WilliamJamesHowardMDMACP, FNLA

PubMed

• Letter to the Editor in response to "Response to Kovanen PT, et al. Letter to the Editor" for original article COVID-19 increases risk of myocardial infarction in pers...
  Kelly D. Myers, Katherine Wilemon, Mary P. McGowan, William James Howard, David Staszak, Daniel J. Rader> ;American Journal of Preventive Cardiology. 2021 Jul 20
• 17 citations
  COVID-19 associated risks of myocardial infarction in persons with familial hypercholesterolemia with or without ASCVD.
  Kelly D. Myers, Katherine Wilemon, Mary P. McGowan, William James Howard, David Staszak, Daniel J. Rader> ;American Journal of Preventive Cardiology. 2021 May 25
• 29 citations
  Precision screening for familial hypercholesterolaemia: a machine learning study applied to electronic health encounter data.
  Kelly D. Myers, Joshua W. Knowles, David Staszak, Michael D. Shapiro, William James Howard, Mrinal Yadava, David Zuzick, Latoya Williamson, Nigam H. Shah, Juan M. Band...> ;The Lancet. Digital Health. 2019 Dec 1
• 8 citations
  All-Cause, Cardiovascular, and Cancer Mortality in Western Alaska Native People: Western Alaska Tribal Collaborative for Health (WATCH)
  Barbara V. Howard, Jesse S. Metzger, Kathryn R. Koller, Stacey E. Jolly, Elvin Asay, Hong Wang, Abbie W. Wolfe, Scarlett E. Hopkins, Cristiane Kaufmann, Terry W. Rayme...> ;American Journal of Public Health. 2014 Jun 11
• 12 citations
  Differences in Risk Factors for Coronary Heart Disease among Diabetic and Nondiabetic Individuals from a Population with High Rates of Diabetes: The Strong Heart Study
  Jiaqiong Xu, Elisa T. Lee, Leif E. Peterson, Richard B. Devereux, Everett R. Rhoades, Jason G. Umans, Lyle G. Best, William James Howard, Jaya Paranilam, Barbara V. Ho...> ;The Journal of Clinical Endocrinology and Metabolism. 2012 Jul 16
• 1199 citations
  Triglycerides and Cardiovascular Disease A Scientific Statement From the American Heart Association
  Michael Miller, Neil J. Stone, Christie M. Ballantyne, Vera Bittner, Michael H. Criqui, Henry N. Ginsberg, Anne C. Goldberg, William James Howard, Marc S. Jacobson, Pe...> ;Circulation. 2011 May 24
• 16 citations
  PREVENTION OF ATHEROSCLEROSIS WITH LDL-C LOWERING - LIPOPROTEIN CHANGES AND INTERACTIONS: THE SANDS STUDY.
  Howard, W. J., Russell, M., Fleg, J. L., Mete, M., Ali, T., Devereux, R. B., Galloway, J. M., Otvos, J. D., Ratner, R. E., Roman, M. J., Silverman, A., Umans, J. G., W...> ;Journal of clinical lipidology. 2010 Feb 18
• 121 citations
  Coronary Heart Disease Risk Equivalence in Diabetes Depends on Concomitant Risk Factors
  Barbara V. Howard, Lyle G. Best, James M. Galloway, William James Howard, Kristina L. Jones, Elisa T. Lee, Robert E. Ratner, Helaine E. Resnick, Richard B. Devereux> ;Diabetes Care. 2006 Feb 1
• 228 citations
  Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group IV: Lifestyle and Medical Management of Risk Factors
  Scott M. Grundy, Alan M. Garber, Ronald N. Goldberg, Stephen Havas, Rory Holman, Cynthia Lamendola, William James Howard, Peter J. Savage, James R. Sowers, Gloria Lena...> ;Circulation. 2002 May 7
• 88 citations
  Long-term cholesterol-lowering effects of psyllium as an adjunct to diet therapy in the treatment of hypercholesterolemia
  James W. Anderson, Michael H. Davidson, L Blonde, W V Brown, William James Howard, Henry N. Ginsberg, L D Allgood, K W Weingand> ;The American Journal of Clinical Nutrition. 2000 Jun 1
• 351 citations
  Rising tide of cardiovascular disease in American Indians. The Strong Heart Study.
