TimothyJLeyMD

PubMed

• Rapid and accurate remethylation of DNA indeficient hematopoietic cells with restoration of DNMT3A activity.
  Li, Y., Abel, H., Cai, M., LaValle, T., Yin, T., Helton, N., Smith, A., Miller, C., Ley, T.> ;Science Advances. 2024 Feb 2
• Author Correction: A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing.
  Allegra A Petti, Stephen R Williams, Christopher A Miller, Ian T Fiddes, Sridhar N Srivatsan, David Y Chen, Catrina C Fronick, Robert S Fulton, Deanna M Church, Timoth...> ;Nature Communications. 2022 Jul 21
• 6 citations
  Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression.
  Andrew J Menssen, Ajay Khanna, Christopher A Miller, Sridhar Nonavinkere Srivatsan, Gue Su Chang, Jin Shao, Joshua Robinson, Michele O'Laughlin, Catrina C Fronick, Rob...> ;Blood Cancer Discovery. 2022 Jul 6
• 5 citations
  Recurrent transcriptional responses in AML and MDS patients treated with decitabine.
  Pawan Upadhyay, Jeremy Beales, Nakul M Shah, Agata Gruszczynska, Christopher A Miller, Allegra A Petti, Sai Mukund Ramakrishnan, Daniel C Link, Timothy J Ley, John S W...> ;Experimental Hematology. 2022 Jul 1
• 9 citations
  Physician-scientists in the United States at 2020: Trends and concerns.
  Howard H Garrison, Timothy J Ley> ;FASEB Journal. 2022 May 1
• 2 citations
  Somaticinactivation leads to slow, canonical DNA methylation loss in murine hematopoietic cells.
  Amanda M Smith, Angela M Verdoni, Haley J Abel, David Y Chen, Shamika Ketkar, Elizabeth R Leight, Christopher A Miller, Timothy J Ley> ;Iscience. 2022 Apr 15
• 14 citations
  Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells.
  Elisabeth R Wilson, Nichole M Helton, Sharon E Heath, Robert S Fulton, Jacqueline E Payton, John S Welch, Matthew J Walter, Peter Westervelt, John F DiPersio, Daniel C...> ;Leukemia. 2022 Apr 1
• 3 citations
  Decitabine salvage for-mutated, relapsed/refractory acute myeloid leukemia after cytotoxic induction therapy.
  Francesca Ferraro, Agata Gruszczynska, Marianna B Ruzinova, Christopher A Miller, Mary Elizabeth Percival, Geoffrey L Uy, Iskra Pusic, Meagan A Jacoby, Mathew J Christ...> ;Haematologica. 2022 Jul 1
• 12 citations
  Failure to Detect Mutations in U2AF1 due to Changes in the GRCh38 Reference Sequence.
  Christopher A Miller, Jason R Walker, Travis L Jensen, William F Hooper, Robert S Fulton, Jeffrey S Painter, Mikkael A Sekeres, Timothy J Ley, David H Spencer, Johanne...> ;The Journal of Molecular Diagnostics. 2022 Mar 1
• 18 citations
  Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes.
  Francesca Ferraro, Christopher A. Miller, Keegan A. Christensen, Nichole M. Helton, Margaret O’Laughlin, Catrina Fronick, Robert S. Fulton, Jessica Kohlschmidt, Ann-Ka...> ;Proceedings of the National Academy of Sciences of the United States of America. 2021 Dec 7
• 10 citations
  DNMT3A Overgrowth Syndrome is associated with the development of hematopoietic malignancies in children and young adults.
