie E. Rose, Sunita Shinde, Manimalha Balasubramani, Guy Uechi, Bulent Mutus, Steven H. Graham, Robert W. Hickey> ;The FEBS Journal. 2015 May 1
• 74 citations
  Inflammation in Ischemic Stroke: Mechanisms, Consequences and Possible Drug Targets
  Muzamil Ahmad, Nawab John Dar, Zubair Shanib Bhat, Aehtesham Hussain, Ayatullah Shah, Hao Liu, Steven H. Graham> ;CNS & Neurological Disorders Drug Targets. 2014 Sep 30
• 25 citations
  Rapid and simultaneous quantitation of prostanoids by UPLC-MS/MS in rat brain.
  Jafar Sadik Shaik, Tricia M. Miller, Steven H. Graham, Mioara D. Manole, Samuel M. Poloyac> ;Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 2014 Jan 15
• 38 citations
  Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke
  Jafar Sadik Shaik, Muzamil Ahmad, Wenjin Li, Marie E. Rose, Lesley M. Foley, T. Kevin Hitchens, Steven H. Graham, Sung Hee Hwang, Bruce D. Hammock, Samuel M. Poloyac> ;American Journal of Physiology. Heart and Circulatory Physiology. 2013 Dec 1
• 33 citations
  Prostaglandin D2 toxicity in primary neurons is mediated through its bioactive cyclopentenone metabolites.
  Hao Liu, Wenjin Li, Marie E. Rose, Jordan L. Pascoe, Tricia M. Miller, Muzamil Ahmad, Samuel M. Poloyac, Robert W. Hickey, Steven H. Graham> ;Neurotoxicology. 2013 Dec 1
• 12 citations
  Increased cytochrome c in rat cerebrospinal fluid after cardiac arrest and its effects on hypoxic neuronal survival.
  Hao Liu, Syana M. Sarnaik, Mioara D. Manole, Yaming Chen, Sunita Shinde, Wenjin Li, Marie E. Rose, Henry Alexander, Jie Chen, Robert S. B. Clark, Steven H. Graham, Rob...> ;Resuscitation. 2012 Dec 1
• 14 citations
  COX2-derived primary and cyclopentenone prostaglandins are increased after asphyxial cardiac arrest.
  Hao Liu, Marie E. Rose, Tricia M. Miller, Wenjin Li, Sunita Shinde, Alicia M. Pickrell, Samuel M. Poloyac, Steven H. Graham, Robert W. Hickey> ;Brain Research. 2013 Jun 26
• 30 citations
  Increased Generation of Cyclopentenone Prostaglandins after Brain Ischemia and Their Role in Aggregation of Ubiquitinated Proteins in Neurons
  Hao Liu, Wenjin Li, Muzamil Ahmad, Marie E. Rose, Tricia M. Miller, Mei Yu, Jie Chen, Jordan L. Pascoe, Samuel M. Poloyac, Robert W. Hickey, Steven H. Graham> ;Neurotoxicity Research. 2013 Jan 25
• 74 citations
  Phosphorylation of HSP27 by Protein Kinase D Is Essential for Mediating Neuroprotection against Ischemic Neuronal Injury
  R. A. Stetler, Yanqin Gao, Lili Zhang, Zhongfang Weng, Feng Zhang, Xiaoming Hu, Suping Wang, Peter S. Vosler, Guodong Cao, Dandan Sun, Steven H. Graham, Jun Chen> ;The Journal of Neuroscience. 2012 Feb 22
• 47 citations
  Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury
  Hao Liu, Wenjin Li, Muzamil Ahmad, Tricia M. Miller, Marie E. Rose, Samuel M. Poloyac, Guy Uechi, Manimalha Balasubramani, Robert W. Hickey, Steven H. Graham> ;Neurobiology of Disease. 2011 Feb 1
• 68 citations
  Inflammation After Stroke: Mechanisms and Therapeutic Approaches
  Muzamil Ahmad, Steven H. Graham> ;Translational Stroke Research. 2010 Jun 1
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Journal Articles

• Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke  
  Shaik JS, Ahmad M, Li W, Rose ME, Foley LM, Hitchens TK, Graham SH, Hwang SH, Hammock BD, Poloyac SM, Am J Physiol Heart Circ Physiol, 1/1/2013
