WilliamBSlaytonMD

Pediatric Hematology & Oncology • Gainesville, FL

Associate Professor, Pediatrics, University of Florida College of Medicine

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Office
1600 Sw Archer Rd
Gainesville, FL 32610
Phone+1 352-273-9120
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Education & Training

University of Utah HealthFellowship, Pediatric Hematology/Oncology, 1997 - 1999
University of FloridaResidency, Pediatrics, 1992 - 1995
University of Florida College of MedicineClass of 1992

Certifications & Licensure

FL State Medical License 1996 - 2025
UT State Medical License 1997 - 2004
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

Fellow (FAAP) American Academy of Pediatrics

Clinical Trials

Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors Start of enrollment: 2004 Mar 25
Recruiting
Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Start of enrollment: 2008 Jul 14
Completed
Phase 2, Phase 3
Neuropsychological and Behavioral Testing in Younger Patients With Cancer Start of enrollment: 2009 Feb 27
Recruiting
Collecting and Storing Malignant, Borderline Malignant Neoplasms, and Related Samples From Young Patients With Cancer Start of enrollment: 2003 Oct 13
Completed
Study of Kidney Tumors in Younger Patients Start of enrollment: 2006 Feb 27
Recruiting
Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma Start of enrollment: 2000 Nov 06
Recruiting
Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma Start of enrollment: 1999 Mar 15
Completed
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Start of enrollment: 2009 Sep 14
Active, not recruiting
Phase 3
Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Ependymoma Start of enrollment: 2010 May 07
Active, not recruiting
Phase 3
Risk-Based Classification System of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Start of enrollment: 2010 Aug 09
Completed
Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma Start of enrollment: 2010 Aug 09
Active, not recruiting
Phase 3
Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors Start of enrollment: 2010 Nov 22
Completed
Phase 2
Caspofungin Versus Fluconazole in Preventing Invasive Fungal Infections (IFI) in Patients Undergoing Chemotherapy for Acute Myeloid Leukemia Start of enrollment: 2011 Apr 04
Completed
Phase 3
Vincristine, Dexamethasone, Doxorubicin, and PEG-asparaginase (VPLD) and Metformin for Relapsed Childhood Acute Lymphoblastic Leukemia (ALL) Start of enrollment: 2011 Jul 18
Completed
Phase 1
Modafinil in Treating Children With Memory and Attention Problems Caused by Cancer Treatment for a Brain Tumor Start of enrollment: 2011 Aug 01
Completed
Phase 2
A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine (IND# 73789, NSC# 606869) in the Very High Risk Stratum Start of enrollment: 2012 Feb 01
Assessing Compliance With Mercaptopurine Treatment in Younger Patients With Acute Lymphoblastic Leukemia in First Remission Start of enrollment: 2012 Feb 21
Active, not recruiting
Phase 3
Metformin in Children With Relapsed or Refractory Solid Tumors Start of enrollment: 2012 Sep 24
Completed
Phase 1
Intergroup Trial for Children or Adolescents With B-Cell NHL or B-AL: Evaluation of Rituximab Efficacy and Safety in High Risk Patients Start of enrollment: 2012 Jun 01
Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors Start of enrollment: 2012 Jun 27
Active, not recruiting
Phase 2
Sorafenib and Topotecan in Refractory/Recurrent Pediatric Malignancies Start of enrollment: 2013 Jan 01
Completed
Phase 1
Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Dinutuximab in Treating Younger Patients With Refractory or Relapsed Neuroblastoma Start of enrollment: 2013 Feb 12
Completed
Phase 2
Open Label, Phase II Study to Evaluate Efficacy and Safety of Oral Nilotinib in Philadelphia Positive (Ph+) Chronic Myelogenous Leukemia (CML) Pediatric Patients. Start of enrollment: 2013 Aug 20
Completed
Phase 2
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Start of enrollment: 2009 Sep 01
Bosutinib in Pediatric Patients With Newly Diagnosed Chronic Phase or Resistant/Intolerant Ph + Chronic Myeloid Leukemia Start of enrollment: 2020 Apr 06
Active, not recruiting
Phase 1, Phase 2
Roles: Contact, Principal Investigator
Chemoradiotherapy With Targeted Immunotherapy in Pediatric Lymphoma Start of enrollment: 2022 Feb 01
Recruiting
Phase 2
Roles: Contact
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Publications & Presentations

