DavidDTranMDPhD

Neuro-Oncology

Co-Director, USC Brain Tumor Center Chief, Neuro-Oncology Professor of Neurosurgery and Neurology University of Southern California Keck School of Medicine

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Office
Department of Neurosurgery, USC Keck School of Medicine
1200 N State St #3300
Los Angeles, CA 90033
Phone+1 323-409-7422
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Clinical Expertise

Neuro-oncology, Tumor immunotherapy, Biomedical research

Education & Training

Washington University/B-JH/SLCH ConsortiumFellowship, Hematology and Medical Oncology, 2007 - 2011
Washington University/B-JH/SLCH ConsortiumResidency, Internal Medicine, 2005 - 2007
Mayo Clinic College of MedicineClass of 2005
Mayo Clinic College of MedicinePhD, Biomedical Sciences, 2003

Certifications & Licensure

CA State Medical License 2023 - 2025
FL State Medical License 2015 - 2023
MO State Medical License 2007 - 2016
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification Allscripts Enterprise EHR, Allscripts, 2012

Clinical Trials

Study of a Drug [DCVax®-L] to Treat Newly Diagnosed GBM Brain Cancer Start of enrollment: 2006 Dec 01
Active, not recruiting
Phase 3
Concentration and Activity of Lapatinib in Vestibular Schwannomas Start of enrollment: 2009 Jun 01
Completed
Early Phase 1
Effect of NovoTTF-100A Together With Temozolomide in Newly Diagnosed Glioblastoma Multiforme (GBM) Start of enrollment: 2009 Jun 01
Completed
Phase 3
Post-approval Study of NovoTTF-100A in Recurrent GBM Patients Start of enrollment: 2012 Dec 01
Terminated
Phase 4
Armodafinil in Reducing Cancer-Related Fatigue in Patients With High Grade Glioma Start of enrollment: 2013 Jun 01
Completed
Phase 3
Vaccine Therapy With Bevacizumab Versus Bevacizumab Alone in Treating Patients With Recurrent Glioblastoma Multiforme That Can Be Removed by Surgery Start of enrollment: 2013 May 01
Terminated
Phase 2
MRI-Guided Laser Surgery and Doxorubicin Hydrochloride in Treating Patients With Recurrent Glioblastoma Multiforme Start of enrollment: 2013 Aug 13
Completed
Phase 1
TTFields and Pulsed Bevacizumab for Recurrent Glioblastoma Start of enrollment: 2016 Dec 19
Terminated
Phase 2
FORWARD Optune and Adjuvant TMZ in Grade II/III Astrocytoma Start of enrollment: 2019 May 20
Terminated
Phase 2
A Dose Finding Phase 1 of Sarilumab Plus Capecitabine in HER2/Neu-Negative Metastatic Breast Cancer and a Single-arm, Historically-controlled Phase 2 Study of Sarilumab Plus Capecitabine in Stage I-III Triple Negative Breast Cancer With High-Risk Residual Disease (EMPOWER) Start of enrollment: 2020 Sep 26
Recruiting
Phase 1, Phase 2
Study Testing The Safety and Efficacy of Adjuvant Temozolomide Plus TTFields (Optune®) Plus Pembrolizumab in Patients With Newly Diagnosed Glioblastoma (2-THE-TOP) Start of enrollment: 2018 Feb 23
Active, not recruiting
Phase 2
MK-3475 in Combination With MRI-guided Laser Ablation in Recurrent Malignant Gliomas Start of enrollment: 2015 Aug 05
Active, not recruiting
Phase 1, Phase 2
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Publications & Presentations

