ThomasPLoughranMD

PubMed

• 4 citations
  DJ4 Targets the Rho-Associated Protein Kinase Pathway and Attenuates Disease Progression in Preclinical Murine Models of Acute Myeloid Leukemia.
  Upendarrao Golla, Melanie A. Ehudin, Charyguly Annageldiyev, Zheng Zeng, Diwakar Bastihalli Tukaramrao, Abhijit A. Date, Irina Elcheva, Arthur Berg, Shantu Amin, Thoma...> ;Cancers. 2021 Sep 29
• 24 citations
  Frequent somatic TET2 mutations in chronic NK-LGL leukemia with distinct patterns of cytopenias
  Thomas L. Olson, Hee Jin Cheon, Jeffrey C. Xing, Kristine C. Olson, Umadevi Paila, Cait E. Hamele, Yaseswini Neelamraju, Bryna C. Shemo, Matt Schmachtenberg, Shriram K...> ;Blood. 2021 Aug 26
• 9 citations
  Intergenerational marijuana use: A life course examination of the relationship between parental trajectories of marijuana use and the onset of marijuana use by offspring.
  Megan Bears Augustyn, Thomas A. Loughran, Pilar Larroulet, Celia J. Fulco, Kimberly L. Henry> ;Psychology of Addictive Behaviors. 2020 Dec 1
• 5 citations
  Large Granular Lymphocyte Leukemia and Precapillary Pulmonary Hypertension.
  Brieuc Cherel, Marc Humbert, Francis R LeBlanc, Renato Zambello, Mohamed Hamidou, François Lifermann, David Montani, Matteo Leoncin, Olivier Decaux, Cedric Pastoret, A...> ;Chest. 2020 Sep 10
• 9 citations
  Large granular lymphocyte leukemia serum and corresponding hematological parameters reveal unique cytokine and sphingolipid biomarkers and associations with STAT3 muta...
  Kristine C. Olson, Katharine B. Moosic, Marieke K. Jones, Paige M. K. Larkin, Thomas L. Olson, Mariella F. Toro, Todd E. Fox, David J. Feith, Thomas P. Loughran> ;Cancer Medicine. 2020 Jul 25
• 2 citations
  T‐cell large granular lymphocytic leukemia successfully treated with oral cyclosporine in a child: Case report and review of literature
  Nupur Mittal, Thomas P. Loughran, Angela Rivers> ;Pediatric Blood & Cancer. 2020 Jun 26
• 2 citations
  How Early Is Too Early? Identification of Elevated, Persistent Problem Behavior in Childhood
  Megan Bears Augustyn, Thomas A. Loughran, Pilar Larroulet Philippi, Terence P. Thornberry, Kimberly L. Henry> ;Prevention Science. 2020 May 1
• 13 citations
  The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia.
  Charyguly Annageldiyev, Su Fern Tan, Shreya Thakur, Pavan Kumar Dhanyamraju, Srinivasa R. Ramisetti, Preeti Bhadauria, Jacob Schick, Zheng Zeng, Varun Sharma, Wendy Du...> ;Frontiers in Oncology. 2020 Apr 1
• 17 citations
  Sphingosine kinase‐2 is overexpressed in large granular lymphocyte leukaemia and promotes survival through Mcl‐1
  Francis R LeBlanc, Jennifer M. Pearson, Su Fern Tan, HeeJin Cheon, Jeffrey C. Xing, Wendy Dunton, David J. Feith, Thomas P. Loughran> ;British Journal of Haematology. 2020 Mar 2
• 20 citations
  Ceramide Analogue SACLAC Modulates Sphingolipid Levels and MCL-1 Splicing to Induce Apoptosis in Acute Myeloid Leukemia
  Jennifer M. Pearson, Su Fern Tan, Arati Sharma, Charyguly Annageldiyev, Todd E. Fox, José Luis Abad, Gemma Fabriàs, Dhimant Desai, Shantu Amin, Hong Gang Wang, Myles C...> ;Molecular Cancer Research. 2020 Mar 1
• 11 citations
  The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia.
  Charyguly Annageldiyev, Krishne Gowda, Trupti Patel, Priyanjali Bhattacharya, Su Fern Tan, Soumya Iyer, Dhimant Desai, Sinisa Dovat, David J. Feith, Thomas P. Loughran...> ;Haematologica. 2020 Mar 1
• 32 citations
  Advances in the Diagnosis and Treatment of Large Granular Lymphocytic Leukemia.
  HeeJin Cheon, Karolina H. Dziewulska, Katharine B. Moosic, Kristine C. Olson, Alejandro A. Gru, David J. Feith, Thomas P. Loughran> ;Current Hematologic Malignancy Reports. 2020 Feb 15
• 4 citations
  Retroviral sero-reactivity in LGL leukaemia patients and family members.
  Susan B. Nyland, David J. Feith, Mary Poss, Thomas L. Olson, Daniel J. Krissinger, Bernard J. Poiesz, Francis W. Ruscetti, Thomas P. Loughran> ;British Journal of Haematology. 2020 Feb 1
• 1 citations
