XiaodongChengMD

PubMed

• 2 citations
  Paradoxes of Cellular SUMOylation Regulation: A Role of Biomolecular Condensates?
  Xiaodong Cheng, Wenli Yang, Wei Lin, Fang Mei> ;Pharmacological Reviews. 2023 Sep 1
• 5 citations
  Protein SUMOylation and phase separation: partners in stress?
  Xiaodong Cheng> ;Trends in Biochemical Sciences. 2023 May 1
• 6 citations
  Epac1 activation by cAMP regulates cellular SUMOylation and promotes the formation of biomolecular condensates.
  Wenli Yang, William G Robichaux 3rd, Fang C Mei, Wei Lin, Li Li, Sheng Pan, Mark A White, Yuan Chen, Xiaodong Cheng> ;Science Advances. 2022 Apr 22
• 4 citations
  Epac1-/- and Epac2-/- mice exhibit deficient epithelial Na+ channel regulation and impaired urinary Na+ conservation.
  Viktor N Tomilin, Kyrylo Pyrshev, Anna Stavniichuk, Naghmeh Hassanzadeh Khayyat, Guohui Ren, Oleg Zaika, Sherif Khedr, Alexander Staruschenko, Fang C Mei, Xiaodong Che...> ;JCI Insight. 2022 Feb 8
• 16 citations
  Pharmacological Inhibition of Epac1 Averts Ferroptosis Cell Death by Preserving Mitochondrial Integrity.
  Nshunge Musheshe, Asmaa Oun, Angélica María Sabogal-Guáqueta, Marina Trombetta-Lima, Sarah C Mitchel, Ahmed Adzemovic, Oliver Speek, Francesca Morra, Christina H J T v...> ;Antioxidants. 2022 Feb 4
• 2 citations
  Origin and Isoform Specific Functions of Exchange Proteins Directly Activated by cAMP: A Phylogenetic Analysis.
  Zhuofu Ni, Xiaodong Cheng> ;Cells. 2021 Oct 14
• 5 citations
  Metformin protects against diclofenac-induced toxicity in primary rat hepatocytes by preserving mitochondrial integrity via a pathway involving EPAC.
  Fabio Alejandro Aguilar Mora, Nshunge Musheshe, Johanna C. Arroyave Ospina, Yana Geng, Juan M. Soto, José Rodrigo, Tatiana Alieva, Manon Buist-Homan, Frank Lezoualc'h,...> ;Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 2021 Aug 28
• 1543 citations
  Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
  Ko, F., Daniel J. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie H. Abildgaard, Yakubu Prin...> ;Autophagy. 2021 Feb 8
• 16 citations
  Epac1 (Exchange Protein Directly Activated by cAMP 1) Upregulates LOX-1 (Oxidized Low-Density Lipoprotein Receptor 1) to Promote Foam Cell Formation and Atherosclerosi...
  William G. Robichaux, Fang C Mei, Wenli Yang, Hui Wang, Hua Sun, Zhen Zhou, Dianna M. Milewicz, Ba-Bie Teng, Xiaodong Cheng> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2020 Oct 15
• 83 citations
  Discovery of COVID-19 Inhibitors Targeting the SARS-CoV-2 Nsp13 Helicase.
  Mark A. White, Wei Lin, Xiaodong Cheng> ;The Journal of Physical Chemistry Letters. 2020 Oct 14
• 10 citations
  Discovery of COVID-19 Inhibitors Targeting the SARS-CoV2 Nsp13 Helicase
  Mark A. White, Wei Lin, Xiaodong Cheng> ;Biorxiv. 2020 Aug 10
• 15 citations
  Novel role of dynamin-related-protein 1 in dynamics of ER-lipid droplets in adipose tissue.
  Xin Li, Li Yang, Zhengmei Mao, Xueyang Pan, Yueshui Zhao, Xue Gu, Kristin Eckel-Mahan, Zhongyuan Zuo, Qiang Tong, Sean M. Hartig, Xiaodong Cheng, Guangwei Du, David D....> ;FASEB Journal. 2020 Jun 1
• 30 citations
  Neuronal Epac1 mediates retinal neurodegeneration in mouse models of ocular hypertension
  Wei Liu, Yonju Ha, Fan Xia, Shuang Zhu, Yi Li, Shuizhen Shi, Fang C Mei, Kevin H. Merkley, Gianmarco Vizzeri, Massoud Motamedi, Xiaodong Cheng, Hua Liu, Wenbo Zhang> ;The Journal of Experimental Medicine. 2020 Apr 6
• 12 citations
  EPAC1 and EPAC2 promote nociceptor hyperactivity associated with chronic pain after spinal cord injury.
