SusanneMarkesberyArnoldMD

Oncology • Lexington, KY

Professor, Internal Medicine, University of Kentucky College of Medicine

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Office
800 Rose St
Lexington, KY 40536
Phone+1 859-257-4490

Fax+1 859-323-0702
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Education & Training

University of Kentucky College of MedicineFellowship, Hematology and Medical Oncology, 1995 - 1998
University of Virginia Medical CenterResidency, Internal Medicine, 1992 - 1995
University of Kentucky College of MedicineClass of 1992

Certifications & Licensure

KY State Medical License 1995 - 2025
American Board of Internal Medicine Medical Oncology

Clinical Trials

Phase I Trial of Biweekly Gemcitabine & Paclitaxel & Low-Dose Radiation for Metastatic or Recurrent Head & Neck Cancer Start of enrollment: 2005 Dec 01
Terminated
Phase 1
Paclitaxel, Carboplatin and Radiotherapy as Induction Therapy in Locally Advanced Head and Neck Cancer Start of enrollment: 2000 May 01
Completed
Phase 2
Paclitaxel, Carboplatin And Low Dose Radiation As Induction Therapy In Locally Advanced Head And Neck Cancer Start of enrollment: 2002 Sep 01
Completed
Phase 2
S0618 E7389 in Treating Patients With Metastatic or Recurrent Head and Neck Cancer Start of enrollment: 2006 May 01
Completed
Phase 2
Phase I Trial of Docetaxel and Low-Dose Fractionated Radiation in the Treatment of Metastatic or Recurrent NSCLC Start of enrollment: 2004 Nov 01
Terminated
Phase 1
Study of AR-67 (Formerly DB-67) in Adult Patients With Refractory or Metastatic Solid Malignancies Start of enrollment: 2006 Oct 01
Completed
Phase 1
Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Start of enrollment: 2008 Aug 08
Active, not recruiting
Phase 3
Gemcitabine Hydrochloride and Cisplatin With or Without Bevacizumab in Treating Patients With Advanced Urinary Tract Cancer Start of enrollment: 2009 Jul 15
Completed
Phase 3
Pemetrexed Disodium and Cisplatin With or Without Cediranib Maleate in Treating Patients With Malignant Pleural Mesothelioma Start of enrollment: 2010 Mar 15
Active, not recruiting
Phase 1, Phase 2
Study of AR-67 in Adult Patients With Recurrence of Glioblastoma Multiforme (GBM) or Gliosarcoma Start of enrollment: 2009 Dec 01
Unknown status
Phase 2
A Phase I Study of AR-67 (7-t-butyldimethylsilyl-10-hydroxycamptothecin) Given on Days 1, 4 8, 12 & 15 of an Every 21-day Cycle in Adult Patients With Refractory or Metastatic Solid Malignancies Start of enrollment: 2010 Sep 01
Completed
Phase 1
Study of Lung Cancer in Appalachian Kentucky: The Role of Environmental Carcinogens Start of enrollment: 2011 Sep 01
Completed
Study of Carfilzomib With Irinotecan in Irinotecan-Sensitive Malignancies and Small Cell Lung Cancer Patients Start of enrollment: 2013 Nov 01
Unknown status
Phase 1, Phase 2
A Study of Chemo +/- Low-dose Radiation as Induction Therapy in SCCHN Start of enrollment: 2014 Oct 01
Completed
Phase 2
Lung-MAP: Biomarker-Targeted Second-Line Therapy in Treating Patients With Recurrent Stage IV Squamous Cell Lung Cancer Start of enrollment: 2014 Jul 08
Completed
