Thomas C. Chen MD

PubMed

• Patient with recurrent grade 4 astrocytoma responding favorably to intranasal delivery of NEO100, highly pure perillyl alcohol: illustrative case.
  Axel H Schönthal, Stephen Swenson, Frank M Senecal, Rhonda Mittenzwei, John L Go
  Journal of Neurosurgery. Case Lessons. 2025-03-17
• 1 citations
  Bringing intranasal drug delivery for malignancies in the brain to market.
  Thomas C Chen, Clovis O da Fonseca, Axel H Schönthal
  Expert Opinion on Drug Delivery. 2025-03-01
• 4 citations
  Application and Safety of Externally Controlled Metronomic Drug Delivery to the Brain by an Implantable Smart Pump in a Sheep Model.
  Thomas C Chen, Winston H Wu, Ki-Eun Chang, Axel H Schönthal, Eli S Gang
  Neurosurgery. 2025-02-01

Journal Articles

• Convection Enhanced Delivery of Bevacizumab Prolongs Survival of Glioma-bearing Animals Compared to Systemic Delivery  
  Wang W, Sivakumar W, Torres S, Jhaveri N, Vaikari WP, Gong A, Howard A, Golden EB, Louie SG, Schonthal AH, Hofman FM, Chen TC, Focus, 1/1/2015
• Quinoline-based antimalarial drugs: a novel class of autophagy inhibitors  
  Golden EB, Cho HY, Hofman FM, Louie SB, Schonthal AH, Chen TC, Focus, 1/1/2015
• A novel temozolomide analog, NEO212, with enhanced activity against MGMT-positive melanoma in vitro and in vivo  
  Chen TC, Cho HY, Wang W, Nguyen J, Jhaveri N, Rosenstein-Sisson R, Hofman FM,Schonthal AH, Cancer Letters, 1/1/2015
• Neuro-oncology: Update on therapeutic options  
  Bruce J, Chen TC, Fults D (eds), Neurosurgical Focus, 1/1/2015
• A novel perillyl-alcohol temozolomide conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo  
  Chen TC, Cho H, Wang W, Barath M, Sharma N, Hofman FM, Schonthal AH, Mol Canc Ther, 1/1/2014
• Tumor vasculature and glioma stem cells: Contributions to glioma progression  
  Jhaveri N, Chen TC, Hofman FM, Cancer, 1/1/2014
• Development of metronomic biofeedback pump for leptomeningeal carcinomatosis: technical note  
  Chen TC, Napolitano GR, Adell F, Schonthal AH, Shachar Y, J Neurosurg, 1/1/2014
• Glioblastoma: an update on pathophysiology and management strategies  
  Berger TC, Chen TC (eds), Neurosurgical Focus, 1/1/2014
• Repositioning of verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I  
  S. Thomas, N. Sharma, R. Gonzalez, P.-W. Pao, F.M. Hofman, T.C. Chen, S.G. Louie, M.C. Pirrung, A.H. Sconthal, PLoS ONE, 1/1/2013
• Exploring the therapeutic efficacy of glioma vaccines based on allo- and syngeneic antigens and distinct immunological costimulation activators  
  Stathopoulos A, Pretto C, Devillier L, Pierre D, Hofman FM, Epstein AL, Farghadani H, Kruse CA, Jadus MR, Chen TC, Schijns VE, J Clin and Cell Immunol, 1/1/2012
• Fasting enhances the response of gliomas to radiation and chemotherapy  
  Safdie F, Brandhorst S, Wei M, Wang W, Lee C, Hwang S, Chen TC, Longo V, PloS One, 1/1/2012
• Perillyl alcohol for the treatment of temozolomide resistant malignant gliomas  