PubMed

A Spatial Interpolation Approach to Assign MRI-Derived Material Properties for Finite Element Models of Aav Infusion Into a Recurrent Brain Tumor.
Reed Chen, Julian Rey, Malisa Sarntinoranont, Ibrahim Tuna, David Tran> ;Journal of Biomechanical Engineering. 2024 Apr 6
39 citations
Tumor Treating Fields dually activate STING and AIM2 inflammasomes to induce adjuvant immunity in glioblastoma.
Dongjiang Chen, Son B Le, Tarun E Hutchinson, Anda-Alexandra Calinescu, Mathew Sebastian, Dan Jin, Tianyi Liu, Ashley Ghiaseddin, Maryam Rahman, David D Tran> ;The Journal of Clinical Investigation. 2022 Apr 15
117 citations
Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma: A P...
Linda M Liau, Keyoumars Ashkan, Steven Brem, Jian L Campian, John E Trusheim, Fabio M Iwamoto, David D Tran, George Ansstas, Charles S Cobbs, Jason A Heth, Michael E S...> ;JAMA Oncology. 2023 Jan 1
1 citations
The trial effect in patients with glioblastoma: effect of clinical trial enrollment on overall survival.
Kaitlyn F Melnick, Patricia Miller, Ethan Carmichael, Kyle McGrath, Ashley Ghiaseddin, David D Tran, Maryam Rahman> ;Journal of Neuro-Oncology. 2022 Sep 1
Corrigendum to: A phase II study of laser interstitial thermal therapy combined with doxorubicin in patients with recurrent glioblastoma.
Omar H Butt, Alice Y Zhou, Jiayi Huang, William A Leidig, Alice E Silberstein, Milan G Chheda, Tanner M Johanns, George Ansstas, Jingxia Liu, Grayson Talcott, Ruth Nak...> ;Neuro-Oncology Advances. 2022 Apr 29
17 citations
A phase II study of laser interstitial thermal therapy combined with doxorubicin in patients with recurrent glioblastoma
Omar H Butt, Alice Y Zhou, Jiayi Huang, William A Leidig, Alice E Silberstein, Milan G Chheda, Tanner Michael Johanns, George Ansstas, Jingxia Liu, Grayson Talcott, Ru...> ;Neuro-Oncology Advances. 2021 Nov 15
11 citations
Role of Laser Interstitial Thermal Therapy in the Management of Primary and Metastatic Brain Tumors.
Kaitlyn Melnick, David Shin, Farhad Dastmalchi, Zain Kabeer, Maryam Rahman, David Tran, Ashley Ghiaseddin> ;Current Treatment Options in Oncology. 2021 Oct 23
8 citations
Tumor Treating Fields for Glioblastoma Therapy During the COVID-19 Pandemic
Na Tosha Gatson, Jill S. Barnholtz-Sloan, Jan Drappatz, Roger Henriksson, Andreas F. Hottinger, Piet Hinoul, Carol Kruchko, Vinay K. Puduvalli, David Tran, Eric T. Won...> ;Frontiers in Oncology. 2021 May 7
12 citations
In situ vaccination with laser interstitial thermal therapy augments immunotherapy in malignant gliomas
David Shin, Kaitlyn Melnick, David Tran, Ashley Ghiaseddin> ;Journal of Neuro-Oncology. 2021 Jan 1
10 citations
Intracranial myxoid mesenchymal neoplasms with EWSR1 gene rearrangement: report of 2 midline cases with one demonstrating durable response to MET inhibitor monotherapy.
Yanel De Los Santos, David Shin, Samuel L. Malnik, Marie Rivera-Zengotita, David Tran, Ashley Ghiaseddin, Jesse Kresak> ;Neuro-Oncology Advances. 2021 Jan 1
22 citations
A Bayesian Adaptive Randomized Phase II Multicenter Trial of Bevacizumab with or without Vorinostat in Adults with Recurrent Glioblastoma.
Vinay K. Puduvalli, Jing Wu, Ying Yuan, Terri S. Armstrong, Elizabeth Vera, Jimin Wu, Jihong Xu, Pierre Giglio, Howard Colman, Tobias Walbert, Jeffrey Raizer, Morris D...> ;Neuro-Oncology. 2020 Oct 14
43 citations
Tumor Treating Fields in the Management of Patients with Malignant Gliomas.
Ashley Ghiaseddin, David Shin, Kaitlyn Melnick, David Tran> ;Current Treatment Options in Oncology. 2020 Jul 30
86 citations
Rindopepimut with Bevacizumab for Patients with Relapsed EGFRvIII-Expressing Glioblastoma (ReACT): Results of a Double-Blind Randomized Phase II Trial.
, , , , , , , , , , , , , , , , , , , , > ;Clinical Cancer Research. 2020 Feb 7
45 citations
A phase 1 and randomized, placebo‐controlled phase 2 trial of bevacizumab plus dasatinib in patients with recurrent glioblastoma: Alliance/North Central Cancer Treatme...
