ThomasEWitzigMD

Professor of Medicine, Mayo Alix School of Medicine Consultant, Division of Hematology Co-PI University of Iowa/Mayo Lymphoma SPORE Distinguished Senior Leader in Translational Research, Mayo Clinic Comprehensive Cancer Center

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Office
200 1st St Sw
Rochester, MN 55905
Phone+1 507-284-0527
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Summary

Dr. Thomas Witzig is a hematologist in Rochester, MN and is affiliated with Mayo Clinic Hospital - Rochester. He received his medical degree from University of Illinois College of Medicine and has been in practice 37 years at the Mayo Clinic in Rochester, MN. He is experienced in hematologic oncology (focus lymphoma) and IgG4 related diseases. His lab research is focused on developing new treatments around impairing the DNA damage response in blood cancer cells. He also has a focus on nutrional oncology (Vitamins D, C and Magnesium). He has more than 400 publications.

Education & Training

Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Hematology and Medical Oncology, 1982 - 1986
University of Iowa Hospitals and ClinicsResidency, Internal Medicine, 1979 - 1982
University of Illinois College of MedicineClass of 1979

Certifications & Licensure

MN State Medical License 1982 - 2025
IA State Medical License 1979 - 1982
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Clinical Trials

Fludarabine Plus Octreotide in Treating Patients With Relapsed Low-Grade Non-Hodgkin's Lymphoma Start of enrollment: 1998 Feb 01
Completed
Phase 2
Epoetin Alfa in Treating Anemia in Patients Who Are Receiving Chemotherapy Start of enrollment: 1998 Dec 01
Completed
Phase 3
Chemotherapy in Treating Patients With Previously Untreated Chronic Lymphocytic Leukemia Start of enrollment: 1999 Aug 01
Completed
Phase 2
Rituximab in Treating Patients With Non-Hodgkin's Lymphoma or Hodgkin's Disease Start of enrollment: 1999 Jul 01
Completed
Phase 2
Combination Chemotherapy Plus Rituximab in Treating Patients With Relapsed Non-Hodgkin's Lymphoma Start of enrollment: 2000 Oct 01
Completed
Phase 2
Radiolabeled Monoclonal Antibody Plus Rituximab With and Without Filgrastim and Interleukin-11 in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma Start of enrollment: 2001 Apr 01
Terminated
Phase 1, Phase 2
Rituximab, Combination Chemotherapy, and 90-Yttrium Ibritumomab Tiuxetan for Patients With Stage I or II Non-Hodgkin's Lymphoma Start of enrollment: 2004 Dec 01
Terminated
Phase 2
Monoclonal Antibody Therapy and Combination Chemotherapy in Treating Patients With Stage II, Stage III, or Stage IV Diffuse Large B-Cell Lymphoma Start of enrollment: 2006 Jan 01
Completed
Phase 2
Zoledronate With or Without Thalidomide in Treating Patients With Early Stage Multiple Myeloma Start of enrollment: 2003 Jul 01
Completed
Phase 3
Everolimus in Treating Patients With Lymphoma That Has Relapsed or Not Responded to Previous Treatment Start of enrollment: 2005 Aug 01
Completed
Phase 2
Alefacept in Treating Patients With Relapsed or Refractory Cutaneous T-Cell Lymphoma or Peripheral T-Cell Non-Hodgkin's Lymphoma Start of enrollment: 2006 Mar 01
Completed
Phase 1
Agatolimod Sodium, Rituximab, and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Recurrent or Refractory Non-Hodgkin Lymphoma Start of enrollment: 2004 Oct 01
Completed
Phase 1, Phase 2
Rituximab and Denileukin Diftitox in Treating Patients With Previously Untreated Stage III or Stage IV Follicular B-Cell Non-Hodgkin's Lymphoma Start of enrollment: 2008 Apr 01
Completed
Phase 2
Sorafenib and Everolimus in Treating Patients With Relapsed or Refractory Lymphoma or Multiple Myeloma Start of enrollment: 2007 Aug 29
Completed
Phase 1, Phase 2
Everolimus in Treating Patients With Relapsed or Refractory Multiple Myeloma Start of enrollment: 2005 Mar 01
Completed
Phase 2
Pentostatin, Alemtuzumab, and Rituximab in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Start of enrollment: 2008 Jul 01
Completed
Phase 2
Rituximab, Cyclophosphamide, Bortezomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Low-Grade Follicular Lymphoma, Waldenstrom Macroglobulinemia, or Mantle Cell Lymphoma Start of enrollment: 2008 Aug 01
Completed
Phase 2
Lenalidomide, Rituximab, Cyclophosphamide, and Dexamethasone in Treating Patients With Previously Untreated Low-Grade Non-Hodgkin Lymphoma Start of enrollment: 2008 Nov 01
Completed
Phase 2
Everolimus and Lenalidomide in Treating Patients With Relapsed or Refractory Non-Hodgkin or Hodgkin Lymphoma Start of enrollment: 2011 Jan 10
Completed
Phase 1, Phase 2
Ruxolitinib Phosphate to Treat Diffuse Large B-Cell or Peripheral T-Cell Non-Hodgkin Lymphoma After Stem Cell Transplant Start of enrollment: 2011 Aug 12
Completed
Phase 2
Phase 1/2, Open-label, Dose-escalation Study of IONIS-STAT3Rx, Administered to Patients With Advanced Cancers Start of enrollment: 2012 Feb 27
Completed
Phase 1, Phase 2
Buparlisib in Treating Patients With Relapsed or Refractory Non-Hodgkin Lymphoma Start of enrollment: 2012 Dec 01
Completed
Early Phase 1
Cholecalciferol in Improving Survival in Patients With Newly Diagnosed Cancer With Vitamin D Insufficiency Start of enrollment: 2013 Mar 06
Recruiting
Not Applicable
Salvia Hispanica Seed in Reducing Risk of Disease Recurrence in Patients With Non-Hodgkin Lymphoma Start of enrollment: 2016 Jan 19
Completed
Not Applicable
Ascorbic Acid and Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma, CCUS, and Chronic Myelomonocytic Leukemia Start of enrollment: 2018 Mar 23
Recruiting
Phase 2
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Publications & Presentations

