WilliamH.IsacoffMD

Oncology • Los Angeles, CA

Clinical Professor, Medicine; Member, JCCC Clinical/Translational, UCLA School of Medicine

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Office
10921 Wilshire Blvd
Ste 505
Los Angeles, CA 90024
Phone+1 310-824-4133

Fax+1 310-208-1584
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Education & Training

University of Southern California/LAC+USC Medical CenterFellowship, Hematology and Medical Oncology, 1972 - 1975
Los Angeles County-Harbor-UCLA Medical CenterResidency, Internal Medicine, 1973 - 1974
New York Medical College (Metropolitan)Residency, Internal Medicine, 1971 - 1973
University of Southern California/LACUSC Medical CenterInternship, Transitional Year, 1970 - 1971
New York Medical CollegeClass of 1970

Certifications & Licensure

CA State Medical License 1973 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Clinical Trials

S9700 Combination Chemotherapy in Treating Patients With Stage II or Stage III Pancreatic Cancer Start of enrollment: 1997 Sep 01
Completed
Phase 2

Publications & Presentations

PubMed

4 citations
ChemoSensitivity Assay Guided Metronomic Chemotherapy Is Safe and Effective for Treating Advanced Pancreatic Cancer.
William H Isacoff, Brandon Cooper, Andrew Bartlett, Brian McCarthy, Kenneth H Yu> ;Cancers. 2022 Jun 13
23 citations
Low-Dose Continuous 5-Fluorouracil Combined with Leucovorin, nab-Paclitaxel, Oxaliplatin, and Bevacizumab for Patients with Advanced Pancreatic Cancer: A Retrospective...
William H. Isacoff, Howard A. Reber, Rudolph A. Bedford, William Arthur Hoos, Lola Rahib, Alexander Upfill-Brown, Timothy R. Donahue, O. Joe Hines> ;Targeted Oncology. 2018 Aug 1
39 citations
Locally Advanced Pancreatic Cancer: Association Between Prolonged Preoperative Treatment and Lymph-Node Negativity and Overall Survival
Brian E. Kadera, Dharma Sunjaya, William H. Isacoff, Luyi Li, O. Joe Hines, James S. Tomlinson, David W. Dawson, Matthew M. Rochefort, Graham W. Donald, Barbara M. Cle...> ;JAMA Surgery. 2014 Feb 1
68 citations
Impact of Tumor Grade on Pancreatic Cancer Prognosis: Validation of a Novel TNMG Staging System
Matthew M. Rochefort, Jacob S. Ankeny, Brian E. Kadera, Graham W. Donald, William H. Isacoff, Zev A. Wainberg, O. Joe Hines, Timothy R. Donahue, Howard A. Reber, James...> ;Annals of Surgical Oncology. 2013 Aug 14
53 citations
Downstaging Chemotherapy and Alteration in the Classic Computed Tomography/Magnetic Resonance Imaging Signs of Vascular Involvement in Patients With Pancreaticobiliary...
Timothy R. Donahue, William H. Isacoff, O. Joe Hines, James S. Tomlinson, James J. Farrell, Yasser M. Bhat, Edward B. Garon, Barbara M. Clerkin, Howard A. Reber> ;Archives of Surgery. 2011 Jul 18
8 citations
Impact of Splenectomy on Thrombocytopenia, Chemotherapy, and Survival in Patients with Unresectable Pancreatic Cancer
Timothy R. Donahue, Kevork Kazanjian, William H. Isacoff, Howard A. Reber, O. Joe Hines> ;Journal of Gastrointestinal Surgery. 2010 Mar 23
3 citations
Clinical management of long-term cancer survivors.
William H. Isacoff, Philip A. Philip> ;Journal of Clinical Oncology. 2008 Jan 1
32 citations
Phase II Trial of Infusional Fluorouracil, Leucovorin, Mitomycin, and Dipyridamole in Locally Advanced Unresectable Pancreatic Adenocarcinoma: SWOG S9700
William H. Isacoff, Jacqueline K. Bendetti, John J. Barstis, Abdul Rahman Jazieh, John S. Macdonald, Philip A. Philip> ;Journal of Clinical Oncology. 2007 May 1
Temozolomide/capecitabine therapy for metastatic neuroendocrine tumors of the pancreas. A retrospective review.
Isacoff WH, Moss RA, Pecora AL, Fine RL> ;J. Clin. Oncol.. 2006-06-20
130 citations
In vivo Therapeutic Responses Contingent on Fanconi Anemia/BRCA2 Status of the Tumor