  Margaret A. Ferris, Amanda Smith, Sharon Heath, Eric J. Duncavage, Matthew J. Oberley, David R. Freyer, Robert Wynn, Sofia Douzgou, John M. Maris, Anne F. Reilly, Meli...> ;Blood. 2021 Nov 17
• 6 citations
  Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia
  Allegra A. Petti, Saad M. Khan, Ziheng Xu, Nichole M. Helton, Catrina Fronick, Robert S. Fulton, Sai Mukund Ramakrishnan, Sridhar Nonavinkere Srivatsan, Sharon Heath, ...> ;Blood Cancer Discovery. 2021 Aug 24
• 36 citations
  Bam-readcount -- rapid generation of basepair-resolution sequence metrics
  Ajay Khanna, David E. Larson, Sridhar Nonavinkere Srivatsan, Matthew Mosior, Travis E. Abbott, Susanna Kiwala, Timothy J. Ley, Eric J. Duncavage, Matthew J. Walter, Ja...> ;Arxiv. 2021 Jul 27
• 16 citations
  Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome.
  Amanda Smith, Taylor A. LaValle, Marwan Shinawi, Sai Mukund Ramakrishnan, Haley J. Abel, Cheryl A. Hill, Nicole M. Kirkland, Michael P. Rettig, Nichole M. Helton, Shar...> ;Nature Communications. 2021 Jul 27
• 11 citations
  Tumor suppressor function of Gata2 in acute promyelocytic leukemia.
  Casey D.S. Katerndahl, Olivia R S Rogers, Ryan B. Day, Michelle A Cai, Timothy P Rooney, Nichole M. Helton, Mieke Hoock, Sai Mukund Ramakrishnan, Sridhar Nonavinkere S...> ;Blood. 2021 Sep 30
• 61 citations
  Co-evolution of tumor and immune cells during progression of multiple myeloma
  Ruiyang Liu, Qingsong Gao, Steven M. Foltz, Jared S. Fowles, Lijun Yao, Julia Tianjiao Wang, Song Cao, Hua Sun, Michael C. Wendl, Sunantha Sethuraman, Amila Weerasingh...> ;Nature Communications. 2021 May 7
• 4 citations
  Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype.
  David Y. Chen, Ian M. Ferguson, Krista A. Braun, Leslie A. Sutton, Nichole M. Helton, Sai Mukund Ramakrishnan, Amanda Smith, Christopher A. Miller, Timothy J. Ley> ;Proceedings of the National Academy of Sciences of the United States of America. 2021 Apr 20
• 117 citations
  Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers.
  Eric J. Duncavage, Molly C Schroeder, Michele O'Laughlin, R. Wilson, Sandra MacMillan, Andrew Bohannon, Scott Kruchowski, John Garza, Feiyu Du, Andrew E. O. Hughes, Jo...> ;The New England Journal of Medicine. 2021 Mar 10
• 6 citations
  Impact of a 40-Gene Targeted Panel Test on Physician Decision Making for Patients With Acute Myeloid Leukemia.
  Erica K. Barnell, Kenneth F. Newcomer, Zachary L. Skidmore, Kilannin Krysiak, Sydney R. Anderson, Lukas D. Wartman, Stephen T. Oh, John S. Welch, Keith Stockerl-Goldst...> ;JCO Precision Oncology. 2021 Jan 14
• 23 citations
  Enhanced Efficacy and Increased Long-Term Toxicity of CNS-Directed, AAV-Based Combination Therapy for Krabbe Disease.
  Yedda Li, Christopher A. Miller, Lauren Shea, Xuntian Jiang, Miguel A. Guzman, Randy J. Chandler, Sai Mukund Ramakrishnan, Stephanie Smith, Charles P. Venditti, Carole...> ;Molecular Therapy. 2021 Feb 3
• 27 citations
  The clonal evolution of metastatic colorectal cancer.
  Ha X. Dang, Bradley A. Krasnick, Brian S. White, Julie G. Grossman, Matthew S. Strand, Jin Zhang, Christopher R. Cabanski, Christopher A. Miller, Robert S. Fulton, S. ...> ;Science Advances. 2020 Jun 1
• 68 citations
  Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression
  Jessica Silva-Fisher, Ha X. Dang, Nicole M. White, Matthew S. Strand, Bradley A. Krasnick, Emily B. Rozycki, Gejae Jeffers, Julie G. Grossman, Maureen Highkin, Cynthia...> ;Nature Communications. 2020 May 1
• 19 citations
  Remethylation of Dnmt3a-/- hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing.
