WilliamRRoeskeMD

Cardiology • Tucson, AZ

Adult Congenital Heart Disease, Cardiac Electrophysiology, Echocardiography

Professor, Medicine, University of Arizona College of Medicine

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Office
1501 N Campbell Ave
Tucson, AZ 85724
Phone+1 520-694-8888

Fax+1 520-694-2565
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Education & Training

University of California (San Diego) Medical CenterFellowship, Cardiovascular Disease, 1975 - 1976
University of California (San Diego) Medical CenterResidency, Internal Medicine, 1973 - 1975
Case Western Reserve University/University Hospitals Cleveland Medical CenterResidency, Internal Medicine, 1970 - 1973
Stanford University School of MedicineClass of 1970

Certifications & Licensure

OH State Medical License 1971 - 2024
CA State Medical License 1973 - 2023
AZ State Medical License 1976 - 2023
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 1982
Fellow (FACC) American College of Cardiology

Publications & Presentations

PubMed

27 citations
Tachykinin NK1 receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activation
Suneeta Tumati, Tally M. Largent-Milnes, Attila Keresztes, Takashi Yamamoto, Todd W. Vanderah, William R. Roeske, Victor J. Hruby, Eva V. Varga> ;European Journal of Pharmacology. 2012 Jun 5
35 citations
Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 ag...
Suneeta Tumati, Tally M. Largent-Milnes, Attila Keresztes, Jiyang Ren, William R. Roeske, Todd W. Vanderah, Eva V. Varga> ;Journal of Neuroimmunology. 2012 Mar 1
18 citations
Intrathecal PKA-selective siRNA treatment blocks sustained morphine-mediated pain sensitization and antinociceptive tolerance in rats.
Suneeta Tumati, William R. Roeske, Tally M. Largent-Milnes, Todd W. Vanderah, Eva V. Varga> ;Journal of Neuroscience Methods. 2011 Jul 15
14 citations
Sustained morphine treatment augments prostaglandin E2-evoked calcitonin gene-related peptide release from primary sensory neurons in a PKA-dependent manner
Suneeta Tumati, William R. Roeske, Todd W. Vanderah, Eva V. Varga> ;European Journal of Pharmacology. 2010 Dec 1
13 citations
Sustained morphine-mediated pain sensitization and antinociceptive tolerance are blocked by intrathecal treatment with Raf-1-selective siRNA
Suneeta Tumati, William R. Roeske, Tally M. Largent-Milnes, R Wang, Todd W. Vanderah, Eva V. Varga> ;British Journal of Pharmacology. 2010 Sep 1
18 citations
Sustained Morphine Treatment Augments Capsaicin-Evoked Calcitonin Gene-Related Peptide Release from Primary Sensory Neurons in a Protein Kinase A- and Raf-1-Dependent ...
Suneeta Tumati, Henry I. Yamamura, Todd W. Vanderah, William R. Roeske, Eva V. Varga> ;The Journal of Pharmacology and Experimental Therapeutics. 2009 Sep 1
2 citations
Sustained cannabinoid agonist treatment augments CGRP release in a PKA-dependent manner.
Suneeta Tumati, Henry I. Yamamura, Paul A. St. John, Todd W. Vanderah, William R. Roeske, Eva V. Varga> ;Neuroreport. 2009 May 27
14 citations
Intrathecal Raf-1-selective siRNA attenuates sustained morphine-mediated thermal hyperalgesia.
Suneeta Tumati, Tally Milnes, Henry I. Yamamura, Todd W. Vanderah, William R. Roeske, Eva V. Varga> ;European Journal of Pharmacology. 2008 Dec 28
29 citations
Sustained morphine treatment augments basal CGRP release from cultured primary sensory neurons in a Raf-1 dependent manner.
Xu Yue, Suneeta Tumati, Edita Navratilova, Dagmar Strop, Paul A. St. John, Todd W. Vanderah, William R. Roeske, Henry I. Yamamura, Eva V. Varga> ;European Journal of Pharmacology. 2008 Apr 28
46 citations
Unique agonist-bound cannabinoid CB1 receptor conformations indicate agonist specificity in signaling
Teodora Georgieva, Savitha Devanathan, Dagmar Stropova, Chad K. Park, Zdzislaw Salamon, Gordon Tollin, Victor J. Hruby, William R. Roeske, Henry I. Yamamura, Eva V. Varga> ;European Journal of Pharmacology. 2008 Feb 26
28 citations
Mediating δ-opioid-initiated heart protection via the β2-adrenergic receptor: role of the intrinsic cardiac adrenergic cell
Ming He Huang, Hui Qun Wang, William R. Roeske, Yochai Birnbaum, Yewen Wu, Ning Ping Yang, Yu Lin, Yumei Ye, David J. McAdoo, Michael G. Hughes, Scott D. Lick, Paul J....> ;American Journal of Physiology. Heart and Circulatory Physiology. 2007 Jul 1
14 citations