Michiel S. van der Heijden, Jonathan R. Brody, David A. Dezentje, Eike Gallmeier, Steven C. Cunningham, Michael J. Swartz, Angelo M. DeMarzo, G. Johan A. Offerhaus, Wi...> ;Clinical Cancer Research. 2005 Oct 15
20 citations
Combination therapy for advanced pancreatic cancer using Herceptin plus chemotherapy.
Peter Büchler, Howard A. Reber, Guido Eibl, Mendel A. Roth, Markus W. Büchler, Helmut Friess, William H. Isacoff, Oscar J. Hines> ;International Journal of Oncology. 2005 Oct 1
94 citations
Improved survival for adenocarcinoma of the ampulla of Vater: fifty-five consecutive resections.
John P. Duffy, Oscar J. Hines, Jerome H. Liu, Clifford Y. Ko, Galen Cortina, William H. Isacoff, Henry Nguyen, Michael J. Leonardi, Ronald K. Tompkins, Howard A. Reber> ;Archives of Surgery. 2003 Sep 1
52 citations
Therapy for pancreatic cancer with a recombinant humanized anti-HER2 antibody (herceptin)
Peter Büchler, Howard A. Reber, Manuela C. Büchler, Mendel A. Roth, Markus W. Büchler, Helmut Friess, William H. Isacoff, Oscar J. Hines> ;Journal of Gastrointestinal Surgery. 2001 Mar 1
71 citations
Resection of locally advanced pancreatic cancer after downstaging with continuous-infusion 5-fluorouracil, mitomycin-C, leucovorin, and dipyridamole
Karen E. Todd, Beat Gloor, John S. Lane, William H. Isacoff, Howard A. Reber> ;Journal of Gastrointestinal Surgery. 1998 Mar 1
35 citations
Chemotherapy for the Treatment of Patients with Metastatic Colorectal Cancer: An Overview
William H. Isacoff, Katrina Borud> ;World Journal of Surgery. 1997 Sep 1
16 citations
Protein-methotrexate-IgG complexes in the serum of patients receiving high-dose antifolate therapy.
Maria da Costa, William H. Isacoff, Sheldon P. Rothenberg, M. Perwaiz Iqbal> ;Cancer. 1980 Aug 1
1 citations
Chemotherapy of Unresectable or Recurrent Metastatic Malignant Melanomas: An Update
Jerome B. Block, Hassan Tabbarah, William Isacoff, Thomas P. Drakes> ;The Journal of Dermatologic Surgery and Oncology. 1979 Feb 1
Phase II clinical trial with high-dose methotrexate therapy and citrovorum factor rescue.
Isacoff, W. H., Eilber, F., Tabbarah, H., Klein, P., Dollinger, M., Lemkin, S., Sheehy, P., Cone, L., Rosenbloom, B., Sieger, L., Block, J. B.> ;Cancer Treat Rep. 1978 Sep
Pharmacokinetics of high-dose methotrexate with citrovorum factor rescue.
Isacoff, W. H., Morrison, P. F., Aroesty, J., Willis, K. L., Block, J. B., Lincoln, T. L.> ;Cancer Treat Rep. 1977 Dec
Adjuvant chemotherapy in cancer.
Block, J. B., Isacoff, W. H.> ;Semin Oncol. 1977 Mar
Abnormal deoxyuridine suppression as a rapid predictor for antimetabolite chemosensitivity: correlation with in vitro tests of growth inhibition.
Block, J. B., Chlebowski, R. T., Dietrich, M. F., Isacoff, W. H.> ;Cancer Treat Rep. 1984 Apr
High dose methotrexate therapy of solid tumors: observations relating to clinical toxicity.
Isacoff, W. H., Townsend, C. M., Eiber, F. R., Forster, T., Morton, D. L., Block, J. B.> ;Med Pediatr Oncol. 1976
Endoscopic ultrasound does not accurately assess pathologic stage of esophageal cancer after neoadjuvant chemoradiotherapy.
Beseth, B. D., Bedford, R., Isacoff, W. H., Holmes, E. C., Cameron, R. B.> ;Am Surg. 2000 Sep
Amphotericin B effects in tissue culture cell lines.
Block, J. B., Isacoff, W., Dietrich, M.> ;Cancer Treat Rep. 1979 Apr
25 citations
Anti-VEGF antibody bevacizumab (Avastin) with 5FU/LV as third line treatment for colorectal cancer
C. Emmanouilides, Mark D. Pegram, R. Robinson, R. Hecht, Fairooz F. Kabbinavar, W. Isacoff> ;Techniques in Coloproctology. 2004 Nov 1
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Press Mentions

Finding Qualified Doctors Made All the DifferenceJanuary 4th, 2019