  Shamika Ketkar, Angela M. Verdoni, Amanda Smith, Celia V. Bangert, Elizabeth R. Leight, David Y. Chen, Meryl K. Brune, Nichole M. Helton, Mieke Hoock, Daniel R. George...> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Feb 11
• 4 citations
  Tumor suppressor function of WT1 in acute promyelocytic leukemia.
  Matthew J. Christopher, Casey D.S. Katerndahl, Hayley R LeBlanc, Tyler T Elmendorf, Vaishali Basu, Margery Gang, Andrew J. Menssen, David H. Spencer, Eric J. Duncavage...> ;Haematologica. 2021 Oct 21
• 26 citations
  Obesity is a risk factor for acute promyelocytic leukemia: evidence from population and cross-sectional studies and correlation with FLT3 mutations and polyunsaturated...
  Luca Mazzarella, Edoardo Botteri, Anthony Matthews, Elena Gatti, Davide Di Salvatore, Vincenzo Bagnardi, Massimo Breccia, Pau Montesinos, Teresa Bernal, Cristina Gil, ...> ;Haematologica. 2020 Jun 1
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Journal Articles

• Transcriptional activation of the human serine protease gene CSP-B in T-lymphocytes.  
  Hanson, R.D., and Ley, T.J, Mol. Cell. Biol. 10:5655-5662
• A novel c-fgr exon utilized in Epstein-Barr Virus infected B-lymphocytes but not in normal monocytes.  
  Gutkind, J.S., Link, D.C., Katamine, S., Lacal, P., Miki, T., Ley, T.J., and Robbins, K.C, Mol. Cell. Biol. 11:1500-1507
• Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2.  
  Heusel, J.W., Hanson, R.D., Silverman, G.A., and Ley, T.J, J. Biol. Chem. 266:6152-6158
• Functional properties of the ?-globin Locus Control Region (LCR) in K562 erythroleukemia cells.  
  Moon, A.M., and Ley, T.J, Blood 77:2272-2284
• 1,25 Dihydroxyvitamin D3 induces monocytic differentiation of the PLB-985 leukemia line and promotes c-fgr mRNA expression.  
  Perkins, S.L., Link, D.C., Kling, S., Ley, T.J., and Teitelbaum, S.L, J. Leukocyte Biol. 50:427-433
• The 5’ flanking region of the human CGL-1/granzyme B gene targets expression of a reporter gene to activated T-lymphocytes in transgenic mice.  
  Hanson, R.D., Sclar, G.M., Kanagawa, O., and Ley, T.J, J. Biol. Chem. 266:24433-24438
• A-T rich scaffold attachment regions flank the hematopoietic serine protease genes clustered on chromosome 14q11.2.  
  Hanson, R.D., and Ley, T.J, Blood 79:610-618
• The genetic basis of early T-cell precursor acute lymphoblastic leukemia.  
  Zhang, J., Ding, L., Holmfeldt, L., Wu, G., Heatley, S.L., Payne-Turner, D., Easton, J., Chen, X., Wang, J., Rusch, M., Lu, C., Chen, S.C., Wei, L., Collins-Underwood,..., Nature;481(7380):157-63. PMCID: PMC3267575
• Molecular cloning, chromosomal localization, and bacterial expression of a novel murine macrophage metalloelastase.  
  Shapiro, S.D., Griffin, G.L., Gilbert, D.J., Jenkins, N.A., Copeland, N.G., Welgus, H.G., Senior, R.M., and Ley, T.J, J. Biol. Chem. 267:4664-4671
• Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter.  
  Link, D.C., Gutkind, S.J., Robbins, K.C., and Ley, T.J, Oncogene 7:877-884
• Clonal architecture of secondary acute myeloid leukemia.  
  Walter, M.J., Shen, D., Ding, L., Shao, J., Koboldt, D.C., Chen, K., Larson, D.E., McLellan, M.D., Dooling, D., Abbott, R., Fulton, R., Magrini, V., Schmidt, H., Kalic..., N Engl J Med. 2012 Mar 22;366(12):1090-8. Epub. PMCID: PMC3320218
• An intramolecular DNA triplex is disrupted by point mutations associated with Hereditary Persistence of Fetal Hemoglobin.  