  Cho HY, Wang W, Jhaveri N, Torres S, Tseng J, Leong MN, Lee DJ, Goldkorn A, Xu T, Petasis N, Chen TC, Mol Cancer Therapeutics, 1/1/2012
• Effective conversion of irinotecan to SN-38 after intratumoral drug delivery to an intracranial murine glioma model in vivo  
  Wang W, Ghandi A, Liebes L, Louie SG, Hofman FM, Schonthal AH, Chen TC, J Neurosurg, 1/1/2011
• Epigallocatechin gallate from green tea enhances the cytotoxic effects of temozolomide in malignant gliomas  
  Chen TC, Wang W, Golden E, Sivakumar W, Ye W, Schonthal AH, Cancer Lett, 1/1/2011
• A Phase I/II study of orally administered synthetic hypericin for treatment of recurrent malignant gliomas  
  Couldwell WT, Surnock A, Tobia A, Cabana B, Stillerman CB, Forsyth P, Appley A, Spence A, Chen TC, Cancer, 1/1/2011
• Noscapine inhibits tumor growth in TMZ-resistant gliomas  
  Jhaveri N, Cho H, Torres S, Wang W, Schonthal AH, Petasis NA, Louie SG, Hofman FM, Chen TC, Cancer Letters, 1/1/2011
• A-Mode ultrasound guidance for pedicle screw advancement in ovine vertebral bodies  
  Raphael D, Chang JH, Zhang, YP, Kudija D, Chen TC, Shung KK, Spine Journal, 1/1/2010
• Enhanced efficancy of prodrug activation therapy by tumor-selective replicating retrovirus vectors armed with the Escherichia coli purine nucleoside phosphorylase gene  
  Tai CK, Wang W, Lai YH, Logg CR, Parker WB, Li YF, Hong JS, Sorscher EJ, Chen TC, Kasahara N, Cancer Gene Ther, 1/1/2010
• A novel method for administering intrathecal chemotherapy in patients with leptomeningeal metastases and shunted hydrocephalus: case report  
  Zada G, Chen TC, Neurosurgery: Neurosurgery, 1/1/2010
• Antiangiogenic activities of 2,5 Dimethylcelecoxib on tumor vasculature  
  Virrey JJ, Liu Z, Cho HY, Kardosh A, Golden EB, Louie SG, Gaffney KJ, Petasis NA, Schonthal A, Chen TC, Hofman F, Mol Cancer Ther, 1/1/2010
• Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress  
  Cho HY, Thomas S, Golden EB, Gaffney KJ, Hofman FM, Chen TC, Louie SG, Petasis NA, Schönthal AH, Cancer Lett, 1/8/2009
• Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors  
  Golden EB, Lam PY, Kardosh A, Gaffney KJ, Cadenas E, Louie SG, Petasis NA, Chen TC, Schonthal AH, Blood, 1/1/2009
• Glioma associated endothelial cells are chemoresistant to temozolomide  
  Virrey J, Hofman F, Chen TC, J Neuro-oncol, 1/1/2009
• The effect of an intensive, progressive exercise program on functional performance in patients post single-level lumbar microdiscectomy  
  Kulig K, Beneck GJ, Selkowitz DM, Popovich JM Jr., Ge TT, Flanagan SP, Poppert EM, amada K, Powers CM, Azen S, Winstein CJ, Gordon J, Samudrala S, Chen TC, Shamie N, K..., Physical Therapy, 1/1/2009
• Pharmacogenomics of brain cancer and personalized medicine in malignant gliomas  
  Shai RM, Reichardt JKV, Chen TC, Future Oncol, 1/1/2009
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Books/Book Chapters

