WilliamGordonFrankleMDMBA

Chief, NYU Langone Hospital Brooklyn; Vice Chair, Department of Psychiatry, NYU Langone Medical Center; Associate Professor of Psychiatry

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Office
1 Park Ave
Fl 8
New York, NY 10016
Phone+1 877-648-2964

Fax+1 212-263-9701
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Education & Training

Massachusetts General Hospital/McLean HospitalResidency, Psychiatry, 1997 - 2001
New York Medical CollegeClass of 1996

Certifications & Licensure

FL State Medical License 2020 - Present
NY State Medical License 2001 - 2025
VT State Medical License 2010 - 2024
CT State Medical License 2022 - 2024
NC State Medical License 2020 - 2022
PA State Medical License 2006 - 2010
MA State Medical License 1998 - 2003
American Board of Psychiatry and Neurology Psychiatry
American Board of Preventive Medicine Addiction Medicine

Clinical Trials

Imaging Dopamine D2 Agonist Binding Sites in Schizophrenia Start of enrollment: 2019 Jul 01
Withdrawn

Publications & Presentations

PubMed

15 citations
Prefrontal and Striatal Dopamine Release Are Inversely Correlated in Schizophrenia.
W Gordon Frankle, Michael Himes, N Scott Mason, Chester A Mathis, Rajesh Narendran> ;Biological Psychiatry. 2022 Nov 15
5 citations
Imaging Cortical Dopamine Transmission in Cocaine Dependence: A [11C]FLB 457-Amphetamine Positron Emission Tomography Study.
Rajesh Narendran, N.S. Mason, Michael L. Himes, W. Gordon Frankle> ;Biological Psychiatry. 2020 Apr 12
3 citations
Distinguishing Schizophrenia Subtypes: Can Dopamine Imaging Improve the Signal-to-Noise Ratio?
W. Gordon Frankle, Rajesh Narendran> ;Biological Psychiatry. 2020 Feb 1
4 citations
Failure to detect amphetamine-induced dopamine release in the cortex with [11 C]FLB 457 positron emission tomography (PET): Methodological considerations.
Joshua Gertler, Savannah Tollefson, Rehima Jordan, Michael L. Himes, N. Scott Mason, W. Gordon Frankle, Rajesh Narendran> ;Synapse. 2018 Sep 1
21 citations
Amphetamine-Induced Striatal Dopamine Release Measured With an Agonist Radiotracer in Schizophrenia
W. Gordon Frankle, Jennifer Paris, Michael L. Himes, N. Scott Mason, Chester A. Mathis, Rajesh Narendran> ;Biological Psychiatry. 2017 Dec 7
8 citations
An open-label positron emission tomography study to evaluate serotonin transporter occupancy following escalating dosing regimens of (R)-(-)-O-desmethylvenlafaxine and...
W. Gordon Frankle, Brigitte Robertson, Gary Maier, Jennifer Paris, Deanna Asmonga, Maureen May, Michael L. Himes, N. Scott Mason, Chester A. Mathis, Rajesh Narendran> ;Synapse. 2018 Mar 1
8 citations
Brain translocator protein occupancy by ONO-2952 in healthy adults: A Phase 1 PET study using [11 C]PBR28.
W. Gordon Frankle, Rajesh Narendran, Andrew T. Wood, Fumitaka Suto, Michael L. Himes, Michiyoshi Kobayashi, Tomoya Ohno, Akinori Yamauchi, Katsukuni Mitsui, Kevin J. D...> ;Synapse. 2017 Mar 1
26 citations
Comment on Analyses and Conclusions of “Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [11C]PBR28 PET Brain Imaging Study”
Raj Narendran, W. Gordon Frankle> ;The American Journal of Psychiatry. 2016 May 1
3 citations
Cortical Dopamine Transmission as Measured with the [11C]FLB 457 - Amphetamine PET Imaging Paradigm Is Not Influenced by COMT Genotype.
Rajesh Narendran, Maureen A. May, Kodavali V. Chowdari, Michael L. Himes, Kelli Fasenmyer, W. Gordon Frankle, Vishwajit L. Nimgaonkar> ;Plos One. 2016 Jun 20
80 citations
In Vivo Measurement of GABA Transmission in Healthy Subjects and Schizophrenia Patients
W. Gordon Frankle, Raymond Y. Cho, Konasale M. Prasad, N. Scott Mason, Jennifer Paris, Michael L. Himes, Christopher Walker, David A. Lewis, Rajesh Narendran> ;The American Journal of Psychiatry. 2015 Jul 2
1 citations
Safety of Oral Amphetamine Administered during Positron Emission Tomography Scans in Medically Screened Humans
Lora D. Weidner, Antonio Paris, W. Gordon Frankle, Rajesh Narendran> ;Plos One. 2015 Dec 14
48 citations
Decreased prefrontal cortical dopamine transmission in alcoholism
Rajesh Narendran, N.S. Mason, Jennifer Paris, Michael L. Himes, Antoine Douaihy, W. Gordon Frankle> ;The American Journal of Psychiatry. 2014 Aug 1