  Ulrich, M.J., Gray, W.G., and Ley, T.J, J. Biol. Chem. 267:18649-18658
• Structure and function of the murine ?-globin Locus Control Region 5' HS-3.  
  Hug, B.A., Moon, A.M., and Ley, T.J, Nuc. Acids Res. 20:5771-5778
• Molecular cloning, chromosomal location, and tissue-specific expression of the murine cathepsin G gene.  
  Heusel, J.W., Scarpati, E.M., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Shapiro, S.D., and Ley, T.J, Blood 81:1614-1623
• Background mutations in parental cells contribute to the genetic heterogeneity of Induced Pluripotent Stem Cells.  
  Young, M.A., Larson, D.E., Sun, C-W., George, D.R., Ding, L., Miller, C.A., Lin, L., Pawlik, K.M., Chen, K., Fan, X., Schmidt, H., Kalicki-Veizer, J., Cook, L.L., Swif..., Cell Stem Cell, 2012 May 4;10(5):570-82. Epub. PMCID: PMC3348423
• The human mast cell chymase gene (CMA1): Mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expression.  
  Caughey, G.H., Schaumberg, T.H., Zerweck, E.H., Butterfield, J.H., Hanson, R.D., Silverman, G.A., and Ley, T.J, Genomics 15:614-620
• Molecular mechanisms regulating the production of collagenase and TIMP in U937 cells: Evidence for involvement of delayed transcriptional activation and enhanced mRNA...  
  Shapiro, S.D., Doyle Glenn A.R., Ley, T.J., Parks, W.C. and Welgus, H.G, Biochemistry 32:4286-4292
• Weinstein, J.N., Ding, L. BreakFusion: Targeted assembly-based identification of gene fusions in whole transcriptome paired-end sequencing data.  
  Chen, K., Wallis, J.W., Kandoth, C., Kalicki-Veizer, J.M., Mungall, K.L., Mungall A.J., Jones, S.J., Marra, M.A., Ley, T.J., Mardis, E.R., Wilson, R.K., Bioinformatics. Epub ahead of print. PubMed – in process
• Consensus AP-1 and CRE motifs upstream from the human cytotoxic serine protease B (CSP-B/CGL-1) gene synergize to activate transcription.  
  Hanson, R.D., Grisolano, J.L., and Ley, T.J, Blood 82:2749-2757
• Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages.  
  Shapiro, S.D., Kobayashi, D.K. and Ley, T.J, J. Biol. Chem. 268:23824-23829
• The pediatric cancer genome project.  
  Downing, J.R., Wilson, R.K., Zhang, J., Mardis, E.R., Pui, C.H., Ding, L., Ley, T.J., Evans, W.E., Nat Genet ;44(6):619-22. PubMed – in process
• 5-azacytidine for ?-thalassemia.  
  Ley, T.J., Anagnou, N.P., Young, N.S., Nienhuis, A.W., DeSimone, J., and Heller, P, Lancet i, 467
• Chelation for transfusion dependent adults. N. Eng.  
  Ley, T.J., and Nienhuis, A.W, J. Med. 308:1422-1423
• Advances in thalassemia research.  
  Nienhuis, A.W., Anagnou, N.P., and Ley, T.J, Blood 63:738-758. Cited: 136
• Induction of hemoglobin F synthesis in patients with ?-thalassemia.  
  Ley, T.J., and Nienhuis, A.W, Ann. Rev. Med. 36:485-498
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Books/Book Chapters

• Clinics in Hematology. 
  Chapter: Transfusion hemosiderosis and chelation therapy 
  Page 437 - 464Ley, T.J., Griffith, P., and Nienhuis, A.WW.B. Saunders Co, London
• March of Dimes - Birth Defects Foundation. 
