WilliamDavidKoltunMD

Obstetrics & Gynecology • San Diego, CA

General Gynecology

Director of Medical Center for Clinical Research

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Office
9040 Friars Rd
Suite 540
San Diego, CA 92108
Phone+1 619-787-7009

Fax+1 619-521-2830
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Education & Training

University of Southern California/LAC+USC Medical CenterResidency, Obstetrics and Gynecology, 1975 - 1979
Keck School of Medicine of the University of Southern CaliforniaClass of 1975

Certifications & Licensure

CA State Medical License 1977 - 2025
American Board of Obstetrics and Gynecology Obstetrics & Gynecology

Clinical Trials

The Plecanatide Chronic Idiopathic Constipation (CIC) Study Start of enrollment: 2011 Oct 01
Completed
Phase 2, Phase 3
Open-label Extension (OLE) Study of Plecanatide for Chronic Idiopathic Constipation (CIC) Start of enrollment: 2013 Aug 01
Completed
Phase 3
12-Week Study of Plecanatide for CIC (The CIC3 Study) Start of enrollment: 2013 Nov 01
Completed
Phase 3
Dose Ranging Safety and Efficacy of Therapeutic HSV-2 Vaccine Start of enrollment: 2014 Jul 01
Completed
Phase 2
A Study of Galcanezumab (LY2951742) in Participants With Migraine Headache Start of enrollment: 2014 Jul 07
Completed
Phase 2
A Comparison of Estradiol Vaginal Cream to Estrace® Cream in 350 Postmenopausal Females With Atrophic Vaginitis Start of enrollment: 2014 Jun 01
Completed
Phase 3
A Study Comparing Different Dosing Regimens of Ixekizumab (LY2439821) in Participants With Moderate to Severe Plaque Psoriasis Start of enrollment: 2015 Aug 01
Completed
Phase 3
A Study of Galcanezumab (LY2951742) in Participants 6 to 17 Years of Age With Episodic Migraine Start of enrollment: 2018 Mar 14
Recruiting
Phase 3
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Publications & Presentations

