VaishaliSanchorawalaMD

Hematology • Boston, MA

Professor, Medicine, Boston University School of Medicine

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Office
1 Boston Medical Ctr Pl
Boston, MA 02118
Phone+1 617-638-6282

Fax+1 617-638-5756
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Education & Training

Boston University Medical CenterFellowship, Hematology and Medical Oncology, 1997
Rutgers Health/New Jersey Medical SchoolResidency, Internal Medicine, 1991 - 1994
Seth G.S. Medical CollegeClass of 1990

Certifications & Licensure

MA State Medical License 1994 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology

Awards, Honors, & Recognition

Super Doctor SuperDoctors.com

Clinical Trials

S0115, High-Dose Melphalan and Autologous Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma or Primary Systemic Amyloidosis Start of enrollment: 2004 Jan 01
Completed
Phase 2
Tandem Autologous Stem Cell Transplantation in Treating Patients With Primary Systemic (AL) Amyloidosis Start of enrollment: 2000 Aug 01
Completed
Phase 2
HD Melphalan and SCT in Patients With IGDD or LCDD Start of enrollment: 2006 Oct 01
Terminated
Phase 2
Melphalan, Bortezomib, and Stem Cell Transplant in Treating Patients With Primary Systemic Amyloidosis Start of enrollment: 2008 Jun 01
Completed
Phase 2
Bortezomib and Dexamethasone Followed by High-Dose Melphalan and Stem Cell Transplantation for Primary (AL) Amyloidosis Start of enrollment: 2009 Sep 01
Completed
Phase 2
Bendamustine and Dexamethasone in Patients With Relapsed AL Amyloidosis Start of enrollment: 2013 Jan 01
Completed
Phase 2
Scleroderma Treatment With Autologous Transplant (STAT) Study Start of enrollment: 2011 Sep 15
Active, not recruiting
Phase 2
A Phase I/II Trial of Pomalidomide and Dexamethasone in Subjects With Previously-Treated AL Amyloidosis Start of enrollment: 2012 Jun 01
Completed
Phase 1, Phase 2
First-line Pomalidomide, Bortezomib, and Dexamethasone For AL Amyloidosis or LCDD Start of enrollment: 2013 Mar 01
Terminated
Phase 1
A Safety Study of Carfilzomib in Patients With Previously-Treated Systemic Light Chain Amyloidosis Start of enrollment: 2013 Feb 01
Completed
Phase 1
The PRONTO Study, a Global Phase 2b Study of NEOD001 in Previously Treated Subjects With Light Chain (AL) Amyloidosis Start of enrollment: 2016 Mar 01
Completed
Phase 2
Daratumumab for the Treatment of Patients With AL Amyloidosis Start of enrollment: 2017 Mar 20
Completed
Phase 1, Phase 2
A Clinical Study of Melphalan Flufenamide (Melflufen) and Dexamethasone for Patients With Immunoglobulin Light Chain (AL) Amyloidosis Start of enrollment: 2020 Aug 06
Terminated
Phase 1
Daratumumab, Pomalidomide, and Dexamethasone (DPd) in Relapsed/Refractory Light Chain Amyloidosis Patients Previously Exposed to Daratumumab Start of enrollment: 2021 Apr 14
Recruiting
Phase 2
Roles: Contact, Principal Investigator
Collection of Samples and Clinical Data From Patients With Amyloid Diseases Start of enrollment: 2000 Jan 01
Recruiting
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