PubMed

Patterns of progression after immune checkpoint inhibitors for Hodgkin lymphoma: implications for radiation therapy.
Jessica F Burlile, Kelsey M Frechette, William G Breen, Steven R Hwang, Alexandra S Higgins, Adrienne N Nedved, William S Harmsen, Sydney D Pulsipher, Thomas E Witzig,...> ;Blood Advances. 2024 Mar 12
Phase III randomized trial of Thal+ZLD versus ZLD in patients with asymptomatic multiple myeloma - updated results after 18-year follow-up.
Nadine Abdallah, Thomas E Witzig, Shaji K Kumar, Martha Q Lacy, Suzanne R Hayman, Angela Dispenzieri, Vivek Roy, Morie A Gertz, P Leif Bergsagel, S Vincent Rajkumar> ;Leukemia. 2024 Feb 28
Rechallenge With High-Dose Methotrexate After Treatment With Glucarpidase in Adult Patients With Lymphoma.
Truong, H., Barreto, J., Mara, K., Hampel, P., Micallef, I., Nowakowski, G., Thanarajasingam, G., Thompson, C., Wang, Y., Witzig, T., Herrmann, S., Leung, N.> ;JCO Oncology Practice. 2024 Feb 26
Follicular lymphoma B cells exhibit heterogeneous transcriptional states with associated somatic alterations and tumor microenvironments.
Jordan E Krull, Kerstin Wenzl, Melissa A Hopper, Michelle K Manske, Vivekananda Sarangi, Matthew J Maurer, Melissa C Larson, Patrizia Mondello, ZhiZhang Yang, Joseph P...> ;Cell Reports. Medicine. 2024 Mar 19
The asymptomatic follicular lymphoma (AFL) trial: single-agent rituximab immunotherapy versus 90Y-ibritumomab tiuxetan radioimmunotherapy (RIT) for patients with new, ...
Laoruangroj, C., Atherton, P., Schumacher, P., Wiseman, G., Ansell, S., Feldman, A., Witzig, T.> ;Leukemia & Lymphoma. 2024 Mar 1
Burkitt Lymphoma Presenting as Ileocolic Intussusception in an Adult.
Borré, C., Boyle, B., Lynch, K., Braithwaite, M., Johnson, I., Kanaparthi, A., Csizmar, C., Larson, D., Witzig, T., Suarez, D.> ;Open Journal of Blood Diseases. 2023 Dec 1
1 citations
Evolving treatment patterns and improved outcomes in relapsed/refractory mantle cell lymphoma: a prospective cohort study.
Allison M Bock, Jennifer J Gile, Melissa C Larson, Kittika Poonsombudlert, Reema K Tawfiq, Seth Maliske, Matthew J Maurer, Brian F Kabat, Jonas Paludo, David J Inwards...> ;Blood Cancer Journal. 2023 Nov 13
Development and validation of a model to predict acute kidney injury following high-dose methotrexate in patients with lymphoma.
Mikhaila L Rice, Erin F Barreto, Andrew D Rule, Catherine E Martin, Huong L Truong, Kristin C Mara, Kianoush B Kashani, Carrie A Thompson, Thomas E Witzig, Jason N Bar...> ;Pharmacotherapy. 2024 Jan 1
1 citations
Dependence of peripheral T-cell lymphoma on constitutively activated JAK3: Implication for JAK3 inhibition as a therapeutic approach.
Kang Le, Jordan Vollenweider, JingJing Han, Nicholas Staudinger, Mary Stenson, Lara Bayraktar, Linda E Wellik, Matthew J Maurer, Ellen D McPhail, Thomas E Witzig, Mamt...> ;Hematological Oncology. 2024 Jan 1
Prognostic relevance of clonal hematopoiesis in myeloid neoplastic transformation in patients with follicular lymphoma treated with radioimmunotherapy.
Zhuoer Xie, Terra Lasho, Arushi Khurana, Alejandro Ferrer, Christy Finke, Abhishek A Mangaonkar, Stephen Ansell, Jenna Fernandez, Mithun Vinod Shah, Aref Al-Kali, Nase...> ;Haematologica. 2024 Feb 1
Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in patients with severe COVID-19.
Xiaosheng Wu, Michelle K Manske, Gordon J Ruan, Taylor L Witter, Kevin E Nowakowski, Jithma P Abeykoon, Xinyi Tang, Yue Yu, Kimberly A Gwin, Annie Wu, Vanessa Taupin, ...> ;Iscience. 2023 Jun 16
Central nervous system involvement (Bing-Neel Syndrome) in patients with Waldenström macroglobulinemia.
Saurabh Zanwar, Jithma P Abeykoon, Stephen M Ansell, Morie A Gertz, Michelle Mauermann, Thomas E Witzig, Patrick Johnston, Robert A Kyle, Rebecca L King, Thomas M Habe...> ;Leukemia & Lymphoma. 2023 Jun 10
1 citations
Relationship between BCL2 mutations and follicular lymphoma outcome in the chemoimmunotherapy era.