• COX2-derived primary and cyclopentenone prostaglandins are increased after asphyxial cardiac arrest  
  Liu H, Rose ME, Miller TM, Li W, Shinde SN, Pickrell AM, Poloyac SM, Graham SH, Hickey RW, Brain Res, 1/1/2013
• Rapid and simultaneous quantitation of prostanoids by UPLC-MS/MS in rat brain  
  Shaik JS, Miller TM, Graham SH, Manole MD, Poloyac SM, J Chromatogr B Analyt Technol Biomed Life Sci, 1/1/2013
• Intravenous Formulation of HET0016 for Inhibition of Rat Brain 20-Hydroxyeicosatetraenoic Acid (20-HETE) Formation  
  Mu Y, Klamerus MM, Miller TM, Rohan LC, Graham SH, Poloyac S, Drug Metab Dispos, 1/1/2008
• Genetic disruption of cyclooxygenase-2 does not improve histological or behavioral outcome after traumatic brain injury in mice  
  Ahmad M., Rose ME, Vagni V, Griffith R; Dixon CE, Kochanek P, Hickey R, Graham SH, J Neurochem Res, 1/1/2008
• Neuronal Cyclooxygenase-2 Activity and Prostaglandins PGE2, PGD2, and PGF2alpha Exacerbate Hypoxic Neuronal Injury in Neuron-enriched Primary Culture  
  Li W, Wu S, Hickey RW, Rose ME, Chen J, Graham SH, Neurochem Res, 1/1/2008
• Cyclooxygenase-2 Activity Contributes to Neuronal Expression of Cyclin D1 after Anoxia/Ischemia in vitro and in vivo  
  Chen RW, Zhang Y, Rose RE, Graham SH, Mol Brain Res, 1/1/2004
• Review of Clinical Approaches to Antiphospholipid Antibodies (book review)  
  Graham SH, Annals Neurol, 1/1/2001
• Programmed cell death in ischemia  
  Graham SH, Chen J, J Cerebr Blood Flow Metabol, 1/1/2001
• Assessment of 2-chloroadenosine treatment after experimental traumatic brain injury in the rat using arterial spin-labeled MRI: a preliminary report  
  Robertson CL, Hendrich KS, Kochanek PM, Jackson EK, Melick JA, Graham SH, Marion DW, Williams DS, Ho C, Acta Neurochir, 1/1/2000
• bcl-2 family genes in ischemia and trauma  
  Graham, S.H., Chen J., Clark R.S.B., J Neurotrauma, 1/1/2000
• Editorial  
  Graham SH, Brain Pathology, 1/1/1997
• Metabolite 1H relaxation in normal and hyponatremic brain  
  Rooney WD, Ebisu T, Mancuso A, Graham S, Weiner MW, Maudsley AA, Magn Reson Med, 1/1/1996
• 33 Neuroprotective use-dependent blockers of Na+ and Ca+2 channels controlling presynaptic release of glutamate  
  Goldin SM, Subbarao K, Margolin LD, Sharma R, Knapp AG, Fischer JB, Daly D, Durant GJ, Reddy NL, Hu LY, Magar S, Graham SH, Chen J, Holt WF, Berlove D, McBurney RN, Ann NY Acad Sci, 1/1/1995
• Neuroprotective use-dependent blockers of Na+ and Ca2+ channels controlling presynaptic release of glutamate  
  Goldin SM, Subbarao K, Sharma R, Knapp AG, Fischer JB, Daly D, Durant GJ, Reddy NL, Hu LY, Magar S, Perlman ME, Chen J, Graham SH, Holt WF, Berlove D, Margolin LD, Neuroprotective Agents, 1/1/1995
• A study of the dose dependency of a glycine receptor antagonist in focal ischemia  
  Chen J, Graham S, Moroni F, Simon R, J Pharmacol Exp Ther, 1/1/1993
• Use of intravenous acyclovir for treatment of herpes zoster ophthalmicus in patients at risk for AIDS  
  Seiff SR, Margolis T, Graham SH, O'Donnell JJ, Ann Ophthalmol, 1/1/1988
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Books/Book Chapters

• Animal Models of Acute Neurological Injuries 
  Chapter: Middle Cerebral artery occlusion suture model for mice. 
