ToddWMillerMD

Internal Medicine • Waterville, ME

Hospital Medicine/Hospitalist

Physician

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Office
149 North St
Waterville, ME 04901
Phone+1 207-872-1270

Fax+1 207-872-1831
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Summary

Dr. Todd Miller, MD is an internist in Waterville, Maine. He is currently licensed to practice medicine in Maine and Pennsylvania. He is affiliated with Franklin Memorial Hospital and Penobscot Valley Hospital.

Education & Training

Penn State Milton S Hershey Medical CenterResidency, Internal Medicine, 1997 - 2001
University of Missouri-Columbia School of MedicineClass of 1997

Certifications & Licensure

ME State Medical License 2001 - 2025
PA State Medical License 1998 - 2002

Publications & Presentations

PubMed

11 citations
Cytokine sensitivity screening highlights BMP4 pathway signaling as a therapeutic opportunity in ER+ breast cancer
Kevin Shee, Amanda Jiang, Frederick S. Varn, Stephanie Liu, Nicole A. Traphagen, Philip Owens, Cynthia X. Ma, Jeremy Hoog, Chao Cheng, Todd R. Golub, Ravid Straussman,...> ;FASEB Journal. 2019 Feb 1
47 citations
Therapeutically targeting tumor microenvironment–mediated drug resistance in estrogen receptor–positive breast cancer
Kevin Shee, Wei Yang, John W Hinds, Riley A. Hampsch, Frederick S. Varn, Nicole A. Traphagen, Kishan Patel, Chao Cheng, Nicole P. Jenkins, Arminja N. Kettenbach, Eugen...> ;The Journal of Experimental Medicine. 2018 Mar 5
Coamplification of miR-4728 Protects HER2-Amplified Breast Cancers from Targeted Therapy
Todd W Miller, Ming Tan, Anthony C Faber, Sosipatros A Boikos> ;Proceedings of the National Academy of Sciences. 2018 Feb 25
Estrogen receptor alpha drives mTORC1 inhibitor-induced feedback activation of PI3K/AKT in ER+ breast cancer.
Yang, W.,Schwartz, G. N.,Marotti, J. D.,Chen, V.,Traphagen, N. A.,Gui, J.,Miller, T. W.> ;Oncotarget. 2018 Mar 07
Trailblazing Precision Oncology for Rare Tumor Subtypes.
Shee, K.,Miller, T. W.> ;Oncologist. 2017 Nov 22
60 citations
P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer
Lloye M. Dillon, Jennifer R. Bean, Wei Yang, Kevin Shee, L. K. Symonds, Justin M. Balko, W. H. McDonald, Shuying Liu, Ana M. Gonzalez-Angulo, Gordon B. Mills, Carlos L...> ;Oncogene. 2015 Jul 23
The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrine-sensitive and endocrine-resistant ER+ breast cancer.
Bean, J. R.,Hosford, S. R.,Symonds, L. K.,Owens, P.,Dillon, L. M.,Yang, W.,Shee, K.,Schwartz, G. N.,Marotti, J. D.,Muller, K. E.,Rosenkranz, K. M.,Barth, R. J.,Chen, V...> ;Breast Cancer Res. Treat.. 2014 Dec 11
Targeting tyrosine-kinases and estrogen receptor abrogates resistance to endocrine therapy in breast cancer.
Liu, S.,Meng, X.,Chen, H.,Liu, W.,Liu, W.,Miller, T.,Murph, M.,Lu, Y.,Zhang, F.,Iurascu, M. G.,Arteaga, C. L.,Mills, G. B.,Meric-Bernstam, F.,González-Angulo, A. M.> ;Oncotarget. 2014 Jul 01
Activation of MAPK pathways due to DUSP4 loss promotes cancer stem cell-like phenotypes in basal-like breast cancer.
Balko, J. M.,Schwarz, L. J.,Bhola, N. E.,Kurupi, R.,Owens, P.,Miller, T. W.,Gómez, H.,Cook, R. S.,Arteaga, C. L.> ;Cancer Res.. 2013 Aug 24
67 citations
Autocrine IGF-I/insulin receptor axis compensates for inhibition of AKT in ER-positive breast cancer cells with resistance to estrogen deprivation
Emily M. Fox, Maria G. Kuba, Todd W. Miller, Barry R. Davies, Carlos L. Arteaga> ;Breast Cancer Research. 2013 Jul 11
Initiating breast cancer by PIK3CA mutation.
Miller, T.W.> ;Breast Cancer Res. 2012
The receptor tyrosine kinase ErbB3 maintains the balance between luminal and basal breast epithelium.
Balko, J. M., Miller, T. W., Morrison, M. M., Hutchinson, K., Young, C., Rinehart, C., Sánchez, V., Jee, D., Polyak, K., Prat, A., Perou, C. M., Arteaga, C. L., Cook, ...> ;Proc Natl Acad Sci U S A. 2012 Jan 3
Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer.
Miller, T.W., Rexer, B.N., Garrett, J.T., Arteaga, C.L.> ;Breast Cancer Res. 2011
123 citations
A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer
Emily M. Fox, Todd W. Miller, Justin M. Balko, Maria G. Kuba, Violeta Sanchez, R. Adam Smith, Shuying Liu, Ana M. Gonzalez-Angulo, Gordon B. Mills, Fei Ye, Yu Shyr, H....> ;Cancer Research. 2011 Nov 1
Phosphatidylinositol 3-Kinase and Antiestrogen Resistance in Breast Cancer.
Miller, T.W., Balko, J.M., Arteaga, C.L.> ;J Clin Oncol. 2011 Nov 20
231 citations
ERα-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer
Todd W. Miller, Justin M. Balko, Emily M. Fox, Zara Ghazoui, Anita K. Dunbier, Helen Anderson, Mitchell Dowsett, Aixiang Jiang, R. Adam Smith, Sauveur-Michel Maira, H....> ;Cancer Discovery. 2011 Jul 20
Using Tandem Mass Spectrometry in Targeted Mode to Identify Activators of Class IA PI3K in Cancer.
Yang, X., Turke, A. B., Qi, J., Song, Y., Rexer, B. N., Miller, T. W., Jänne, P. A., Arteaga, C. L., Cantley, L. C., Engelman, J. A., Asara, J. M.> ;Cancer Res. 2011 Sep 15
Determination of preservative and antimicrobial compounds in fish from Manila Bay, Philippines using ultra high performance liquid chromatography tandem mass spectrome...
Ramaswamy, B.R., Kim, J., Isobe, T., Chang, K., Amano, A., Miller, T.W., Siringan, F.P., Tanabe, S.> ;J Hazard Mater. 2011 Sep 15
The prognostic relevance of altered antiglycan antibody profiles in the sera of primary melanoma patients.
Haimovic A, Ma MW, Vuskovic MI, Miller T, DiBenedetto M, Grossman J, Shapiro RL, Pavlick AC, Berman RS, Pass HI, Huflejt M, Osman I> ;J. Clin. Oncol.. 2011-05-20
A gene expression signature from human breast cancer cells with acquired hormone independence identifies MYC as a mediator of antiestrogen resistance.
Miller, T. W., Balko, J. M., Ghazoui, Z., Dunbier, A., Anderson, H., Dowsett, M., González-Angulo, A. M., Mills, G. B., Miller, W. R., Wu, H., Shyr, Y., Arteaga, C. L.> ;Clin Cancer Res. 2011 Apr 1
Hypoxia in Manila Bay, Philippines during the northeast monsoon.
Jacinto, G. S.,Sotto, L. P.,Senal, M. I.,San Diego-McGlone, M. L.,Escobar, M. T.,Amano, A.,Miller, T. W.> ;Mar Pollut Bull. 2011
Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer.
Miller, T. W., Hennessy, B. T., González-Angulo, A. M., Fox, E. M., Mills, G. B., Chen, H., Higham, C., García-Echeverría, C., Shyr, Y., Arteaga, C. L.> ;J Clin Invest. 2010 Jul
99 citations
Inhibition of Mammalian Target of Rapamycin Is Required for Optimal Antitumor Effect of HER2 Inhibitors against HER2-Overexpressing Cancer Cells
Todd W. Miller, James T. Forbes, Chirayu Shah, Shelby K. Wyatt, H. Charles Manning, Maria Graciela Olivares, Violeta Sanchez, Teresa C. Dugger, Nara de Matos Granja, A...> ;Clinical Cancer Research. 2009 Dec 1
Imaging biomarkers predict response to anti-HER2 (ErbB2) therapy in preclinical models of breast cancer.
Shah, C., Miller, T.W., Wyatt, S.K., McKinley, E.T., Olivares, M.G., Sanchez, V., Nolting, D.D., Buck, J.R., Zhao, P., Ansari, M.S., Baldwin, R.M., Gore, J.C., Schiff,...> ;Clin Cancer Res. 2009-07-15
Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance ...
Miller, T. W., Pérez-Torres, M., Narasanna, A., Guix, M., Stål, O., Pérez-Tenorio, G., Gonzalez-Angulo, A. M., Hennessy, B. T., Mills, G. B., Kennedy, J. P., Lindsley,...> ;Cancer Res. 2009-05-15
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Grant Support

The Effects Of PTEN On Tyrosine Kinase Signaling In Breast CancerNational Cancer Institute2010–2011
Modulation Of Aromatase: Implications For Breast CancerNational Cancer Institute2007–2008
Intrabody Therapy For Huntington'S DiseaseNational Institute Of Neurological Disorders And Stroke2002–2004

Hospital Affiliations

Franklin Memorial HospitalFarmington, Maine
Penobscot Valley HospitalLincoln, Maine