  Chapter: Thalassemia: Recent advances in detection and treatment 
  Page 69 - 79Nienhuis, A.W., Ley, T.J., Pepe, G., Tam, J., and Kantor, and JEditors: Cao, Antonio, Carcassi, Ugo, and P.T. Rowley.Alan R. Liss, Inc. , New YorkEdition Vol.,
• Proceedings of the Regulation of Hemoglobin Biosynthesis. 
  Chapter: Expression of human normal and thalassemic globin genes 
  Page 385 - 389Nienhuis, A.W., Ley, T.J., and Humphries, R.KEditors: E. Goldwasser.Elsevier, North Holland
• Globin Gene Expression and Hematopoietic Differentiation. 
  Chapter: Globin gene methylation and expression in patients treated with 5-azacytidine 
  Page 457 - 474Ley, T.J., Anagnou, N.P., Turner, P., DeSimone, J., Heller, P., and Nienhuis, A.WEditors: G. Stamatoyannopoulos and A.W. Nienhuis.Alan R. Liss, New York
• Globin Gene Expression and Hematopoietic Differentiation. 
  Chapter: A. Abundance and structure of globin mRNAs in K562 human leukemia cells 
  Page 323 - 335Dean, A., Ley, T.J., Humphries, R.K., Fordis, C.M., and SchechterEditors: G. Stamatoyannopoulos and A.W. Nienhuis.Alan R. Liss, New York
• Globin Gene Expression and Hematopoietic Differentiation. 
  Chapter: Globin gene expression in somatic cell hybrids 
  Page 39 - 52Anderson, W.F., Chiang, Y.L., Sanders-Haigh, L., and Ley, T.JEditors: G. Stamatoyannopoulos and A.W. Nienhuis.Alan R. Liss, New York
• Globin Gene Expression and Hematopoietic Differentiation. 
  Chapter: A silent nucleotide substitution activates a cryptic splice site in coding sequence RNA 
  Page 123 - 126Humphries, R.K., Ley, T.J., Goldsmith, M., Cline, A., Kantor, J.A., and Nienhuis, A.WEditors: G. Stamatoyannopoulos and A.W. Nienhuis.Alan R. Liss, New York
• Principles and Techniques of Human Research and Therapeutics. 
  Chapter: Prospects for therapeutic manipulation of human gene function 
  Page 59 - 85Ley, T.J., and Nienhuis, A.WEditors: F.G. McMahon and T.J. Ley.Futura, Mt. Kisco, New YorkEdition Vol.,
• Experimental Approaches for the Study of Hemoglobin Switching. 
  Chapter: Pharmacologic manipulation of fetal hemoglobin synthesis 
  Page 447 - 454Dover, G.J., Humphries, R.K., Young, N.S., Ley, T.J., Boyer, S., Charache, S., and Nienhuis, and A.WEditors: G. Stamatoyannopoulos and A.W. Nienhuis.Alan R. Liss, New York
• Experimental Approaches for the Study of Hemoglobin Switching. 
  Chapter: Augmentation of hemoglobin synthesis by S-phase specific drugs in the K562 cell line 
  Page 205 - 216Dean, A., Wu, Y., Ley, T.J., Fordis, C.M., and Schechter, A.NEditors: G. Stamatoyannopoulos and A.W. Nienhuis.Alan R. Liss, New York
• Developmental Control of Globin Gene Expression. 
  Chapter: A transient assay system to study ?-globin gene expression in K562 cells 
  Page 189 - 200Bodine, D.M., and Ley, T.JAlan R. Liss, New York
• Conn's Current Therapy. 
  Chapter: Thalassemia 
  Page 307 - 312Ley, T.JEditors: R.E. Rakel.W. B. Saunders Co., Philadelphia, PA
• Conn's Current Therapy. 
  Chapter: Thalassemia 
  Page 311 - 315Ley, T.JEditors: R.E. Rakel.W.B. Saunders Co., Philadelphia, PA
• Annals New York Academy of Sciences. 
  Chapter: Regulatory regions flanking the human fetal ?-globin genes 565 
  Page 13 - 22Lin, H.J., Bodine, D.M., Rutherford, T.R., Anagnou, N.P., McDonagh, K.T., Ley, T.J., and Nienhuis, and A.W
• Annals New York Academy of Sciences. 
