StevenLeMD

PubMed

• 3 citations
  Enzyme Replacement Therapy for Mucopolysaccharidosis IIID using Recombinant Human α-N-Acetylglucosamine-6-Sulfatase in Neonatal Mice.
  Feng Wang, Derek R. Moen, Chelsee Sauni, Shih Hsin Kan, Shan Li, Steven Q. Le, Brett Lomenick, Xiaoyi Zhang, Sean Ekins, Srikanth Singamsetty, Jill Wood, Patricia I. D...> ;Molecular Pharmaceutics. 2021 Jan 4
• Myelin and Lipid Composition of the Corpus Callosum in Mucopolysaccharidosis Type I Mice
  Steven Q. Le, Igor Nestrasil, Shih hsin Kan, Martin T. Egeland, Jonathan D. Cooper, David Elashoff, Rong Guo, Jakub Tolar, Jennifer K. Yee, Patricia I. Dickson> ;Lipids. 2020 Nov 1
• 1 citations
  Comparison of dermatan sulfate and heparan sulfate concentrations in serum, cerebrospinal fluid and urine in patients with mucopolysaccharidosis type I receiving intra...
  Haoyue Zhang, Patricia I. Dickson, Ashlee R. Stiles, Agnes Chen, Steven Q. Le, Patricia McCaw, James Beasley, David S. Millington, Sarah P. Young> ;Clinica Chimica Acta. 2020 May 20
• Evaluation of non-reducing end pathologic glycosaminoglycan detection method for monitoring therapeutic response to enzyme replacement therapy in human mucopolysacchar...
  Moin Vera, Steven Q. Le, Alla Victoroff, Merry Passage, Jillian R. Brown, Brett E. Crawford, Lynda E. Polgreen, Agnes Chen, Patricia I. Dickson> ;Molecular Genetics and Metabolism. 2020 Feb 1
• 8 citations
  Intrathecal enzyme replacement for cognitive decline in mucopolysaccharidosis type I, a randomized, open-label, controlled pilot study.
  Agnes Chen, Paul Harmatz, Igor Nestrasil, Julie B. Eisengart, Kelly King, Kyle Rudser, Alexander M. Kaizer, Alena Svátková, Amy Wakumoto, Steven Q. Le, Jacqueline Madd...> ;Molecular Genetics and Metabolism. 2020 Feb 1
• 14 citations
  Intrathecal enzyme replacement for Hurler syndrome: biomarker association with neurocognitive outcomes
  Julie B. Eisengart, Elizabeth I. Pierpont, Alexander M. Kaizer, Kyle Rudser, Kelly King, Marzia Pasquali, Lynda E. Polgreen, Patricia I. Dickson, Steven Q. Le, Weston ...> ;Genetics in Medicine. 2019 Nov 1
• 6 citations
  Genetically Corrected iPSC-Derived Neural Stem Cell Grafts Deliver Enzyme Replacement to Affect CNS Disease in Sanfilippo B Mice.
  Don Clarke, Yewande Pearse, Shih-hsin Kan, Steven Q. Le, Valentina Sanghez, Jonathan D. Cooper, Patricia I. Dickson, Michelina Iacovino> ;Molecular therapy. Methods & clinical development. 2018 Jul 23
• 8 citations
  A Humoral Immune Response Alters the Distribution of Enzyme Replacement Therapy in Murine Mucopolysaccharidosis Type I
  Steven Q. Le, Shih hsin Kan, Don Clarke, Valentina Sanghez, Martin T. Egeland, Kristen N. Vondrak, Terence M. Doherty, Moin Vera, Michelina Iacovino, Jonathan D. Coope...> ;Molecular therapy. Methods & clinical development. 2018 Mar 16
• 3 citations
  Behavioral deficits and cholinergic pathway abnormalities in male Sanfilippo B mice.
  Shih-hsin Kan, Steven Q. Le, Quang D. Bui, Braeden Benedict, Jesse D. Cushman, Mark S. Sands, Patricia I. Dickson> ;Behavioural Brain Research. 2016 Oct 1
• 7 citations
  Data from subjects receiving intrathecal laronidase for cervical spinal stenosis due to mucopolysaccharidosis type I
  Patricia I. Dickson, Ilkka Kaitila, Paul Harmatz, Anton Mlikotic, Agnes Chen, Alla Victoroff, Merry Passage, Jacqueline Madden, Steven Q. Le, David E. Naylor> ;Data in Brief. 2015 Dec 1
• 12 citations
  Diffusion tensor imaging and myelin composition analysis reveal abnormal myelination in corpus callosum of canine mucopolysaccharidosis I.