  Page 187 - 196Zhang F, Graham SH, Chen JEditors: J.Chen, Z.C. Xu, X.M. Xu J.H. Zhang.Humana Press, Totowa, NJ2009
• The Eicosanoids 
  Chapter: Eicosanoids: roles in the pathophysiology of cerebral ischemia. 
  Page 481 - 486Hickey RW, Graham SHEditors: Peter Curtis-Prior.Wiley2004
• Vol 37: Cerebral Blood Flow: Mechanisms of Ischemia, Diagnosis and Therapy. 
  Chapter: The genetic control of ischemic neuronal cell death. In: Update in Intensive Care and Emergency Medicine. 
  Page 96 - 105Graham SH, Hickey RWSpringer, New York, NY2002
• The American College of Neuropsychopharmacology, Fifth Generation of Progress. 
  Chapter: Molecular Pathophysiology of Stroke. 
  Page 1317 - 1326Graham SH, Hickey RWLippincott Williams and Wilkins, Baltimore, MD2002
• Brain Injury: Molecular and Cellular Biology of Critical Care Medicine. 
  Chapter: Apoptosis. 
  Page 199 - 230Zhang X, Satchell MA, Clark RSB, Nathaniel PD, Kochanek PM, Graham SHEditors: RSB Clark and PM Kochanek.Kluwer Academic Publishers, Boston, MA2001
• Pharmacology of Cerebral Ischemia 
  Chapter: The role of bcl-2 family genes in the induction of tolerance to focal ischemia. 
  Shimuzu S., Graham SH, Simon R.P.Editors: J. Krieglstein.1998
• Cerebrovascular Diseases, Nineteenth Princeton Conference 
  Chapter: N-methyl-D-aspartate-mediated neurotoxicity is associated with oxygen-derived free radicals. 
  Chan PK, Chen J, Gafni J, Lan JQ, Chen S, Carlson E, Graham SH, Simon R, Epstein CJEditors: Moskowitz MA and Caplan LR.Butterworth Heinemann, Stoneham, MA1995
• Markers of Neuronal Injury 
  Chapter: Heat shock proteins used to show that haloperidol prevents neuronal injury produced by ketamine, MK801 and phencyclidine. 
  Sharp FR, Butman M, Wang S, Koistinaho J, Graham SH, Sagar SM, Berger P, Longo FREditors: J.N. Johannessen.New York Academy of Sciences, New York, NY1993
• Neurochemical Correlates of Cerebral Ischemia, Volume 7 of Advances in Neurochemistry 
  Chapter: Biochemical changes and secondary tissue injury after brain and spinal cord ischemia. 
  Faden AI, Weinstein PR, Bakshi R, Yum S, Lemke M, Graham SHEditors: Bazan NG, Braquet P, and Ginzberg M.Plenum Press, New York, NY1992
• Excitatory Amino Acids 
  Chapter: A new strategy for ameliorating excitoxicity in cerebral ischemia: Inhibition of glutamate release by 5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine. 
  Simon RP, Chen J, Graham SHEditors: Simon RP.Thieme Medical Publishers, Inc., New York, NY1992
• Intracranial Pressure VI 
  Chapter: An automated method of measurement of intracranial mechanical properties. 
  Page 234 - 236Graham SH, Miner ME, Drennon D, Hackenberry LEEditors: Ishii S, Nagai H, and Brock M.Springer-Verlag, New York, NY1983
• Seminars in Neurologic Surgery 
  Chapter: Disseminated intravascular coagulation and fibrinolysis following severe head trauma in children. 