  Barbara V. Howard, Elisa T. Lee, Linda D. Cowan, Richard B. Devereux, James M. Galloway, Oscar Go, William James Howard, Everett R. Rhoades, David C. Robbins, Maurice ...> ;Circulation. 1999 May 11
• 689 citations
  Cardiovascular Events and Their Reduction With Pravastatin in Diabetic and Glucose-Intolerant Myocardial Infarction Survivors With Average Cholesterol Levels Subgroup ...
  Ronald B. Goldberg, Margot J. Mellies, Frank M. Sacks, Lemuel A. Moyé, Barbara V. Howard, William James Howard, Barry R. Davis, Thomas G. Cole, Marc A. Pfeffer, Eugene...> ;Circulation. 1998 Dec 8
• 131 citations
  All-Cause Morality and Cardiovascular Disease Mortality in Three American Indian Populations, Aged 45–74 Years, 1984–1988 The Strong Heart Study
  Elisa T. Lee, Linda D. Cowan, Thomas K. Welty, Maurice L. Sievers, William James Howard, Arvo J. Oopik, Wenyu Wang, Jeunliang Yeh, Richard B. Devereux, Everett R. Rhoa...> ;American Journal of Epidemiology. 1998 Jun 1
• 3 citations
  Binding affinity and particle size of LDL in subjects with moderate hypercholesterolemia: relationship with in vivo LDL metabolism.
  Kiminori Yamane, Shinkuro Kataoka, Ngoc-Anh Le, Michael Paidi, William James Howard, Judy S. Hannah, Barbara V. Howard> ;Journal of Lipid Research. 1996 Aug 1
• 63 citations
  Dyslipidemia in Non-Insulin-Dependent Diabetes Mellitus
  Barbara V. Howard, William James Howard> ;Endocrine Reviews. 1994 Jun 1
• 12 citations
  Lipoid Proteinosis: Demonstration of Normal Lipid Metabolism in Cultured Cells
  , , > ;Archives of Dermatology. 1974 Oct 1
• 33 citations
  Lipid Metabolism in Cultured Cells
  Barbara V. Howard, William James Howard> ;Advances in Lipid Research. 1974 Jan 1
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Journal Articles

• Safety and Feasibility of Achieving Lower Systolic Blood Pressure Goals in People with Type 2 Diabetes: The SANDS Trial  
  Weir MR, Yeh F, Silverman A, Devereux RB, Galloway JM, Henderson JA, Howard WJ, Russell M, Wilson C, Ratner R, Sorkin J, Umans J, Fleg JL, Stylianou M, Lee E, Howard BV, Journal of Clinical Hypertension, 10/1/2009
• Prevention of atherosclerosis with low-density lipoprotein cholesterol lowering - lipoprotein changes and interactions: the SANDS study  
  Howard WJ, Russell M, Fleg JL, Mete M, Ali T, Devereux RB, Galloway JM, Otvos JD, Ratner RE, Roman MJ, Silverman A, Umans JG, Weissman NJ, Wilson C, Howard BV, Journal of Clinical Lipidology, 10/1/2009
• Relationship of Glycemic Control to Lipid and Blood Pressure Lowering and Atherosclerosis: the SANDS Experience Short running title: Glycemia, Lipids, & BP Control: ...  
