TetsuoAshizawaMD

Neurology • Houston, TX

Movement Disorder, Neuromuscular Medicine

Adjunct Professor, Neurology, Baylor College of Medicine

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Office
6560 Fannin Street
Suite 802
Houston, TX 77030
Phone+1 713-441-3780

Fax+1 713-441-5182
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Education & Training

Baylor College of MedicineResidency, Neurology, 1975 - 1979
Allegheny Health Network Medical Education Consortium (AGH)Internship, Internal Medicine, 1974 - 1975
Keio Gujuku University School of MedicineClass of 1973

Certifications & Licensure

TX State Medical License 1976 - 2025
FL State Medical License 2009 - 2017
PA State Medical License 1975 - 1988
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2010-2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013

Clinical Trials

Clinical and Molecular Correlations in Spinocerebellar Ataxia Type 10 (SCA10) Start of enrollment: 1999 Nov 01
Completed
Creatine Safety, Tolerability, & Efficacy in Huntington's Disease (CREST-E) Start of enrollment: 2009 Sep 01
Terminated
Phase 3
Natural History Study of and Genetic Modifiers in Spinocerebellar Ataxias Start of enrollment: 2010 Apr 01
Recruiting
Clinical Trial Readiness for SCA1 and SCA3 Start of enrollment: 2018 Aug 16
Active, not recruiting
Genetic Mechanism of Conserved Ancestral Haplotype in SCA10 Start of enrollment: 2020 Sep 15
Recruiting
Roles: Principal Investigator, Contact
A Pharmacokinetics and Safety Study of BIIB132 in Adults With Spinocerebellar Ataxia 3 Start of enrollment: 2022 Feb 02
Terminated
Phase 1
Roles: Principal Investigator
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Publications & Presentations