• Spine Surgery Techniques, Complications, Avoidance, and Management 
  Chapter: Cervical Spine Trauma 
  Page 625 - 641Chen TC, Vaccaro A, Stillerman CEditors: Benzel EC.Edition 3rd,2012
• Spine Surgery Techniques, Complications, Avoidance, and Management 
  Chapter: Thoracic Discectomy 
  Page 741 - 757Chen TC, Benzel E, Stillerman CEditors: Benzel EC.Edition 3rd,2012
• Controversies in Neuro-oncology: Avastin and Gliomas 
  Editors: Chen TC, Chamberlain MC.Bentham Books2011
• Emerging Therapeutic Targets and Agents or Glioblastoma Therapy 
  Chapter: Active immuunotherapy against malignant glioblastoma 
  Hofman F, Stathopoulos A, Kruse C, Chen TC, Schijns VEJCEditors: Lo HW.2011
• The Unfolded Protein Response and Cellular Stress, Part C. Methods in Enzymology 
  Chapter: Modulation of GRP78/BiP in altering sensitivity to chemotherapy 
  Chen TCEditors: Conn MP.2011
• Controversies of Neuro-oncology 
  Chapter: Bevacizumab for malignant gliomas: comparative study with other malignancies 
  Gu H, Chen TCEditors: Chen TC and Chamberlain MC.Bentham Books2011
• Controversies of Neuro-oncology 
  Chapter: The basic science of avastin (bevacizmab therapy) 
  Hofman FM, Chen TCEditors: Chen TC and Chamberlain MC.Bentham Books2011
• Anti-Cancer Agents in Medicinal Chemistry 
  Chapter: Immunotherapy of Malignant Gliomas Using Autologous and Allogeneic Tissue Cells 
  Hofman FM, Stathopoulos A, Kruse CA, Chen TC, Schijns VEJC2010
• Methods of Cancer Diagnosis, Therapy, and Prognosis Brain Cancer. Series: Methods of Cancer Diagnosis, Therapy and Prognosis 
  Chapter: Anti-Vascular Therapy for Brain Tumors 
  Hofman FM, Chen TC.Editors: Hayat, M. A..Springer2010
• CNS Cancer 
  Chapter: Targeting endoplasmic reticulum stress for malignant gliomas 
  Page 1037 - 1057Pyrko P, Schonthal AH, Chen TCEditors: Van Meier EG.Humana Press2009
• Neuro-Oncology Textbook 
  Chapter: Adult Supratentorial Primitive Neuroectodermal Tumors 
  Chamberlain MC, Cummins D, Kim S, Chen TCElsevier Science, Philadelphia, PA2003
• Youmans Neurological Surgery 
  Chapter: Intradiskal and Percutaneous Treatment of Lumbar Disk Disease 
  Chen TC, Khoo L, Stillerman CBElsevier Science2003
• ACS Atlas of Tumor Biology: Germ Cell Tumors 
  Chapter: Management of brain metastasis 
  Quinn D, Streeter O E, Chen TCEditors: Raghavan, D.2002
• The Thoracic Spine 
  Chapter: Algorithm for Management 
  Page 304 - 310Stillerman CB, Chen TC, Couldwell WT, Weiss MHEditors: Benzel EC, Stillerman CB.1999
• The Thoracic Spine 
  Chapter: The osteopenic patient 
  Page 457 - 480Hollowell JP, Chen TCEditors: Benzel EC, Stillerman CB.1999
• The Thoracic Spine 
  Chapter: Transfacet Pedicle-Sparing Approach 
  Page 338 - 345Stillerman CB, Chen TC, Couldwell WT, Weiss MHEditors: Benzel EC, Stillerman CB.1999
• The Gliomas 
  Chapter: Tumor removal devices 
  Page 1437 - 1449Day JD, Chen TC, Apuzzo MLJEditors: Berger MS, Wilson CB.1999
• Handbook of Clinical Neurology 
  Chapter: Principles and New Techniques in Neurosurgery 
  Chen TC, Apuzzo MLJ1998
• Cancer of the Nervous System 
  Chapter: Principles of Stereotactic Neurosurgery 
  Page 156 - 178Chen TC, Apuzzo MLJEditors: Black PM, Loeffler JS.Blackwell Science1997
• Textbook of Stereotactic Surgery 
  Chapter: Techniques of stereotactic biopsy 
  Chen TC, Apuzzo MLJEditors: Gildenberg PL, Tasker R.1997
• Surgery of the Third Ventricle 
  Chapter: Colloid cysts 
  Page 1071 - 1132Chen TC, Krieger M, Apuzzo MLJEdition 2nd,1996
• Surgery of the Third Ventricle 
  Chapter: Applications of stereotactic procedures to tumors of the third ventricle 
  Page 847 - 884Chen TC, Lavine S, Amar A, Apuzzo MLJEditors: Apuzzo MLJ.Edition 2nd,1996
• Practice of Neurosurgery 
  Chapter: Closed spinal neural tube defects 
  Page 2753 - 2779McComb JG, Chen TCEditors: Tindall GT, Cooper PR, Barrow DL.Williams & Wilkins1996
• Youman's Neurological Surgery 
  Chapter: Diagnostic biopsy for neurological disease 
  Page 315 - 349Chen TC, Hinton DR, Apuzzo MLJW.B. SaundersEdition 4th,1996
• Benign Cerebral Gliomas 
  Chapter: Malignant progression in gliomas 
  Page 181 - 189Chen TC, Hinton DR, Apuzzo MLJEditors: Apuzzo MLJ.American Association of Neurological Surgeons, Park Ridge, IL1995
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Abstracts/Posters