  Samantha C. Berkey, Juan J. Herrera, Max A. Odem, Simran Rahman, Sai S. Cheruvu, Xiaodong Cheng, Edgar T. Walters, Carmen W. Dessauer, Alexis Bavencoffe> ;Neurobiology of Pain. 2020 Jan 1
• 19 citations
  Epac1 inhibition ameliorates pathological angiogenesis through coordinated activation of Notch and suppression of VEGF signaling
  Hua Liu, Fang C Mei, Wenli Yang, Hui Wang, Eitan Wong, Jingjing Cai, Emma Toth, Pei Luo, Yue Ming Li, Wenbo Zhang, Xiaodong Cheng> ;Science Advances. 2020 Jan 1
• 9 citations
  Conformational States of Exchange Protein Directly Activated by cAMP (EPAC1) Revealed by Ensemble Modeling and Integrative Structural Biology.
  Mark A. White, Tamara Tsalkova, Fang C Mei, Xiaodong Cheng> ;Cells. 2019 Dec 21
• 14 citations
  Recent Advances in EPAC-Targeted Therapies: A Biophysical Perspective
  Alveena Ahmed, Stephen Boulton, Hongzhao Shao, Madoka Akimoto, Amarnath Natarajan, Xiaodong Cheng, Giuseppe Melacini> ;Cells. 2019 Nov 19
• 22 citations
  β Cell–intrinsic β-arrestin 1 signaling enhances sulfonylurea-induced insulin secretion
  Luiz Felipe Barella, Mario Rossi, Lu Zhu, Yinghong Cui, Fang C. Mei, Xiaodong Cheng, Wei Chen, Vsevolod V. Gurevich, Jürgen Wess> ;The Journal of Clinical Investigation. 2019 Sep 3
• 20 citations
  Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators.
  Stephen Boulton, Rajeevan Selvaratnam, Rashik Ahmed, Katherine Van, Xiaodong Cheng, Giuseppe Melacini> ;Journal of Medicinal Chemistry. 2019 May 10
• Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine.
  Yang, J.,Horton, J. R.,Li, J.,Huang, Y.,Zhang, X.,Blumenthal, R. M.,Cheng, X.> ;Nucleic Acids Res.. 2019 May 14
• 18 citations
  Structural basis for effects of CpA modifications on C/EBPβ binding of DNA
  Jie Yang, John R. Horton, Dongxue Wang, Ren Ren, Jia Li, Deqiang Sun, Yun Huang, Xing Zhang, Robert Blumenthal, Xiaodong Cheng> ;Nucleic Acids Research. 2019 Feb 28
• 6 citations
  Urinary concentrating defect in mice lacking Epac1 or Epac2.
  Alena Cherezova, Viktor N. Tomilin, Vadym Buncha, Oleg Zaika, Pablo A. Ortiz, Fang Mei, Xiaodong Cheng, Mykola Mamenko, Oleh Pochynyuk> ;FASEB Journal. 2019 Feb 1
• 85 citations
  SETD3 is an actin histidine methyltransferase that prevents primary dystocia
  Alex W. Wilkinson, Jonathan Diep, Shaobo Dai, Shuo Liu, Yaw Shin Ooi, Dan Song, Tie-Mei Li, John R. Horton, Xing Zhang, Chao Liu, Darshan V. Trivedi, Katherine M. Rupp...> ;Nature. 2019 Jan 1
• 33 citations
  Detecting and interpreting DNA methylation marks.
  Ren Ren, John R. Horton, Xing Zhang, Robert Blumenthal, Xiaodong Cheng> ;Current Opinion in Structural Biology. 2018 Jul 19
• 81 citations
  KDM5 histone demethylases repress immune response via suppression of STING
  Lizhen Wu, Jian Cao, Wesley L. Cai, Sabine Lang, John R. Horton, Daniel J. Jansen, Zongzhi Liu, Jocelyn F. Chen, Meiling Zhang, Bryan T. Mott, Katherine Pohida, Ganesh...> ;Plos Biology. 2018 Aug 6
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