SunilSinghalMD

Thoracic Surgery • Philadelphia, PA

Cardiovascular Surgery

Professor, Surgery, University of Pennsylvania Perelman School of Medicine

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Office
3400 Spruce St
6th Fl., Silverstein Pvln.
Philadelphia, PA 19104
Phone+1 215-662-4767

Fax+1 215-349-5798
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Education & Training

University of Pennsylvania Health SystemFellowship, Thoracic Surgery, 2005 - 2007
Johns Hopkins UniversityResidency, Surgery, 1998 - 2005
Perelman School of Medicine at the University of PennsylvaniaClass of 1998

Certifications & Licensure

NJ State Medical License 2010 - 2025
PA State Medical License 2001 - 2024
GA State Medical License 2007 - 2009
American Board of Surgery Surgery
American Board of Thoracic Surgery Thoracic and Cardiac Surgery

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012
Fellow (FACS) American College of Surgeons

Clinical Trials

Intraoperative Imaging of Thoracic Malignancies With Indocyanine Green Start of enrollment: 2011 May 01
Completed
Phase 1
Pilot and Feasibility Study of the Imaging Potential of EC17: Intraoperative Folate-fluorescein Conjugate (EC17) Lung Cancer (CA) Start of enrollment: 2012 Apr 01
Completed
Phase 1
Intraoperative Imagery of Renal Nodules With Folate-fluorescein Conjugate(EC17) Start of enrollment: 2013 May 01
Completed
Early Phase 1
Intraoperative Imaging of Breast Cancer With Indocyanine Green Start of enrollment: 2011 Jul 01
Completed
Early Phase 1
Intraoperative Imagery of Breast Cancer With Folate-FITC (EC17) Start of enrollment: 2014 May 01
Completed
Phase 1
EC17 for Intraoperative Imaging for Parathyroidectomy Start of enrollment: 2013 Nov 01
Completed
Phase 1
EC17 for Intraoperative Imaging in Occult Ovarian Cancer Start of enrollment: 2013 Nov 01
Completed
Phase 1
Intraoperative Imaging of Pituitary Adenomas by OTL Start of enrollment: 2015 Oct 01
Terminated
Phase 1
Intraoperative Imaging With ICG Registry Start of enrollment: 2016 Jul 01
Completed
Optional Sub-study to Intraoperative Imaging With ICG Registry Start of enrollment: 2015 Dec 01
Completed
Intraoperative Imaging of Pulmonary Adenocarcinoma Start of enrollment: 2016 Jan 01
Withdrawn
Phase 1
A Pilot & Feasibility Study of Intraoperative Imaging With OTL38 In Patients With Lung and Pleural Nodules Start of enrollment: 2015 Jun 01
A Phase 1, Single Dose, Open-Label Study to Investigate the Safety and Efficacy of OTL38 Injection (OTL38) for Intra-operative Imaging of Folate Receptor-alpha Positive Pituitary Adenoma Start of enrollment: 2015 Sep 01
Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer Start of enrollment: 2019 Jun 17
Recruiting
Phase 3
OTL38 Injection (OTL38) for Intra-Operative Imaging of Folate Receptor Positive Ovarian Cancer Start of enrollment: 2022 May 28
Withdrawn
Phase 1
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Publications & Presentations