Cristina Correia, Matthew J Maurer, Samantha J McDonough, Paula A Schneider, Paige E Ross, Anne J Novak, Andrew L Feldman, James R Cerhan, Susan L Slager, Thomas E Wit...> ;Blood Cancer Journal. 2023 May 17
4 citations
Barriers to enrollment in clinical trials of patients with aggressive B-cell NHL that progressed after CAR T-cell therapy.
Bezerra, E., Iqbal, M., Munoz, J., Khurana, A., Wang, Y., Maurer, M., Bansal, R., Hathcock, M., Bennani, N., Murthy, H., Rosenthal, A., Paludo, J., Villasboas, J., Joh...> ;Blood Advances. 2023 Apr 25
1 citations
Outcomes of Patients With Classic Hodgkin Lymphoma Who Relapsed After Autologous Stem Cell Transplant.
Yucai Wang, Aasiya Matin, David J Inwards, Thomas M Habermann, Ivana Micallef, Patrick B Johnston, Luis Porrata, Jonas Paludo, Jose Villasboas Bisneto, Allison Rosenth...> ;Hemasphere. 2023 Apr 1
1 citations
Functional humoral and cellular response of monovalent COVID-19-vaccines against Omicron BA.2 variant of SARS-CoV-2 in patients with chronic lymphocytic leukemia.
Matteo Passerini, Tamar Ratishvili, Jonathon M Monroe, Zelalem Temesgen, Thomas E Witzig, Neil E Kay, Richard B Kennedy, Sameer A Parikh> ;Leukemia & Lymphoma. 2023 Apr 1
Tissue Inhibitor Metalloproteinase-2 and Insulin-Like Growth Factor Binding Protein-7 Kinetics Following Exposure to High-Dose Methotrexate.
Jason N Barreto, Erin F Barreto, Kristin C Mara, Andrew D Rule, John C Lieske, Callen D Giesen, Carrie A Thompson, Nelson Leung, Thomas E Witzig, Kianoush B Kashani> ;Kidney360. 2023 May 1
Yttrium-90 Ibritumomab Tiuxetan is Cost-Effective Compared to Bendamustine + Rituximab in Low-grade Lymphomas.
Muhamad Alhaj Moustafa, Bijan J Borah, James P Moriarty, Ruchita Dholakia, Liuyan Jiang, Ke Li, Thomas E Witzig, Bradford S Hoppe, Jennifer Peterson, James R Cerhan, H...> ;Clinical Lymphoma, Myeloma & Leukemia. 2023 Apr 1
4 citations
Durvalumab as monotherapy and in combination therapy in patients with lymphoma or chronic lymphocytic leukemia: The FUSION NHL 001 trial.
Carla Casulo, Armando Santoro, Guillaume Cartron, Kiyoshi Ando, Javier Munoz, Steven Le Gouill, Koji Izutsu, Simon Rule, Pieternella Lugtenburg, Jia Ruan, Luca Arcaini...> ;Cancer Reports. 2023 Jan 1
4 citations
Survival trends in young patients with Waldenström macroglobulinemia: Over five decades of experience.
Karan L Chohan, Jonas Paludo, Nishanth Vallumsetla, Dirk Larson, Rebecca L King, Rong He, Wilson Gonsalves, David Inwards, Thomas E Witzig, Abhisek Swaika, Tania Jain,...> ;American Journal of Hematology. 2023 Mar 1
5 citations
Central nervous system involvement by mantle cell lymphoma.
Nicole McLaughlin, Yucai Wang, Thomas Witzig, Jose Villasboas, Thomas Habermann, David Inwards, Nora Bennani, Gita Thanarajasingam, Grzegorz Nowakowski, Luis Porrata, ...> ;Leukemia & Lymphoma. 2023 Feb 1
1 citations
Cell of origin is not associated with outcomes of relapsed or refractory diffuse large B cell lymphoma.
Sanjal H Desai, Raphael Mwangi, Alexandra N Smith, Matthew J Maurer, Umar Farooq, Rebecca L King, James R Cerhan, Andrew L Feldman, Thomas M Habermann, Carrie A Thomps...> ;Hematological Oncology. 2023 Feb 1
1 citations
High-Dose Methotrexate in Patients With Lymphoma: Predictors of a Complicated Course.
Darragh F O'Donoghue, Huong L Truong, Heidi D Finnes, Jennifer S McDonald, Heather P May, Stephen M Ansell, N Nora Bennani, Thomas M Habermann, David J Inwards, Patric...> ;JCO Oncology Practice. 2022 Dec 1
2 citations
The Tumor Suppressor Protein TRAF3 Modulates GSK3 Activity and Susceptibility of B Lymphoma Cells to GSK3 Inhibition.
Emma L Hornick, Laura L Stunz, Xiaosheng Wu, Thomas E Witzig, Gail A Bishop, Shakoora Sabree> ;Cancers. 2022 Oct 14
13 citations
Outcomes After Treatment With Cobimetinib in Patients With Rosai-Dorfman Disease Based on KRAS and MEK Alteration Status.
Jithma P Abeykoon, Karen L Rech, Jason R Young, Aishwarya Ravindran, Gordon J Ruan, Surendra Dasari, Diana M Morlote, Rebecca L King, Claire Rummage, Saurabh Zanwar, A...> ;JAMA Oncology. 2022 Dec 1
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Journal Articles