  Chapter: Function of transfected globin promoters and the globin locus activator in K562 erythroleukemia cells 
  Page 207 - 214Ulrich, M.J., Moon, A.M., and Ley, T.J
• 7th Hemoglobin Switching Conference Proceedings. 
  Chapter: Conservation of the primary structure, organization, and function of the human and mouse ?-globin locus control regions 
  Page 138 - 152Moon, A.M., and Ley, T.JJohns Hopkins University Press, Baltimore, MD
• Matrix Metalloproteinases and Inhibitors. 
  Chapter: Neutral proteinase expression by human mononuclear phagocytes: A prominent role of cellular differentiation 
  Page 363 - 367Welgus, H.G., Senior, R.M., Parks, W.C., Kahn, A.J., Ley, T.J., Shapiro, S.S., and Campbell, E.JGustav Fischer Verlag, Stuttgart, GermanyEdition Supp,
• Annals New York Academy of Sciences. 
  Chapter: Reduced ?-globin gene expression in adult mice containing deletions of locus control region 5' HS-2 or 5' HS-3. 
  Page 445 - 453Ley, T.J., Hug, B., Fiering, S., Epner, E., Bender, M.A., and Groudine, and M
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Abstracts/Posters

• Whole Genome Bisulfite Sequencing of 63 Primary AML Samples Identifies a Unique DNA Hypermethylation Signature for Mutant IDH1/2 Cases That Is Different from That of T...
  Timothy J Ley, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• The Molecular Basis of Long First Remissions in Normal Karyotype AML Patients
  Timothy J Ley, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Gata2 Expression and Function in PML-RARA-driven Preleukemia and APL
  Timothy J Ley, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019

Lectures

• Direct Detection of Expressed Mutations in AML Cells Using Single Cell RNA-Sequencing, and Its Impact on Defining Sources of Expression Heterogeneity 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Evidence for Complete Mutation Clearance in Normal Karyotype AML Patients with Very Long (> 5 years) Remissions after Chemotherapy Alone 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Immunology Seminar Series. 
  Washington University, 1995, 1996, 1997, 1998
• Tinsley Randolf Harrison Society Lectureship. 
  Vanderbilt University
• Distinguished Lecturer Series. 
  University of Oklahoma Department of Biochemistry
• Cytotoxic Lymphocyte Biology Symposium and Plenary Talk. 
  International Congress of Immunology
• Basic Science Seminar Series. 
  Merck Pharmaceuticals, 2000; Blood Center, Harvard University, 2002; Siteman Cancer Center, 2004
• American Society of Investigative Dermatology. 
  Herman Beerman Lecture and Award
• Janet Rowley Symposium. 
  University of Chicago
• Distinguished Speaker Series, Department of Medicine Research Day. 
  University of Texas Health Sciences Center at San Antonio
• Cytotoxic T cells Symposium. 
  International Congress of Immunology
• Immunology Scientific Symposium. 
  American Society of Hematology, 1994
• Immunology Seminar Series. 
  University of Miami, 2005, 2006
• Seminars in Biomedical Sciences. 
  UCSF
• The Broad Institute. 
  Genomics of Common Disease Symposia
• Basic Science Symposium on AML Genomics. 
  American Society of Hematology
• Dept of Biochemistry & Molecular Genetics Red Banner Seminar Series. 
  University of Alabama, Birmingham, AL
• Benning Society Seminar Series. 
  University of Utah
• Lewis-Sigler Institute Seminar Series. 
  Princeton University
• Biology Seminar Series. 
  Drake University
• Leukemia Retreat Keynote Speaker. 
  UCSF
• Cancer Center Seminar Series. 
  Terry Fox Laboratory, University of British Columbia, 1999, 2006, 2010
• Institute for Genomic Medicine Inaugural Symposium. 
  UCSD
• Distinguished Scientist Seminar Series. 
  University of Cincinnati
• Kierkow Memorial Lecture. 
  Northwestern University
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