  Whole Genome Sequencing of Spontaneously Occurring Rat Natural Killer Large Granular Lymphocyte Leukemia Identifies JAK1 Somatic Activating Mutation
  T. Tiffany Wang, Jun Yang, Shubha Dighe, Matthew W. Schmachtenberg, Nathan T. Leigh, Emily Farber, Suna Onengut-Gumuscu, David J. Feith, Aakrosh Ratan, Thomas P. Lough...> ;Cancers. 2020 Jan 3
• 22 citations
  Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia
  Brian M. Barth, Weiyuan Wang, Paul T. Toran, Todd E. Fox, Charyguly Annageldiyev, Regina M. Ondrasik, Nicole R. Keasey, Timothy J Brown, Viola Devine, Emily Sullivan, ...> ;Blood Advances. 2019 Sep 10
• 9 citations
  Genomics of LGL leukemia and select other rare leukemia/lymphomas.
  Katharine B. Moosic, Umadevi Paila, Kristine C. Olson, Karolina H. Dziewulska, T. Tiffany Wang, Jeffrey C. Xing, Aakrosh Ratan, David J. Feith, Thomas P. Loughran, Tho...> ;Best Practice & Research. Clinical Haematology. 2019 Sep 1
• 19 citations
  Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells.
  Li-Pin Kao, Samy A.F. Morad, Traci S. Davis, Matthew R. MacDougall, Miki Kassai, Noha Abdelmageed, Todd E. Fox, Mark Kester, Thomas P. Loughran, José L. Abad, Gemma Fa...> ;Journal of Lipid Research. 2019 Jul 30
• 13 citations
  Pivotal role of mitophagy in response of acute myelogenous leukemia to a ceramide-tamoxifen-containing drug regimen
  Samy A.F. Morad, Matthew R. MacDougall, Noha Abdelmageed, Li-Pin Kao, David J. Feith, Su Fern Tan, Mark Kester, Thomas P. Loughran, Hong Gang Wang, Myles C. Cabot> ;Experimental Cell Research. 2019 Aug 15
• 10 citations
  Retrovirus insertion site analysis of LGL leukemia patient genomes.
  Weiling Li, Lei Yang, Robert S. Harris, Lin Lin, Thomas L. Olson, Cait E. Hamele, David J. Feith, Thomas P. Loughran, Mary Poss> ;BMC Medical Genomics. 2019 Jun 17
• 31 citations
  IL-2 and IL-15 blockade by BNZ-1, an inhibitor of selective γ-chain cytokines, decreases leukemic T-cell viability
  T. Tiffany Wang, Jun Yang, Yong Zhang, Meili Zhang, Sigrid Dubois, Kevin C. Conlon, Yutaka Tagaya, Cait E. Hamele, Shubha Dighe, Thomas L. Olson, David J. Feith, Nazli...> ;Leukemia. 2019 May 1
• Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-kB-dependent P-glycoprotein upregulation.
  Tan, S. F.,Dunton, W.,Liu, X.,Fox, T. E.,Morad, SAF.,Desai, D.,Doi, K.,Conaway, M. R.,Amin, S.,Claxton, D. F.,Wang, H. G.,Kester, M.,Cabot, M. C.,Feith, D. J.,Loughran...> ;J. Lipid Res.. 2019 Apr 10
• 17 citations
  Vitamin D pathway activation selectively deactivates signal transducer and activator of transcription (STAT) proteins and inflammatory cytokine production in natural k...
  Kristine C. Olson, Paige M. K. Larkin, Rossana Signorelli, Cait E. Hamele, Thomas L. Olson, Mark R. Conaway, David J. Feith, Thomas P. Loughran> ;Cytokine. 2018 Nov 1
• 1 citations
  Restoring the Long Noncoding RNA MEG3 Indicates a Potential Role for JAK-STAT Signaling in Chronic Myeloid Leukemia.
  Thomas L. Olson, Thomas P. Loughran> ;Ebiomedicine. 2018 Aug 24
• 30 citations
  TRAIL mediates and sustains constitutive NF-κB activation in LGL leukemia.
  Jun Yang, Francis R LeBlanc, Shubha Dighe, Cait E. Hamele, Thomas L. Olson, David J. Feith, Thomas P. Loughran> ;Blood. 2018 Jun 21
• 89 citations
  Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target
  Olli Dufva, Matti Kankainen, Tiina Kelkka, Nodoka Sekiguchi, Shady Adnan Awad, Samuli Eldfors, Bhagwan Yadav, Heikki Kuusanmäki, Disha Malani, Emma I. Andersson, Paavo...> ;Nature Communications. 2018 Apr 19
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Abstracts/Posters

• Blockade of IL-15 Utilizing Bnz-1, a Selective _-Chain Inhibiting Peptide, Is Safe and Has Clinical Activity in Patients with T-Cell Large Granular Lymphocytic Leukemi...
  Thomas P Loughran Jr., 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• GDF1 Regulation of Ceramide Metabolism Restores Effective Hematopoiesis in Myelodysplastic Syndrome
  Thomas P Loughran Jr., 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019