  Mete M, Wilson C, Lee ET, Silverman A, Fleg JL, Russell M, Stylianou M, Umans JG, Wang W, Howard WJ, Howard BV, Ratner RE, Diabetes Care, 1/1/2009
• Cardiovascular Disease Prevalence and its Relation to Risk Factors in Alaska Eskimos (Short title) CVD and Risk Factors in Eskimos  
  Howard BV, Comuzzie A, Ebbesson SOE, Fabsitz RR, Howard WJ, Silverman A, Umans JG, Wang H, Weissman NJ, Nutrition and Metabolism and Cardiovascular Disease (NMCD), 1/1/2009
• C-Reactive Protein, Insulin Resistance, and Metabolic Syndrome in a Population with a High Burden of Subclinical Infection: Insights from the GOCADAN Study  
  Howard BV, Best L, Comuzzie A, Ebbesson SOE, Epstein SE, Fabsitz RR, Howard WJ, Silverman A, Wang H, Zhu J, and Umans J, Diabetes Care, 9/16/2008
• Effect of Lower Targets for Blood Pressure and LDL Cholesterol on Atherosclerosis in Diabetes: The SANDS Randomized Trial  
  Howard BV, Roman MJ, Devereux RB, Fleg JL, Galloway JM, Henderson JA, Howard WJ, Lee ET, Mete M, Poolaw B, Ratner RE, Russell M, Silverman A, Stylianou M, Umans JG, Wa..., JAMA, 1/1/2008
• Incidence and Risk Factors for Stroke in American Indians The Strong Heart Study  
  Zhang Y, Galloway JM, Welty TK, Wiebers DO, Whisnant JP, Devereux RB, Kizer JR, Howard BV, Cowan LD, Yeh J, Howard WJ, Wang W, Best L, Best ETL, Circulation, 1/1/2008
• Effect of Statins Alone Versus Statins Plus Ezetimibe on Carotid Atherosclerosis in Type 2 Diabetes: The SANDS (Stop Atherosclerosis in Native Diabetics Study) Trial  
  Fleg JL, Mete M, Howard BV, Umans JG, Roman MJ, Ratner RE, Silverman A, Galloway JM, Henderson JA, Weir MR, Wilson C, Stylianou M and Howard WM, Journal of the American College of Cardiology, 1/1/2008
• Coronary Heart Disease Risk Equivalence in Diabetes Depends on Concomitant Risk Factors  
  oward BV, Best LG, Galloway JM, Howard WJ, Jones K, Lee ET, Ratner RE, Resnick HE, Devereux RB, Diabetes Care, 2/1/2006
• Examination of Lower Targets for Low-Density Lipoprotein Cholesterol and Blood Pressure in Diabetes - the Stop Atherosclerosis in Native Diabetics Study (SANDS)  
  Russell M, Fleg J. Galloway J, Henderson J, Howard Wm, Lee E, Poolaw B, Ratner R, Roman M, Silverman A, Stylianou M, Weir M, Wilson C, Yeh F, Zhu J, Howard BV, Am Heart J, 1/1/2006
• Non-HDL Cholesterol as a Predictor of Cardiovascular Disease in Type 2 Diabetes: The Strong Heart Study  
  Lu W, Resnick HE, Jablonski KA, Jones KL, Jain AK, Howard WJ, Robbins DC, Howard BV, Diabetes Care, 1/1/2003
• LDL cholesterol is a strong predictor of coronary heart disease in diabetic individuals with insulin resistance and low LDL: The Strong Heart Study  
  Howard BV, Lee ET, Cowan LD, Devereux RB, Gray RS, Go OT, Howard WJ, Rhoades D, Robbins DC, Welty TK, Ather Thromb Vasc Biol, 1/1/2000
• The rising tide of cardiovascular disease in American Indians: The Strong Heart Study  
  Howard BV, Lee ET, Cowan LD, Devereux RB, Galloway JM, Go O, Howard WJ, Rhoades ER, Robbins DC, Sievers ML, Welty TK, Circulation, 1/1/1999
• All-Cause Mortality and Cardiovascular Disease Mortality in Three American Indian Populations, Aged 45-74 Years, 1984-88: The Strong Heart Study  
  Lee, E.T., Cowan, L.D., Welty, T.K., Sievers, M., Howard, W.J., Oopik, A., Wang, W., Yeh, J., Devereux, R.B., Rhoades, E.R., Fabsitz, R.R., Go, O., Howard, B.V., American Journal of Epidemiology, 1/1/1998
• Cardiovascular events and their reduction with pravastatin in diabetic and glucose-intolerant myocardial infarction survivors with average cholesterol levels  
  Goldberg RB, Mellies MJ, Sacks FM, Moye LA, Howard BV, Howard WJ, Davis BR, Circulation, 1/1/1998
• Effects of Psyllium on Cholesterol and Low-Density Lipoprotein Metabolism in Subjects with Hypercholesterolemia  
  Weingand, K.W.; Le, N.; Kuzmak, B.R.; Brown, W.V.; Daggy, B.P.; Miettinen, T.A.; Howard, B.V., Howard, W.J., Endocrinology and Metabolism, 1/1/1997
• Binding Affinity and Particle Size of LDL in Subjects with Moderate Hypercholesterolemia: Relationship with In Vivo LDL Metabolism  
  Yamane, K.; Kataoka, S.; Le, N.A.; Paidi, M.; Howard, W.J.; Hannah, J.S.; and Howard, B.V., Journal of Lipid Research, 1/1/1996
• Polyunsaturated Fatty Acids Result in Greater Cholesterol Lowering and Less Triacylglycerol Elevation than do Monounsaturated Fatty Acids in a Dose-response Comparison...  