Evanthia Galanis, S. Keith Anderson, Erin Twohy, Xiomara W. Carrero, Jesse G. Dixon, David Tran, Suriya A. Jeyapalan, Timothy J. Kaufmann, Ryan W. Feathers, Caterina G...> ;Cancer. 2019 Nov 1
15 citations
Combining CDK4/6 inhibitors ribociclib and palbociclib with cytotoxic agents does not enhance cytotoxicity.
Dan Jin, Nguyen Tran, Nagheme Thomas, David Tran> ;Plos One. 2019 Oct 10
52 citations
Quantitative characterization of 3D bioprinted structural elements under cell generated forces.
Cameron Morley, S. Tori Ellison, Tapomoy Bhattacharjee, Christopher S. O’Bryan, Yifan Zhang, Kourtney F Smith, Christopher P. Kabb, Mathew Sebastian, Ginger Moore, Kyl...> ;Nature Communications. 2019 Jul 10
9 citations
Correction: First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma [J Transl Med., 16, (...
Linda M. Liau, Keyoumars Ashkan, David Tran, Jian Campian, John E. Trusheim, Charles S. Cobbs, Jason Heth, Michael Salacz, Sarah A. Taylor, Stacy D. D’Andre, Fabio M. ...> ;Journal of Translational Medicine. 2018 Jun 29
167 citations
First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma.
Linda M Liau, Keyoumars Ashkan, David D Tran, Jian L Campian, John E Trusheim, Charles S Cobbs, Jason A Heth, Michael Salacz, Sarah Taylor, Stacy D D'Andre, Fabio M Iw...> ;Journal of Translational Medicine. 2018 May 29
35 citations
Biological and therapeutic implications of multisector sequencing in newly diagnosed glioblastoma
Tatenda Mahlokozera, Ananth K. Vellimana, Tiandao Li, Diane D. Mao, Zohny Zohny, David Kim, David Tran, Daniel S. Marcus, Sarah Jost Fouke, Jian Campian, Gavin P. Dunn...> ;Neuro-Oncology. 2018 Mar 27
34 citations
Final results of a phase I dose-escalation, dose-expansion study of adding disulfiram with or without copper to adjuvant temozolomide for newly diagnosed glioblastoma.
Jiayi Huang, Jian Campian, Amit D. Gujar, Christina I. Tsien, George Ansstas, David Tran, Todd DeWees, A. Craig Lockhart, Albert H. Kim> ;Journal of Neuro-Oncology. 2018 Jan 27
1297 citations
Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma: A Randomized Clinical Trial
Roger Stupp, Sophie Taillibert, Andrew A. Kanner, William L. Read, David M. Steinberg, Benoit Lhermitte, Steven A. Toms, Ahmed Idbaih, Manmeet Ahluwalia, Karen Fink, F...> ;JAMA. 2017 Dec 19
Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial.
Weller M, Butowski N, Tran DD, Recht LD, Lim M, Hirte H, Ashby L, Mechtler L, Goldlust SA, Iwamoto F, Drappatz J, O'Rourke DM, Wong M, Hamilton MG, Finocchiaro G, Perr...> ;The Lancet. Oncology. 2017-08-23
5 citations
Eleven Month Progression–Free Survival on Vemurafenib Monotherapy in a Patient With Recurrent and Metastatic BRAF V600E–Mutated Glioblastoma WHO Grade 4
Kanita Beba Abadal, Meggen A. Walsh, Anthony T. Yachnis, David Tran, Ashley Ghiaseddin> ;JCO Precision Oncology. 2017 Aug 16
80 citations
An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma
Amit D. Gujar, Son Le, Diane D. Mao, David Y. A. Dadey, Alice Turski, Yo Sasaki, Diane J. Aum, Jingqin Luo, Sonika Dahiya, Liya Yuan, Keith M. Rich, Jeffrey Milbrandt,...> ;Proceedings of the National Academy of Sciences of the United States of America. 2016 Dec 20
19 citations
Molecular and histologic characteristics of pseudoprogression in diffuse gliomas.
Andrew L. Lin, Michael White, Michelle M. Miller-Thomas, Robert S. Fulton, Christina Tsien, Keith M. Rich, Robert E. Schmidt, David Tran, Sonika Dahiya> ;Journal of Neuro-Oncology. 2016 Oct 4
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Press Mentions

Zai Lab Announces First Quarter 2022 Financial Results and Corporate UpdatesMay 11th, 2022
Updated 2-THE-TOP Data Suggest Improvements in Progression-Free Survival, Overall Survival Compared to Matched-Control Patients from EF-14 TrialMarch 24th, 2022
Study Shows TTFields Holds Promise to Potentially Trigger Immune Response Against GBM RecurrenceFebruary 25th, 2022
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