WilliamRoySmytheMD

Thoracic Surgery • Boulder, CO

Cardiovascular Surgery, Clinical Informatics

Chief Executive Officer, SomaLogic

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Office
2945 Wilderness Place
Boulder, CO 80301
Phone+1 720-417-7542
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Education & Training

University of Pennsylvania Health SystemFellowship, Thoracic Surgery, 1996 - 1998
University of Pennsylvania Health SystemResidency, Surgery, 1989 - 1996
Texas A&M; Health Science Center College of MedicineClass of 1989

Certifications & Licensure

TX State Medical License 1998 - 2015

Awards, Honors, & Recognition

Fellow (FACS) American College of Surgeons

Publications & Presentations

PubMed

16 citations
Association between diabetes and esophageal cancer, independent of obesity, in the United States Veterans Affairs population.
J. L. Dixon, Laurel A. Copeland, John E. Zeber, Andrea A. MacCarthy, Scott I. Reznik, W. R. Smythe, Philip A. Rascoe> ;Diseases of the Esophagus. 2016 Oct 1
2 citations
RECOMBINANT BCL-XL ATTENUATES VASCULAR HYPERPERMEABILITY IN A RAT MODEL OF HEMORRHAGIC SHOCK.
Binu Tharakan, SI McNeal, Felicia A. Hunter, DA Sawant, WR Smythe, Ed W. Childs> ;Cell Death Discovery. 2015 Nov 9
Enhancing Surgical Safety Using Digital Multimedia Technology
Dhriti Mukhopadhyay, Jennifer L Dixon, William R Smythe, Harry T Papaconstantinou> ;American Journal of Surgery. 2015 Nov 09
8 citations
Can Laparoscopic Cholecystectomy Be Performed with a Positive Margin at Medicaid Reimbursement Rates
Richard C. Frazee, Victoria G. Elliott, Wilma I. Larsen, Seth Lerner, Keith W. Minnis, Court Huber, James Nolan, Harry T. Papaconstantinou, W. Roy Smythe> ;Journal of the American College of Surgeons. 2014 Apr 1
Doxycycline attenuates burn-induced microvascular hyperpermeability.
Stagg, H. W.,Whaley, J. G.,Tharakan, B.,Hunter, F. A.,Jupiter, D.,Little, D. C.,Davis, M. L.,Smythe, W. R.,Childs, E. W.> ;J Trauma Acute Care Surg. 2013 Nov 22
42 citations
Surgical Safety Checklist Compliance: A Job Done Poorly!
Eric A. Sparks, Hania Wehbe-Janek, Rebecca L. Johnson, W. Roy Smythe, Harry T. Papaconstantinou> ;Journal of the American College of Surgeons. 2013 Nov 1
Surgical Safety Checklist and Operating Room Efficiency: Results from a Large Multispecialty Tertiary Care Hospital
Harry T Papaconstantinou, Stephen Sibbitt, William R Smythe, Scott I Reznik> ;American Journal of Surgery. 2013 Oct 8
4 citations
Thymic neuroendocrine carcinoma producing ectopic adrenocorticotropic hormone and Cushing's syndrome.
Jennifer L. Dixon, Sanket P. Borgaonkar, Anupa K. Patel, Scott I. Reznik, W. Roy Smythe, Philip A. Rascoe> ;The Annals of Thoracic Surgery. 2013 Oct 1
Quick Response codes for surgical safety: a prospective pilot study.
Dixon, J. L.,Smythe, W. R.,Momsen, L. S.,Jupiter, D.,Papaconstantinou, H. T.> ;J. Surg. Res.. 2013 Sep
1 citations
Surgical resection of giant fibrous dysplasia for near respiratory collapse.
Jennifer L. Dixon, W. Roy Smythe, Philip A. Rascoe, Scott I. Reznik> ;The Annals of Thoracic Surgery. 2013 Jun 1
51 citations
Surgical care improvement project and surgical site infections: can integration in the surgical safety checklist improve quality performance and clinical outcomes?
Matthew M. Tillman, Hania Wehbe-Janek, Bonnie Hodges, W. Roy Smythe, Harry T. Papaconstantinou> ;The Journal of Surgical Research. 2013 Sep 1
29 citations