PubMed

Precision Oncology in Lung Cancer Surgery.
Bou-Samra, P., Singhal, S.> ;Surgical Oncology Clinics of North America. 2024 Apr 1
Red Blood Cells Function as Reservoirs of Tumor DNA.
Jeffrey C Thompson, Sue Li, Joshua S Jose, Aasha Gupta, Evgeniy Eruslanov, Steven M Albelda, Jarrod Predina, Sunil Singhal, Nilam S Mangalmurti> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2024 Mar 26
Human Tumor-Associated Macrophages and Neutrophils Regulate Antitumor Antibody Efficacy through Lethal and Sublethal Trogocytosis.
Sunil Singhal, Abhishek S Rao, Jason Stadanlick, Kyle Bruns, Neil T Sullivan, Andres Bermudez, Adam Honig-Frand, Ryan Krouse, Sachinthani Arambepola, Emily Guo, Edmund...> ;Cancer Research. 2024 Apr 1
Preoperative predictors of successful tumour localization by intraoperative molecular imaging with pafolacianine in lung cancer to create predictive nomogram.
Joffe, J., Chang, A., Guo, E., Segil, A., Kennedy, G., Din, A., Hwang, W., Bou-Samra, P., Azari, F., Singhal, S.> ;European Journal of Cardio-Thoracic Surgery. 2024 Jan 2
Clinical PDT dose dosimetry for pleural Photofrin-mediated photodynamic therapy.
Sun, H., Ong, Y., Yang, W., Sourvanos, D., Dimofte, A., Busch, T., Zhu, T., Singhal, S., Cengel, K.> ;Journal of Biomedical Optics. 2024 Jan 1
Cathepsin detection to identify malignant cells during robotic pulmonary resection.
Chang, A., Guo, E., Kennedy, G., Santini, J., Bensen, E., Bou-Samra, P., Azari, F., Jarrar, D., Singhal, S.> ;Translational Lung Cancer Research. 2023 Dec 26
A pH-Activatable Nanoprobe Labels Diverse Histologic Subtypes of Human Lung Cancer During Resection.
Gregory Thomas Kennedy, Feredun S Azari, Ashley Chang, Austin Chang, Patrick Bou-Samra, Charuhas Desphande, Edward J Delikatny, Evgeniy Eruslanov, John C Kucharczuk, D...> ;Molecular Imaging and Biology. 2023 Oct 1
1 citations
Strategies to reduce morbidity following pleurectomy and decortication for malignant pleural mesothelioma.
Patrick Bou-Samra, Austin Chang, Kevin Zhang, Feredun Azari, Gregory Kennedy, Emily Guo, Wei-Ting Hwang, Sunil Singhal> ;Thoracic Cancer. 2023 Sep 1
Molecular Imaging in Precision-Cut Non-Small Cell Lung Cancer Slices.
Feredun Azari, Gregory T Kennedy, Ashley Chang, Philip Low, Maria Basil, Joseph Planer, Jeremy Katzen, Evgeniy Eruslanov, Steven Albelda, Sunil Singhal> ;The Annals of Thoracic Surgery. 2024 Feb 1
Preclinical Lymph Node Model for Intraoperative Molecular Imaging of Cancer.
Patrick Bou-Samra, Austin Chang, Sachinthani Arambepola, Emily Guo, Feredun Azari, Gregory Kennedy, Alix Segil, Sunil Singhal> ;Research Square. 2023 Jun 12
Prospective Feasibility and Phase 1/2 Trial of Preoperative Proton Beam Therapy With Concurrent Chemotherapy for Resectable Stage IIIA or Superior Sulcus Non-Small Cel...
Charles B Simone 2nd, Nikhil Yegya-Raman, Shwetha Manjunath, Vivek Verma, Jacob E Shabason, Lee Xu, Keith A Cengel, William P Levin, Abigail T Berman, John P Christodo...> ;International Journal of Radiation Oncology, Biology, Physics. 2023 Nov 1
3 citations
Intraoperative molecular imaging: 3rd biennial clinical trials update.
Patrick Bou-Samra, Najib Muhammad, Austin Chang, Ritesh Karsalia, Feredun Azari, Gregory Kennedy, Walter Stummer, Janos Tanyi, Linda Martin, Alexander Vahrmeijer, Barb...> ;Journal of Biomedical Optics. 2023 May 1
Bioinspired color-near infrared endoscopic imaging system for molecular guided cancer surgery.
Mebin B George, Benjamin Lew, Steven Blair, Zhongmin Zhu, Zuodong Liang, Indrajit Srivastava, Austin Chang, Hyungsoo Choi, Kyekyoon Kim, Shuming Nie, Sunil Singhal, Vi...> ;Journal of Biomedical Optics. 2023 May 1
4 citations
Epidemiological, therapeutic, and survival trends in malignant pleural mesothelioma: A review of the National Cancer Database.
Patrick Bou-Samra, Austin Chang, Feredun Azari, Gregory Kennedy, Alix Segil, Emily Guo, Melina Marmarelis, Corey Langer, Sunil Singhal> ;Cancer Medicine. 2023 Jun 1
Proceduralist criteria for evaluating interface utility of novel imaging modalities in early phase clinical trials: evaluating the need for standardized criteria.