Quantitative Evaluation of Human δ Opioid Receptor Desensitization Using the Operational Model of Drug Action
Edita Navratilova, Sue Waite, Dagmar Stropova, Miriam C. Eaton, Isabel D. Alves, Victor J. Hruby, William R. Roeske, Henry I. Yamamura, Eva V. Varga> ;Molecular Pharmacology. 2007 May 1
17 citations
New paradigms and tools in drug design for pain and addiction.
Victor J. Hruby, Frank Porreca, Henry I. Yamamura, Gordon Tollin, Richard S. Agnes, Yeon Sun Lee, Minying Cai, Isabel D. Alves, Scott Cowell, Eva V. Varga, Peg Davis, ...> ;The AAPS Journal. 2006 Sep 1
19 citations
Chronic morphine-mediated adenylyl cyclase superactivation is attenuated by the Raf-1 inhibitor, GW5074.
Xu Yue, Eva V. Varga, Dagmar Stropova, Todd W. Vanderah, Henry I. Yamamura, William R. Roeske> ;European Journal of Pharmacology. 2006 Jul 1
11 citations
Morphine promotes phosphorylation of the human δ-opioid receptor at serine 363
Edita Navratilova, Miriam C. Eaton, Dagmar Stropova, Eva V. Varga, Todd W. Vanderah, William R. Roeske, Henry I. Yamamura> ;European Journal of Pharmacology. 2005 Sep 20
40 citations
Neuroendocrine properties of intrinsic cardiac adrenergic cells in fetal rat heart
Ming He Huang, Joseph J. Bahl, Yewen Wu, F. Hu, Douglas F. Larson, William R. Roeske, G. A. Ewy> ;American Journal of Physiology. Heart and Circulatory Physiology. 2005 Feb 1
8 citations
Antinociception depends on the presence of G protein γ2-subunits in brain
Eva V. Varga, Keiko Hosohata, Dariusz Borys, Edita Navratilova, Anders Nylen, Todd W. Vanderah, Frank Porreca, William R. Roeske, Henry I. Yamamura> ;European Journal of Pharmacology. 2005 Jan 31
33 citations
Agonist-specific regulation of the δ-opioid receptor
Eva V. Varga, Edita Navratilova, Dagmar Stropova, Janelle C. Jambrosic, William R. Roeske, Henry I. Yamamura> ;Life Sciences. 2004 Dec 24
4 citations
Mutation S363A in the human δ-opioid receptor selectively reduces down-regulation by a peptide agonist
Edita Navratilova, Eva V. Varga, Dagmar Stropova, Janelle C. Jambrosic, William R. Roeske, Henry I. Yamamura> ;European Journal of Pharmacology. 2004 Feb 6
10 citations
Postural position and neurocardiogenic syncope in late pregnancy.
Ming He Huang, William R. Roeske, Hong Hu, Julia H. Indik, Frank I. Marcus> ;The American Journal of Cardiology. 2003 Nov 15
32 citations
Molecular mechanisms of excitatory signaling upon chronic opioid agonist treatment
Eva V. Varga, Henry I. Yamamura, Marc Rubenzik, Dagmar Stropova, Edita Navratilova, William R. Roeske> ;Life Sciences. 2003 Dec 5
40 citations
Converging Protein Kinase Pathways Mediate Adenylyl Cyclase Superactivation upon Chronic δ-Opioid Agonist Treatment
Eva V. Varga, Marc Rubenzik, Dagmar Stropova, Masano Sugiyama, Vanessa Grife, Victor J. Hruby, Kenner C. Rice, William R. Roeske, Henry I. Yamamura> ;The Journal of Pharmacology and Experimental Therapeutics. 2003 Jul 1
6 citations
(2S, 3R)β-methyl-2', 6'-dimethyltyrosine-L-tetrahydroisoquinoline-3-carboxylic acid [(2S, 3R)TMT-L-Tic-OH] is a potent, selective δ-opioid receptor antagonist in mouse...
Keiko Hosohata, Eva V. Varga, Josue Alfaro-Lopez, Xuejun Tang, Todd W. Vanderah, Frank Porreca, Victor J. Hruby, William R. Roeske, Henry I. Yamamura> ;The Journal of Pharmacology and Experimental Therapeutics. 2003 Feb 1
19 citations
Agonist-specific down-regulation of the human δ-opioid receptor
Takashi Okura, Eva V. Varga, Yoshiaki Hosohata, Edita Navratilova, Scott Cowell, Kenner C. Rice, Hiroshi Nagase, Victor J. Hruby, William R. Roeske, Henry I. Yamamura> ;European Journal of Pharmacology. 2003 Jan 10
39 citations
Involvement of Raf-1 in chronic δ-opioid receptor agonist-mediated adenylyl cyclase superactivation
Eva V. Varga, Marc Rubenzik, Vanessa Grife, Masano Sugiyama, Dagmar Stropova, William R. Roeske, Henry I. Yamamura> ;European Journal of Pharmacology. 2002 Sep 6
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Grant Support

Cardiac Neurohumoral ReceptorsNational Heart, Lung, And Blood Institute1993–1997
Neurohumoral Receptors In Cardiac Growth, Hypertension, HypertrophyNational Heart, Lung, And Blood Institute1988–1992
The Heart In Organ CultureNational Heart, Lung, And Blood Institute1985–1987
Neurohumoral Receptors In Cardiac Growth And Compensatory HypertrophyNational Heart, Lung, And Blood Institute1985–1987