PubMed

Fatigue Impacts Quality of Life in People with Spinocerebellar Ataxias.
Ruo-Yah Lai, Christian Rummey, Christian J Amlang, Chi-Ying R Lin, Tiffany X Chen, Susan Perlman, George Wilmot, Christopher M Gomez, Jeremy D Schmahmann, Henry Paulso...> ;Movement Disorders Clinical Practice. 2024 Feb 29
The Cerebellar Cognitive Affective/Schmahmann Syndrome Scale in Spinocerebellar Ataxias.
Selvadurai, L., Perlman, S., Ashizawa, T., Wilmot, G., Onyike, C., Rosenthal, L., Shakkottai, V., Paulson, H., Subramony, S., Bushara, K., Kuo, S., Dietiker, C., Gesch...> ;Cerebellum. 2024 Jan 2
Comparison of Live and Remote Video Ratings of the Scale for Assessment and Rating of Ataxia.
Arian Taheri Amin, Jennifer Faber, Demet Önder, Okka Kimmich, Matthis Synofzik, Tetsuo Ashizawa, Thomas Klockgether, Marcus Grobe-Einsler> ;Movement Disorders Clinical Practice. 2023 Sep 1
3 citations
Synaptic Loss in Spinocerebellar Ataxia Type 3 Revealed by SV2A Positron Emission Tomography.
Zhao Chen, Guang Liao, Na Wan, Zhiyou He, Daji Chen, Zhichao Tang, Zhe Long, Guangdong Zou, Linliu Peng, Linlin Wan, Chunrong Wang, Huirong Peng, Yuting Shi, Yongxiang...> ;Movement Disorders. 2023 Jun 1
SCAview: an Intuitive Visual Approach to the Integrative Analysis of Clinical Data in Spinocerebellar Ataxias.
Mischa Uebachs, Philipp Wegner, Sebastian Schaaf, Simon Kugai, Heike Jacobi, Sheng-Han Kuo, Tetsuo Ashizawa, Juliane Fluck, , , , , , Thomas Klockgether, Jennifer Faber> ;Cerebellum. 2023 Mar 31
6 citations
Antisense oligonucleotide targeting DMPK in patients with myotonic dystrophy type 1: a multicentre, randomised, dose-escalation, placebo-controlled, phase 1/2a trial.
Charles A Thornton, Richard Thomas Moxley 3rd, Katy Eichinger, Chad Heatwole, Laurence Mignon, W David Arnold, Tetsuo Ashizawa, John W Day, Gersham Dent, Matthew K Tan...> ;The Lancet. Neurology. 2023 Mar 1
2 citations
Baseline Clinical and Blood Biomarkers in Patients With Preataxic and Early-Stage Disease Spinocerebellar Ataxia 1 and 3.
Sophie Tezenas du Montcel, Emilien Petit, Titilayo Olubajo, Jennifer Faber, Pauline Lallemant-Dudek, Khalaf Bushara, Susan Perlman, Sub H Subramony, David Morgan, Bria...> ;Neurology. 2023 Apr 25
11 citations
Clinically Meaningful Magnetic Resonance Endpoints Sensitive to Preataxic Spinocerebellar Ataxia Types 1 and 3.
Jayashree Chandrasekaran, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M Joers, Dinesh K Deelchand, Michal Považan, Guita Banan, Romain Valabregue, ...> ;Annals of Neurology. 2023 Apr 1
7 citations
ATTCT and ATTCC repeat expansions in the ATXN10 gene affect disease penetrance of spinocerebellar ataxia type 10.
C Alejandra Morato Torres, Faria Zafar, Yu-Chih Tsai, Jocelyn Palafox Vazquez, Michael D Gallagher, Ian McLaughlin, Karl Hong, Jill Lai, Joyce Lee, Amanda Chirino-Pere...> ;HGG Advances. 2022 Oct 13
4 citations
The S-Factor, a New Measure of Disease Severity in Spinocerebellar Ataxia: Findings and Implications.
Louisa P Selvadurai, Susan L Perlman, George R Wilmot, Sub H Subramony, Christopher M Gomez, Tetsuo Ashizawa, Henry L Paulson, Chiadi U Onyike, Liana S Rosenthal, Hari...> ;Cerebellum. 2023 Oct 1
19 citations
Paving the Way Toward Meaningful Trials in Ataxias: An Ataxia Global Initiative Perspective.
Thomas Klockgether, Tetsuo Ashizawa, Bernard Brais, Rosalind Chuang, Alexandra Durr, Brent Fogel, Julie Greenfield, Sue Hagen, Laura Bannach Jardim, Hong Jiang, Osamu ...> ;Movement Disorders. 2022 Jun 1
4 citations
Mechanistic and Therapeutic Insights into Ataxic Disorders with Pentanucleotide Expansions.
Nan Zhang, Tetsuo Ashizawa> ;Cells. 2022 May 6
3 citations
Brief assessment of cognitive function in myotonic dystrophy: Multicenter longitudinal study using computer-assisted evaluation.
Gayle K Deutsch, Katharine A Hagerman, Jacinda Sampson, Gersham Dent, Jeanne Dekdebrun, Dana M Parker, Charles A Thornton, Chad R Heatwole, Sub H Subramony, Ami K Mank...> ;Muscle & Nerve. 2022 May 1
13 citations