Imaging Dopamine Transmission in the Frontal Cortex: A Simultaneous Microdialysis and [(11)C]FLB 457 PET Study
W G Frankle, R Narendran> ;Nature. 2013 Feb 26
21 citations
Improved Working Memory but No Effect on Striatal Vesicular Monoamine Transporter Type 2 after Omega-3 Polyunsaturated Fatty Acid Supplementation
Rajesh Narendran, William G. Frankle, N.S. Mason, Matthew F. Muldoon, Bita Moghaddam> ;Plos One. 2012 Oct 3
42 citations
Sustained Recreational Use of Ecstasy Is Associated with Altered Pre and Postsynaptic Markers of Serotonin Transmission in Neocortical Areas: A PET Study with [11C]DAS...
Nina Urban, Ragy R. Girgis, Peter S. Talbot, Lawrence S. Kegeles, Xiaoming Xu, W. Gordon Frankle, Carl L. Hart, Mark Slifstein, Anissa Abi-Dargham, Marc Laruelle> ;Neuropsychopharmacology. 2012 Feb 22
41 citations
[11C]NNC 112 Selectivity for Dopamine D1 and Serotonin 5-HT2A Receptors: A PET Study in Healthy Human Subjects
Mark Slifstein, Lawrence S. Kegeles, Robyn Gonzales, William Gordon Frankle, Xiaoyan Xu, Marc Laruelle, Anissa Abi-Dargham> ;Journal of Cerebral Blood Flow and Metabolism. 2007 Feb 21
88 citations
Prefrontal cortical projections to the midbrain in primates: evidence for a sparse connection.
William Gordon Frankle, Mark Laruelle, Suzanne N. Haber> ;Neuropsychopharmacology. 2006 Jan 4
25 citations
Bipolar depression: relationship between episode length and antidepressant treatment
W. G. Frankle, Roy H. Perlis, Thilo Deckersbach, Louisa D. Grandin, Stephen M. Gray, Gary S. Sachs, Andrew A. Nierenberg> ;Psychological Medicine. 2002 Nov 1
32 citations
[11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels.
W. Gordon Frankle, Raymond Y. Cho, N. Scott Mason, Chi Min Chen, Michael L. Himes, Christopher Walker, David A. Lewis, Chester A. Mathis, Rajesh Narendran> ;Plos One. 2012 Feb 27
23 citations
Clozapine-Associated Reduction in Arrest Rates of Psychotic Patients With Criminal Histories
W. Gordon Frankle, David Shera, Herbert Berger-Hershkowitz, A. Eden Evins, Christine E. Connolly, Donald C. Goff, David C. Henderson> ;The American Journal of Psychiatry. 2001 Feb 1
Occupancy of dopamine D2 receptors by the atypical antipsychotic drugs risperidone and olanzapine: theoretical implications.
Frankle, W. G., Gil, R., Hackett, E., Mawlawi, O., Zea-Ponce, Y., Zhu, Z., Kochan, L. D., Cangiano, C., Slifstein, M., Gorman, J. M., Laruelle, M., Abi-Dargham, A.> ;Psychopharmacology (Berl). 2004 Oct
116 citations
Comparative Evaluation of Serotonin Transporter Radioligands 11C-DASB and 11C-McN 5652 in Healthy Humans
W. Gordon Frankle, Yiyun Huang, Dah Ren Hwang, Peter S. Talbot, Mark Slifstein, Ronald L. Van Heertum, Anissa Abi-Dargham, Marc Laruelle> ;Journal of Nuclear Medicine. 2004 Apr 1
15 citations
Positron emission tomography and single photon emission CT molecular imaging in schizophrenia.
David Erritzoe, Peter S. Talbot, W. Gordon Frankle, Anissa Abi-Dargham> ;Neuroimaging Clinics of North America. 2003 Nov 1
Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior.
Martinez, D., Broft, A., Foltin, R. W., Slifstein, M., Hwang, D. R., Huang, Y., Perez, A., Frankle, W. G., Cooper, T., Kleber, H. D., Fischman, M. W., Laruelle, M., Fr...> ;Neuropsychopharmacology. 2004 Jun
Presence of irritability during depressive episodes in bipolar disorder.
Deckersbach, T., Perlis, R. H., Frankle, W. G., Gray, S. M., Grandin, L., Dougherty, D. D., Nierenberg, A. A., Sachs, G. S.> ;CNS Spectr. 2004 Mar
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Grant Support

In Vivo Measurement Of Dopamine Transmission In SchizophreniaNational Institute Of Mental Health2010
The Effects Of Cannabis Use/Abuse On In Vivo Dopamine FunctionNational Institute On Drug Abuse2008
The Neuroanatomy Of Antipsychotic Drug ActionNational Institute Of Mental Health2006–2008
The Neuroanatomy Of Antipsychotic Drug ActionNational Institute Of Mental Health2005
Neuroanatomy Of Antipsychotic Drug ActionNational Institute Of Mental Health2004

Hospital Affiliations

NYU Langone Hospital - BrooklynBrooklyn, New York
NYU Langone HospitalsNew York, New York