PubMed

Epstein Barr virus-directed T-cell therapy for refractory EBV-PTLD in a toddler post Orthotopic heart transplantation.
Emily Work, Dipankar Gupta, William B Slayton, John Rees, John-Anthony Coppola, Robert Seifert, Mark S Bleiweis, Jeffrey P Jacobs, Giles Peek, Joseph Philip, Alan Broc...> ;Pediatric Transplantation. 2024 Mar 1
2 citations
Dasatinib with intensive chemotherapy in de novo paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (CA180-372/COG AALL1122): a single-arm, mult...
Stephen P Hunger, Thai Hoa Tran, Vaskar Saha, Meenakshi Devidas, Maria Grazia Valsecchi, Julie M Gastier-Foster, Giovanni Cazzaniga, Shalini C Reshmi, Michael J Borowi...> ;The Lancet. Haematology. 2023 Jul 1
2 citations
Feasibility study of busulfan, fludarabine, and thiotepa conditioning regimen for allogeneic hematopoietic stemcell transplantationfor children and young adults with n...
Ally Fraser, Paul Castillo, Erika Cascio, Giselle Moore-Higgs, Nosha Farhadfar, John Fort, William Slayton, Jatinder Lamba, Biljana Horn> ;Pediatric Blood & Cancer. 2023 Jul 1
1 citations
Trends in Pediatric Cancer Care in Florida From 1981-2020: Changing Patterns in a Growing and Increasingly Diverse Population.
Peter H Shaw, Jonathan Metts, Ernest Amankwah, Don E Eslin, Scott Bradfield, William B Slayton, Brian Hays, Brian Calkins, Juan Rico, Jeffrey Krischer> ;Cureus. 2023 Feb 1
7 citations
Establishing Cost-Effective Allocation of Proton Therapy for Patients With Mediastinal Hodgkin Lymphoma
Raymond B. Mailhot Vega, Homan Mohammadi, Samir Patel, Adam L. Holtzman, Natalie A. Lockney, James W. Lynch, Manisha M. Bansal, Xiaoying Liang, William B. Slayton, Sus...> ;International Journal of Radiation Oncology, Biology, Physics. 2021 Aug 2
1 citations
Eating behaviors and dietary quality in childhood acute lymphoblastic leukemia survivors
Marie L. Chardon, Stefania Pinto, William B. Slayton, Rachel S. Fisher, David M. Janicke> ;Pediatric Blood & Cancer. 2021 Apr 1
Incidence and Risk Factors for 30-Day Readmission after Inpatient Chemotherapy among Acute Lymphoblastic Leukemia Patients.
Phuong T. Tran, William B. Slayton, Mansi Dalal, Joshua D. Brown> ;Healthcare. 2020 Oct 14
12 citations
How we approach Philadelphia chromosome-positive acute lymphoblastic leukemia in children and young adults.
William B. Slayton, Kirk R. Schultz, Lewis B. Silverman, Stephen P. Hunger> ;Pediatric Blood & Cancer. 2020 Oct 1
1 citations
Irradiating Residual Disease to 30 Gy with Proton Therapy in Pediatric Mediastinal Hodgkin Lymphoma
Bradford S. Hoppe, Raymond B. Mailhot Vega, Nancy P. Mendenhall, Eric Sandler, William B. Slayton, Howard M. Katzenstein, Michael Joyce, Zuofeng Li, S. Flampouri> ;International Journal of Particle Therapy. 2020 Mar 1
4 citations
Post Transplant Lymphoproliferative Disorder risk factors in children: Analysis of a 23‐year single‐institutional experience
Raphael C. Bosse, Aaron J Franke, William Paul Skelton, Lindsey E. Woody, Rohit Bishnoi, Yu Wang, Dhanashree Rajderkar, Renata Shih, Nam H. Dang, William B. Slayton, S...> ;Pediatric Transplantation. 2020 Aug 1
Primary pulmonary artery sarcoma in the pediatric patient: Review of literature and a case report
Yong Yean Kim, Tung Wynn, John D. Reith, William B. Slayton, Joanne Lagmay, John Fort, Dhanashree Rajderkar> ;Radiology Case Reports. 2020 May 24
33 citations
GD2 chimeric antigen receptor modified T cells in synergy with sub-toxic level of doxorubicin targeting osteosarcomas.
Monrat Chulanetra, Atthapan Morchang, Elias Sayour, Lamis Eldjerou, Rowan J. Milner, Joanne Lagmay, Matt Cascio, Brian Stover, William B. Slayton, Wanpen Chaicumpa, Pa...> ;American Journal of Cancer Research. 2020 Feb 1
10 citations
A genomics-informed computational biology platform prospectively predicts treatment responses in AML and MDS patients.
Leylah Drusbosky, Neeraj Kumar Singh, Kimberly E. Hawkins, Cesia Salan, Madeleine Turcotte, Elizabeth Wise, Amy Meacham, Vindhya Vijay, Glenda G. Anderson, Charlie C. ...> ;Blood Advances. 2019 Jun 25
28 citations
