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Vincent W. Yang, MD, Gastroenterology, East Setauket, NY, Stony Brook University Hospital

Vincent W.WYangMDPhD

Gastroenterology East Setauket, NY

Gastrointestinal Cancer, Inflammatory Bowel Disease, Malabsorption

Professor and Chair, Medicine, Stony Brook University

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Summary

  • As the Simons Chair of Medicine at Stony Brook University School of Medicine, Dr. Yang brings a remarkable blend of clinical expertise, research acumen, teaching skill and leadership experience to the position. He oversees the largest department within the School of Medicine, covering a broad residency and fellowship training program and nine clinical divisions, including centers of excellence in Cardiology, Gastroenterology and Hematology/Oncology.

    An internationally renowned physician-scientist with a focus on the understanding and treatment of gastrointestinal malignancies, Dr. Yang also is a pioneer in the cloning and characterization of Krüppel-like factors (KLFs), a group of proteins with important physiologic functions. One of the KLFs that Dr. Yang's group identified, KLF4, has gained significant attention due to its ability to convert somatic cells to induced pleuripotenti stem cells (iPSC) with remarkable therapeutic potential.

    Dr. Yang comes to Stony Brook from Emory University School of Medicine, where he served as the R. Bruce Logue Professor of Medicine and the Director of the Division of Digestive Diseases. Previously, he held clinical and teaching positions at Johns Hopkins University School of Medicine.

    His goals at Stony Brook include broadening the scope of the department to better serve both the residents of Suffolk County and the surrounding community hospitals with the most advanced medicine available. In addition, he plans to integrate its existing strengths — excellent clinical programs and superb research facilities in a university setting — to grow the translational research program.

Education & Training

  • Johns Hopkins University
    Johns Hopkins UniversityFellowship, Gastroenterology, 1987 - 1989
  • Johns Hopkins University
    Johns Hopkins UniversityResidency, Internal Medicine, 1984 - 1987
  • Rutgers Robert Wood Johnson Medical School
    Rutgers Robert Wood Johnson Medical SchoolClass of 1984
  • Princeton University
    Princeton UniversityPhD, Biochemistry, 1976 - 1980
  • Princeton University
    Princeton UniversityPhD, 1980
  • National Taiwan University
    National Taiwan UniversityBS, Agricultural Chemistry, 1972 - 1976
  • National Taiwan University
    National Taiwan UniversityBSc, 1976

Certifications & Licensure

  • NY State Medical License
    NY State Medical License 2011 - 2025
  • GA State Medical License
    GA State Medical License 2001 - 2013
  • MD State Medical License
    MD State Medical License 1986 - 2001
  • American Board of Internal Medicine Internal Medicine

Awards, Honors, & Recognition

  • Shanghai Cancer Forum Award for Distinguished Achievement sin Cancer Research and Oncology Chinese Association of Clinical Oncology & Chinese Association of Professions in Science and Technology, 2011
  • "One in One Hundred" Outstanding Postdoctoral Fellow Mentor Award Emory University School of Medicine, 2009
  • Guide to America's Top Physicians Consumers' Research Council of American, 2008
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Publications & Presentations

PubMed

Journal Articles

  • Intestinal stem cell (Lgr5)-specific deletion of Kruppel-like factor 5 in mice results in acute loss of proliferation and chronic depletion of stem cells  
    M.O. Nandan, A.M. Ghaleb, A.B. Bialkowska, V.W. Yang, Gastroenterology, 1/1/2014
  • Kruppel-like factor 6 regulates mitochondrial function in the kidney  
    Mallipattu, S.K., Horne, S.J., D'Agati, V., Narla, G., Liu, R., Dickman, K., Chen, E.Y., Ma'ayan, A., Bialkowska, A.B., Ghaleb, A.M., Nandan, M.O., Jain, M.K., Daehn, ..., Journal of Clinical Investigation, 1/1/2014
  • Kruppel-like factor 4 is a radio-protective factor of the intestine following gamma radiation-induced gut injury in mice  
    D. Talmasov, A.M. Ghaleb, B. Yu, M.O. Nandan, V.W. Yang, Gastroenterology, 1/1/2013
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Books/Book Chapters

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Abstracts/Posters

  • Kruppel-like factor 5 modulates intestinal epithelial barrier function by regulating components of the tight junction in vitro.
    Y. Liu, A.B. Bialkowska, V.W. Yang, Gastroenterology, 1/1/2014
  • Intestine-specific deletion of Klf4 renders mice susceptible to inflammation-associated tumorigenesis and increases colonic adenoma incidence in ApcMin/+ mice.
    A.M. Ghaleb, V.W. Yang, Gastroenterology, 1/1/2014
  • A colon cancer-derived mutant of Kruppel-like factor 5 inhibits its degradation by glycogen synthase kinase 3Beta and the E3 ubiquitin ligase FBW7.
    A.B. Bialkowska, Y. Liu, M.O. Nandan , V.W. Yang, Gastroenterology, 1/1/2013
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Lectures

  • The Career Journey of a Physician Scientist and Department Chair. 
    Stony Brook, NY - 1/1/2014
  • GI Cancer Program. 
    Stony Brook, NY - 1/1/2014
  • Department of Medicine, Cancer Center, and Beyond. 
    Stony Brook, NY - 1/1/2014
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Other

Grant Support

  • Mechanisms Of Intestinal TumorigenesisNational Cancer Institute2012
  • Regulation Of Intestinal Epithelial Cell ProliferationNational Institute Of Diabetes And Digestive And Kidney Diseases2011
  • Mechanisms Of Intestinal TumorigenesisNational Cancer Institute2001–2011
  • Biology And Pathobiology Of Kr??Ppel-Like Factors (KLFS)National Cancer Institute2010
  • Emory Epithelial Pathobiology Research Development CenterNational Institute Of Diabetes And Digestive And Kidney Diseases2007–2010
  • Regulation Of Intestinal Epithelial Cell ProliferationNational Institute Of Diabetes And Digestive And Kidney Diseases2001–2010
  • High Throughput Screen For Small Molecule Inhibitors Of Colorectal Cancer Cell PRNational Institute On Drug Abuse2008
  • Emory Epithelial Pathobiology Research Development Cent*National Institute Of Diabetes And Digestive And Kidney Diseases2004–2006
  • Division Of Physiology And PathologyCenter For Scientific Review2004–2005
  • Emory Epithelial Pathobiology Research DevelopmentNational Institute Of Diabetes And Digestive And Kidney Diseases2003
  • Differential Gene Expression In Intestinal Cell LinesNational Institute Of Diabetes And Digestive And Kidney Diseases1992–2002
  • Molecular Medicine Of Colorectal CancerNational Cancer Institute2001
  • Mechanisms Of Intestinal TumorigenesisNational Cancer Institute2000–2001
  • Regulation Of Intestinal Epithelial Cell ProliferationNational Institute Of Diabetes And Digestive And Kidney Diseases1997–2000
  • Transcriptional Regulation Of Alcohol Dehydrogenase GeneNational Institute On Alcohol Abuse And Alcoholism1992–1993
  • Characterization Of Cellular Substrate Of InsulinNational Institute Of Diabetes And Digestive And Kidney Diseases1987–1990

Hospital Affiliations