Trilaciclib (G1T28), a CDK 4/6 Inhibitor, in Combination With Etoposide and Carboplatin in Extensive Stage Small Cell Lung Cancer (SCLC) Start of enrollment: 2015 Jun 26
Completed
Phase 1, Phase 2
Study of Rovalpituzumab Tesirine (SC16LD6.5) for Third-Line and Later Treatment of Subjects With Relapsed or Refractory Delta-Like Protein 3-Expressing Small Cell Lung Cancer Start of enrollment: 2016 Jan 25
Completed
Phase 2
Lung-MAP: Taselisib as Therapy in Treating Patients With Stage IV Squamous Cell Lung Cancer and Positive Biomarker Matches Start of enrollment: 2014 Nov 01
Completed
Phase 2
Lung-MAP: Palbociclib as Second-Line Therapy in Treating Cell Cycle Gene Alteration Positive Patients With Recurrent Stage IV Squamous Cell Lung Cancer Start of enrollment: 2014 Sep 01
Completed
Phase 2, Phase 3
Lung-MAP: Nivolumab With or Without Ipilimumab as Second-Line Therapy in Treating Patients With Recurrent Stage IV Squamous Cell Lung Cancer and No Matching Biomarkers Start of enrollment: 2015 Dec 29
Active, not recruiting
Phase 3
Testing the Use of Targeted Treatment for RET Positive Advanced Non-small Cell Lung Cancer Start of enrollment: 2022 Jul 25
Recruiting
Phase 2
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Trends in Oral Tongue Cancer Incidence in the US.
Todd Burus, Haluk Damgacioglu, Bin Huang, W Jay Christian, Pamela C Hull, Amanda R Ellis, Ashish A Deshmukh, Krystle A Lang Kuhs, Susanne M Arnold> ;JAMA Otolaryngology-- Head & Neck Surgery. 2024 Apr 4
Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies.
Li, Y., Xiao, X., Li, J., Han, Y., Cheng, C., Fernandes, G., Slewitzke, S., Rosenberg, S., Zhu, M., Byun, J., Bossé, Y., McKay, J., Albanes, D., Lam, S., Tardon, A., C...> ;Cancer Epidemiology, Biomarkers & Prevention. 2024 Mar 1
"Pathways": A hope-enhancing intervention for patients undergoing treatment for advanced lung cancer.
Laurie E McLouth, Brent J Shelton, Vilma Bursac, Jessica L Burris, Jennifer S Cheavens, Kaitlyn Weyman, Amy H Peterman, Lauren Corum, Jamie L Studts, Susanne M Arnold> ;Psycho-Oncology. 2024 Mar 1
CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility.
Mulong Du, Junyi Xin, Rui Zheng, Qianyu Yuan, Zhihui Wang, Hongliang Liu, Hanting Liu, Guoshuai Cai, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Stig E B...> ;Cancer Research. 2024 Feb 15
Impact of individual level uncertainty of lung cancer polygenic risk score (PRS) on risk stratification.
Wang, X., Zhang, Z., Ding, Y., Chen, T., Mucci, L., Albanes, D., Landi, M., Caporaso, N., Lam, S., Tardon, A., Chen, C., Bojesen, S., Johansson, M., Risch, A., Bickebö...> ;Genome Medicine. 2024 Feb 5
Feasibility and Clinical Utility of Reporting Hereditary Cancer Predisposition Pathogenic Variants Identified in Research Germline Sequencing: A Prospective Interventi...
Hutchcraft, M. G., Megan L Hutchcraft, Shulin Zhang, Nan Lin, Justine C Pickarski, Elizabeth A Belcher, Sainan Wei, Thèrése Bocklage, Rachel W Miller, John L Villano, ...> ;JCO Precision Oncology. 2024 Jan 1
1 citations
Identification of genetically predicted DNA methylation markers associated with non-small cell lung cancer risk among 34,964 cases and 448,579 controls.