• Metronomic biofeedback pump and the vision of local delivery
  Chen TC, Case Western Reserve, 1/30/2015
• NEO212: A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against temozolomide resistant gliomas and intracranial triple negative breast cance...
  Chen TC, Asilomar, 1/22/2014
• C2 fracture/odontoid
  Chen TC, AO Spine, Davos, Switzerland, 1/14/2014
• Nonoperative treatment of thoracolumbar fractures
  Chen TC, AO spine, Davos, Switzerland, 1/14/2014
• Chance fractures
  Chen TC, Chance fractures –Expert opinion and lecture, AO Spine, Davos, Switzerland, 1/14/2014
• Inhalational Therapy of NEO100 for the treatment of recurrent malignant gliomas: Upcoming Phase IIa trial
  Chen TC, Fonseca C, Cho H, Wang W, Hofman F, Schwartzmann G, Society of Neuro-oncology, Miami, FL, 1/13/2014
• Intratumoral bevacizumab is more effective than intravenous bevacizumab in treating intracranial glioblastomas
  Chen TC, Wang W, Hofman F, NY Academy Sciences, 1/1/2014
• Temozolomide-perillyl alcohol conjugate is cytotoxic for glioma cancer stem cells
  Jhaveri N, Agasse F, Hofman FM, Chen TC, Tumor Invasion and Metastasis, AACR Conference, San Diego, CA, 1/2/2013
• Implanted metronomic biofeedback pump for treatment of leptomeningeal carcinomatosis
  Chen TC, 2nd International Meeting for the Society for Interstitial Delivery of Therapeutics (SCIDOT), Chicago, IL, 1/5/2012
• Metronomic local delivery using an implanted biofeedback pump
  Chen TC, Wu W, Jordan H, Chan H, Shachar J, 11th US-Japan Symposium on Drug Delivery Systems, Maui, Hawaii, 1/16/2011
• Noscapine is effective for TMZ resistant gliomas
  Javeri N, Cho H, Torres S, Wang W, Schonthal A, Petasis N, Louie SG, Hofman F, Chen TC, Soc of Neuro-oncology (SNO), Anaheim, CA, 1/1/2011
• Intranasal perillyl alcohol for the treatment of malignant gliomas: preclinical validation
  Cho H, Wang W, Weintraub M, Jhaver N, Torres S, Petasiss N, Schonthal A, Louie SG, Hofman FM, Chen TC, Society of Neuro-oncology (SN), Anaheim, CA, 1/1/2011
• Intatumoral delivery of bevacizumab inhibits angiogenesis and cancer stem cells compared to intravenous bevaciuzmab
  Torres, S, Jhaveri N, Wang W, Schonthal AH, Louie SG, Hofman FM, Chen TC, Society of Neuro-oncology (SNO), Anaheim, CA, 1/1/2011
• Interleukin-11 induces survivin expression in brain endothelial cells
  Zhi Liu, Yuan R, Armstrong D, Louie S, Schonthal AH, Chen TC, Hofman FH, AACR, WA, 1/1/2010
• Use of PET imaging for in- vivo monitoring of replication competent retrovirus (RCR) transduction of malignant gliomas
  Wang W, Park R, Cai H, Conti PS, Kasahara N, Chen TC, American Society Gene Therapy (ASGT), WA, 1/1/2010
• Monomeric disintegrin vicrostatin inhibits glioma cell growth and angiogenesis in-vivo
  Chen TC, CNS, San Francisco, CA, 1/1/2010
• Fasting sensitizes glioma to radiation and multiple chemotherapies
  Chen TC, CNS, San Francisco, CA, 1/1/2010
• Development of a personalized chemotherapy treatment paradigm for leptomeningeal carcinomatosis
  Chen TC, Wu W, Jordan B, Chan H, Zimmerman K, Shachar J, CNS, San Francisco, CA, 1/1/2010
• Metronomic delivery of chemotherapeutic agents using an implanted pump for treatment of leptomeningeal carcinomatosis
  Chen TC, Wu W, Jordan B, Chan H, Zimmerman K, Schachar J, International Drug Discovery and Technology, Beijing, 1/1/2010
• Heterocellular contracts between endothelial cells and subventricular zone cells modulate stem/progenitor cell neurogenic capacities: evidence for involvement of lamin...
  Rosa Al, Hofman FM, Chen TC, Melva JO, Agasse F, Society of Neuroscience Meeting, San Diego, CA, 1/1/2010
• Use of sorafenib in the treatment of meningiomas
  Chen TC, Society of Neuro-oncology, Montreal, Canada, 1/1/2010
• 2,5 Dimethyl-celecoxib exerts anti-angiogenic effects on the tumor vasculature
  Virrey JJ, Kardosh A, Golden EB, Louie SG, Petasis NA, Schonthal AH, Chen TC, Hofman FM, American Association Cancer Research, CO, 1/18/2009
• Green tea products extinguish therapeutic efficacy of proteasome inhibitors, such as bortezomib, in vitro and in vivo
  Golden EB, Kardosh A, Chen TC, Hofman FM, Louie SG, Petasis NA, Schonthal AH, American Association of Cancer Research, CO, 1/18/2009
• Temozolomide and chloroquine trigger glioblastoma cell death via enhanced induction of the apoptotic arm of the endoplasmic reticulum stress response
  Golden EB, Louie SG, Schonthal AH, Chen TC, American Association of Cancer Research, CO, 1/18/2009
• An implantable magnetic breather pump for metronomic convection enhanced delivery of biological agents in malignant gliomas
  Chen TC, Shachar JY, Farkas L, Wu WH, Zimmerman KN, Cerf M, Adell F, World Federaton Neuro-oncology, Yokohoma, Japan, 1/11/2009
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Lectures