Systemic Amyloidosis and Kidney Transplantation: An Update.
Verma, A., Shankara K Anand, Vaishali Sanchorawala, Ashish Verma> ;Seminars in Nephrology. 2024 Mar 14
1 citations
Quantification of Right Ventricular Amyloid Burden with 18F-florbetapir PET/CT and its Association with Right Ventricular Dysfunction and Outcomes in Light-Chain Amylo...
Datar, Y., Clerc, O., Cuddy, S., Kim, S., Taylor, A., Neri, J., Benz, D., Bianchi, G., Yee, A., Sanchorawala, V., Ruberg, F., Landau, H., Liao, R., Kijewski, M., Jeros...> ;European Heart Journal. Cardiovascular Imaging. 2024 Jan 9
1 citations
Neurofilament light chain kinetics as a biomarker for polyneuropathy in V122I hereditary transthyretin amyloidosis.
Lau, K., Prokaeva, T., Zheng, L., Doros, G., Kaku, M., Spencer, B., Berk, J., Sanchorawala, V.> ;Amyloid. 2023 Dec 11
Safety and Efficacy of Propylene Glycol-Free Melphalan in Patients with AL Amyloidosis Undergoing Autologous Stem Cell Transplantation: Results of a Phase II Study.
Shayna Sarosiek, Michelle H Lee, Gheorghe Doros, Camille Vanessa Edwards, Karen Quillen, Dina Brauneis, Anthony C Shelton, Vaishali Sanchorawala, John Mark Sloan> ;Transplantation and Cellular Therapy. 2023 Nov 1
1 citations
Predictors of treatment response and survival outcomes in patients with advanced cardiac AL amyloidosis.
Joshua N Gustine, Andrew Staron, Lisa Mendelson, Tracy Joshi, Deepa M Gopal, Omar K Siddiqi, Vaishali Sanchorawala, Ruberg, F.> ;Blood Advances. 2023 Oct 24
Mapping cellular response to destabilized transthyretin reveals cell- and amyloidogenic protein-specific signatures.
Sabrina Ghosh, Carlos Villacorta-Martin, Jonathan Lindstrom-Vautrin, Devin Kenney, Carly S Golden, Camille V Edwards, Vaishali Sanchorawala, Lawreen H Connors, Richard...> ;Amyloid. 2023 Dec 1
8 citations
Birtamimab plus standard of care in light-chain amyloidosis: the phase 3 randomized placebo-controlled VITAL trial.
Morie A Gertz, Adam D Cohen, Raymond L Comenzo, Efstathios Kastritis, Heather J Landau, Edward N Libby, Michaela Liedtke, Vaishali Sanchorawala, Stefan Schönland, Ashu...> ;Blood. 2023 Oct 5
Hereditary gelsolin amyloidosis: a rare cause of cranial, peripheral and autonomic neuropathies linked to D187N and Y447H substitutions.
Lisa Mendelson, Tatiana Prokaeva, K H Vincent Lau, Vaishali Sanchorawala, Kristen McCausland, Brian Spencer, Surendra Dasari, Ellen D McPhail, Michelle C Kaku> ;Amyloid. 2023 Dec 1
Eureka Moment-Innovation Comes of an Age in Light Chain Amyloidosis.
Vaishali Sanchorawala> ;JCO Oncology Practice. 2023 May 1
Factors affecting the accuracy of amyloidosis identification and referral to a specialty centre.
Andrew Staron, Lisa M Mendelson, Tracy Joshi, Frederick L Ruberg, Vaishali Sanchorawala> ;Amyloid. 2023 Sep 1
1 citations
Quality of life and symptoms among patients with relapsed/refractory AL amyloidosis treated with ixazomib-dexamethasone versus physician's choice.
Vaishali Sanchorawala, Ashutosh D Wechalekar, Kihyun Kim, Stefan O Schönland, Heather J Landau, Fiona Kwok, Kenshi Suzuki, Angela Dispenzieri, Giampaolo Merlini, Raymo...> ;American Journal of Hematology. 2023 May 1
Non-producer multiple myeloma presenting with acute hyperammonemic encephalopathy: case report.
Karina Verma, Tina Zhang, David Mueller, Julie Li, Vaishali Sanchorawala, Andrew Staron> ;Diagnostic Pathology. 2023 Jan 4
3 citations
Complete variable domain sequences of monoclonal antibody light chains identified from untargeted RNA sequencing data.
Allison Nau, Yun Shen, Vaishali Sanchorawala, Tatiana Prokaeva, Gareth J Morgan> ;Frontiers in Immunology. 2023 Jan 1
1 citations
Health-Related Quality of Life Instruments for Clinical Trials in AL Amyloidosis: Report from the Amyloidosis Forum HRQOL Working Group.
Avery A Rizio, Michelle K White, Anita D'Souza, Kristen Hsu, Paula Schmitt, Tiffany P Quock, James Signorovitch, Isabelle Lousada, Vaishali Sanchorawala> ;Patient Related Outcome Measures. 2023 Jan 1
Evaluating the Amyloidosis Speakers Bureau: the influence of amyloidosis patients' narratives on medical students' knowledge, attitudes, and behavioral intent.
Adebanke L Adebayo, Katherine E Rowan, Vaishali Sanchorawala, Mackenzie N Boedicker, Deborah D Boedicker> ;Mededpublish. 2023 Jan 1
2 citations
Light chain amyloidosis associated with Waldenström macroglobulinemia: treatment and survival outcomes.
Joshua N Gustine, Raphael E Szalat, Andrew Staron, Tracy Joshi, Lisa Mendelson, J Mark Sloan, Vaishali Sanchorawala> ;Haematologica. 2023 Jun 1
5 citations
Light Chain Testing Abnormalities Among Patients With Transthyretin Amyloid Cardiomyopathy Referred for Technetium-99m Pyrophosphate Imaging.
Rabah Alreshq, Matthew Cozzolino, Brian Lilleness, Alexandra Pipilas, Lisa Mendelson, Tracy Joshi, Varsha Muralidhar, Eric Guardino, John L Berk, Omar K Siddiqi, Deepa...> ;The American Journal of Cardiology. 2022 Oct 15
9 citations
Graded Cardiac Response Criteria for Patients With Systemic Light Chain Amyloidosis.
Eli Muchtar, Angela Dispenzieri, Brendan Wisniowski, Giovanni Palladini, Paolo Milani, Giampaolo Merlini, Stefan Schönland, Kaya Veelken, Ute Hegenbart, Susan M Geyer,...> ;Journal of Clinical Oncology. 2023 Mar 1
7 citations
Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics.
Cameron S Fraser, Johan K E Spetz, Xingping Qin, Adam Presser, Jonathan Choiniere, Chendi Li, Stacey Yu, Frances Blevins, Aaron N Hata, Jeffrey W Miller, Gary A Bradsh...> ;Nature Communications. 2022 Oct 2
Prevalence of plasma cell and lymphoproliferative disorders among blood relatives of patients with light chain amyloidosis.
Andrew Staron, Karina Verma, Vaishali Sanchorawala> ;British Journal of Haematology. 2022 Sep 1
10 citations
Predictors of hematologic response and survival with stem cell transplantation in AL amyloidosis: A 25-year longitudinal study.
Joshua N Gustine, Andrew Staron, Raphael E Szalat, Lisa M Mendelson, Tracy Joshi, Frederick L Ruberg, Omar Siddiqi, Deepa M Gopal, Camille V Edwards, Andrea Havasi, Mi...> ;American Journal of Hematology. 2022 Sep 1
10 citations
Outcomes of renal transplantation in patients with AL amyloidosis: an international collaboration through The International Kidney and Monoclonal Gammopathy Research G...
Havasi, A., Heybeli, C., Leung, N., Angel-Korman, A., Sanchorawala, V., Cohen, O., Wechalekar, A., Bridoux, F., Jaffer, I., Gutgarts, V., Hassoun, H., Levinson, M., Ro...> ;Blood Cancer Journal. 2022 Aug 18
1 citations
Modified High-Dose versus High-Dose Melphalan Conditioning in Older Patients Undergoing Autologous Stem Cell Transplantation for Immunoglobulin Light Chain Amyloidosis.
Hamza Hassan, Karina Verma, Grace Ferri, Dina Brauneis, Karen Quillen, J Mark Sloan, Vaishali Sanchorawala, Camille Vanessa Edwards> ;Transplantation and Cellular Therapy. 2022 Nov 1
1 citations
Standard 30-minute Monitoring Time and Less Intensive Pre-medications is Safe in Patients Treated With Subcutaneous Daratumumab for Multiple Myeloma and Light Chain Am...
David M Hughes, Lynnette Henshaw, Frances Blevins, Camille Edwards, Adam Lerner, John Mark Sloan, Vaishali Sanchorawala> ;Clinical Lymphoma, Myeloma & Leukemia. 2022 Aug 1
19 citations
Guidelines for non-transplant chemotherapy for treatment of systemic AL amyloidosis: EHA-ISA working group.
Ashutosh D Wechalekar, M Teresa Cibeira, Simon D Gibbs, Arnaud Jaccard, Shaji Kumar, Giampaolo Merlini, Giovanni Palladini, Vaishali Sanchorawala, Stefan Schönland, Ch...> ;Amyloid. 2023 Mar 1
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Journal Articles