Are Commercial Negative Pressure Systems Worth the Cost in Open Abdomen Management
Richard C. Frazee, Stephen W. Abernathy, Daniel C. Jupiter, John C. Hendricks, Matthew J. Davis, Justin L. Regner, Travis V. Isbell, Randall W. Smith, W. Roy Smythe> ;Journal of the American College of Surgeons. 2013 Apr 1
Microvascular endothelial cell hyperpermeability induced by endogenous caspase 3 activator staurosporine.
Sawant, D. A.,Tharakan, B.,Tobin, R. P.,Reilly, J.,Hunter, F. A.,Newell, M. K.,Smythe, W. R.,Childs, E. W.> ;J Trauma Acute Care Surg. 2013 Feb
8 citations
Inhibition of Fas-Fas ligand interaction attenuates microvascular hyperpermeability following hemorrhagic shock.
Devendra A. Sawant, Binu Tharakan, Richard P Tobin, Hayden W. Stagg, Felicia A. Hunter, M. Karen Newell, W. Roy Smythe, Ed W. Childs> ;Shock. 2013 Feb 1
66 citations
The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition
Chander Peddaboina, Daniel C. Jupiter, Steven Fletcher, Jeremy L. Yap, Arun Rai, Richard P Tobin, Weihua Jiang, Philip A. Rascoe, M. Karen Newell Rogers, W. Roy Smythe...> ;BMC Cancer. 2012 Nov 21
38 citations
Molecular pathogenesis of malignant mesothelioma.
Philip A. Rascoe, Daniel C. Jupiter, Xiaobo Cao, James E. Littlejohn, W. Roy Smythe> ;Expert Reviews in Molecular Medicine. 2012 May 24
40 citations
Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors.
Jeremy L. Yap, Xiaobo Cao, Kenno Vanommeslaeghe, Kwan-Young Jung, Chander Peddaboina, Paul T. Wilder, Anjan Nan, Alexander D. MacKerell, W. Roy Smythe, Steven Fletcher> ;Organic & Biomolecular Chemistry. 2012 Mar 22
34 citations
β-Catenin dynamics in the regulation of microvascular endothelial cell hyperpermeability.
Binu Tharakan, Joseph Hellman, Devendra A. Sawant, John H. Tinsley, Alan R. Parrish, Felicia A. Hunter, W. Roy Smythe, Ed W. Childs> ;Shock. 2012 Mar 1
8 citations
Benign emptying of the postpneumonectomy space
Robert E. Merritt, Scott I. Reznik, Marcelo C. DaSilva, David J. Sugarbaker, Richard I. Whyte, Dean M. Donahue, Chuong D. Hoang, W. Roy Smythe, Joseph B. Shrager> ;The Annals of Thoracic Surgery. 2011 Sep 1
18 citations
Chondrosarcoma of the Thorax
Philip A. Rascoe, Scott I. Reznik, W. Roy Smythe> ;Sarcoma. 2011 May 11
20 citations
Role of β-catenin in regulating microvascular endothelial cell hyperpermeability.
Devendra A Sawant, Binu Tharakan, Felicia A. Hunter, W. Roy Smythe, Ed W. Childs> ;The Journal of Trauma. 2011 Feb 1
Inhibition of VE-cadherin proteasomal degradation attenuates microvascular hyperpermeability.
Sawant, D.A., Tharakan, B., Adekanbi, A., Hunter, F.A., Smythe, W.R., Childs, E.W.> ;Microcirculation. 2011 Jan
19 citations
Curcumin inhibits reactive oxygen species formation and vascular hyperpermeability following haemorrhagic shock
Binu Tharakan, Felicia A. Hunter, W. Roy Smythe, Ed W. Childs> ;Clinical and Experimental Pharmacology & Physiology. 2010 Sep 1
26 citations
17beta-estradiol mediated protection against vascular leak after hemorrhagic shock: role of estrogen receptors and apoptotic signaling.
Ed W. Childs, Binu Tharakan, Felicia A. Hunter, W. Roy Smythe> ;Shock. 2010 Sep 1
21 citations
Characterization of bortezomib-adapted I-45 mesothelioma cells
Lidong Zhang, James E. Littlejohn, Yu Cui, Xiaobo Cao, Chander Peddaboina, W. Roy Smythe> ;Molecular Cancer. 2010 May 18
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Professional Memberships

American College of Surgeons - ACS
Member