• Management of Malignant Gliomas 
  Tsingtao, China - 1/29/2011
• Immunotherapy for Malignant Gliomas: Potential Collaborations 
  Luzhou, China - 1/27/2011
• Malignant Gliomas: Potential Future Treatments 
  1/26/2011
• Inhalational chemotherapy for brain tumors 
  1/24/2011
• Multimodality treatment of brain cancer: current concepts and recent advances 
  1/24/2011
• Perillyl alcohol derivatives for the treatment of malignant gliomas 
  Dalian, China - 1/23/2011
• Metronomic delivery of chemotherapeutic agents using an implantable pump for treatment of leptomeningeal carcnomatosis 
  Beijing, China - 1/1/2010
• The academic medical center and development of novel therapies for malignant gliomas 
  Irvine, CA - 1/1/2010
• Metastatic spine tumors 
  Los Angeles, CA - 1/1/2009
• Use of carbon nanotubes for treatment of malignant gliomas 
  Descanso Gardens, CA - 1/1/2009
• Spine Research Updates at USC 
  Los Angeles, CA - 1/1/2009
• Use of carbon nanotubes in the treatment of malignant gliomas 
  1/1/2009
• Past immunotherapy trials and malignant gliomas: what can we learn from previous trials? 
  Paris, France - 1/1/2009
• Perillyl alcohol: future directions 
  Rio de Janeiro, Brazil - 1/1/2009
• Establishment of International Brain Tumor Bank Consortium 
  Belgium - 1/1/2009
• Current and Future Treatments of Malignant Gliomas 
  Tainan, Taiwan - 1/1/2009
• Management of Spine and Spinal Cord Tumors 
  Tainan, Taiwan - 1/1/2009
• Use of endoplasmic reticulum stress to induce apoptosis in glioma cancer stem cells 
  Catalina Island, CA - 1/1/2009
• Development of novel cancer therapeutics based on induction of ER stress 
  Los Angeles, CA - 1/1/2009
• Treatment of Malignant Gliomas 
  Los Angeles, CA - 1/1/2009
• Treatment of malignant gliomas. USC Oncology Fellows Lecture 
  Los Angeles, CA - 1/1/2009
• Efficacy of noscopine as therapeutic or chemosensitizing agent for glioma therapy 
  Los Angeles, CA - 1/1/2009
• What is in the pipeline for neuro-oncology at USC? 
  Los Angeles, CA - 1/1/2009
• Replication Competent Retroviruses for Gene Therapy of Malignant Gliomas 
  San Francisco, CA - 1/1/2006
• My Aching Back 
  Industry City, CA - 1/1/2004
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Other