  Howard, B.V., Hannah, J., Heiser, C.C., Jablonski, K.A., Paidi, M.C., Alarif, L., Robbins, D.C., and Howard, W.J., Am J Clin Nutr, 1/1/1995
• Coronary Heart Disease Prevalence and its Relation to Risk Factors in American Indians: The Strong Heart Study  
  Howard, B.V.; Lee, E.T.; Cowan, L.D.; Fabsitz, R.R.; Howard, W.J.; Oopik, A.J.; Robbins, D.C.; Savage, P.J.; Yeh, J.L.; and Welty, T.K., Am J Epidemiology, 1/1/1995
• Hypocholesterolemic Effects Of A Dietary Fiber Supplement  
  Hunninghake, D.B., Miller, V.T., LaRosa, J.C., Kinosian, B., Brown, V., Howard, W.J., DiSerio, J.J., and O'Connor, R.R, Am J Clin Nutr, 1/1/1994
• Dyslipidemia in Non-Insulin-Dependent Diabetes Mellitus  
  Howard, B.V. and Howard, W.J., Endocrine Reviews, 1/1/1994
• Long-Term Treatment of Hypercholesterolemia with Dietary Fiber  
  Hunninghake, D.B., Miller, V.T., LaRosa, J.C., Kinosian, B., Jacobson, T., Brown, V., Howard, W.J., Edelman, D. and O'Connor, R.R., Am J Med, 1/1/1994
• Dyslipidemia in non-insulin dependent diabetes mellitus  
  Howard BV, Howard WJ, Endocr Rev, 1/1/1994
• Aspetti Clinici della Cardiopatia Ischemica nel Paziente Diabetico  
  Howard, Wm. James, Il Diabete, 1/1/1993
• Is It Time for a Clinical Trial of Dietary Fish Oil Supplementation in Individuals with NIDDM?  
  Howard, W.J., Annals of New York Academy of Sciences, 1/1/1993
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Books/Book Chapters

• Medical Knowledge Self-assessment Program: MKSAP 13. 
  Chapter: Hyperlipoproteinemia. 
  Page 21 - 27Howard, W.J.American College of Physicians2004
• Clinical Medicine of Native Americans 
  Chapter: Primary Care of Native American Patients: Diagnosis, Therapy, and Epidemiology, Lipid abnormalities. 
  Page 141 - 150Robbins DC, Howard WJ, Howard BVEditors: Galloway JM, Goldberg BW and Alpert JS.The Center for Native American Health, Tucson, AZ1998
• Clinical Medicine of Native Americans. 
  Chapter: Lipid abnormalities. 
  Page 141 - 150Robbins, D.C.; Howard, W.J.; Howard B.V.Editors: J.M. Galloway , B.W. Goldberg and J.S. Alpert.The Center for Native American Health, Tucson, AZ1998
• Principles and Practice of Endocrinology and Metabolism. 
  Chapter: Lipid Abnormalities in Diabetes Mellitus. 
  Page 1402 - 1409Ratner, R.E.; Howard, B.V.; and Howard, W.J.Editors: Kenneth Becker.J.B. LippincottEdition 2nd,1995
• Joslin's Diabetes Mellitus. 
  Chapter: The Pathophysiology and Treatment of Lipid Disorders in Diabetes Mellitus. 
  Page 372 - 396Brown, W.V., Howard, W.J. and Field, LEditors: C.R. Kahn and G.C. Weir.Lea and FebigerEdition 13th,1994
• Drug Treatment of Hyperlipidemi. 
  Chapter: Nicotinic Acid and its Derivatives. 
  Page 189 - 213Brown, W.V., Howard, W.J. and Field, LEditors: B. Rifkind.Marcel Dekker1991
• Lipids in Tumors. 