  Page 251 - 258Miner ME, Kaufman HH, Graham SH, McKeller D, Gildenberg PLEditors: Grossman R and Gildenberg P.Raven Press, New York, NY1982
• Intracranial Pressure IV 
  Chapter: A microcomputer system for ICP analysis. 
  Page 409 - 413Graham SH, Hackenberry LE, Rea GL, Miner MEEditors: Shulman K, Marmarou A, Miller JD, Becker DP, and Brock M.Springer-Verlag, New York, NY1980
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Abstracts/Posters

• Assessment of 2-Chloroadenosine Treatment After Experimental Traumatic Brain Injury in the Rat Using Arterial Spin-Labeled MRI: A Preliminary Report.
  Robertson CL, Hendrich KS, Kochanek PM, Jackson EK, Melick JA, Graham SH, Marion DW, Williams DS, Ho C, Acta Neurochir, 1/1/2000
• Traumatic Brain Injury in Mice Deficient in Poly-ADP(Ribose) Polymerase: A Preliminary Report.
  Whalen MJ, Clark RSB, Dixon CE, Robichaud P, Marion DW, Vagni V, Graham SH, Virag L, Hasko G, Stachlewitz, Szabo C, Kochanek PM, Acta Neurochir, 1/1/2000
• Assessment of 2-chloroadenosine Treatment after Experimental Traumatic Brain Injury in the Rat using Arterial Spin-Labeled MRI: A Preliminary Report.
  Robertson CL, Hendrich KS, Kochanek PM, Jackson EK, Melick JA, Graham SH, Marion DW, Williams DS, Ho C, Proceedings of the 11th International Brain Oedema and Mechanisms of Cellular Injury Meeting, 1/1/1999
• Traumatic Brain Injury in Mice Deficient in Poly-ADP (Ribose) Polymerase: A Preliminary Report.
  Whalen MJ, Clark RSB, Dixon CE, Robichaud P, Marion DW, Vagni V, Graham SH, Virarg Laszlo, Hasko G, Stachlewitz R, Szabo C, Kochanek PM, Proceedings of the 11th International Brain Oedema and Mechanisms of Cellular Injury Meeting, 1/1/1999
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Lectures

• Human Research Protection Programs and CQI, Panel Discussion 
  San Diego, CA - 1/1/2002
• Cerebral Ischemia 
  1/1/2002
• Cerebrovacular Disorders 
  1/1/2002
• Cerebral Blood Flow, Diagnosis and Treatment 
  Pittsburgh, PA - 1/1/2000
• Mechanisms of ischemic brain injury and protection. 
  Shanghai, China - 1/1/2000
• Gene Responses to Brain Injury 
  Copenhagen, Denmark - 1/1/1999
• Strategies in the use of animal models for the study of brain ischemia: a reappraisal. 
  Madrid, Spain - 1/1/1999
• Neurobiology of CNS Injury 
  1/1/1998
• Naval Medical Research and Development Command 
  1/1/1997
• Weakness 
  Mercy Hospital, Pittsburgh, PA - 1/1/1996
• New Treatments for Stroke 
  University of Pittsburgh - 1/1/1996
• Pathophysiology of secondary brain injury and implications for contemporary Treatment. 
  University of Pittsburgh - 1/1/1996
• The Biological Bases of Neuropsychiatric Disorders 
  1/1/1996
• Genes in Ischemia 
  1/1/1996
• International symposium on oxidative stress, apoptosis and oxidative brain damage. 
  Allegheny University - 1/1/1995
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Other

• Global ischemia induced gene. 
  K. Jin, J. Chen, S.H. Graham, R.P. Simon, U.S. Patent 5,968,771
  1/19/1999
• The relationship between cerebral blood flow and cerebral electrical impedance pulsations. (Ph.D. thesis) 
  Graham SH, University of Texas Graduate School of Biomedical Science at Houston
  1/1/1982
• Spin-spin nuclear magnetic resonance relaxation times of water protons in oxidizing mitochondrial solutions. (Senior thesis) 
  Graham SH, Rice University, Physics Department
  1/1/1975