Xiaoyu Zhao, Meiqi Yang, Jingyi Fan, Mei Wang, Yifan Wang, Na Qin, Meng Zhu, Yue Jiang, Olga Y Gorlova, Ivan P Gorlov, Demetrius Albanes, Stephen Lam, Adonina Tardón, ...> ;Cancer. 2024 Mar 15
The T Cell Immunoscore as a Reference for Biomarker Development Utilizing Real-World Data from Patients with Advanced Malignancies Treated with Immune Checkpoint Inhib...
Islam Eljilany, Payman Ghasemi Saghand, James Chen, Aakrosh Ratan, Martin McCarter, John Carpten, Howard Colman, Alexandra P Ikeguchi, Igor Puzanov, Susanne Arnold, Mi...> ;Cancers. 2023 Oct 10
Candidate pathway analysis of surfactant proteins identifies CTSH and SFTA2 that influences lung cancer risk.
Jennifer Luyapan, Yohan Bossé, Zhonglin Li, Xiangjun Xiao, Albert Rosenberger, Rayjean J Hung, Stephen Lam, Shanbeh Zienolddiny, Geoffrey Liu, Lambertus A Kiemeney, Ch...> ;Human Molecular Genetics. 2023 Sep 5
Bridging the Biomarker Chasm With Interprofessional Molecular Tumor Boards.
Jill M Kolesar, Susanne M Arnold, Frederick R Ueland, B Mark Evers> ;JCO Oncology Practice. 2023 Aug 1
11 citations
Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population.
Jianxin Shi, Kouya Shiraishi, Jiyeon Choi, Keitaro Matsuo, Tzu-Yu Chen, Juncheng Dai, Rayjean J Hung, Kexin Chen, Xiao-Ou Shu, Young Tae Kim, Maria Teresa Landi, Dongx...> ;Nature Communications. 2023 May 26
Mosaic Chromosomal Alterations Are Associated With Increased Lung Cancer Risk: Insight From the INTEGRAL-ILCCO Cohort Analysis.
Chao Cheng, Wei Hong, Yafang Li, Xiangjun Xiao, James McKay, Younghun Han, Jinyoung Byun, Bo Peng, Demetrios Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Stig E Boj...> ;Journal of Thoracic Oncology. 2023 Aug 1
1 citations
A Phase I Dose Escalation and Expansion Study of Epidiolex (Cannabidiol) in Patients with Biochemically Recurrent Prostate Cancer.
Zin W Myint, William H St Clair, Stephen E Strup, Donglin Yan, Ning Li, Derek B Allison, Laurie E McLouth, Carleton S Ellis, Peng Wang, Andrew C James, Patrick J Hensl...> ;Cancers. 2023 Apr 27
Loss of the endocytic tumor suppressor HD-PTP phenocopies LKB1 and promotes RAS-driven oncogenesis.
Chang-Soo Seong, Chunzi Huang, Austin C Boese, Yuning Hou, Junghui Koo, Janna K Mouw, Manali Rupji, Greg Joseph, H Richard Johnston, Henry Claussen, Jeffrey M Switchen...> ;Biorxiv. 2023 Jan 27
3 citations
Association of first primary cancer with risk of subsequent primary cancer among survivors of adult-onset cancers in Kentucky and Appalachian Kentucky.
Quan Chen, Bin Huang, Abigail M Anderson, Eric B Durbin, Susanne M Arnold, Jill M Kolesar> ;Frontiers in Oncology. 2023 Jan 1
1 citations
Case report: A unique presentation of a high-grade neuroepithelial tumor with EWSR1::PATZ1 fusion with diagnostic, molecular, and therapeutic insights.
Andre Ene, Jing Di, Janna H Neltner, Susanne M Arnold, Jill M Kolesar, John L Villano, Sara E Bachert, Derek B Allison, Pittman, T.> ;Frontiers in Oncology. 2023 Jan 1
3 citations
Replicative Instability Drives Cancer Progression.
Benjamin B Morris, Jason P Smith, Qi Zhang, Zhijie Jiang, Oliver A Hampton, Michelle L Churchman, Susanne M Arnold, Dwight H Owen, Jhanelle E Gray, Patrick M Dillon, H...> ;Biomolecules. 2022 Oct 26