Neurodegenerative diseases associated with non-coding CGG tandem repeat expansions.
Zhi-Dong Zhou, Joseph Jankovic, Tetsuo Ashizawa, Eng-King Tan> ;Nature Reviews. Neurology. 2022 Mar 1
1 citations
Comparing loss of balance and functional capacity among patients with SCA2, SCA3 and SCA10.
Marise Bueno Zonta, Hélio A G Teive, Carlos Henrique F Camargo, Alex T Meira, Francisco Diego Negrão Lopes Neto, Fernando Spina Tensini, Cláudia Bonfim Braga, Tetsuo A...> ;Clinical Neurology and Neurosurgery. 2022 Mar 1
3 citations
The genetic and molecular features of the intronic pentanucleotide repeat expansion in spinocerebellar ataxia type 10.
Tatsuaki Kurosaki, Tetsuo Ashizawa> ;Frontiers in Genetics. 2022 Jan 1
Reply to: "Cognitive Impairments in Spinocerebellar Ataxia Type 10 and Their Relation to Cortical Thickness".
Alex T Meira, Walter O Arruda, Gustavo L Franklin, Léo Coutinho, Giovanna Strobel, Sergio E Ono, Arnolfo de Carvalho Neto, Carlos H F Camargo, Renato P Munhoz, Tetsuo ...> ;Movement Disorders. 2021 Dec 1
9 citations
CCG•CGG interruptions in high-penetrance SCA8 families increase RAN translation and protein toxicity
Barbara A. Perez, Hannah K. Shorrock, Monica Banez-Coronel, Tao Zu, Lisa E.L. Romano, Lauren A. Laboissonniere, Tammy Reid, Yoshio Ikeda, Kaalak Reddy, Christopher M. ...> ;EMBO Molecular Medicine. 2021 Oct 11
7 citations
Blood Neurofilament Light Chain in Genetic Ataxia: A Meta-Analysis.
Linliu Peng, Shang Wang, Zhao Chen, Yun Peng, Chunrong Wang, Zhe Long, Huirong Peng, Yuting Shi, Xuan Hou, Lijing Lei, Linlin Wan, Mingjie Liu, Guangdong Zou, Lu Shen,...> ;Movement Disorders. 2021 Sep 14
5 citations
DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases
Nan Zhang, Brittani Bewick, Jason Schultz, Anjana Tiwari, Robert Krencik, Aijun Zhang, Kaho Adachi, Guangbin Xia, Kyuson Yun, Partha S. Sarkar, Tetsuo Ashizawa> ;Neurotherapeutics. 2021 Jun 23
4 citations
Balance and physical functioning in Spinocerebellar ataxias 3 and 10.
Katia Mayumi Konno, Marise Bueno Zonta, Ana Tereza Bittencourt Guimarães, Carlos Henrique Ferreira Camargo, Renato P. Munhoz, Salmo Raskin, Tetsuo Ashizawa, Hélio A.G....> ;Acta Neurologica Scandinavica. 2021 Apr 1
Response to ATXN10 Microsatellite Distribution in a Peruvian Amerindian Population
Diego Véliz-Otani, Diana Cubas-Montecino, Karina Milla-Neyra, Tetsuo Ashizawa, Maria Luiza Saraiva-Pereira, Laura Bannach Jardim, Mario Cornejo-Olivas> ;Cerebellum. 2021 Mar 17
7 citations
Clinical and genomic analysis of a large Chinese family with familial cortical myoclonic tremor with epilepsy and SAMD12 intronic repeat expansion.
Yongxing Zhou, Raman Sood, Qun Wang, Blake Carrington, Morgan Park, Alice C. Young, Daniel P. Birnbaum, Zhao Liu, Tetsuo Ashizawa, James C. Mullikin, Mohamad Z. Koubei...> ;Epilepsia Open. 2021 Feb 2
14 citations
A CRISPR-Cas13a Based Strategy That Tracks and Degrades Toxic RNA in Myotonic Dystrophy Type 1
Nan Zhang, Brittani Bewick, Guangbin Xia, Denis Furling, Tetsuo Ashizawa> ;Frontiers in Genetics. 2020 Dec 10
37 citations
Biallelic Intronic AAGGG Expansion of RFC1 is Related to Multiple System Atrophy.
Linlin Wan, Zhao Chen, Na Wan, Mingjie Liu, Jin Xue, Hongsheng Chen, Youming Zhang, Yun Peng, Zhichao Tang, Yiqing Gong, Hongyu Yuan, Shang Wang, Qi Deng, Xuan Hou, Ch...> ;Annals of Neurology. 2020 Dec 1
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Press Mentions

Houston Methodist Leads International Clinical Research for Rare Neurodegenerative DisorderApril 10th, 2018
Alzheimer’s Expert Appointed Director of McKnight Brain InstituteNovember 11th, 2016

Grant Support

Clinical Research Consortium For Spinocerebellar AtaxiasNational Institute Of Neurological Disorders And Stroke2009–2010
Pathogenic Mechanism Of Spinocerebellar Ataxia Type 10National Institute Of Neurological Disorders And Stroke2006–2009
Spinocerebellar Ataxia Type 10National Institute Of Neurological Disorders And Stroke2002–2004
Spinocerebellar Ataxia Type 10National Institute Of Neurological Disorders And Stroke2001–2002