  James M. Provenzale, Igor Nestrasil, Steven Chen, Shih hsin Kan, Steven Q. Le, J. K. Jens, Elizabeth M. Snella, Kristen N. Vondrak, Jennifer K. Yee, Charles H. Vite, D...> ;Experimental Neurology. 2015 Nov 1
• 21 citations
  Safety of laronidase delivered into the spinal canal for treatment of cervical stenosis in mucopolysaccharidosis I
  Patricia I. Dickson, Ilkka Kaitila, Paul Harmatz, Anton Mlikotic, Agnes Chen, Alla Victoroff, Merry Passage, Jacqueline Madden, Steven Q. Le, David E. Naylor> ;Molecular Genetics and Metabolism. 2015 Sep 1
• 10 citations
  A novel, long-lived, and highly engraftable immunodeficient mouse model of mucopolysaccharidosis type I
  Daniel C. Mendez, Alexander E. Stover, Anthony D. Rangel, David J. Brick, Hubert E. Nethercott, Marissa A. Torres, Omar Khalid, Andrew Wong, Jonathan D. Cooper, James ...> ;Molecular therapy. Methods & clinical development. 2015 Jan 1
• 10 citations
  Intra-articular enzyme replacement therapy with rhIDUA is safe, well-tolerated, and reduces articular GAG storage in the canine model of mucopolysaccharidosis type I
  Raymond Y. Wang, Afshin Aminian, Michael F. McEntee, Shih-hsin Kan, Calogera M. Simonaro, William C. Lamanna, Roger Lawrence, N. Matthew Ellinwood, Catalina Guerra, St...> ;Molecular Genetics and Metabolism. 2014 Aug 1
• 21 citations
  Insulin-like growth factor II peptide fusion enables uptake and lysosomal delivery of α-N-acetylglucosaminidase to mucopolysaccharidosis type IIIB fibroblasts
  Shih hsin Kan, Larisa A. Troitskaya, Carolyn S. Sinow, Karyn Haitz, Amanda K. Todd, Ariana Di Stefano, Steven Q. Le, Patricia I. Dickson, Brigette L. Tippin> ;Biochemical Journal. 2014 Mar 1
• 16 citations
  Immune response to intrathecal enzyme replacement therapy in mucopolysaccharidosis I patients.
  Moin Vera, Steven Q. Le, Shih hsin Kan, Hermes Garban, David E. Naylor, Anton Mlikotic, Ilkka Kaitila, Paul Harmatz, Agnes Chen, Patricia I. Dickson> ;Pediatric Research. 2013 Sep 3
• 1 citations
  Mannose 6-Phosphate Conjugation Is Not Sufficient to Allow Induction of Immune Tolerance to Phenylalanine Ammonia-Lyase in Dogs
  Moin Vera, Thomas Lester, Bin Zhao, Pascale M.N. Tiger, Scott Clarke, Brigette L. Tippin, Merry Passage, Steven Q. Le, Javier Femenia, Jeffrey F. Lemontt, Emil D. Kakk...> ;JIMD reports. 2012 Jul 6
• 21 citations
  Specific antibody titer alters the effectiveness of intrathecal enzyme replacement therapy in canine mucopolysaccharidosis I.
  Patricia I. Dickson, N. Matthew Ellinwood, Jillian R. Brown, Robert G. Witt, Steven Q. Le, Merry Passage, Moin Vera, Brett E. Crawford> ;Molecular Genetics and Metabolism. 2012 May 1
• Early versus late treatment of spinal cord compression with long-term intrathecal enzyme replacement therapy in canine mucopolysaccharidosis type I.
  Dickson, P.I., Hanson, S., McEntee, M.F., Vite, C.H., Vogler, C.A., Mlikotic, A., Chen, A.H., Ponder, K.P., Haskins, M.E., Tippin, B.L., Le, S.Q., Passage, M.B., Guerr...> ;Mol Genet Metab. 2010-10-01
• 5 citations
  Continuous infusion of enzyme replacement therapy is inferior to weekly infusions in MPS I dogs.
  Merry Passage, A. W. Krieger, Maryn Peinovich, Thomas Lester, Steven Q. Le, Patricia I. Dickson, Emil D. Kakkis> ;Journal of Inherited Metabolic Disease. 2009 Jun 28
• 124 citations
  Intrathecal enzyme replacement therapy reduces lysosomal storage in the brain and meninges of the canine model of MPS I.
  Emil D. Kakkis, Michael F. McEntee, Carole Vogler, Steven Q. Le, Beth Levy, Pavel V. Belichenko, William C. Mobley, Patricia I. Dickson, Stephen Hanson, Merry Passage> ;Molecular Genetics and Metabolism. 2004 Sep 1
• 22 citations
  Features of brain MRI in dogs with treated and untreated mucopolysaccharidosis type I.
  Charles H. Vite, Igor Nestrasil, Anton Mlikotic, Jackie K. Jens, Elizabeth M. Snella, William Gross, Elsa G Shapiro, Victor Kovac, James M. Provenzale, Steven Chen, St...> ;Comparative Medicine. 2013 Apr 1
• 25 citations
  The murine cardiac 26S proteasome: An organelle awaiting exploration
  Aldrin V. Gomes, Chenggong Zong, Ricky D. Edmondson, Beniam Berhane, Guang Wu Wang, Steven Q. Le, Glen Young, Jun Zhang, Thomas M. Vondriska, Julian P. Whitelegge, Ric...> ;Annals of the New York Academy of Sciences. 2005 Jun 1
• 63 citations
  Cardiovascular-related proteins identified in human plasma by the HUPO Plasma Proteome Project pilot phase.
  Beniam Berhane, Chenggong Zong, David A. Liem, Aaron Huang, Steven Q. Le, Ricky D. Edmondson, Richard C. Jones, Xin Qiao, Julian P. Whitelegge, Peipei Ping, Thomas M. ...> ;Proteomics. 2005 Aug 1
• Replacing the enzyme alpha-L-iduronidase at birth ameliorates symptoms in the brain and periphery of dogs with mucopolysaccharidosis type I.
  Dierenfeld, A. D., McEntee, M. F., Vogler, C. A., Vite, C. H., Chen, A. H., Passage, M., Le, S., Shah, S., Jens, J. K., Snella, E. M., Kline, K. L., Parkes, J. D., War...> ;Sci Transl Med. 2010 Dec 1
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