Primary Systemic Amyloidosis in Patients with Waldenström Macroglobulinemia
Angela Dispenzieri, Eli Muchtar, Ronald Go, Saurabh Zanwar, Surbhi Sidana, Francis Buadi, Stephen M Ansell, Prashant Kapoor, David Dingli, Thomas Habermann, Shaji Kuma..., Nature
Targeting CD38 with Daratumumab Is Lethal to Waldenström Macroglobulinaemia Cells
Richard Furman, Stephen M Ansell, Sikander Ailawadhi, Thomas E Witzig, Vivek Roy, Taimur Sher, Liuyan Jiang, British Journal of Haematology
Phase I Study of Pomalidomide and Dexamethasone for relapsed/refractory Primary CNS or Vitreo-Retinal Lymphoma
Lisa M DeAngelis, Han W Tun, David Schiff, Kurt A Jaeckle, Christian Grommes, Patrick B Johnston, Craig B Reeder, Thomas E Witzig, Blood

Abstracts/Posters

Distal Enhancer Elements in ASXL1-Mutant Chronic Myelomonocytic Leukemia
Thomas E. Witzig, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Long-Term Outcome of Patients with Marginal Zone Non-Hodgkin Lymphoma (MZL) Treated with Yttrium-90 Ibritumomab Tiuxetan: The Mayo Clinic Experience
Thomas E. Witzig, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Quality of Life Was Not Negatively Impacted By the Addition of Lenalidomide to R-CHOP Chemotherapy (R2-CHOP) Compared with Placebo Plus R-CHOP Chemotherapy in Patients...
Thomas E. Witzig, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Minimal Residual Disease (MRD) Assessment in the ECOG1411 Randomized Phase 2 Trial of Front-Line Bendamustine-Rituximab (BR)-Based Induction Followed By Rituximab (R) ...
Thomas E. Witzig, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Genomic Analysis of R2CHOP-Treated DLBCL Reveals a High-Risk Population Driven By Inflammatory Pathways
Thomas E. Witzig, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Waldenstr_m Macroglobulinemia with Excess Plasma Cells: Is It a Distinct Entity?
Thomas E. Witzig, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
A Randomized Phase 2 Study Comparing Acalabrutinib with or without Obinutuzumab in the Treatment of Early Stage High Risk Patients with Chronic Lymphocytic Leukemia (C...
Thomas E. Witzig, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Clinical Categorization of Chronic Myelomonocytic Leukemia into Proliferative and Dysplastic Subtypes Correlates with Distinct Genomic, Transcriptomic and Epigenomic S...
Thomas E. Witzig, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Maximizing FDG-PET/CT Utility in Staging of Follicular Lymphoma (FL): The Role of Spleen Involvement and Bone Standardized Uptake Values
Thomas E. Witzig, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Prevalence and the Impact of Hypogammaglobulinemia in Newly Diagnosed, Untreated Diffuse Large B Cell Lymphoma
Thomas E. Witzig, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Potential Factors That Impact Lenalidomide/R-CHOP Efficacy in Previously Untreated Diffuse Large B-Cell Lymphoma in the ROBUST and ECOG-ACRIN 1412 Studies
Thomas E. Witzig, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
A Phase II Study of Nivolumab in Patients with Relapsed or Refractory Peripheral T-Cell Lymphoma