Development and Validation of a Survival Staging System Incorporating BNP in Patients with Light Chain (AL) Amyloidosis
Frederick L Ruberg, Vaishali Sanchorawala, Blood
Heparin-Induced Thrombocytopenia and Thrombosis During High Dose Melphalan and Autologous Stem Cell Transplantation
Dina Brauneis, Vaishali Sanchorawala, J Mark Sloan, Shayna Sarosiek, Blood

Abstracts/Posters

Results of the Phase 3 VITAL Study of NEOD001 (Birtamimab) Plus Standard of Care in Patients with Light Chain (AL) Amyloidosis Suggest Survival Benefit for Mayo Stage ...
Vaishali Sanchorawala, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Primary Results from the Phase 3 Tourmaline-AL1 Trial of Ixazomib-Dexamethasone Versus PhysicianÍs Choice of Therapy in Patients (Pts) with Relapsed/Refractory Primary...
Vaishali Sanchorawala, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Safety and Efficacy of Propylene Glycol-Free Melphalan (Evomela) in Patients with AL Amyloidosis Undergoing Autologous Stem Cell Transplantation: Preliminary Results o...
Vaishali Sanchorawala, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
The Use of Next Generation Gene Sequencing to Measure Minimal Residual Disease in Patients with AL Amyloidosis and Low Plasma Cell Burden: A Feasibility Study
Vaishali Sanchorawala, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Successful Transition from Bortezomib Subcutaneous (SubQ) to Generic Intravenous (IV) Bortezomib: Cost Savings Initiative with Global Economic Impact
Vaishali Sanchorawala, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
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Lectures

Untangling Amyloidosis 2019
61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
Safety, Tolerability and Response Rates of Daratumumab in Patients with Relapsed Light Chain (AL) Amyloidosis: Results of a Phase II Study
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018

Press Mentions

Vaishali Sanchorawala: Her Pioneering Research into the Rare Disease Amyloidosis Defines the FieldFebruary 24th, 2021
Organ Responses After Highdose Melphalan and Stemcell Transplantation in AL AmyloidosisJuly 31st, 2020
Anti-Cancer Drug Safe and Effective for Treating Light Chain (AL) AmyloidosisFebruary 3rd, 2020
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Hospital Affiliations

Boston Medical CenterBoston, Massachusetts
Veterans Affairs Connecticut Healthcare SystemWest Haven, Connecticut
Maine Veterans Affairs Medical CenterAugusta, Maine