• The Choroid Plexus and Cerebrospinal Fluid: Emerging Roles in CNS Development, Maintenance, and Disease Progression 
  Neman J, Chen T (ed)
  1/1/2015
• Deuterated POH and its derivatives for increasing stability 
  
  1/1/2011
• Use of noscapine for temozolomide resistant malignant gliomas 
  
  1/1/2011
• Pharmaceutial compositions comprising isoPOH derivatives 
  
  1/1/2010
• Pharmaceutical compositions comprising POH derivatives 
  
  1/1/2010
• An apparatus for detecting and regulating vascular endothelial growth factor (VEGF) by forming a homeostatic loop employing a half-antibody biosensor 
  
  1/1/2010
• An enhanced method for delivering gene therapy vector into a tumor or targeted organ using an implanted metronomic biofeedback pump 
  
  1/1/2010
• Pharmaceutical compositions comprising monoterpenes 
  
  1/1/2010
• An implantable inertial based sensing system for real-time, in vivo detection of spinal pseudarthrosis and adjacent segment motion 
  
  1/1/2010
• Metronomic convection enhanced delivery of intrathecal chemotherapy using an implanted magnetic breather pump (MBP) for leptomeningeal carcinomatosis 
  
  1/1/2009
• A remotely activated piezoelectric pump for delivery of biological agents to the intervertebral disc and spine 
  
  1/1/2009
• An enhanced method for delivering becvacizumab (Avastin) into a brain tumor using an implanted magnetic breather pump 
  
  1/1/2009
• Method and apparatus for forming a homeostatic loop employing an aptamer biosensor 
  
  1/1/2009
• Therapeutic compositions comprising monoterpenes 
  USC file
  1/1/2009
• Radiosurgery compatible bone anchor 
  
  1/1/2009
• Brain retractor apparatus for measuring and predicting electrophysiological parameters 
  
  1/1/2009
• A magnetic breather pump and a method for treating a brain tumor using the same 
  
  1/1/2008
• Improved radiation and drug delivery method and apparatus: spine brachytherapy 
  
  1/1/2008
• Methods & compositions for inducing apoptosis by stimulating ER stress 
  USC file
  1/1/2008
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