PubMed

23 citations
Effects of Different Doses of GEN-003, a Therapeutic Vaccine for Genital Herpes Simplex Virus-2, on Viral Shedding and Lesions: Results of a Randomized Placebo-Control...
Nicholas Van Wagoner, Kenneth H. Fife, Peter A. Leone, David I. Bernstein, Terri Warren, Lori Panther, Richard M. Novak, Richard H. Beigi, John D. Kriesel, Stephen K. ...> ;The Journal of Infectious Diseases. 2018 Nov 5
33 citations
A phase-3, double-blind, placebo-controlled study of the effectiveness and safety of single oral doses of secnidazole 2 g for the treatment of women with bacterial vag...
Jane R. Schwebke, Franklin G. Morgan, William D. Koltun, Paul Nyirjesy> ;American Journal of Obstetrics and Gynecology. 2017 Sep 1
17 citations
Experts explore the state of bacterial vaginosis and the unmet needs facing women and providers.
Steven E. Chavoustie, Scott E. Eder, William D. Koltun, Tracey R. Lemon, Caroline M. Mitchell, Paul Nyirjesy, Jack D. Sobel, Ryan Sobel, Rachel Villanueva> ;International Journal of Gynaecology and Obstetrics. 2017 May 1
90 citations
A Randomized Phase III Clinical Trial of Plecanatide, a Uroguanylin Analog, in Patients With Chronic Idiopathic Constipation.
Philip B. Miner, William Koltun, Gregory J Wiener, Marianela De La Portilla, Blas Prieto, Kunwar Shailubhai, Mary Beth Layton, Laura Barrow, Leslie Magnus, Patrick Gri...> ;The American Journal of Gastroenterology. 2017 Feb 7
9 citations
A Selective Estrogen Receptor Beta Agonist for the Treatment of Hot Flushes: Phase 2 Clinical Trial.
Mary Tagliaferri, Margit Cecile Tagliaferri, Jennifer M. Creasman, William D Koltun> ;Journal of Alternative and Complementary Medicine. 2016 Sep 1
43 citations
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinar...
Fernand Labrie, David F Archer, William Koltun, Andrée Vachon, Douglas Young, Louise Frenette, David Portman, Marlene Montesino, Isabelle Côté, Julie Parent, Lyne Lavo...> ;Menopause. 2016 Mar 1
61 citations
Effect of Intravaginal Prasterone on Sexual Dysfunction in Postmenopausal Women with Vulvovaginal Atrophy
Fernand Labrie, Leonard R. Derogatis, David F. Archer, William D. Koltun, Andrée Vachon, Douglas Young, Louise Frenette, David Portman, Marlene Montesino, Isabelle Côt...> ;The Journal of Sexual Medicine. 2015 Dec 1
55 citations
Lack of effect of intravaginal dehydroepiandrosterone (DHEA, prasterone) on the endometrium in postmenopausal women.
David Portman, Fernand Labrie, David F. Archer, Céline Bouchard, Leonello Cusan, Ginette Girard, Normand Ayotte, William D. Koltun, François Blouin, Douglas Young, Ant...> ;Menopause. 2015 Dec 1
65 citations
Treatment of pain at sexual activity (dyspareunia) with intravaginal dehydroepiandrosterone (prasterone).
David F. Archer, Fernand Labrie, Céline Bouchard, David Portman, William D. Koltun, Leonello Cusan, Claude Labrie, Isabelle Côté, Lyne Lavoie, Céline Martel, John Balser> ;Menopause. 2015 Sep 1
40 citations
Prasterone has parallel beneficial effects on the main symptoms of vulvovaginal atrophy: 52-week open-label study.
Fernand Labrie, David F. Archer, Céline Bouchard, Ginette Girard, Normand Ayotte, J. C. Gallagher, Leonello Cusan, Mira Baron, François Blouin, Arthur Waldbaum, Willia...> ;Maturitas. 2015 May 1
29 citations
Decreased efficacy of twice-weekly intravaginal dehydroepiandrosterone on vulvovaginal atrophy
Céline Bouchard, Fernand Labrie, David F. Archer, David Portman, W Koltun, É Elfassi, D A Grainger, Normand Ayotte, T A Cooper, M Martens, A S Waldbaum, Claude Labrie,...> ;Climacteric. 2015 Mar 3
8 citations
Randomized, Double-Blind, Multicenter Safety and Efficacy Study of Rifalazil Compared with Azithromycin for Treatment of Uncomplicated Genital Chlamydia trachomatis In...
William M. Geisler, Maria Luz G. Pascual, Judy S. Mathew, William Koltun, Franklin G. Morgan, Byron E. Batteiger, Annette Mayes, Sijia Tao, Selwyn J. Hurwitz, Chalom S...> ;Antimicrobial Agents and Chemotherapy. 2014 Jul 1
17 citations
Assessment of ospemifene or lubricants on clinical signs of VVA.
