WilliamChutkowMD

PubMed

• Machine Learning for Proteomic Risk Scores in Heart Failure.
  Dongchu Xu, Jonathan Cunningham, Pablo-Miki Marti-Castellote, Luqing Zhang, Natasha L Patel-Murray, Margaret F Prescott, William Chutkow, Michael M Mendelson, Scott D ...> ;Journal of Cardiac Failure. 2023 Nov 1
• 4 citations
  Sensory ataxia and cardiac hypertrophy caused by neurovascular oxidative stress in chemogenetic transgenic mouse lines.
  Shambhu Yadav, Markus Waldeck-Weiermair, Fotios Spyropoulos, Roderick Bronson, Arvind K Pandey, Apabrita Ayan Das, Alexander C Sisti, Taylor A Covington, Venkata Thula...> ;Nature Communications. 2023 May 29
• 1 citations
  Clinical characteristics of heart failure with reduced ejection fraction patients with rare pathogenic variants in dilated cardiomyopathy-associated genes: A subgroup ...
  Ana Barat, Chien-Wei Chen, Natasha Patel-Murray, John J V McMurray, Milton Packer, Scott D Solomon, Akshay S Desai, Jean L Rouleau, Michael R Zile, Zenab Attari, Cong ...> ;European Journal of Heart Failure. 2023 Aug 1
• 9 citations
  Aptamer Proteomics for Biomarker Discovery in Heart Failure With Reduced Ejection Fraction.
  Luqing Zhang, Jonathan W Cunningham, Brian L Claggett, Jaison Jacob, Michael M Mendelson, Pablo Serrano-Fernandez, Sergio Kaiser, Denise P Yates, Margaret Healey, Chie...> ;Circulation. 2022 Nov 1
• 6 citations
  The genomics of heart failure: design and rationale of the HERMES consortium
  R. Thomas Lumbers, Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, Daniel I. Swerdlow, Anders Mälarstig, Charlotte Andersson, Niek Verweij, Michael V. Holmes, J...> ;ESC Heart Failure. 2021 Sep 3
• 335 citations
  Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.
  Sonia Shah, Albert Henry, Carolina Roselli, Honghuang Lin, G Sveinbjörnsson, Ghazaleh Fatemifar, Åsa K. Hedman, Jemma B. Wilk, Morley Mp, Mark Chaffin, Anna Helgadotti...> ;Nature Communications. 2020 Jan 9
• 45 citations
  The effects of licogliflozin, a dual SGLT1/2 inhibitor, on body weight in obese patients with or without diabetes.
  Yan-Ling He, William Haynes, Charles D. Meyers, Ahmed Amer, Yiming Zhang, Ping Mahling, Anisha E. Mendonza, Shenglin Ma, William A. Chutkow, Eric Bachman> ;Diabetes, Obesity & Metabolism. 2019 Jun 1
• 42 citations
  Thioredoxin‐interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress
  Samuel Lee, Soo Min Kim, James R Dotimas, Letitia Li, Edward P. Feener, Stephan Baldus, Ronald B Myers, William A. Chutkow, Parth Patwari, Jun Yoshioka, Richard T. Lee> ;EMBO Molecular Medicine. 2014 Jun 1
• 55 citations
  Myocardial Infarction Triggers Chronic Cardiac Autoimmunity in Type 1 Diabetes
  Raju V. S. R. K. Gottumukkala, HuiJuan Lv, Lizbeth Cornivelli, Amy J. Wagers, Raymond Y. Kwong, Roderick T. Bronson, Garrick C. Stewart, P. Christian Schulze, William ...> ;Science Translational Medicine. 2012 Jun 13
• 118 citations
  Deletion of thioredoxin-interacting protein in mice impairs mitochondrial function but protects the myocardium from ischemia-reperfusion injury
  Jun Yoshioka, William A. Chutkow, Samuel C. K. Lee, Jae Bum Kim, Jie Yan, Rong Tian, Merry L. Lindsey, Edward P. Feener, Christine E. Seidman, Jonathan G. Seidman, Ric...> ;The Journal of Clinical Investigation. 2012 Jan 3
• 86 citations
  The Arrestin Domain-Containing 3 Protein Regulates Body Mass and Energy Expenditure
  Parth Patwari, Valur Emilsson, Eric E. Schadt, William A. Chutkow, Samuel Lee, Alessandro Marsili, Yongzhao Zhang, Radu Dobrin, David E. Cohen, P. Reed Larsen, Ann Mar...> ;Cell Metabolism. 2011 Nov 2
• 42 citations
  Thioredoxin Regulates Adipogenesis through Thioredoxin-interacting Protein (Txnip) Protein Stability
  William A. Chutkow, Richard T. Lee> ;The Journal of Biological Chemistry. 2011 Aug 19
• 110 citations
  Deletion of the α-Arrestin Protein Txnip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity
  William A. Chutkow, Andreas L. Birkenfeld, Jonathan D. Brown, Hui-Young Lee, David W. Frederick, Jun Yoshioka, Parth Patwari, Romy Kursawe, Samuel W. Cushman, Jorge Pl...> ;Diabetes. 2010 Jun 1
• 22 citations
  A Crisis in Late Pregnancy
  Akshay S. Desai, William A. Chutkow, Elazer R. Edelman, Katherine E. Economy, G. William Dec> ;The New England Journal of Medicine. 2009 Dec 16
• 5 citations
  Interactive medical case. A crisis in late pregnancy.