Eric R Henderson, Jonathan Elliott, Shudong Jiang, I Leah Gitajn, John Lee, Summer Gibbs, Michael Bouvet, Anita Mahadevan-Jansen, Michael Daly, Samuel S Streeter, Keit...> ;Proceedings of SPIE--the International Society for Optical Engineering. 2023 Mar 14
Early identification of life-threatening soft-tissue infection using dynamic fluorescence imaging: first-in-kind clinical study of first-pass kinetics.
Samuel S Streeter, Gabrielle S Ray, Logan M Bateman, Kendra A Hebert, Fallon E Bushee, Scott W Rodi, I Leah Gitajn, Jaimo Ahn, Sunil Singhal, Niels D Martin, Nicholas ...> ;Proceedings of SPIE--the International Society for Optical Engineering. 2023 Mar 14
1 citations
Prospective validation of tumor folate receptor expression density with the association of pafolacianine fluorescence during intraoperative molecular imaging-guided lu...
Feredun Azari, Kevin Zhang, Gregory Kennedy, Patrick Bou-Samra, Ashley Chang, Bilal Nadeem, Austin Chang, Aysuna Galandarova, Arturan Ibrahimli, Ziya Karimov, Azra Din...> ;European Journal of Nuclear Medicine and Molecular Imaging. 2023 Jul 1
2 citations
Pafolacianine for intraoperative molecular imaging of cancer in the lung: The ELUCIDATE trial.
Inderpal S Sarkaria, Linda W Martin, David C Rice, Shanda H Blackmon, Herbert B Slade, Sunil Singhal> ;The Journal of Thoracic and Cardiovascular Surgery. 2023 Dec 1
5 citations
Neuromodulation for the Treatment of Refractory Ventricular Arrhythmias.
Timothy M Markman, Douglas Gugger, Jeffrey Arkles, Michael P Riley, Sanjay Dixit, Gustavo S Guandalini, David S Frankel, Andrew E Epstein, David J Callans, Sunil Singh...> ;JACC. Clinical Electrophysiology. 2023 Feb 1
2 citations
Single-institution experience of 500 pulmonary resections guided by intraoperative molecular imaging.
Gregory T Kennedy, Feredun S Azari, Ashley Chang, Bilal Nadeem, Elizabeth Bernstein, Alix Segil, Azra Din, Charuhas Desphande, Olugbenga Okusanya, Jane Keating, Jarrod...> ;The Journal of Thoracic and Cardiovascular Surgery. 2023 Jun 1
5 citations
Carcinoembryonic Antigen-Related Cell Adhesion Molecule Type 5 Receptor-Targeted Fluorescent Intraoperative Molecular Imaging Tracer for Lung Cancer: A Nonrandomized C...
Feredun Azari, Ruben P J Meijer, Gregory T Kennedy, Andrew Hanna, Ashley Chang, Bilal Nadeem, Azra Din, André Pèlegrin, Bérénice Framery, Françoise Cailler, Neil T Sul...> ;JAMA Network Open. 2023 Jan 3
Fluorescence-guided surgery with indocyanine green to identify an idiopathic chyle leak-case report.
Patrick Bou-Samra, Austin Chang, Sunil Singhal, Maxim Itkin> ;AME Case Reports. 2023 Jan 1
1 citations
Toxicities and Deaths From Intercurrent Disease Following Contemporary Postoperative Radiotherapy in Resected Non-Small-Cell Lung Cancer.
Kristine N Kim, Jonathan Heintz, Nikhil Yegya-Raman, Roger Cohen, Timothy Kegelman, Keith Cengel, Melina Marmarelis, Lova Sun, Corey Langer, Charu Aggarwal, Aditi Sing...> ;Clinical Lung Cancer. 2023 Mar 1
1 citations
Sodium Multivitamin Transporter-Targeted Fluorochrome Facilitates Enhanced Metabolic Evaluation of Tumors Through Coenzyme-R Dependent Intracellular Signaling Pathways.
Feredun Azari, Gregory T Kennedy, Ashley Chang, Bilal Nadeem, Patrick Bou-Samra, Austin Chang, Alix Segil, Elizabeth Bernstein, Neil T Sullivan, Evgeniy Eruslanov, Jam...> ;Molecular Imaging and Biology. 2023 Jun 1
3 citations
Tumor factors stimulate lysosomal degradation of tumor antigens and undermine their cross-presentation in lung cancer.
Zhen Lu, Jinyun Chen, Pengfei Yu, Matthew J Atherton, Jun Gui, Vivek S Tomar, Justin D Middleton, Neil T Sullivan, Sunil Singhal, Subin S George, Ashley G Woolfork, Aa...> ;Nature Communications. 2022 Nov 4
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Journal Articles

Implications of Hospital Volume on Costs Following Esophagectomy in the United States
Gregory T Kennedy, Sunil Singhal, John C Kucharczuk, Jarrod D Predina, Andrew D Newton, Journal of gastrointestinal surgery

Press Mentions

Artificial Intelligence Guided Intraoperative Molecular Imaging Biopsy of Indeterminate Pulmonary Nodules During Robotic SurgeryMay 8th, 2023
FDA Approves Drug Which Makes Lung Cancer GlowDecember 29th, 2022
FDA Approves Cancer-Targeting Imaging Agent for Lung CancerDecember 19th, 2022
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