Ginger D. Constantine, Shelli Graham, William D. Koltun, Sheryl A. Kingsberg> ;The Journal of Sexual Medicine. 2014 Apr 1
22 citations
Norethindrone acetate 1.0 milligram and ethinyl estradiol 10 micrograms as an ultra low-dose oral contraceptive.
David F. Archer, Steven T. Nakajima, Allan T. Sawyer, Jeffrey Wentworth, Suzanne Trupin, William D. Koltun, Richard D. Gilbert, Herman Ellman> ;Obstetrics and Gynecology. 2013 Sep 1
67 citations
Solifenacin plus tamsulosin combination treatment in men with lower urinary tract symptoms and bladder outlet obstruction: a randomized controlled trial.
Steven A. Kaplan, Weizhong He, William D. Koltun, Jana Cummings, Tim Schneider, Allam Fakhoury> ;European Urology. 2013 Jan 1
9 citations
Safety and Efficacy of WC2031 Versus Vibramycin for the Treatment of Uncomplicated Urogenital Chlamydia trachomatis Infection: A Randomized, Double-blind, Double-Dummy...
William M. Geisler, William Koltun, Nader Abdelsayed, John Burigo, Leandro Mena, Stephanie N. Taylor, Byron E. Batteiger, Andrea R. Thurman, Edward W. Hook, Toby A. Va...> ;Clinical Infectious Diseases. 2012 Jul 1
27 citations
Treatment of moderate acne vulgaris using a combined oral contraceptive containing ethinylestradiol 20 μg plus drospirenone 3 mg administered in a 24/4 regimen: a pool...
William Koltun, J. Michael Maloney, Joachim Marr, Michael Kunz> ;European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2011 Apr 1
1 citations
Estradiol gel 0.1% relieves vasomotor symptoms independent of age, ovarian status, or uterine status.
Richard E Hedrick, Ronald T Ackerman, William D. Koltun, Mark Halvorsen> ;Menopause. 2010 Nov 1
8 citations
Single-day famciclovir for the treatment of genital herpes: follow-up results of time to next recurrence and assessment of antiviral resistance.
Neil Bodsworth, Kenneth H. Fife, William Koltun, Stephen K. Tyring, Mohammed Abudalu, Mark N. Prichard, Kamal Hamed> ;Current Medical Research and Opinion. 2009 Sep 29
48 citations
MF101, a selective estrogen receptor beta modulator for the treatment of menopausal hot flushes: a phase II clinical trial.
Deborah Grady, George F. Sawaya, Karen C. Johnson, William D Koltun, Rachel Hess, Eric Vittinghoff, Margaret Kristof, Mary Tagliaferri, Isaac Cohen, Kristine E. Ensrud> ;Menopause. 2009 May 1
20 citations
Transdermal estradiol gel 0.1% for the treatment of vasomotor symptoms in postmenopausal women.
Richard E Hedrick, Ronald T Ackerman, William D. Koltun, Mark Halvorsen, Lawrence J. Lambrecht> ;Menopause. 2009 Jan 1
20 citations
Single-day, Patient-Initiated Famciclovir Therapy Versus 3-day Valacyclovir Regimen for Recurrent Genital Herpes: A Randomized, Double-Blind, Comparative Trial
Mohammed Abudalu, Stephen K. Tyring, William Koltun, Neil Bodsworth, Kamal Hamed> ;Clinical Infectious Diseases. 2008 Sep 1
26 citations
A combined oral contraceptive containing 3-mg drospirenone/ 20-microg ethinyl estradiol in the treatment of acne vulgaris: a randomized, double-blind, placebo-controll...
Anne W. Lucky, William Koltun, Diane Thiboutot, Minoo Niknian, Carole Sampson-Landers, Paul Korner, Joachim Marr> ;Cutis. 2008 Aug 1
38 citations
Low-dose estradiol spray to treat vasomotor symptoms: a randomized controlled trial.
John E. Buster, William Koltun, Maria Luz G. Pascual, Wesley W. Day, Craig A. Peterson> ;Obstetrics and Gynecology. 2008 Jun 1
59 citations
Efficacy and safety of 3 mg drospirenone/20 mcg ethinylestradiol oral contraceptive administered in 24/4 regimen in the treatment of acne vulgaris: a randomized, doubl...
William Koltun, Anne W. Lucky, Diane Thiboutot, Minoo Niknian, Carole Sampson-Landers, Paul Korner, Joachim Marr> ;Contraception. 2008 Apr 1
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Journal Articles

Effects of Different Doses of GEN-003, a Therapeutic Vaccine for Genital HSV-2, on Viral Shedding and Lesions: Results of a Randomized Placebo-Controlled Trial
David I Bernstein, John Kriesel, William Koltun, Gregg Lucksinger, Peter A Leone, Richard Beigi, Stephen Tyring, Richard M Novak, Seth Hetherington, The Journal of Infectious Diseases