Thomas E. Witzig, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Utility and Patterns of Use of PET/CT and Bone Marrow Biopsy for Staging in Non-Hodgkin Lymphoma in the Clinical Setting: A Retrospective Analysis Using the LEO Database
Thomas E. Witzig, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Patient-Level Meta-Analysis of End-of-Therapy PET-CR as a Surrogate Endpoint for PFS and OS in Patients with Previously Untreated DLBCL: Implications for Clinical Tria...
Thomas E. Witzig, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Long-Term Outcome of Patients with Marginal Zone Non-Hodgkin Lymphoma (MZL) Treated with Yttrium-90 Ibritumomab Tiuxetan: The Mayo Clinic Experience
Thomas E. Witzig, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Intrafollicular CD4+ T-Cells As an Independent Predictor of Early Clinical Failure in Newly Diagnosed Follicular Lymphoma
Thomas E. Witzig, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
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Lectures

Emerging Paradigms to Address Unmet Needs in Relapsed/Refractory DLBCL
61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
Phase 1/2 trial of acalabrutinib plus pembrolizumab (Pem) in relapsed/refractory (r/r) diffuse large B-cell lymphoma (DLBCL).
2019 ASCO Annual Meeting - 6/1/2019
Ibrutinib Therapy in Patients with Waldenstrom Macroglobulinemia: Outcomes Outside of Clinical Trial Setting
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
The Prognostic Impact of Baseline Positron Emission Tomography (PET) Imaging in Untreated High Risk (HR) Follicular Lymphoma (FL): Analysis from E0, the Bortezomib Ind...
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Avadomide (CC-), a Novel Cereblon Modulating Agent, Plus Rituximab in Patients with Relapsed or Refractory Follicular Lymphoma
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
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Press Mentions

Yale Cancer Center Trial Identifies New Treatment Option for Certain Patients with T-cell LymphomaDecember 13th, 2021
NCI Awards $12.4 Million Lymphoma Research Grant to University of Iowa and Mayo ClinicSeptember 18th, 2017
Diagnosis of Autoimmune Pancreatitis: The Evolution of Diagnostic Criteria for a Rare DiseaseJune 17th, 2017
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Grant Support

P2 - Signal Transduction Inhibitor Therapy For LymphomaNational Cancer Institute2010–2011
Signal Transduction Inhibitor Therapy For LymphomaNational Cancer Institute2007–2011
Signal Transduction Inhibitor Therapy For LymphomaNational Cancer Institute2007–2009
PI3K Pathway Inhibitors For Mantle Cell LymphomaNational Cancer Institute2005–2006
Enhancement Of Lymphoma Radioimmunotherapy By CPG ODNNational Cancer Institute2002
Radioimmunotherapy For LymphomaNational Cancer Institute2001–2002
HematologyNational Cancer Institute2001–2002
Characterization And Growth Of Clonally Related Myeloma CellNational Cancer Institute2000–2002
Apoptosis And %S As Prognostic Factors For Colon CancerNational Cancer Institute1998–1999