  John J. Ross, Akshay S. Desai, William A. Chutkow, Katherine E. Economy, Dec Gw> ;The New England Journal of Medicine. 2009 Nov 12
• 150 citations
  Thioredoxin-independent Regulation of Metabolism by the α-Arrestin Proteins
  Parth Patwari, William A. Chutkow, Kiersten Cummings, Valerie L. R. M. Verstraeten, Jan Lammerding, Eric R. Schreiter, Richard T. Lee> ;The Journal of Biological Chemistry. 2009 Sep 11
• 152 citations
  Thioredoxin-interacting Protein (Txnip) Is a Critical Regulator of Hepatic Glucose Production
  William A. Chutkow, Parth Patwari, Jun Yoshioka, Richard T. Lee> ;The Journal of Biological Chemistry. 2008 Jan 25
• 85 citations
  Targeted Deletion of Thioredoxin-Interacting Protein Regulates Cardiac Dysfunction in Response to Pressure Overload
  Jun Yoshioka, Kenichi Imahashi, Scott A. Gabel, William A. Chutkow, Aurora A. Burds, Joseph Gannon, P. Christian Schulze, Catherine MacGillivray, Robert E. London, Eli...> ;Circulation Research. 2007 Dec 7
• 384 citations
  TXNIP regulates peripheral glucose metabolism in humans
  Hemang Parikh, Emma Carlsson, William A. Chutkow, Lovisa Johansson, Heidi Storgaard, Pernille Poulsen, Richa Saxena, Christine Ladd, P. Christian Schulze, Michael J. M...> ;Plos Medicine. 2007 May 1
• 242 citations
  The Interaction of Thioredoxin with Txnip: Evidence for Formation of a Mixed Disulfide by Disulfide Exchange
  Parth Patwari, Luke J. Higgins, William A. Chutkow, Jun Yoshioka, Richard T. Lee> ;The Journal of Biological Chemistry. 2006 Aug 4
• 189 citations
  Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 KATP channels
  William A. Chutkow, Jielin Pu, Matthew T. Wheeler, Tomoyuki Wada, Jonathan C. Makielski, Charles F. Burant, Elizabeth M. McNally> ;The Journal of Clinical Investigation. 2002 Jul 15
• 95 citations
  Disruption of Sur2-containing KATP channels enhances insulin-stimulated glucose uptake in skeletal muscle
  William A. Chutkow, Varman Samuel, Polly A. Hansen, Jielin Pu, Carmen R. Valdivia, Jonathan C. Makielski, Charles F. Burant> ;Proceedings of the National Academy of Sciences of the United States of America. 2001 Sep 25
• 81 citations
  Alternative Splicing of sur2 Exon 17 Regulates Nucleotide Sensitivity of the ATP-sensitive Potassium Channel
  William A. Chutkow, Jonathan C. Makielski, Deborah J. Nelson, Charles F. Burant, Zheng Fan> ;The Journal of Biological Chemistry. 1999 May 7
• 203 citations
  Cloning, Tissue Expression, and Chromosomal Localization of SUR2, the Putative Drug-Binding Subunit of Cardiac, Skeletal Muscle, and Vascular KATP Channels
  William A. Chutkow, M. Celeste Simon, Michelle M. Le Beau, Charles F. Burant> ;Diabetes. 1996 Oct 1
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