14 citations
A Large-Scale Genome-Wide Gene-Gene Interaction Study of Lung Cancer Susceptibility in Europeans With a Trans-Ethnic Validation in Asians.
Ruyang Zhang, Sipeng Shen, Yongyue Wei, Ying Zhu, Yi Li, Jiajin Chen, Jinxing Guan, Zoucheng Pan, Yuzhuo Wang, Meng Zhu, Junxing Xie, Xiangjun Xiao, Dakai Zhu, Yafang ...> ;Journal of Thoracic Oncology. 2022 Aug 1
8 citations
Molecular Tumor Board-Assisted Care in an Advanced Cancer Population: Results of a Phase II Clinical Trial.
Rachel W Miller, Megan L Hutchcraft, Heidi L Weiss, Jianrong Wu, Chi Wang, Jinpeng Liu, Rani Jayswal, Mikayla Buchanan, Abigail Anderson, Derek B Allison, Riham H El K...> ;JCO Precision Oncology. 2022 Aug 1
24 citations
Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer.
Jinyoung Byun, Younghun Han, Yafang Li, Jun Xia, Erping Long, Jiyeon Choi, Xiangjun Xiao, Meng Zhu, Wen Zhou, Ryan Sun, Yohan Bossé, Zhuoyi Song, Ann Schwartz, Christi...> ;Nature Genetics. 2022 Aug 1
5 citations
Cancer diagnosis is associated with a lower burden of dementia and less Alzheimer's-type neuropathology.
Shama D Karanth, Yuriko Katsumata, Peter T Nelson, David W Fardo, Jaclyn K McDowell, Frederick A Schmitt, Richard J Kryscio, Steven R Browning, Dejana Braithwaite, Sus...> ;Brain. 2022 Jul 29
3 citations
Tempering the 21st Century Cures Act: Physicians, Policy Advocacy, and Kentucky's Solution.
Susanne M Arnold, Catherine L Allison, Philip Bernard> ;JCO Oncology Practice. 2022 Sep 1
3 citations
Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk.
Yafang Li, Xiangjun Xiao, Jianrong Li, Jinyoung Byun, Chao Cheng, Yohan Bossé, James McKay, Demetrios Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Stig E Bojesen, M...> ;Human Molecular Genetics. 2022 Aug 23
3 citations
hPG(Circulating Progastrin), a Novel Blood-Based Biomarker for Detection of Poorly Differentiated Neuroendocrine Carcinoma and Well Differentiated Neuroendocrine Tumors.
Aman Chauhan, Alexandre Prieur, Jill Kolesar, Susanne Arnold, Léa Payen, Younes Mahi, Berengere Vire, Madison Sands, B Mark Evers, Dominique Joubert, Lowell Anthony> ;Cancers. 2022 Feb 9
90 citations
Durvalumab plus tremelimumab alone or in combination with low-dose or hypofractionated radiotherapy in metastatic non-small-cell lung cancer refractory to previous PD(...
Jonathan D Schoenfeld, Anita Giobbie-Hurder, Srinika Ranasinghe, Katrina Z Kao, Ana Lako, Junko Tsuji, Yang Liu, Ryan C Brennick, Ryan D Gentzler, Carrie Lee, Joleen H...> ;The Lancet. Oncology. 2022 Feb 1
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Lectures

Phase II trial of carfilzomib and irinotecan in relapsed small cell lung cancer (NCT01941316).
ASCO Annual Meeting 2019 - Chicago, IL - 6/2/2019

Press Mentions

No Evidence That Hydroxychloroquine and Ivermectin Cure Cancer; Cancer and Multiple Sclerosis Aren’t Caused Solely by Parasites, Contrary to Claim by Orthopedic SurgeonMay 12th, 2023
No, Ivermectin Isn’t Being Withheld as Cancer ‘Cure’February 16th, 2023
University of Kentucky Launches Clinical Trial to Evaluate New Treatments for COVID-19May 10th, 2020
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