Functional Improvement of Chimeric Antigen Receptor Through Intrinsic Interleukin-15Rα Signaling.
Sushmita Nair, Jing-Bo Wang, Shih-Ting Tsao, Yuchen Liu, Wei Zhu, William B. Slayton, Jan S. Moreb, Lujia Dong, Lung-Ji Chang> ;Current Gene Therapy. 2019 Jan 31
147 citations
Dasatinib plus intensive chemotherapy in children, adolescents, and young adults with philadelphia chromosome–positive acute lymphoblastic leukemia: Results of childre...
William B. Slayton, Kirk R. Schultz, John A. Kairalla, Meenakshi Devidas, Xinlei Mi, Michael A. Pulsipher, Bill H. Chang, Charles G. Mullighan, Ilaria Iacobucci, Lewis...> ;Journal of Clinical Oncology. 2018 May 29
12 citations
Developmental Stage-Specific Manifestations of Absent TPO/c-MPL Signalling in Newborn Mice.
Viola Lorenz, Haley E. Ramsey, Zhi-Jian Liu, Joseph E. Italiano, Karin M. Hoffmeister, Sihem Bihorel, Donald E. Mager, Zhongbo Hu, William B. Slayton, Benjamin T. Kile...> ;Thrombosis and Haemostasis. 2017 Dec 6
1 citations
Minimal Change Disease as Initial Presentation of ALK-Positive Anaplastic Large-Cell Lymphoma in a Pediatric Patient.
Karla Diaz, William B. Slayton, Nirupama Gupta> ;Case Reports in Oncology. 2017 Sep 1
9 citations
Importance of baseline PET/CT imaging on radiation field design and relapse rates in patients with Hodgkin Lymphoma
Nick Figura, Stella Flampouri, Nancy P. Mendenhall, Christopher G. Morris, Barry McCook, Savas Ozdemir, William B. Slayton, Eric Sandler, Bradford S. Hoppe> ;Advances in Radiation Oncology. 2017 Apr 1
31 citations
Post-transplant lymphoproliferative disorder (PTLD): single institutional experience of 141 patients
Rohit Bishnoi, Ravneet Bajwa, Aaron J Franke, William Paul Skelton, Yu Wang, Niraj Patel, William B. Slayton, Fei Zou, Nam H. Dang> ;Experimental Hematology & Oncology. 2017 Sep 29
20 citations
Proton Therapy for Pediatric Hodgkin Lymphoma
Justin Wray, Stella Flampouri, William B. Slayton, Michael Joyce, Eric Sandler, Christopher G. Morris, Zuofeng Li, Daniel J. Indelicato, Nancy P. Mendenhall, Bradford ...> ;Pediatric Blood & Cancer. 2016 Sep 1
9 citations
Proton therapy to the subdiaphragmatic region in the management of patients with Hodgkin lymphoma.
Suzanne Sachsman, Bradford S. Hoppe, Nancy P. Mendenhall, Adam L. Holtzman, Zuofeng Li, William B. Slayton, Mike Joyce, Eric Sandler, Stella Flampouri> ;Leukemia & Lymphoma. 2015 Jul 1
15 citations
Two novel RUNX1 mutations in a patient with congenital thrombocytopenia that evolved into a high grade myelodysplastic syndrome
Jessica M. Schmit, Daniel Turner, Robert Hromas, John R. Wingard, Randy A. Brown, Ying Li, Marilyn M. Li, William B. Slayton, Christopher R. Cogle> ;Leukemia Research Reports. 2015 Jan 1
52 citations
Involved-node proton therapy in combined modality therapy for Hodgkin lymphoma: results of a phase 2 study.
Bradford S. Hoppe, Stella Flampouri, Robert Zaiden, William B. Slayton, Eric Sandler, Savas Ozdemir, Nam H. Dang, James W. Lynch, Zuofeng Li, Christopher G. Morris, Na...> ;International Journal of Radiation Oncology, Biology, Physics. 2014 Aug 1
18 citations
Integrin VLA-5 and FAK are Good Targets to Improve Treatment Response in the Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia
Zhongbo Hu, William B. Slayton> ;Frontiers in Oncology. 2014 May 15
19 citations
Bartonella henselae infection inducing hemophagocytic lymphohistiocytosis in a kidney transplant recipient
Atul Poudel, Judy F. Lew, William B. Slayton, Vikas R. Dharnidharka> ;Pediatric Transplantation. 2014 May 1
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Press Mentions

HealthSteps & AMA Form Data Model Collaboration to SupportFebruary 11th, 2019
Mobile Health Company HealthSteps Wins the American Medical Association Health Care Interoperability and Innovation ChallengeJuly 19th, 2018

Grant Support

Progenitors For Erythrocytic &Megakaryocytic LineagesNational Heart, Lung, And Blood Institute2002–2003
Progenitors For Erythrocytic &Megakaryocytic LineagesNational Heart, Lung, And Blood Institute2000–2001
Progenitors For Erythrocytic And Megakaryocytic LineagesNational Heart, Lung, And Blood Institute1999