  Chapter: Lipids in Normal and Tumor Cells in Culture. 
  Page 136 - 166Howard, B.V. and Howard W.J.Editors: K.K.Carroll.Karager1975
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Abstracts/Posters

• Lessons in Lipid Lowering from the SANDS trial.
  Fleg JL,Howard BV, Howard WJ, Clin Lipidol, 1/1/2009
• Stop Atherosclerosis in Native Diabetics study (SANDS): Baseline Characteristics of the randomized cohort.
  Silverman A, Huang CJ, Russell M, Mete M, Roman MJ, Stylianou M, Lee ET, Yeh F, Fleg J, Wilson C, Henderson JA, Ratner RE, Howard BV, Journal of Health Disparities Research and Practice, 1/1/2009
• Feasibility and Safety of More Intensive Blood Pressure Reduction: The SANDS Experience.
  Weir MR, Yeh F, Silverman A, Galloway J, Henderson JA, Howard WJ, Russell M, Wilson C, Sorkin J, Umans J, Fleg J, Lee E, Howard BV, American Society of Hypertension Meeting, 1/1/2008
• Safety and Efficacy of Achieving Lower LDL- and non-HDL-Cholesterol Goals in Type 2 Diabetes.
  Russell M, Howard BV, A Silverman, R E. Ratner, F Yeh, J L. Fleg, J Galloway, WJ. Howard., Multiple Presentations, 1/1/2008
• Coronary Risk Factors Predict Recurrent Coronary Events After Myocardial Infarction.
  Brown, L.; Nash D.T.; Cuddy, T. E.; Wilt, T.J.; Howard, W.J.; Moye, A.; Simpson, L.; Sacks, F.M., Circulation, 1/1/1998
• The SANDS Trial: Does Aggressive Lowering of LDL-C and Non-HDL-C in Diabetes Decrease the Plasma ApoB and LDL-C Particle Number?
  Barbara V Howard, Richard B Devereux, Jerome L Fleg, Wm. James Howard, Mihriye Mete, James D Otvos, Robert E Ratner, Mary J Roman, Marie Russell, Jason G Umans, Neil J..., AHA, 1/1/1998
• Effects of Psyllium on Serum Lipoproteins and Cholesterol Metabolism in Hypercholesterolemic Patients.
  Weingand, K.W.; Howard, B.V.; Le, N.A.; Kuzmak, B.R.; Miettinen, T.; Daggy, B.; Albrecht, H.; Allgood, L.; Brown, V.; Howard, W.J., American Heart Association's Scientific Conference on the Efficacy of Hypocholesterolemic Dietary Interventions, TX, 1/1/1995
• Effects of Obesity on the Response to a Low Fat Diet.
  Hannah, J.S.; Heiser, C.C.; Jablonski, K.A.; Paidi, M.C.; Robbins, D.C.; Howard, W.J.; Howard, B.V., Circulation, 10/1/1994
• Effects of monounsaturated (MONO) and polunsaturated (POLY) fat on HDL and triglycerides in moderate hypercholesterolemia.
  Hannah, J.S.; Heiser, C.C.; Jablonski, K.A.; Paidi, M.C.; Robbins, D.C.; Howard, W.J.; Howard, B.V., Athersclerosis, 1/1/1994
• The Influence of Hypertriglyceridemic Serum on Triglyceride Metabolism in Cultured Human Fibroblasts.
  Howard, W.J., Howard, B.V. and Kefalides, N.A., Clin Research, 1/1/1975
• Stimulation of Lipid Biosynthesis in WI-38 Cells. Different Passage Levels in Lipid-Free Medium in the Presence and Absence of Delipidized Serum Protein in vitro.
  Howard, B.V. and Howard, W.J., Proceedings of the Tissue Culture Association, 1/1/1974
• Treatment of Acromegaly with Medroxyprogesterone.
  Atkinson, R.L., Howard, W.J., Dimond, R.C., et al., Clin Research, 1/1/1971
• Control of Purine Biosynthesis: FGAR Amidotransferase.
  Howard, W.J. and Appel, S.H., Clin Research, 1/1/1968
• Effect of Lower Urinary Tract Infection On Ureteral Function.
  Schoenberg, H.W., Beisswanger, P., Howard, W.J., et al, Surgical Forum, 1/1/1963
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