Timothy Ley, MD, Hematology, Saint Louis, MO, Barnes-Jewish Hospital

TimothyJLeyMD

Hematology Saint Louis, MO

Hematologic Oncology, Sickle Cell & Other Anemias

Professor of Medicine

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Education & Training

  • Washington University - Barnes-Jewish Hospital
    Washington University - Barnes-Jewish HospitalFELLOWSHIP
  • National Institutes of Health Clinical Center
    National Institutes of Health Clinical CenterFELLOWSHIP
  • Massachusetts General Hospital
    Massachusetts General HospitalRESIDENCY
  • Massachusetts General Hospital
    Massachusetts General HospitalINTERNSHIP
  • Washington University School of Medicine in St. Louis
    Washington University School of Medicine in St. LouisMEDICAL_SCHOOL
  • Drake UniversityOTHER_TRAINING

Certifications & Licensure

  • MO State Medical License
    MO State Medical License 1986 - 2021
  • MD State Medical License
    MD State Medical License 1981 - 1986
  • American Board of Internal Medicine Internal Medicine
  • American Board of Internal Medicine Hematology

Awards, Honors, & Recognition

  • Elected National Academy of Sciences, 2019
  • Elected American Academy of Arts and Sciences, 2010
  • Elected National Academy of Medicine, 2003
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Clinical Trials

Publications & Presentations

PubMed

Journal Articles

  • Transcriptional activation of the human serine protease gene CSP-B in T-lymphocytes.  
    Hanson, R.D., and Ley, T.J, Mol. Cell. Biol. 10:5655-5662
  • A novel c-fgr exon utilized in Epstein-Barr Virus infected B-lymphocytes but not in normal monocytes.  
    Gutkind, J.S., Link, D.C., Katamine, S., Lacal, P., Miki, T., Ley, T.J., and Robbins, K.C, Mol. Cell. Biol. 11:1500-1507
  • Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2.  
    Heusel, J.W., Hanson, R.D., Silverman, G.A., and Ley, T.J, J. Biol. Chem. 266:6152-6158
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Books/Book Chapters

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Abstracts/Posters

  • Whole Genome Bisulfite Sequencing of 63 Primary AML Samples Identifies a Unique DNA Hypermethylation Signature for Mutant IDH1/2 Cases That Is Different from That of T...
    Timothy J Ley, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
  • The Molecular Basis of Long First Remissions in Normal Karyotype AML Patients
    Timothy J Ley, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
  • Gata2 Expression and Function in PML-RARA-driven Preleukemia and APL
    Timothy J Ley, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019

Lectures

  • Direct Detection of Expressed Mutations in AML Cells Using Single Cell RNA-Sequencing, and Its Impact on Defining Sources of Expression Heterogeneity 
    2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
  • Evidence for Complete Mutation Clearance in Normal Karyotype AML Patients with Very Long (> 5 years) Remissions after Chemotherapy Alone 
    2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
  • Immunology Seminar Series. 
    Washington University, 1995, 1996, 1997, 1998
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Press Mentions

  • $5 Million Grant Endows Research to Advance Blood Disorder Therapies
    $5 Million Grant Endows Research to Advance Blood Disorder TherapiesSeptember 11, 2019
  • $15 Million Supports Quest for Personalized Leukemia Therapies
    $15 Million Supports Quest for Personalized Leukemia TherapiesAugust 21, 2019
  • Colonna, Ley Elected to National Academy of Sciences
    Colonna, Ley Elected to National Academy of SciencesApril 30, 2019
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Grant Support

  • Genomics Of Acute Myelogenous Leukemia (Aml): Somatic Mutations &ConsequencesNational Cancer Institute2008–2012
  • AdministrationNational Cancer Institute2008–2012
  • The Biology Of Promyelocytic Leukemia In A Mouse ModelNational Cancer Institute2005–2012
  • Genomics Of Acute Myelogenous LeukemiaNational Cancer Institute2003–2012
  • Dmnt3a Mutations In Patients With Acute Myeloid LeukemiaNational Center For Research Resources2011
  • DNMT3A Mutations In Acute Myeloid LeukemiaNational Cancer Institute2011
  • Embryonic Stem Cell CoreNational Cancer Institute2010–2011
  • Regulation Of Fetal And Adult Human Hemoglobin ProductionNational Institute Of Diabetes And Digestive And Kidney Diseases2010
  • Genomics Of AML: Whole Genome ResequencingNational Cancer Institute2010
  • Genomics Of Acute Myelogenous Leukemia (2po1ca101937-06)National Cancer Institute2010
  • Role Of Granzymes In Cytotoxic Lymphocyte FunctionsNational Center For Research Resources2008–2010
  • Role Of Granzymes In Cytotoxic Lymphocyte FunctionsNational Institute Of Diabetes And Digestive And Kidney Diseases2005–2009
  • Regulation Of Fetal And Adult Human Hemoglobin ProdNational Institute Of Diabetes And Digestive And Kidney Diseases2004–2008
  • Core--Embryonic Stem Cell FacilityNational Cancer Institute2004–2008
  • Hematopoietic Development And Malignancy ProgramNational Cancer Institute2004
  • The Role Of Granzymes In Cytotoxic Lymphocyte FunctionsNational Institute Of Diabetes And Digestive And Kidney Diseases2000–2004
  • The Biology Of Promyelocytic Leukemia In A Mouse MODEL.National Cancer Institute2000–2004
  • Regulation Of Fetal And Adult Human Hemoglobin ProductiNational Institute Of Diabetes And Digestive And Kidney Diseases2001–2003
  • Stem Cell BiologyNational Cancer Institute2001–2002
  • Core--Embryonic Stem CellNational Cancer Institute2001–2002
  • Fetal And Adult Human Hemoglobin ProductionNational Institute Of Diabetes And Digestive And Kidney Diseases1999–2000
  • Gene Regulation In Normal And Transformed CellsNational Cancer Institute1999
  • Regulation Of Human Cathepsin G Gene In Normal And Leukemic Blood CellsNational Cancer Institute1997–1999
  • Core--Embryonic Stem CellsNational Cancer Institute1997–1999
  • Granzymes And Cytotoxic Lymphocyte FunctionsNational Institute Of Diabetes And Digestive And Kidney Diseases1995–1999
  • Regulation Of HemoglobinNational Institute Of Diabetes And Digestive And Kidney Diseases1997–1998
  • Regulation Of HemoglobinNational Institute Of Diabetes And Digestive And Kidney Diseases1996
  • Regulation Of Hemoglobin ProductionNational Institute Of Diabetes And Digestive And Kidney Diseases1995
  • Regulation Of Hemoglobin ProductionNational Institute Of Diabetes And Digestive And Kidney Diseases1994
  • Regulation Of Fetal &Adult Human Hemoglobin ProductionNational Institute Of Diabetes And Digestive And Kidney Diseases1987–1993

Hospital Affiliations